Alexander E Gorbalenya

InstitutionLeiden University Medical Center
AddressThe
Netherlands
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    Publication Timeline
    COVID-19 publications
    Bar chart showing 7 Covid-19 publications, with a maximum of 2 publications in March 2021 and July 2021
    All Publications
    Bar chart showing 121 publications over 28 distinct years, with a maximum of 11 publications in 2006
    These graphs show COVID-19 publications by month since August 2019 and all publications written by authors of COVID-19 publications over the past 30 years.

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    Publication Field Summary
    This graph shows the number and percent of publications by field. Fields are based on how the National Library of Medicine (NLM) classifies the publications' journals and might not represent the specific topics of the publications. Note that an individual publication can be assigned to more than one field. As a result, the publication counts in this graph might add up to more than the number of publications the person has written. To see the data as text, click here.
    Publication List
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Calisher CH, Carroll D, Colwell R, Corley RB, Daszak P, Drosten C, Enjuanes L, Farrar J, Field H, Golding J, Gorbalenya AE, Haagmans B, Hughes JM, Keusch GT, Lam SK, Lubroth J, Mackenzie JS, Madoff L, Mazet JK, Perlman SM, Poon L, Saif L, Subbarao K, Turner M. Science, not speculation, is essential to determine how SARS-CoV-2 reached humans. Lancet. 2021 07 17; 398(10296):209-211. PMID: 34237296.
      Citations: 3     Fields:    Translation:Humans
    2. Citations: 24     Fields:    Translation:Humans
    3. Jungreis I, Nelson CW, Ardern Z, Finkel Y, Krogan NJ, Sato K, Ziebuhr J, Stern-Ginossar N, Pavesi A, Firth AE, Gorbalenya AE, Kellis M. Conflicting and ambiguous names of overlapping ORFs in the SARS-CoV-2 genome: A homology-based resolution. Virology. 2021 06; 558:145-151. PMID: 33774510.
      Citations: 5     Fields:    
    4. Gorbalenya AE, Siddell SG. Recognizing species as a new focus of virus research. PLoS Pathog. 2021 03; 17(3):e1009318. PMID: 33662033.
      Citations: 2     Fields:    Translation:Cells
    5. Slanina H, Madhugiri R, Bylapudi G, Schultheiß K, Karl N, Gulyaeva A, Gorbalenya AE, Linne U, Ziebuhr J. Coronavirus replication-transcription complex: Vital and selective NMPylation of a conserved site in nsp9 by the NiRAN-RdRp subunit. Proc Natl Acad Sci U S A. 2021 02 09; 118(6). PMID: 33472860.
      Citations: 16     Fields:    Translation:HumansCells
    6. Gulyaeva AA, Gorbalenya AE. A nidovirus perspective on SARS-CoV-2. Biochem Biophys Res Commun. 2021 01 29; 538:24-34. PMID: 33413979.
      Citations: 5     Fields:    Translation:HumansCells
    7. Calisher C, Carroll D, Colwell R, Corley RB, Daszak P, Drosten C, Enjuanes L, Farrar J, Field H, Golding J, Gorbalenya A, Haagmans B, Hughes JM, Karesh WB, Keusch GT, Lam SK, Lubroth J, Mackenzie JS, Madoff L, Mazet J, Palese P, Perlman S, Poon L, Roizman B, Saif L, Saif L, Subbarao K, Turner M. Statement in support of the scientists, public health professionals, and medical professionals of China combatting COVID-19. Lancet. 2020 03 07; 395(10226):e42-e43. PMID: 32087122.
      Citations: 54     Fields:    Translation:HumansCellsPHPublic Health
    8. Kanitz M, Blanck S, Heine A, Gulyaeva AA, Gorbalenya AE, Ziebuhr J, Diederich WE. Structural basis for catalysis and substrate specificity of a 3C-like cysteine protease from a mosquito mesonivirus. Virology. 2019 07; 533:21-33. PMID: 31078932.
