"CD4 Antigens" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
55-kDa antigens found on HELPER-INDUCER T-LYMPHOCYTES and on a variety of other immune cell types. They are members of the immunoglobulin supergene family and are implicated as associative recognition elements in MAJOR HISTOCOMPATIBILITY COMPLEX class II-restricted immune responses. On T-lymphocytes they define the helper/inducer subset. T4 antigens also serve as INTERLEUKIN-15 receptors and bind to the HIV receptors, binding directly to the HIV ENVELOPE PROTEIN GP120.
| Descriptor ID |
D015704
|
| MeSH Number(s) |
D12.776.543.750.705.852.420.810.500 D12.776.543.750.830.700.025 D23.050.301.264.894.100 D23.101.100.894.100
|
| Concept/Terms |
CD4 Antigens- CD4 Antigens
- Antigens, CD4
- CD4 Molecule
- T4 Antigens, T-Cell
- Antigens, T-Cell T4
- T-Cell T4 Antigens
- T4 Antigens, T Cell
- Receptors, CD4
- Surface CD4 Receptor
- CD4 Receptor, Surface
- Receptors, Surface CD4
- CD4 Receptors, Surface
- Surface CD4 Receptors
- CD4 Antigen
- Antigen, CD4
- CD4 Receptors
|
Below are MeSH descriptors whose meaning is more general than "CD4 Antigens".
- Chemicals and Drugs [D]
- Amino Acids, Peptides, and Proteins [D12]
- Proteins [D12.776]
- Membrane Proteins [D12.776.543]
- Receptors, Cell Surface [D12.776.543.750]
- Receptors, Immunologic [D12.776.543.750.705]
- Receptors, Cytokine [D12.776.543.750.705.852]
- Receptors, Interleukin [D12.776.543.750.705.852.420]
- Receptors, Interleukin-16 [D12.776.543.750.705.852.420.810]
- CD4 Antigens [D12.776.543.750.705.852.420.810.500]
- Receptors, Virus [D12.776.543.750.830]
- Receptors, HIV [D12.776.543.750.830.700]
- CD4 Antigens [D12.776.543.750.830.700.025]
- Biological Factors [D23]
- Antigens [D23.050]
- Antigens, Surface [D23.050.301]
- Antigens, Differentiation [D23.050.301.264]
- Antigens, Differentiation, T-Lymphocyte [D23.050.301.264.894]
- CD4 Antigens [D23.050.301.264.894.100]
- Biomarkers [D23.101]
- Antigens, Differentiation [D23.101.100]
- Antigens, Differentiation, T-Lymphocyte [D23.101.100.894]
- CD4 Antigens [D23.101.100.894.100]
Below are MeSH descriptors whose meaning is more specific than "CD4 Antigens".
This graph shows the total number of publications written about "CD4 Antigens" by people in this website by year, and whether "CD4 Antigens" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1995 | 1 | 1 | 2 |
| 1997 | 0 | 1 | 1 |
| 1999 | 0 | 1 | 1 |
| 2004 | 1 | 1 | 2 |
| 2005 | 0 | 2 | 2 |
| 2008 | 1 | 1 | 2 |
| 2009 | 1 | 1 | 2 |
| 2012 | 0 | 4 | 4 |
| 2013 | 0 | 4 | 4 |
| 2014 | 0 | 1 | 1 |
| 2015 | 1 | 0 | 1 |
| 2016 | 0 | 2 | 2 |
| 2017 | 18 | 21 | 39 |
| 2018 | 10 | 13 | 23 |
| 2019 | 2 | 4 | 6 |
| 2020 | 0 | 3 | 3 |
To return to the timeline, click here.
Below are the most recent publications written about "CD4 Antigens" by people in Profiles.
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Fox3+ CD25+ CD4+ T-regulatory cells may transform the nCoV's final destiny to CNS! J Med Virol. 2021 10; 93(10):5673-5675.
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The role of CD4+FoxP3+ regulatory T cells in the immunopathogenesis of COVID-19: implications for treatment. Int J Biol Sci. 2021; 17(6):1507-1520.
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Dynamic data-driven meta-analysis for prioritisation of host genes implicated in COVID-19. Sci Rep. 2020 12 18; 10(1):22303.
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Lymphocyte Subset Alteration and Monocyte CD4 Expression Reduction in Patients with Severe COVID-19. Viral Immunol. 2021 06; 34(5):342-351.
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Vascular obliteration because of endothelial and myointimal growth in COVID-19 patients. Int J Dermatol. 2021 Jan; 60(1):73-80.
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The phenotypic changes of ?d T cells in COVID-19 patients. J Cell Mol Med. 2020 10; 24(19):11603-11606.
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Evaluation of the mRNA-1273 Vaccine against SARS-CoV-2 in Nonhuman Primates. N Engl J Med. 2020 10 15; 383(16):1544-1555.
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Decreased T cell populations contribute to the increased severity of COVID-19. Clin Chim Acta. 2020 Sep; 508:110-114.
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A New Family of Small-Molecule CD4-Mimetic Compounds Contacts Highly Conserved Aspartic Acid 368 of HIV-1 gp120 and Mediates Antibody-Dependent Cellular Cytotoxicity. J Virol. 2019 12 15; 93(24).
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Lovastatin Inhibits HIV-1-Induced MHC-I Downregulation by Targeting Nef-AP-1 Complex Formation: A New Strategy to Boost Immune Eradication of HIV-1 Infected Cells. Front Immunol. 2019; 10:2151.