"alpha Karyopherins" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Nucleocytoplasmic transport molecules that bind to the NUCLEAR LOCALIZATION SIGNALS of cytoplasmic molecules destined to be imported into the CELL NUCLEUS. Once attached to their cargo they bind to BETA KARYOPHERINS and are transported through the NUCLEAR PORE COMPLEX. Inside the CELL NUCLEUS alpha karyopherins dissociate from beta karypherins and their cargo. They then form a complex with CELLULAR APOPTOSIS SUSCEPTIBILITY PROTEIN and RAN GTP-BINDING PROTEIN which is exported to the CYTOPLASM.
| Descriptor ID |
D028901
|
| MeSH Number(s) |
D12.776.157.530.750.500.100 D12.776.543.585.750.500.100 D12.776.660.502.100
|
| Concept/Terms |
alpha Karyopherins- alpha Karyopherins
- Karyopherins, alpha
- Karyopherin alpha
- Nuclear Localization Signal-Binding Protein
- NLS-Binding Protein
- NLSBP
- Nuclear Localization Sequence Receptor
- Importin-alpha
- NLS Receptor
- receptor, NLS
|
Below are MeSH descriptors whose meaning is more general than "alpha Karyopherins".
Below are MeSH descriptors whose meaning is more specific than "alpha Karyopherins".
This graph shows the total number of publications written about "alpha Karyopherins" by people in this website by year, and whether "alpha Karyopherins" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 2004 | 0 | 1 | 1 |
| 2007 | 0 | 1 | 1 |
| 2017 | 1 | 0 | 1 |
| 2018 | 2 | 0 | 2 |
| 2020 | 0 | 1 | 1 |
| 2021 | 0 | 1 | 1 |
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Below are the most recent publications written about "alpha Karyopherins" by people in Profiles.
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Comparative study of the interaction of ivermectin with proteins of interest associated with SARS-CoV-2: A computational and biophysical approach. Biophys Chem. 2021 11; 278:106677.
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Repurposing Ivermectin for COVID-19: Molecular Aspects and Therapeutic Possibilities. Front Immunol. 2021; 12:663586.
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Antivirals that target the host IMPa/ß1-virus interface. Biochem Soc Trans. 2021 02 26; 49(1):281-295.
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Binding mechanism and structural insights into the identified protein target of COVID-19 and importin-a with in-vitro effective drug ivermectin. J Biomol Struct Dyn. 2022 Mar; 40(5):2217-2226.
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The broad spectrum host-directed agent ivermectin as an antiviral for SARS-CoV-2 ? Biochem Biophys Res Commun. 2021 01 29; 538:163-172.
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Evasion of Type I Interferon by SARS-CoV-2. Cell Rep. 2020 10 06; 33(1):108234.
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MicroRNA-302 Cluster Downregulates Enterovirus 71-Induced Innate Immune Response by Targeting KPNA2. J Immunol. 2018 07 01; 201(1):145-156.
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Intersectin goes nuclear: secret life of an endocytic protein. Biochem J. 2018 04 27; 475(8):1455-1472.
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H7N9 Influenza A Virus Exhibits Importin-a7-Mediated Replication in the Mammalian Respiratory Tract. Am J Pathol. 2017 Apr; 187(4):831-840.
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Severe acute respiratory syndrome coronavirus ORF6 antagonizes STAT1 function by sequestering nuclear import factors on the rough endoplasmic reticulum/Golgi membrane. J Virol. 2007 Sep; 81(18):9812-24.