      Citations: 3     Fields:    Translation:AnimalsCells
    9. Saberi A, Gulyaeva AA, Brubacher JL, Newmark PA, Gorbalenya AE. A planarian nidovirus expands the limits of RNA genome size. PLoS Pathog. 2018 11; 14(11):e1007314. PMID: 30383829.
      Citations: 46     Fields:    Translation:AnimalsCells
    10. Romette JL, Prat CM, Gould EA, de Lamballerie X, de Lamballerie X, Charrel R, Coutard B, Coutard B, Fooks AR, Bardsley M, Carroll M, Drosten C, Drexler JF, Günther S, Klempa B, Pinschewer D, Klimkait T, Avsic-Zupanc T, Capobianchi MR, Dicaro A, Ippolito G, Ippolito G, Nitsche A, Koopmans M, Reusken C, Gorbalenya A, Raoul H, Bourhy H, Mettenleiter T, Reiche S, Batten C, Sabeta C, Paweska JT, Eropkin M, Zverev V, Hu Z, Mac Cullough S, Mirazimi A, Pradel F, Lieutaud P. The European Virus Archive goes global: A growing resource for research. Antiviral Res. 2018 10; 158:127-134. PMID: 30059721.
      Citations: 14     Fields:    Translation:HumansCellsPHPublic Health
    11. Lehmann KC, Gorbalenya AE, Snijder EJ, Posthuma CC. Arterivirus RNA-dependent RNA polymerase: Vital enzymatic activity remains elusive. Virology. 2016 Jan; 487:68-74. PMID: 26499043.
      Citations: 5     Fields:    Translation:Cells
    12. Lehmann KC, Gulyaeva A, Zevenhoven-Dobbe JC, Janssen GM, Ruben M, Overkleeft HS, van Veelen PA, Samborskiy DV, Kravchenko AA, Leontovich AM, Sidorov IA, Snijder EJ, Posthuma CC, Gorbalenya AE. Discovery of an essential nucleotidylating activity associated with a newly delineated conserved domain in the RNA polymerase-containing protein of all nidoviruses. Nucleic Acids Res. 2015 Sep 30; 43(17):8416-34. PMID: 26304538.
      Citations: 79     Fields:    Translation:Cells
    13. Lehmann KC, Hooghiemstra L, Gulyaeva A, Samborskiy DV, Zevenhoven-Dobbe JC, Snijder EJ, Gorbalenya AE, Posthuma CC. Arterivirus nsp12 versus the coronavirus nsp16 2'-O-methyltransferase: comparison of the C-terminal cleavage products of two nidovirus pp1ab polyproteins. J Gen Virol. 2015 Sep; 96(9):2643-2655. PMID: 26041874.
      Citations: 8     Fields:    Translation:Cells
    14. Lobodanov SA, Kiselev IS, Ammour YI, Gorbalenya AE, Claas EC, Zverev VV, Faizuloev EB. [The prevalence of the human rhinoviruses and coronaviruses circulating in the Moscow region during 2007-2012]. Vopr Virusol. 2015; 60(3):31-6. PMID: 26281304.
      Citations:    Fields:    Translation:HumansCells
    15. Lehmann KC, Snijder EJ, Posthuma CC, Gorbalenya AE. What we know but do not understand about nidovirus helicases. Virus Res. 2015 Apr 16; 202:12-32. PMID: 25497126.
      Citations: 27     Fields:    Translation:HumansAnimalsCells
    16. Subissi L, Posthuma CC, Collet A, Zevenhoven-Dobbe JC, Gorbalenya AE, Decroly E, Snijder EJ, Canard B, Imbert I. One severe acute respiratory syndrome coronavirus protein complex integrates processive RNA polymerase and exonuclease activities. Proc Natl Acad Sci U S A. 2014 Sep 16; 111(37):E3900-9. PMID: 25197083.
      Citations: 198     Fields:    Translation:HumansCells
    17. de Groot RJ, Baker SC, Baric RS, Brown CS, Drosten C, Enjuanes L, Fouchier RA, Galiano M, Gorbalenya AE, Memish ZA, Perlman S, Poon LL, Snijder EJ, Stephens GM, Woo PC, Zaki AM, Zambon M, Ziebuhr J. Middle East respiratory syndrome coronavirus (MERS-CoV): announcement of the Coronavirus Study Group. J Virol. 2013 Jul; 87(14):7790-2. PMID: 23678167.
