Polycomb Repressive Complex 1
"Polycomb Repressive Complex 1" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A multisubunit polycomb protein complex with affinity for CHROMATIN that contains methylated HISTONE H3. It contains an E3 ubiquitin ligase activity that is specific for HISTONE H2A and works in conjunction with POLYCOMB REPRESSIVE COMPLEX 2 to effect EPIGENETIC REPRESSION.
Descriptor ID |
D063150
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MeSH Number(s) |
D05.500.781.100 D08.811.464.938.750.280 D12.776.660.235.600.100 D12.776.664.235.800.100 D12.776.930.780.890.100
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Concept/Terms |
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Below are MeSH descriptors whose meaning is more general than "Polycomb Repressive Complex 1".
Below are MeSH descriptors whose meaning is more specific than "Polycomb Repressive Complex 1".
This graph shows the total number of publications written about "Polycomb Repressive Complex 1" by people in this website by year, and whether "Polycomb Repressive Complex 1" was a major or minor topic of these publications.
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Year | Major Topic | Minor Topic | Total |
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2016 | 0 | 1 | 1 |
2017 | 3 | 1 | 4 |
2018 | 0 | 1 | 1 |
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Below are the most recent publications written about "Polycomb Repressive Complex 1" by people in Profiles.
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MPEG-CS/Bmi-1RNAi Nanoparticles Synthesis and Its Targeted Inhibition Effect on CD133+ Laryngeal Stem Cells. J Nanosci Nanotechnol. 2018 Mar 01; 18(3):1577-1584.
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Epigenetic factors Polycomb (Pc) and Suppressor of zeste (Su(z)2) negatively regulate longevity in Drosophila melanogaster. Biogerontology. 2018 02; 19(1):33-45.
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Kdm2b Regulates Somatic Reprogramming through Variant PRC1 Complex-Dependent Function. Cell Rep. 2017 Nov 21; 21(8):2160-2170.
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Hepatic expression of oncogenes Bmi1 and Dkk1 is up-regulated in hepatitis B virus surface antigen-transgenic mice and can be induced by treatment with HBV particles or lipopolysaccharides in vitro. Int J Cancer. 2017 07 15; 141(2):354-363.
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miR-155 is positively regulated by CBX7 in mouse embryonic fibroblasts and colon carcinomas, and targets the KRAS oncogene. BMC Cancer. 2017 03 04; 17(1):170.
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Comment on "Structural basis of histone H3K27 trimethylation by an active polycomb repressive complex 2". Science. 2016 12 23; 354(6319):1543.