Rolf Hilgenfeld

InstitutionUniversity of Lübeck
AddressGermany
vCardDownload vCard
    Publication Timeline
    COVID-19 publications
    Bar chart showing 9 Covid-19 publications, with a maximum of 3 publications in April 2021
    All Publications
    Bar chart showing 115 publications over 19 distinct years, with a maximum of 11 publications in 2011
    These graphs show COVID-19 publications by month since August 2019 and all publications written by authors of COVID-19 publications over the past 30 years.

    To see the data from both graphs as text, click here.
    Publication Field Summary
    This graph shows the number and percent of publications by field. Fields are based on how the National Library of Medicine (NLM) classifies the publications' journals and might not represent the specific topics of the publications. Note that an individual publication can be assigned to more than one field. As a result, the publication counts in this graph might add up to more than the number of publications the person has written. To see the data as text, click here.
    Publication List
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications.
    Sort By:     Newest   |   Oldest   |   Most Cited   |   Most Discussed
    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Lei J, Ma-Lauer Y, Han Y, Thoms M, Buschauer R, Jores J, Thiel V, Beckmann R, Deng W, Leonhardt H, Hilgenfeld R, von Brunn A. The SARS-unique domain (SUD) of SARS-CoV and SARS-CoV-2 interacts with human Paip1 to enhance viral RNA translation. EMBO J. 2021 06 01; 40(11):e102277. PMID: 33876849.
      Citations: 5     Fields:    Translation:HumansCells
    2. Dai W, Jochmans D, Xie H, Yang H, Li J, Su H, Chang D, Wang J, Peng J, Zhu L, Nian Y, Hilgenfeld R, Jiang H, Chen K, Zhang L, Xu Y, Neyts J, Liu H. Design, Synthesis, and Biological Evaluation of Peptidomimetic Aldehydes as Broad-Spectrum Inhibitors against Enterovirus and SARS-CoV-2. J Med Chem. 2022 02 24; 65(4):2794-2808. PMID: 33872498.
      Citations: 2     Fields:    
    3. Günther S, Reinke PYA, Fernández-García Y, Lieske J, Lane TJ, Ginn HM, Koua FHM, Ehrt C, Ewert W, Oberthuer D, Yefanov O, Meier S, Lorenzen K, Krichel B, Kopicki JD, Gelisio L, Brehm W, Dunkel I, Seychell B, Gieseler H, Norton-Baker B, Escudero-Pérez B, Domaracky M, Saouane S, Tolstikova A, White TA, Hänle A, Groessler M, Fleckenstein H, Trost F, Galchenkova M, Gevorkov Y, Li C, Awel S, Peck A, Barthelmess M, Schlünzen F, Lourdu Xavier P, Werner N, Andaleeb H, Ullah N, Falke S, Srinivasan V, França BA, Schwinzer M, Brognaro H, Rogers C, Melo D, Zaitseva-Doyle JJ, Knoska J, Peña-Murillo GE, Mashhour AR, Hennicke V, Fischer P, Hakanpää J, Meyer J, Gribbon P, Ellinger B, Kuzikov M, et al. X-ray screening identifies active site and allosteric inhibitors of SARS-CoV-2 main protease. Science. 2021 05 07; 372(6542):642-646. PMID: 33811162.
      Citations: 28     Fields:    Translation:AnimalsCells
    4. Zhang L, Howland M, Hilgenfeld R, Anderson MO, Eagon S. Identification of non-covalent SARS-CoV-2 main protease inhibitors by a virtual screen of commercially available drug-like compounds. Bioorg Med Chem Lett. 2021 06 01; 41:127990. PMID: 33775840.
      Citations:    Fields:    Translation:Cells
    5. Bárcena M, Barnes CO, Beck M, Bjorkman PJ, Canard B, Gao GF, Gao Y, Hilgenfeld R, Hummer G, Patwardhan A, Santoni G, Saphire EO, Schaffitzel C, Schendel SL, Smith JL, Thorn A, Veesler D, Zhang P, Zhou Q. Structural biology in the fight against COVID-19. Nat Struct Mol Biol. 2021 01; 28(1):2-7. PMID: 33437043.