      Citations: 498     Fields:    Translation:HumansCells
    18. van Boheemen S, de Graaf M, Lauber C, Bestebroer TM, Raj VS, Zaki AM, Osterhaus AD, Haagmans BL, Gorbalenya AE, Snijder EJ, Fouchier RA. Genomic characterization of a newly discovered coronavirus associated with acute respiratory distress syndrome in humans. mBio. 2012 Nov 20; 3(6). PMID: 23170002.
      Citations: 444     Fields:    Translation:HumansCells
    19. Zlateva KT, Coenjaerts FE, Crusio KM, Lammens C, Leus F, Viveen M, Ieven M, Spaan WJ, Claas EC, Gorbalenya AE. No novel coronaviruses identified in a large collection of human nasopharyngeal specimens using family-wide CODEHOP-based primers. Arch Virol. 2013 Jan; 158(1):251-5. PMID: 23053517.
      Citations: 9     Fields:    Translation:HumansCells
    20. Zhao L, Jha BK, Wu A, Elliott R, Ziebuhr J, Gorbalenya AE, Silverman RH, Weiss SR. Antagonism of the interferon-induced OAS-RNase L pathway by murine coronavirus ns2 protein is required for virus replication and liver pathology. Cell Host Microbe. 2012 Jun 14; 11(6):607-16. PMID: 22704621.
      Citations: 137     Fields:    Translation:AnimalsCells
    21. Zlateva KT, Crusio KM, Leontovich AM, Lauber C, Claas E, Kravchenko AA, Spaan WJ, Gorbalenya AE. Design and validation of consensus-degenerate hybrid oligonucleotide primers for broad and sensitive detection of corona- and toroviruses. J Virol Methods. 2011 Nov; 177(2):174-83. PMID: 21864579.
      Citations: 7     Fields:    Translation:HumansAnimalsCells
    22. Wojdyla JA, Manolaridis I, van Kasteren PB, Kikkert M, Snijder EJ, Gorbalenya AE, Tucker PA. Papain-like protease 1 from transmissible gastroenteritis virus: crystal structure and enzymatic activity toward viral and cellular substrates. J Virol. 2010 Oct; 84(19):10063-73. PMID: 20668092.
      Citations: 32     Fields:    Translation:HumansAnimalsCells
    23. Nedialkova DD, Gorbalenya AE, Snijder EJ. Arterivirus Nsp1 modulates the accumulation of minus-strand templates to control the relative abundance of viral mRNAs. PLoS Pathog. 2010 Feb 19; 6(2):e1000772. PMID: 20174607.
      Citations: 32     Fields:    Translation:AnimalsCells
    24. Wojdyla JA, Manolaridis I, Snijder EJ, Gorbalenya AE, Coutard B, Piotrowski Y, Hilgenfeld R, Tucker PA. Structure of the X (ADRP) domain of nsp3 from feline coronavirus. Acta Crystallogr D Biol Crystallogr. 2009 Dec; 65(Pt 12):1292-300. PMID: 19966415.
      Citations: 13     Fields:    Translation:Cells
    25. Manolaridis I, Wojdyla JA, Panjikar S, Snijder EJ, Gorbalenya AE, Berglind H, Nordlund P, Coutard B, Tucker PA. Structure of the C-terminal domain of nsp4 from feline coronavirus. Acta Crystallogr D Biol Crystallogr. 2009 Aug; 65(Pt 8):839-46. PMID: 19622868.
      Citations: 12     Fields:    Translation:HumansAnimalsCells
    26. Nedialkova DD, Ulferts R, van den Born E, Lauber C, Gorbalenya AE, Ziebuhr J, Snijder EJ. Biochemical characterization of arterivirus nonstructural protein 11 reveals the nidovirus-wide conservation of a replicative endoribonuclease. J Virol. 2009 Jun; 83(11):5671-82. PMID: 19297500.
