"Glutaredoxins" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A family of thioltransferases that contain two active site CYSTEINE residues, which either form a disulfide (oxidized form) or a dithiol (reduced form). They function as an electron carrier in the GLUTHIONE-dependent synthesis of deoxyribonucleotides by RIBONUCLEOTIDE REDUCTASES and may play a role in the deglutathionylation of protein thiols. The oxidized forms of glutaredoxins are directly reduced by the GLUTATHIONE.
| Descriptor ID |
D054477
|
| MeSH Number(s) |
D08.811.682.667.084
|
| Concept/Terms |
Glutaredoxin 1- Glutaredoxin 1
- TTase-1
- TTase 1
- Thioltransferase-1
- Thioltransferase 1
|
Below are MeSH descriptors whose meaning is more general than "Glutaredoxins".
Below are MeSH descriptors whose meaning is more specific than "Glutaredoxins".
This graph shows the total number of publications written about "Glutaredoxins" by people in this website by year, and whether "Glutaredoxins" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2016 | 0 | 2 | 2 |
| 2017 | 1 | 0 | 1 |
| 2019 | 2 | 0 | 2 |
| 2021 | 0 | 1 | 1 |
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Below are the most recent publications written about "Glutaredoxins" by people in Profiles.
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Regulation of the Dimerization and Activity of SARS-CoV-2 Main Protease through Reversible Glutathionylation of Cysteine 300. mBio. 2021 08 31; 12(4):e0209421.
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The thioredoxin-1 and glutathione/glutaredoxin-1 systems redundantly fuel murine B-cell development and responses. Eur J Immunol. 2019 05; 49(5):709-723.
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GLRX inhibition enhances the effects of geftinib in EGFR-TKI-resistant NSCLC cells through FoxM1 signaling pathway. J Cancer Res Clin Oncol. 2019 Apr; 145(4):861-872.
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Iron-sulfur glutaredoxin 2 protects oligodendrocytes against damage induced by nitric oxide release from activated microglia. Glia. 2017 09; 65(9):1521-1534.
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Redox status in a model of cancer stem cells. Arch Biochem Biophys. 2017 Mar 01; 617:120-128.
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PEP-1-GRX-1 Modulates Matrix Metalloproteinase-13 and Nitric Oxide Expression of Human Articular Chondrocytes. Cell Physiol Biochem. 2017; 41(1):252-264.