"MicroRNAs" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Small double-stranded, non-protein coding RNAs, 21-25 nucleotides in length generated from single-stranded microRNA gene transcripts by the same RIBONUCLEASE III, Dicer, that produces small interfering RNAs (RNA, SMALL INTERFERING). They become part of the RNA-INDUCED SILENCING COMPLEX and repress the translation (TRANSLATION, GENETIC) of target RNA by binding to homologous 3'UTR region as an imperfect match. The small temporal RNAs (stRNAs), let-7 and lin-4, from C. elegans, are the first 2 miRNAs discovered, and are from a class of miRNAs involved in developmental timing.
| Descriptor ID |
D035683
|
| MeSH Number(s) |
D13.150.650.319 D13.444.735.150.319 D13.444.735.790.552.500
|
| Concept/Terms |
MicroRNAs- MicroRNAs
- MicroRNA
- miRNAs
- Micro RNA
- RNA, Micro
- miRNA
Primary MicroRNA- Primary MicroRNA
- MicroRNA, Primary
- Primary miRNA
- miRNA, Primary
- pri-miRNA
- pri miRNA
|
Below are MeSH descriptors whose meaning is more general than "MicroRNAs".
Below are MeSH descriptors whose meaning is more specific than "MicroRNAs".
This graph shows the total number of publications written about "MicroRNAs" by people in this website by year, and whether "MicroRNAs" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 2006 | 1 | 0 | 1 |
| 2008 | 1 | 0 | 1 |
| 2009 | 4 | 0 | 4 |
| 2010 | 2 | 0 | 2 |
| 2011 | 4 | 0 | 4 |
| 2012 | 2 | 0 | 2 |
| 2013 | 5 | 1 | 6 |
| 2014 | 14 | 1 | 15 |
| 2015 | 8 | 2 | 10 |
| 2016 | 23 | 1 | 24 |
| 2017 | 263 | 60 | 323 |
| 2018 | 265 | 37 | 302 |
| 2019 | 90 | 19 | 109 |
| 2020 | 5 | 4 | 9 |
| 2021 | 15 | 4 | 19 |
To return to the timeline, click here.
Below are the most recent publications written about "MicroRNAs" by people in Profiles.
-
Biomarkers for Prognosis and Treatment Response in COVID-19 Patients. Ann Lab Med. 2021 Nov 01; 41(6):540-548.
-
Comment on: "MicroRNA Mimics or Inhibitors as Antiviral Therapeutic Approaches Against COVID-19". Drugs. 2021 09; 81(14):1691-1692.
-
Reply to Zhang and Zhu "MicroRNA Mimics or Inhibitors as Antiviral Therapeutic Approaches Against COVID-19". Drugs. 2021 09; 81(14):1693-1695.
-
Role of endothelial miR-24 in COVID-19 cerebrovascular events. Crit Care. 2021 08 25; 25(1):306.
-
MicroRNA-28-3p inhibits angiotensin-converting enzyme 2 ectodomain shedding in 293T cells treated with the spike protein of severe acute respiratory syndrome coronavirus 2 by targeting A disintegrin and metalloproteinase 17. Int J Mol Med. 2021 Oct; 48(4).
-
Anti-SARS-CoV-2 Strategies and the Potential Role of miRNA in the Assessment of COVID-19 Morbidity, Recurrence, and Therapy. Int J Mol Sci. 2021 Aug 12; 22(16).
-
Detection of SARS-CoV-2 Derived Small RNAs and Changes in Circulating Small RNAs Associated with COVID-19. Viruses. 2021 08 11; 13(8).
-
Decreased inhibition of exosomal miRNAs on SARS-CoV-2 replication underlies poor outcomes in elderly people and diabetic patients. Signal Transduct Target Ther. 2021 08 11; 6(1):300.
-
Reply to 'COVID-19 severity, miR-21 targets, and common human genetic variation'. Eur J Heart Fail. 2021 11; 23(11):1987-1988.
-
COVID-19 severity, miR-21 targets, and common human genetic variation. Letter regarding the article 'Circulating cardiovascular microRNAs in critically ill COVID-19 patients'. Eur J Heart Fail. 2021 11; 23(11):1986-1987.