      Citations: 57     Fields:    Translation:Cells
    27. Roth-Cross JK, Stokes H, Chang G, Chua MM, Thiel V, Weiss SR, Gorbalenya AE, Siddell SG. Organ-specific attenuation of murine hepatitis virus strain A59 by replacement of catalytic residues in the putative viral cyclic phosphodiesterase ns2. J Virol. 2009 Apr; 83(8):3743-53. PMID: 19176619.
      Citations: 31     Fields:    Translation:AnimalsCells
    28. Piotrowski Y, Hansen G, Boomaars-van der Zanden AL, Snijder EJ, Gorbalenya AE, Hilgenfeld R. Crystal structures of the X-domains of a Group-1 and a Group-3 coronavirus reveal that ADP-ribose-binding may not be a conserved property. Protein Sci. 2009 Jan; 18(1):6-16. PMID: 19177346.
      Citations: 28     Fields:    Translation:Cells
    29. van Hemert MJ, van den Worm SH, Knoops K, Mommaas AM, Gorbalenya AE, Snijder EJ. SARS-coronavirus replication/transcription complexes are membrane-protected and need a host factor for activity in vitro. PLoS Pathog. 2008 May 02; 4(5):e1000054. PMID: 18451981.
      Citations: 131     Fields:    Translation:AnimalsCells
    30. Decroly E, Imbert I, Coutard B, Bouvet M, Selisko B, Alvarez K, Gorbalenya AE, Snijder EJ, Canard B. Coronavirus nonstructural protein 16 is a cap-0 binding enzyme possessing (nucleoside-2'O)-methyltransferase activity. J Virol. 2008 Aug; 82(16):8071-84. PMID: 18417574.
      Citations: 121     Fields:    Translation:AnimalsCells
    31. Tijms MA, Nedialkova DD, Zevenhoven-Dobbe JC, Gorbalenya AE, Snijder EJ. Arterivirus subgenomic mRNA synthesis and virion biogenesis depend on the multifunctional nsp1 autoprotease. J Virol. 2007 Oct; 81(19):10496-505. PMID: 17626105.
      Citations: 27     Fields:    Translation:Cells
    32. Ziebuhr J, Schelle B, Karl N, Minskaia E, Bayer S, Siddell SG, Gorbalenya AE, Thiel V. Human coronavirus 229E papain-like proteases have overlapping specificities but distinct functions in viral replication. J Virol. 2007 Apr; 81(8):3922-32. PMID: 17251282.
      Citations: 36     Fields:    Translation:HumansCells
    33. Imbert I, Guillemot JC, Bourhis JM, Bussetta C, Coutard B, Egloff MP, Ferron F, Gorbalenya AE, Canard B. A second, non-canonical RNA-dependent RNA polymerase in SARS coronavirus. EMBO J. 2006 Oct 18; 25(20):4933-42. PMID: 17024178.
      Citations: 133     Fields:    Translation:Cells
    34. Minskaia E, Hertzig T, Gorbalenya AE, Campanacci V, Cambillau C, Canard B, Ziebuhr J. Discovery of an RNA virus 3'->5' exoribonuclease that is critically involved in coronavirus RNA synthesis. Proc Natl Acad Sci U S A. 2006 Mar 28; 103(13):5108-13. PMID: 16549795.
      Citations: 253     Fields:    Translation:Cells
    35. Putics Á, Gorbalenya AE, Ziebuhr J. Identification of protease and ADP-ribose 1''-monophosphatase activities associated with transmissible gastroenteritis virus non-structural protein 3. J Gen Virol. 2006 Mar; 87(Pt 3):651-656. PMID: 16476987.
      Citations: 26     Fields:    Translation:AnimalsCells
    36. Gorbalenya AE, Enjuanes L, Ziebuhr J, Snijder EJ. Nidovirales: evolving the largest RNA virus genome. Virus Res. 2006 Apr; 117(1):17-37. PMID: 16503362.
