Structure-Activity Relationship
"Structure-Activity Relationship" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
The relationship between the chemical structure of a compound and its biological or pharmacological activity. Compounds are often classed together because they have structural characteristics in common including shape, size, stereochemical arrangement, and distribution of functional groups.
| Descriptor ID |
D013329
|
| MeSH Number(s) |
G02.111.830 G07.690.773.997
|
| Concept/Terms |
Structure-Activity Relationship- Structure-Activity Relationship
- Relationship, Structure-Activity
- Relationships, Structure-Activity
- Structure Activity Relationship
- Structure-Activity Relationships
|
Below are MeSH descriptors whose meaning is more general than "Structure-Activity Relationship".
Below are MeSH descriptors whose meaning is more specific than "Structure-Activity Relationship".
This graph shows the total number of publications written about "Structure-Activity Relationship" by people in this website by year, and whether "Structure-Activity Relationship" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1994 | 0 | 2 | 2 |
| 1995 | 0 | 1 | 1 |
| 1997 | 0 | 1 | 1 |
| 1999 | 0 | 1 | 1 |
| 2000 | 0 | 1 | 1 |
| 2003 | 0 | 3 | 3 |
| 2004 | 0 | 1 | 1 |
| 2005 | 0 | 7 | 7 |
| 2006 | 0 | 11 | 11 |
| 2007 | 0 | 1 | 1 |
| 2008 | 0 | 6 | 6 |
| 2009 | 0 | 2 | 2 |
| 2010 | 0 | 2 | 2 |
| 2011 | 0 | 3 | 3 |
| 2012 | 0 | 3 | 3 |
| 2013 | 0 | 4 | 4 |
| 2014 | 1 | 5 | 6 |
| 2015 | 0 | 2 | 2 |
| 2016 | 0 | 11 | 11 |
| 2017 | 5 | 157 | 162 |
| 2018 | 6 | 148 | 154 |
| 2019 | 0 | 63 | 63 |
| 2020 | 0 | 17 | 17 |
| 2021 | 0 | 23 | 23 |
To return to the timeline, click here.
Below are the most recent publications written about "Structure-Activity Relationship" by people in Profiles.
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Flavonoids as inhibitors of human neutrophil elastase. J Enzyme Inhib Med Chem. 2021 Dec; 36(1):1016-1028.
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Pan-coronavirus fusion inhibitors possess potent inhibitory activity against HIV-1, HIV-2, and simian immunodeficiency virus. Emerg Microbes Infect. 2021 Dec; 10(1):810-821.
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Drug Repurposing for the SARS-CoV-2 Papain-Like Protease. ChemMedChem. 2022 01 05; 17(1):e202100455.
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DNA-encoded chemistry technology yields expedient access to SARS-CoV-2 Mpro inhibitors. Proc Natl Acad Sci U S A. 2021 09 07; 118(36).
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Binding of boswellic acids to functional proteins of the SARS-CoV-2 virus: Bioinformatic studies. Arch Pharm (Weinheim). 2021 Nov; 354(11):e2100160.
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Challenges of short substrate analogues as SARS-CoV-2 main protease inhibitors. Bioorg Med Chem Lett. 2021 10 15; 50:128333.
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Selective Binding and Redox-Activity on Parallel G-Quadruplexes by Pegylated Naphthalene Diimide-Copper Complexes. Molecules. 2021 Aug 19; 26(16).
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Discovery of juglone and its derivatives as potent SARS-CoV-2 main proteinase inhibitors. Eur J Med Chem. 2021 Dec 05; 225:113789.
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[Induced degradation of proteins by PROTACs and other strategies: towards promising drugs]. Biol Aujourdhui. 2021; 215(1-2):25-43.
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CuCl2-catalyzed inexpensive, faster and ligand/additive free synthesis of isoquinolin-1(2H)-one derivatives via the coupling-cyclization strategy: Evaluation of a new class of compounds as potential PDE4 inhibitors. Bioorg Chem. 2021 10; 115:105265.