Proteinase Inhibitory Proteins, Secretory
"Proteinase Inhibitory Proteins, Secretory" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Peptides and proteins found in BODILY SECRETIONS and BODY FLUIDS that are PROTEASE INHIBITORS. They play a role in INFLAMMATION, tissue repair and innate immunity (IMMUNITY, INNATE) by inhibiting endogenous proteinases such as those produced by LEUKOCYTES and exogenous proteases such as those produced by invading microorganisms.
| Descriptor ID |
D053491
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| MeSH Number(s) |
D12.644.822 D12.776.645
|
| Concept/Terms |
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Below are MeSH descriptors whose meaning is more general than "Proteinase Inhibitory Proteins, Secretory".
Below are MeSH descriptors whose meaning is more specific than "Proteinase Inhibitory Proteins, Secretory".
This graph shows the total number of publications written about "Proteinase Inhibitory Proteins, Secretory" by people in this website by year, and whether "Proteinase Inhibitory Proteins, Secretory" was a major or minor topic of these publications.
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click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 2005 | 0 | 1 | 1 |
| 2010 | 1 | 0 | 1 |
| 2015 | 1 | 0 | 1 |
| 2017 | 2 | 0 | 2 |
| 2018 | 1 | 0 | 1 |
| 2019 | 1 | 0 | 1 |
| 2020 | 1 | 1 | 2 |
| 2021 | 1 | 0 | 1 |
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Below are the most recent publications written about "Proteinase Inhibitory Proteins, Secretory" by people in Profiles.
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a1-Antitrypsin: Key Player or Bystander in Acute Respiratory Distress Syndrome? Anesthesiology. 2021 05 01; 134(5):792-808.
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Priming of SARS-CoV-2 S protein by several membrane-bound serine proteinases could explain enhanced viral infectivity and systemic COVID-19 infection. J Biol Chem. 2021 Jan-Jun; 296:100135.
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Tissue damage from neutrophil-induced oxidative stress in COVID-19. Nat Rev Immunol. 2020 09; 20(9):515-516.
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Neutrophil elastase inhibitor (sivelestat) may be a promising therapeutic option for management of acute lung injury/acute respiratory distress syndrome or disseminated intravascular coagulation in COVID-19. J Clin Pharm Ther. 2020 Dec; 45(6):1515-1519.
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Neutrophil Elastase Inhibitors: A potential prophylactic treatment option for SARS-CoV-2-induced respiratory complications? Crit Care. 2020 06 08; 24(1):311.
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Peptidase inhibitor 15 as a novel blood diagnostic marker for cholangiocarcinoma. EBioMedicine. 2019 Feb; 40:422-431.
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TMPRSS11A activates the influenza A virus hemagglutinin and the MERS coronavirus spike protein and is insensitive against blockade by HAI-1. J Biol Chem. 2018 09 07; 293(36):13863-13873.
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Characterisation of eppin function: expression and activity in the lung. Eur Respir J. 2017 07; 50(1).
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The Role of Neutrophil Elastase Inhibitors in Lung Diseases. Chest. 2017 08; 152(2):249-262.
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The Ability of Secretory Leukocyte Protease Inhibitor to Inhibit Apoptosis in Monocytes Is Independent of Its Antiprotease Activity. J Immunol Res. 2015; 2015:507315.