      Citations: 3     Fields:    Translation:Humans
    6. Rut W, Groborz K, Zhang L, Sun X, Zmudzinski M, Pawlik B, Wang X, Jochmans D, Neyts J, Mlynarski W, Hilgenfeld R, Drag M. SARS-CoV-2 Mpro inhibitors and activity-based probes for patient-sample imaging. Nat Chem Biol. 2021 02; 17(2):222-228. PMID: 33093684.
      Citations: 36     Fields:    Translation:HumansCells
    7. Zhang L, Lin D, Sun X, Curth U, Drosten C, Sauerhering L, Becker S, Rox K, Hilgenfeld R. Crystal structure of SARS-CoV-2 main protease provides a basis for design of improved a-ketoamide inhibitors. Science. 2020 04 24; 368(6489):409-412. PMID: 32198291.
      Citations: 763     Fields:    Translation:HumansAnimalsCells
    8. Krichel B, Falke S, Hilgenfeld R, Redecke L, Uetrecht C. Processing of the SARS-CoV pp1a/ab nsp7-10 region. Biochem J. 2020 03 13; 477(5):1009-1019. PMID: 32083638.
      Citations: 35     Fields:    Translation:Cells
    9. Zhang L, Lin D, Kusov Y, Nian Y, Ma Q, Wang J, von Brunn A, Leyssen P, Lanko K, Neyts J, de Wilde A, Snijder EJ, Liu H, Hilgenfeld R. a-Ketoamides as Broad-Spectrum Inhibitors of Coronavirus and Enterovirus Replication: Structure-Based Design, Synthesis, and Activity Assessment. J Med Chem. 2020 05 14; 63(9):4562-4578. PMID: 32045235.
      Citations: 127     Fields:    Translation:HumansAnimalsCells
    10. Badolo A, Burt F, Daniel S, Fearns R, Gudo ES, Kielian M, Lescar J, Shi Y, von Brunn A, Weiss SR, Hilgenfeld R. Third Tofo Advanced Study Week on Emerging and Re-emerging Viruses, 2018. Antiviral Res. 2019 02; 162:142-150. PMID: 30597184.
      Citations: 1     Fields:    Translation:HumansAnimalsCellsPHPublic Health
    11. Lei J, Kusov Y, Hilgenfeld R. Nsp3 of coronaviruses: Structures and functions of a large multi-domain protein. Antiviral Res. 2018 01; 149:58-74. PMID: 29128390.
      Citations: 180     Fields:    Translation:HumansCells
    12. Ma-Lauer Y, Carbajo-Lozoya J, Hein MY, Müller MA, Deng W, Lei J, Meyer B, Kusov Y, von Brunn B, Bairad DR, Hünten S, Drosten C, Hermeking H, Leonhardt H, Mann M, Hilgenfeld R, von Brunn A. p53 down-regulates SARS coronavirus replication and is targeted by the SARS-unique domain and PLpro via E3 ubiquitin ligase RCHY1. Proc Natl Acad Sci U S A. 2016 08 30; 113(35):E5192-201. PMID: 27519799.
      Citations: 64     Fields:    Translation:HumansCells
    13. Lei J, Hilgenfeld R. Structural and mutational analysis of the interaction between the Middle-East respiratory syndrome coronavirus (MERS-CoV) papain-like protease and human ubiquitin. Virol Sin. 2016 Aug; 31(4):288-99. PMID: 27245450.
      Citations: 16     Fields:    Translation:HumansCells
    14. Kusov Y, Tan J, Alvarez E, Enjuanes L, Hilgenfeld R. A G-quadruplex-binding macrodomain within the "SARS-unique domain" is essential for the activity of the SARS-coronavirus replication-transcription complex. Virology. 2015 Oct; 484:313-322. PMID: 26149721.
