"Casein Kinase II" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A ubiquitous casein kinase that is comprised of two distinct catalytic subunits and dimeric regulatory subunit. Casein kinase II has been shown to phosphorylate a large number of substrates, many of which are proteins involved in the regulation of gene expression.
| Descriptor ID |
D047390
|
| MeSH Number(s) |
D08.811.913.696.620.682.700.140.600 D12.776.476.150.600
|
| Concept/Terms |
Casein Kinase II- Casein Kinase II
- Protein Kinase CKII
- Kinase CKII, Protein
- Casein Kinase-2
- Protein Kinase CK2
- Casein Kinase 2
- Casein Kinase TS
|
Below are MeSH descriptors whose meaning is more general than "Casein Kinase II".
Below are MeSH descriptors whose meaning is more specific than "Casein Kinase II".
This graph shows the total number of publications written about "Casein Kinase II" by people in this website by year, and whether "Casein Kinase II" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 2005 | 0 | 1 | 1 |
| 2017 | 2 | 0 | 2 |
| 2018 | 1 | 0 | 1 |
| 2020 | 0 | 1 | 1 |
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Below are the most recent publications written about "Casein Kinase II" by people in Profiles.
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Molecular Plasticity of Crystalline CK2a' Leads to KN2, a Bivalent Inhibitor of Protein Kinase CK2 with Extraordinary Selectivity. J Med Chem. 2022 01 27; 65(2):1302-1312.
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Nopp140-chaperoned 2'-O-methylation of small nuclear RNAs in Cajal bodies ensures splicing fidelity. Genes Dev. 2021 08 01; 35(15-16):1123-1141.
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Chemical probes targeting the kinase CK2: a journey outside the catalytic box. Org Biomol Chem. 2021 05 26; 19(20):4380-4396.
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Protein kinase CK2: a potential therapeutic target for diverse human diseases. Signal Transduct Target Ther. 2021 05 17; 6(1):183.
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Downfalls of Chemical Probes Acting at the Kinase ATP-Site: CK2 as a Case Study. Molecules. 2021 Mar 31; 26(7).
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A New Chemical Probe Challenges the Broad Cancer Essentiality of CK2. Trends Pharmacol Sci. 2021 05; 42(5):313-315.
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The Global Phosphorylation Landscape of SARS-CoV-2 Infection. Cell. 2020 08 06; 182(3):685-712.e19.
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TCO, a Putative Transcriptional Regulator in Arabidopsis, Is a Target of the Protein Kinase CK2. Int J Mol Sci. 2018 Dec 28; 20(1).
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CK2 modulates adipocyte insulin-signaling and is up-regulated in human obesity. Sci Rep. 2017 12 14; 7(1):17569.
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Yeast casein kinase 2 governs morphology, biofilm formation, cell wall integrity, and host cell damage of Candida albicans. PLoS One. 2017; 12(11):e0187721.