"Perforin" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A calcium-dependent pore-forming protein synthesized in cytolytic LYMPHOCYTES and sequestered in secretory granules. Upon immunological reaction between a cytolytic lymphocyte and a target cell, perforin is released at the plasma membrane and polymerizes into transmembrane tubules (forming pores) which lead to death of a target cell.
Descriptor ID |
D054353
|
MeSH Number(s) |
D12.776.543.695.875
|
Concept/Terms |
Perforin- Perforin
- Lymphocyte Pore-Forming Protein
- Lymphocyte Pore Forming Protein
- Pore-Forming Protein, Lymphocyte
- Perforin 1
- Cytolysin
|
Below are MeSH descriptors whose meaning is more general than "Perforin".
Below are MeSH descriptors whose meaning is more specific than "Perforin".
This graph shows the total number of publications written about "Perforin" by people in this website by year, and whether "Perforin" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
Year | Major Topic | Minor Topic | Total |
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2002 | 0 | 1 | 1 |
2004 | 0 | 1 | 1 |
2005 | 0 | 1 | 1 |
2006 | 0 | 2 | 2 |
2009 | 1 | 0 | 1 |
2012 | 0 | 1 | 1 |
2014 | 1 | 2 | 3 |
2015 | 0 | 1 | 1 |
2017 | 0 | 4 | 4 |
2018 | 0 | 6 | 6 |
2019 | 0 | 1 | 1 |
2020 | 2 | 2 | 4 |
2021 | 0 | 1 | 1 |
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Below are the most recent publications written about "Perforin" by people in Profiles.
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In vitro Interleukin-7 treatment partially rescues MAIT cell dysfunction caused by SARS-CoV-2 infection. Sci Rep. 2021 07 08; 11(1):14090.
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Immunological and inflammatory profiles during acute and convalescent phases of severe/ critically ill COVID-19 patients. Int Immunopharmacol. 2021 Aug; 97:107685.
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Perforin gene variant A91V in young patients with severe COVID-19. Haematologica. 2020 12 01; 105(12):2844-2846.
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An Inflammatory Profile Correlates With Decreased Frequency of Cytotoxic Cells in Coronavirus Disease 2019. Clin Infect Dis. 2020 11 19; 71(16):2272-2275.
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Defining the CD39/CD73 Axis in SARS-CoV-2 Infection: The CD73- Phenotype Identifies Polyfunctional Cytotoxic Lymphocytes. Cells. 2020 07 22; 9(8).
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COVID-19 pneumonia: CD8+ T and NK cells are decreased in number but compensatory increased in cytotoxic potential. Clin Immunol. 2020 09; 218:108516.
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Aberrant hyperactivation of cytotoxic T-cell as a potential determinant of COVID-19 severity. Int J Infect Dis. 2020 Aug; 97:313-321.
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Perforin and resistance to SARS coronavirus 2. J Allergy Clin Immunol. 2020 Jul; 146(1):52-53.
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Adoptive lymphocyte transfer to an HIV-infected progressor from an elite controller. JCI Insight. 2019 09 19; 4(18).
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Fine Tuning the Cytokine Storm by IFN and IL-10 Following Neurotropic Coronavirus Encephalomyelitis. Front Immunol. 2018; 9:3022.