      Citations: 49     Fields:    Translation:Cells
    15. Shukla A, Hilgenfeld R. Acquisition of new protein domains by coronaviruses: analysis of overlapping genes coding for proteins N and 9b in SARS coronavirus. Virus Genes. 2015 Feb; 50(1):29-38. PMID: 25410051.
      Citations: 10     Fields:    Translation:HumansCells
    16. Hilgenfeld R. From SARS to MERS: crystallographic studies on coronaviral proteases enable antiviral drug design. FEBS J. 2014 Sep; 281(18):4085-96. PMID: 25039866.
      Citations: 192     Fields:    Translation:HumansAnimalsCells
    17. Liu DX, Fung TS, Chong KK, Shukla A, Hilgenfeld R. Accessory proteins of SARS-CoV and other coronaviruses. Antiviral Res. 2014 Sep; 109:97-109. PMID: 24995382.
      Citations: 136     Fields:    Translation:HumansAnimalsCells
    18. Lei J, Mesters JR, Drosten C, Anemüller S, Ma Q, Hilgenfeld R. Crystal structure of the papain-like protease of MERS coronavirus reveals unusual, potentially druggable active-site features. Antiviral Res. 2014 Sep; 109:72-82. PMID: 24992731.
      Citations: 40     Fields:    Translation:Cells
    19. Hilgenfeld R, Peiris M. From SARS to MERS: 10 years of research on highly pathogenic human coronaviruses. Antiviral Res. 2013 Oct; 100(1):286-95. PMID: 24012996.
      Citations: 135     Fields:    Translation:HumansAnimalsCells
    20. Xiao Y, Ma Q, Restle T, Shang W, Svergun DI, Ponnusamy R, Sczakiel G, Hilgenfeld R. Nonstructural proteins 7 and 8 of feline coronavirus form a 2:1 heterotrimer that exhibits primer-independent RNA polymerase activity. J Virol. 2012 Apr; 86(8):4444-54. PMID: 22318142.
      Citations: 40     Fields:    Translation:AnimalsCells
    21. Pfefferle S, Schöpf J, Kögl M, Friedel CC, Müller MA, Carbajo-Lozoya J, Stellberger T, von Dall'Armi E, Herzog P, Kallies S, Niemeyer D, Ditt V, Kuri T, Züst R, Pumpor K, Hilgenfeld R, Schwarz F, Zimmer R, Steffen I, Weber F, Thiel V, Herrler G, Thiel HJ, Schwegmann-Wessels C, Pöhlmann S, Haas J, Drosten C, von Brunn A. The SARS-coronavirus-host interactome: identification of cyclophilins as target for pan-coronavirus inhibitors. PLoS Pathog. 2011 Oct; 7(10):e1002331. PMID: 22046132.
      Citations: 196     Fields:    Translation:HumansAnimalsCells
    22. Zhu L, George S, Schmidt MF, Al-Gharabli SI, Rademann J, Hilgenfeld R. Peptide aldehyde inhibitors challenge the substrate specificity of the SARS-coronavirus main protease. Antiviral Res. 2011 Nov; 92(2):204-12. PMID: 21854807.
      Citations: 47     Fields:    Translation:Cells
    23. Chen S, Jonas F, Shen C, Hilgenfeld R, Higenfeld R. Liberation of SARS-CoV main protease from the viral polyprotein: N-terminal autocleavage does not depend on the mature dimerization mode. Protein Cell. 2010 Jan; 1(1):59-74. PMID: 21203998.
      Citations: 23     Fields:    Translation:Cells
    24. Steuber H, Hilgenfeld R. Recent advances in targeting viral proteases for the discovery of novel antivirals. Curr Top Med Chem. 2010; 10(3):323-45. PMID: 20166951.
      Citations: 19     Fields:    Translation:Cells
    25. Wojdyla JA, Manolaridis I, Snijder EJ, Gorbalenya AE, Coutard B, Piotrowski Y, Hilgenfeld R, Tucker PA. Structure of the X (ADRP) domain of nsp3 from feline coronavirus. Acta Crystallogr D Biol Crystallogr. 2009 Dec; 65(Pt 12):1292-300. PMID: 19966415.