      Citations: 376     Fields:    Translation:Cells
    37. Posthuma CC, Nedialkova DD, Zevenhoven-Dobbe JC, Blokhuis JH, Gorbalenya AE, Snijder EJ. Site-directed mutagenesis of the Nidovirus replicative endoribonuclease NendoU exerts pleiotropic effects on the arterivirus life cycle. J Virol. 2006 Feb; 80(4):1653-61. PMID: 16439522.
      Citations: 44     Fields:    Translation:AnimalsCells
    38. Putics A, Slaby J, Filipowicz W, Gorbalenya AE, Ziebuhr J. ADP-ribose-1"-phosphatase activities of the human coronavirus 229E and SARS coronavirus X domains. Adv Exp Med Biol. 2006; 581:93-6. PMID: 17037511.
      Citations: 7     Fields:    Translation:Cells
    39. Putics A, Filipowicz W, Hall J, Gorbalenya AE, Ziebuhr J. ADP-ribose-1"-monophosphatase: a conserved coronavirus enzyme that is dispensable for viral replication in tissue culture. J Virol. 2005 Oct; 79(20):12721-31. PMID: 16188975.
      Citations: 89     Fields:    Translation:AnimalsCells
    40. Seybert A, Posthuma CC, van Dinten LC, Snijder EJ, Gorbalenya AE, Ziebuhr J. A complex zinc finger controls the enzymatic activities of nidovirus helicases. J Virol. 2005 Jan; 79(2):696-704. PMID: 15613297.
      Citations: 62     Fields:    Translation:Cells
    41. Ivanov KA, Hertzig T, Rozanov M, Bayer S, Thiel V, Gorbalenya AE, Ziebuhr J. Major genetic marker of nidoviruses encodes a replicative endoribonuclease. Proc Natl Acad Sci U S A. 2004 Aug 24; 101(34):12694-9. PMID: 15304651.
      Citations: 147     Fields:    Translation:HumansCells
    42. Gorbalenya AE, Snijder EJ, Spaan WJ. Severe acute respiratory syndrome coronavirus phylogeny: toward consensus. J Virol. 2004 Aug; 78(15):7863-6. PMID: 15254158.
      Citations: 116     Fields:    Translation:Cells
    43. Egloff MP, Ferron F, Campanacci V, Longhi S, Rancurel C, Dutartre H, Snijder EJ, Gorbalenya AE, Cambillau C, Canard B. The severe acute respiratory syndrome-coronavirus replicative protein nsp9 is a single-stranded RNA-binding subunit unique in the RNA virus world. Proc Natl Acad Sci U S A. 2004 Mar 16; 101(11):3792-6. PMID: 15007178.
      Citations: 110     Fields:    Translation:Cells
    44. González JM, Gomez-Puertas P, Cavanagh D, Gorbalenya AE, Enjuanes L. A comparative sequence analysis to revise the current taxonomy of the family Coronaviridae. Arch Virol. 2003 Nov; 148(11):2207-35. PMID: 14579179.
      Citations: 141     Fields:    Translation:Cells
    45. Thiel V, Ivanov KA, Putics Á, Hertzig T, Schelle B, Bayer S, Weißbrich B, Snijder EJ, Rabenau H, Doerr HW, Gorbalenya AE, Ziebuhr J. Mechanisms and enzymes involved in SARS coronavirus genome expression. J Gen Virol. 2003 Sep; 84(Pt 9):2305-2315. PMID: 12917450.
      Citations: 374     Fields:    Translation:Cells
    46. Snijder EJ, Bredenbeek PJ, Dobbe JC, Thiel V, Ziebuhr J, Poon LL, Guan Y, Rozanov M, Spaan WJ, Gorbalenya AE. Unique and conserved features of genome and proteome of SARS-coronavirus, an early split-off from the coronavirus group 2 lineage. J Mol Biol. 2003 Aug 29; 331(5):991-1004. PMID: 12927536.
      Citations: 603     Fields:    Translation:HumansAnimalsCells
    47. Ziebuhr J, Bayer S, Cowley JA, Gorbalenya AE. The 3C-like proteinase of an invertebrate nidovirus links coronavirus and potyvirus homologs. J Virol. 2003 Jan; 77(2):1415-26. PMID: 12502857.
