Luhua Lai

InstitutionPeking University
AddressBeijing
China
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    Publication Timeline
    COVID-19 publications
    Bar chart showing 4 Covid-19 publications, with a maximum of 1 publications in August 2020 and May 2021 and November 2021 and December 2021
    All Publications
    Bar chart showing 162 publications over 20 distinct years, with a maximum of 15 publications in 2018
    These graphs show COVID-19 publications by month since August 2019 and all publications written by authors of COVID-19 publications over the past 30 years.

    To see the data from both graphs as text, click here.
    Publication Field Summary
    This graph shows the number and percent of publications by field. Fields are based on how the National Library of Medicine (NLM) classifies the publications' journals and might not represent the specific topics of the publications. Note that an individual publication can be assigned to more than one field. As a result, the publication counts in this graph might add up to more than the number of publications the person has written. To see the data as text, click here.
    Publication List
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications.
    Sort By:     Newest   |   Oldest   |   Most Cited   |   Most Discussed
    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Liu H, Ye F, Sun Q, Liang H, Li C, Li S, Lu R, Huang B, Tan W, Lai L. Scutellaria baicalensis extract and baicalein inhibit replication of SARS-CoV-2 and its 3C-like protease in vitro. J Enzyme Inhib Med Chem. 2021 Dec; 36(1):497-503. PMID: 33491508.
      Citations: 31     Fields:    Translation:HumansAnimalsCells
    2. Wang S, Sun Q, Xu Y, Pei J, Lai L. A transferable deep learning approach to fast screen potential antiviral drugs against SARS-CoV-2. Brief Bioinform. 2021 11 05; 22(6). PMID: 34081143.
      Citations: 1     Fields:    Translation:HumansPHPublic Health
    3. Sun Q, Ye F, Liang H, Liu H, Li C, Lu R, Huang B, Zhao L, Tan W, Lai L. Bardoxolone and bardoxolone methyl, two Nrf2 activators in clinical trials, inhibit SARS-CoV-2 replication and its 3C-like protease. Signal Transduct Target Ther. 2021 05 29; 6(1):212. PMID: 34052830.
      Citations: 2     Translation:Humans
    4. Liu P, Liu H, Sun Q, Liang H, Li C, Deng X, Liu Y, Lai L. Potent inhibitors of SARS-CoV-2 3C-like protease derived from N-substituted isatin compounds. Eur J Med Chem. 2020 Nov 15; 206:112702. PMID: 32798789.
      Citations: 7     Fields:    Translation:HumansCells
    5. Li C, Teng X, Qi Y, Tang B, Shi H, Ma X, Lai L. Conformational Flexibility of a Short Loop near the Active Site of the SARS-3CLpro is Essential to Maintain Catalytic Activity. Sci Rep. 2016 Feb 16; 6:20918. PMID: 26879383.
      Citations: 7     Fields:    Translation:Cells
    6. Li C, Qi Y, Teng X, Yang Z, Wei P, Zhang C, Tan L, Zhou L, Liu Y, Lai L. Maturation mechanism of severe acute respiratory syndrome (SARS) coronavirus 3C-like proteinase. J Biol Chem. 2010 Sep 03; 285(36):28134-40. PMID: 20489209.
      Citations: 23     Fields:    Translation:Cells
    7. Zhou L, Liu Y, Zhang W, Wei P, Huang C, Pei J, Yuan Y, Lai L. Isatin compounds as noncovalent SARS coronavirus 3C-like protease inhibitors. J Med Chem. 2006 Jun 15; 49(12):3440-3. PMID: 16759084.
      Citations: 32     Fields:    Translation:HumansCells
    8. Chen H, Wei P, Huang C, Tan L, Liu Y, Lai L. Only one protomer is active in the dimer of SARS 3C-like proteinase. J Biol Chem. 2006 May 19; 281(20):13894-8. PMID: 16565086.
      Citations: 34     Fields:    Translation:Cells
    9. Lai L, Han X, Chen H, Wei P, Huang C, Liu S, Fan K, Zhou L, Liu Z, Pei J, Liu Y. Quaternary structure, substrate selectivity and inhibitor design for SARS 3C-like proteinase. Curr Pharm Des. 2006; 12(35):4555-64. PMID: 17168761.
      Citations: 17     Fields:    Translation:HumansAnimalsCells
    10. Wei P, Fan K, Chen H, Ma L, Huang C, Tan L, Xi D, Li C, Liu Y, Cao A, Lai L. The N-terminal octapeptide acts as a dimerization inhibitor of SARS coronavirus 3C-like proteinase. Biochem Biophys Res Commun. 2006 Jan 20; 339(3):865-72. PMID: 16329994.
      Citations: 34     Fields:    Translation:Cells
    11. Ding L, Zhang XX, Wei P, Fan K, Lai L. The interaction between severe acute respiratory syndrome coronavirus 3C-like proteinase and a dimeric inhibitor by capillary electrophoresis. Anal Biochem. 2005 Aug 01; 343(1):159-65. PMID: 15935325.
      Citations: 14     Fields:    Translation:Cells
    12. Fan K, Ma L, Han X, Liang H, Wei P, Liu Y, Lai L. The substrate specificity of SARS coronavirus 3C-like proteinase. Biochem Biophys Res Commun. 2005 Apr 15; 329(3):934-40. PMID: 15752746.
      Citations: 28     Fields:    Translation:Cells
    13. Liu Z, Huang C, Fan K, Wei P, Chen H, Liu S, Pei J, Shi L, Li B, Yang K, Liu Y, Lai L. Virtual screening of novel noncovalent inhibitors for SARS-CoV 3C-like proteinase. J Chem Inf Model. 2005 Jan-Feb; 45(1):10-17. PMID: 15667124.
      Citations: 22     Fields:    Translation:Cells
    14. Yuan K, Yi L, Chen J, Qu X, Qing T, Rao X, Jiang P, Hu J, Xiong Z, Nie Y, Shi X, Wang W, Ling C, Yin X, Fan K, Lai L, Ding M, Deng H. Suppression of SARS-CoV entry by peptides corresponding to heptad regions on spike glycoprotein. Biochem Biophys Res Commun. 2004 Jul 02; 319(3):746-52. PMID: 15184046.
      Citations: 47     Fields:    Translation:HumansCells
    15. Huang C, Wei P, Fan K, Liu Y, Lai L. 3C-like proteinase from SARS coronavirus catalyzes substrate hydrolysis by a general base mechanism. Biochemistry. 2004 Apr 20; 43(15):4568-74. PMID: 15078103.
      Citations: 85     Fields:    Translation:Cells
    16. Fan K, Wei P, Feng Q, Chen S, Huang C, Ma L, Lai B, Pei J, Liu Y, Chen J, Lai L. Biosynthesis, purification, and substrate specificity of severe acute respiratory syndrome coronavirus 3C-like proteinase. J Biol Chem. 2004 Jan 16; 279(3):1637-42. PMID: 14561748.
      Citations: 127     Fields:    Translation:Cells
    17. Liu S, Pei J, Chen H, Zhu X, Liu Z, Ma W, He F, Lai L. [Modeling of the SARS coronavirus main proteinase and conformational flexibility of the active site]. Beijing Da Xue Xue Bao Yi Xue Ban. 2003 May 31; 35 Suppl:62-5. PMID: 12914221.
      Citations: 3     Fields:    Translation:Cells