      Citations: 13     Fields:    Translation:Cells
    26. Tan J, Vonrhein C, Smart OS, Bricogne G, Bollati M, Kusov Y, Hansen G, Mesters JR, Schmidt CL, Hilgenfeld R. The SARS-unique domain (SUD) of SARS coronavirus contains two macrodomains that bind G-quadruplexes. PLoS Pathog. 2009 May; 5(5):e1000428. PMID: 19436709.
      Citations: 72     Fields:    Translation:Cells
    27. Piotrowski Y, Hansen G, Boomaars-van der Zanden AL, Snijder EJ, Gorbalenya AE, Hilgenfeld R. Crystal structures of the X-domains of a Group-1 and a Group-3 coronavirus reveal that ADP-ribose-binding may not be a conserved property. Protein Sci. 2009 Jan; 18(1):6-16. PMID: 19177346.
      Citations: 28     Fields:    Translation:Cells
    28. Ponnusamy R, Moll R, Weimar T, Mesters JR, Hilgenfeld R. Variable oligomerization modes in coronavirus non-structural protein 9. J Mol Biol. 2008 Nov 28; 383(5):1081-96. PMID: 18694760.
      Citations: 25     Fields:    Translation:Cells
    29. Verschueren KH, Pumpor K, Anemüller S, Chen S, Mesters JR, Hilgenfeld R. A structural view of the inactivation of the SARS coronavirus main proteinase by benzotriazole esters. Chem Biol. 2008 Jun; 15(6):597-606. PMID: 18559270.
      Citations: 34     Fields:    Translation:Cells
    30. Schmidt MF, Isidro-Llobet A, Lisurek M, El-Dahshan A, Tan J, Hilgenfeld R, Rademann J. Sensitized detection of inhibitory fragments and iterative development of non-peptidic protease inhibitors by dynamic ligation screening. Angew Chem Int Ed Engl. 2008; 47(17):3275-8. PMID: 18348134.
      Citations: 16     Fields:    Translation:Cells
    31. Piotrowski Y, Ponnusamy R, Glaser S, Daabach A, Moll R, Hilgenfeld R. Production of coronavirus nonstructural proteins in soluble form for crystallization. Methods Mol Biol. 2008; 454:139-59. PMID: 19057878.
      Citations: 1     Fields:    Translation:HumansCells
    32. Tan J, Kusov Y, Mutschall D, Tech S, Nagarajan K, Hilgenfeld R, Schmidt CL. The "SARS-unique domain" (SUD) of SARS coronavirus is an oligo(G)-binding protein. Biochem Biophys Res Commun. 2007 Dec 28; 364(4):877-82. PMID: 17976532.
      Citations: 23     Fields:    Translation:Cells
    33. Al-Gharabli SI, Shah ST, Weik S, Schmidt MF, Mesters JR, Kuhn D, Klebe G, Hilgenfeld R, Rademann J. An efficient method for the synthesis of peptide aldehyde libraries employed in the discovery of reversible SARS coronavirus main protease (SARS-CoV Mpro) inhibitors. Chembiochem. 2006 Jul; 7(7):1048-55. PMID: 16688706.
      Citations: 16     Fields:    Translation:HumansCells
    34. Matthes N, Mesters JR, Coutard B, Canard B, Snijder EJ, Moll R, Hilgenfeld R. The non-structural protein Nsp10 of mouse hepatitis virus binds zinc ions and nucleic acids. FEBS Lett. 2006 Jul 24; 580(17):4143-9. PMID: 16828088.
      Citations: 21     Fields:    Translation:Cells
    35. Hilgenfeld R, Pumpor K. Sometimes intermediates. Do the job! Chem Biol. 2006 Mar; 13(3):235-6. PMID: 16638527.
      Citations: 3     Fields:    Translation:Cells
    36. Piotrowski Y, van der Hoek L, Pyrc K, Berkhout B, Moll R, Hilgenfeld R. Nonstructural proteins of human coronavirus NL63. Adv Exp Med Biol. 2006; 581:97-100. PMID: 17037512.