      Citations: 22     Fields:    Translation:Cells
    48. Hegyi A, Friebe A, Gorbalenya AE, Ziebuhr J. Mutational analysis of the active centre of coronavirus 3C-like proteases. J Gen Virol. 2002 Mar; 83(Pt 3):581-593. PMID: 11842253.
      Citations: 26     Fields:    Translation:AnimalsCells
    49. Chouljenko VN, Lin XQ, Storz J, Kousoulas KG, Gorbalenya AE. Comparison of genomic and predicted amino acid sequences of respiratory and enteric bovine coronaviruses isolated from the same animal with fatal shipping pneumonia. J Gen Virol. 2001 Dec; 82(Pt 12):2927-2933. PMID: 11714968.
      Citations: 30     Fields:    Translation:AnimalsCells
    50. Ziebuhr J, Thiel V, Gorbalenya AE. The autocatalytic release of a putative RNA virus transcription factor from its polyprotein precursor involves two paralogous papain-like proteases that cleave the same peptide bond. J Biol Chem. 2001 Aug 31; 276(35):33220-32. PMID: 11431476.
      Citations: 74     Fields:    Translation:HumansAnimalsCells
    51. Herold J, Siddell SG, Gorbalenya AE. A human RNA viral cysteine proteinase that depends upon a unique Zn2+-binding finger connecting the two domains of a papain-like fold . J Biol Chem. 1999 May 21; 274(21):14918-25. PMID: 10329692.
      Citations: 31     Fields:    Translation:HumansCells
    52. Herold J, Gorbalenya AE, Thiel V, Schelle B, Siddell SG. Proteolytic processing at the amino terminus of human coronavirus 229E gene 1-encoded polyproteins: identification of a papain-like proteinase and its substrate. J Virol. 1998 Feb; 72(2):910-8. PMID: 9444982.
      Citations: 35     Fields:    Translation:HumansCells
    53. Bonilla PJ, Gorbalenya AE, Weiss SR. Mouse hepatitis virus strain A59 RNA polymerase gene ORF 1a: heterogeneity among MHV strains. Virology. 1994 Feb; 198(2):736-40. PMID: 8291254.
      Citations: 43     Fields:    Translation:Cells
    54. Baker SC, Yokomori K, Dong S, Carlisle R, Gorbalenya AE, Koonin EV, Lai MM. Identification of the catalytic sites of a papain-like cysteine proteinase of murine coronavirus. J Virol. 1993 Oct; 67(10):6056-63. PMID: 8396668.
      Citations: 50     Fields:    Translation:AnimalsCells
    55. Gorbalenya AE, Koonin EV, Lai MM. Putative papain-related thiol proteases of positive-strand RNA viruses. Identification of rubi- and aphthovirus proteases and delineation of a novel conserved domain associated with proteases of rubi-, alpha- and coronaviruses. FEBS Lett. 1991 Aug 19; 288(1-2):201-5. PMID: 1652473.
      Citations: 146     Fields:    Translation:Cells
    56. Lee HJ, Shieh CK, Gorbalenya AE, Koonin EV, La Monica N, Tuler J, Bagdzhadzhyan A, Lai MM. The complete sequence (22 kilobases) of murine coronavirus gene 1 encoding the putative proteases and RNA polymerase. Virology. 1991 Feb; 180(2):567-82. PMID: 1846489.
      Citations: 166     Fields:    Translation:AnimalsCells
    57. Gorbalenya AE, Koonin EV, Donchenko AP, Blinov VM. Coronavirus genome: prediction of putative functional domains in the non-structural polyprotein by comparative amino acid sequence analysis. Nucleic Acids Res. 1989 Jun 26; 17(12):4847-61. PMID: 2526320.
      Citations: 137     Fields:    Translation:Cells
    58. Gorbalenya AE, Blinov VM, Donchenko AP, Koonin EV. An NTP-binding motif is the most conserved sequence in a highly diverged monophyletic group of proteins involved in positive strand RNA viral replication. J Mol Evol. 1989 Mar; 28(3):256-68. PMID: 2522556.
      Citations: 69     Fields:    Translation:Cells