"Proline" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A non-essential amino acid that is synthesized from GLUTAMIC ACID. It is an essential component of COLLAGEN and is important for proper functioning of joints and tendons.
| Descriptor ID |
D011392
|
| MeSH Number(s) |
D12.125.072.401.623
|
| Concept/Terms |
|
Below are MeSH descriptors whose meaning is more general than "Proline".
Below are MeSH descriptors whose meaning is more specific than "Proline".
This graph shows the total number of publications written about "Proline" by people in this website by year, and whether "Proline" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 2006 | 0 | 1 | 1 |
| 2012 | 0 | 1 | 1 |
| 2014 | 2 | 1 | 3 |
| 2015 | 0 | 2 | 2 |
| 2016 | 1 | 2 | 3 |
| 2017 | 4 | 25 | 29 |
| 2018 | 2 | 26 | 28 |
| 2019 | 1 | 5 | 6 |
| 2020 | 1 | 2 | 3 |
| 2021 | 3 | 2 | 5 |
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Below are the most recent publications written about "Proline" by people in Profiles.
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Supervised Molecular Dynamics (SuMD) Insights into the mechanism of action of SARS-CoV-2 main protease inhibitor PF-07321332. J Enzyme Inhib Med Chem. 2021 Dec; 36(1):1646-1650.
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Challenges of short substrate analogues as SARS-CoV-2 main protease inhibitors. Bioorg Med Chem Lett. 2021 10 15; 50:128333.
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Repurposing nonnucleoside antivirals against SARS-CoV2 NSP12 (RNA dependent RNA polymerase): In silico-molecular insight. Biochem Biophys Res Commun. 2021 09 24; 571:26-31.
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Natural Transmission of Bat-like Severe Acute Respiratory Syndrome Coronavirus 2 Without Proline-Arginine-Arginine-Alanine Variants in Coronavirus Disease 2019 Patients. Clin Infect Dis. 2021 07 15; 73(2):e437-e444.
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Expedited Approach toward the Rational Design of Noncovalent SARS-CoV-2 Main Protease Inhibitors. J Med Chem. 2022 02 24; 65(4):2848-2865.
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A mechanism for matrikine regulation in acute inflammatory lung injury. JCI Insight. 2021 04 08; 6(7).
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Targeted design of drug binding sites in the main protease of SARS-CoV-2 reveals potential signatures of adaptation. Biochem Biophys Res Commun. 2021 05 28; 555:147-153.
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Is PF-00835231 a Pan-SARS-CoV-2 Mpro Inhibitor? A Comparative Study. Molecules. 2021 Mar 17; 26(6).
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Drug repositioning to target NSP15 protein on SARS-CoV-2 as possible COVID-19 treatment. J Comput Chem. 2021 05 15; 42(13):897-907.
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Virus vaccines: proteins prefer prolines. Cell Host Microbe. 2021 03 10; 29(3):327-333.