      Citations:    Fields:    Translation:Cells
    37. Hilgenfeld R, Anand K, Mesters JR, Rao Z, Shen X, Jiang H, Tan J, Verschueren KH. Structure and dynamics of SARS coronavirus main proteinase (Mpro). Adv Exp Med Biol. 2006; 581:585-91. PMID: 17037602.
      Citations: 6     Fields:    Translation:Cells
    38. Ponnusamy R, Mesters JR, Ziebuhr J, Moll R, Hilgenfeld R. Non structural proteins 8 and 9 of human coronavirus 229E. Adv Exp Med Biol. 2006; 581:49-54. PMID: 17037503.
      Citations: 2     Fields:    Translation:HumansCells
    39. Tan J, Verschueren KH, Anand K, Shen J, Yang M, Xu Y, Rao Z, Bigalke J, Heisen B, Mesters JR, Chen K, Shen X, Jiang H, Hilgenfeld R. pH-dependent conformational flexibility of the SARS-CoV main proteinase (M(pro)) dimer: molecular dynamics simulations and multiple X-ray structure analyses. J Mol Biol. 2005 Nov 18; 354(1):25-40. PMID: 16242152.
      Citations: 71     Fields:    Translation:Cells
    40. Yang H, Xie W, Xue X, Yang K, Ma J, Liang W, Zhao Q, Zhou Z, Pei D, Ziebuhr J, Hilgenfeld R, Yuen KY, Wong L, Gao G, Chen S, Chen Z, Ma D, Bartlam M, Rao Z. Design of wide-spectrum inhibitors targeting coronavirus main proteases. PLoS Biol. 2005 Oct; 3(10):e324. PMID: 16128623.
      Citations: 219     Fields:    Translation:HumansAnimalsCells
    41. Groneberg DA, Hilgenfeld R, Zabel P. Molecular mechanisms of severe acute respiratory syndrome (SARS). Respir Res. 2005 Jan 20; 6:8. PMID: 15661082.
      Citations: 41     Fields:    Translation:HumansAnimalsCells
    42. Luo C, Luo H, Zheng S, Gui C, Yue L, Yu C, Sun T, He P, Chen J, Shen J, Luo X, Li Y, Liu H, Bai D, Shen J, Yang Y, Li F, Zuo J, Hilgenfeld R, Pei G, Chen K, Shen X, Jiang H. Nucleocapsid protein of SARS coronavirus tightly binds to human cyclophilin A. Biochem Biophys Res Commun. 2004 Aug 27; 321(3):557-65. PMID: 15358143.
      Citations: 53     Fields:    Translation:HumansCells
    43. Yang H, Yang M, Ding Y, Liu Y, Lou Z, Zhou Z, Sun L, Mo L, Ye S, Pang H, Gao GF, Anand K, Bartlam M, Hilgenfeld R, Rao Z. The crystal structures of severe acute respiratory syndrome virus main protease and its complex with an inhibitor. Proc Natl Acad Sci U S A. 2003 Nov 11; 100(23):13190-5. PMID: 14585926.
      Citations: 375     Fields:    Translation:Cells
    44. Anand K, Ziebuhr J, Wadhwani P, Mesters JR, Hilgenfeld R. Coronavirus main proteinase (3CLpro) structure: basis for design of anti-SARS drugs. Science. 2003 Jun 13; 300(5626):1763-7. PMID: 12746549.
      Citations: 563     Fields:    Translation:HumansCells
    45. Anand K, Palm GJ, Mesters JR, Siddell SG, Ziebuhr J, Hilgenfeld R. Structure of coronavirus main proteinase reveals combination of a chymotrypsin fold with an extra alpha-helical domain. EMBO J. 2002 Jul 01; 21(13):3213-24. PMID: 12093723.
      Citations: 229     Fields:    Translation:Cells