Clara C Posthuma

InstitutionLeiden University Medical Center
AddressThe
Netherlands
vCardDownload vCard
    Publication Timeline
    COVID-19 publications
    Bar chart showing 1 Covid-19 publications, with a maximum of 1 publications in November 2020
    All Publications
    Bar chart showing 28 publications over 15 distinct years, with a maximum of 5 publications in 2014
    These graphs show COVID-19 publications by month since August 2019 and all publications written by authors of COVID-19 publications over the past 30 years.

    To see the data from both graphs as text, click here.
    Publication Field Summary
    This graph shows the number and percent of publications by field. Fields are based on how the National Library of Medicine (NLM) classifies the publications' journals and might not represent the specific topics of the publications. Note that an individual publication can be assigned to more than one field. As a result, the publication counts in this graph might add up to more than the number of publications the person has written. To see the data as text, click here.
    Publication List
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications.
    Sort By:     Newest   |   Oldest   |   Most Cited   |   Most Discussed
    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Ogando NS, Zevenhoven-Dobbe JC, van der Meer Y, Bredenbeek PJ, Posthuma CC, Snijder EJ. The Enzymatic Activity of the nsp14 Exoribonuclease Is Critical for Replication of MERS-CoV and SARS-CoV-2. J Virol. 2020 11 09; 94(23). PMID: 32938769.
      Citations: 45     Fields:    Translation:HumansAnimalsCells
    2. de Wilde AH, Boomaars-van der Zanden AL, de Jong AWM, Bárcena M, Snijder EJ, Posthuma CC. Adaptive Mutations in Replicase Transmembrane Subunits Can Counteract Inhibition of Equine Arteritis Virus RNA Synthesis by Cyclophilin Inhibitors. J Virol. 2019 09 15; 93(18). PMID: 31243130.
      Citations: 1     Fields:    Translation:HumansCells
    3. Ogando NS, Ferron F, Decroly E, Canard B, Posthuma CC, Snijder EJ. The Curious Case of the Nidovirus Exoribonuclease: Its Role in RNA Synthesis and Replication Fidelity. Front Microbiol. 2019; 10:1813. PMID: 31440227.
      Citations: 45     
    4. Yoon JS, Kim G, Jarhad DB, Kim HR, Shin YS, Qu S, Sahu PK, Kim HO, Lee HW, Wang SB, Kong YJ, Chang TS, Ogando NS, Kovacikova K, Snijder EJ, Posthuma CC, van Hemert MJ, Jeong LS. Design, Synthesis, and Anti-RNA Virus Activity of 6'-Fluorinated-Aristeromycin Analogues. J Med Chem. 2019 07 11; 62(13):6346-6362. PMID: 31244113.
      Citations: 15     Fields:    Translation:HumansAnimalsCells
    5. de Wilde AH, Pham U, Posthuma CC, Snijder EJ. Cyclophilins and cyclophilin inhibitors in nidovirus replication. Virology. 2018 09; 522:46-55. PMID: 30014857.
      Citations: 29     Fields:    Translation:HumansAnimalsCells
    6. de Wilde AH, Zevenhoven-Dobbe JC, Beugeling C, Chatterji U, de Jong D, Gallay P, Szuhai K, Posthuma CC, Snijder EJ. Coronaviruses and arteriviruses display striking differences in their cyclophilin A-dependence during replication in cell culture. Virology. 2018 04; 517:148-156. PMID: 29249267.
      Citations: 5     Fields:    Translation:HumansAnimalsCells
    7. Posthuma CC, Te Velthuis AJW, Snijder EJ. Nidovirus RNA polymerases: Complex enzymes handling exceptional RNA genomes. Virus Res. 2017 04 15; 234:58-73. PMID: 28174054.
      Citations: 40     Fields:    Translation:HumansAnimalsCells
    8. de Wilde AH, Falzarano D, Zevenhoven-Dobbe JC, Beugeling C, Fett C, Martellaro C, Posthuma CC, Feldmann H, Perlman S, Snijder EJ. Alisporivir inhibits MERS- and SARS-coronavirus replication in cell culture, but not SARS-coronavirus infection in a mouse model. Virus Res. 2017 01 15; 228:7-13. PMID: 27840112.
      Citations: 33     Fields:    Translation:HumansAnimalsCells
    9. Lehmann KC, Gorbalenya AE, Snijder EJ, Posthuma CC. Arterivirus RNA-dependent RNA polymerase: Vital enzymatic activity remains elusive. Virology. 2016 Jan; 487:68-74. PMID: 26499043.
      Citations: 5     Fields:    Translation:Cells
    10. Lehmann KC, Gulyaeva A, Zevenhoven-Dobbe JC, Janssen GM, Ruben M, Overkleeft HS, van Veelen PA, Samborskiy DV, Kravchenko AA, Leontovich AM, Sidorov IA, Snijder EJ, Posthuma CC, Gorbalenya AE. Discovery of an essential nucleotidylating activity associated with a newly delineated conserved domain in the RNA polymerase-containing protein of all nidoviruses. Nucleic Acids Res. 2015 Sep 30; 43(17):8416-34. PMID: 26304538.
      Citations: 79     Fields:    Translation:Cells
    11. Lehmann KC, Hooghiemstra L, Gulyaeva A, Samborskiy DV, Zevenhoven-Dobbe JC, Snijder EJ, Gorbalenya AE, Posthuma CC. Arterivirus nsp12 versus the coronavirus nsp16 2'-O-methyltransferase: comparison of the C-terminal cleavage products of two nidovirus pp1ab polyproteins. J Gen Virol. 2015 Sep; 96(9):2643-2655. PMID: 26041874.
      Citations: 8     Fields:    Translation:Cells
    12. Peters HL, Jochmans D, de Wilde AH, Posthuma CC, Snijder EJ, Neyts J, Seley-Radtke KL. Design, synthesis and evaluation of a series of acyclic fleximer nucleoside analogues with anti-coronavirus activity. Bioorg Med Chem Lett. 2015 Aug 01; 25(15):2923-6. PMID: 26048809.
      Citations: 29     Fields:    Translation:HumansAnimalsCells
    13. Lehmann KC, Snijder EJ, Posthuma CC, Gorbalenya AE. What we know but do not understand about nidovirus helicases. Virus Res. 2015 Apr 16; 202:12-32. PMID: 25497126.
      Citations: 27     Fields:    Translation:HumansAnimalsCells
    14. Subissi L, Posthuma CC, Collet A, Zevenhoven-Dobbe JC, Gorbalenya AE, Decroly E, Snijder EJ, Canard B, Imbert I. One severe acute respiratory syndrome coronavirus protein complex integrates processive RNA polymerase and exonuclease activities. Proc Natl Acad Sci U S A. 2014 Sep 16; 111(37):E3900-9. PMID: 25197083.
      Citations: 198     Fields:    Translation:HumansCells
    15. Bouvet M, Lugari A, Posthuma CC, Zevenhoven JC, Bernard S, Betzi S, Imbert I, Canard B, Guillemot JC, Lécine P, Pfefferle S, Drosten C, Snijder EJ, Decroly E, Morelli X. Coronavirus Nsp10, a critical co-factor for activation of multiple replicative enzymes. J Biol Chem. 2014 Sep 12; 289(37):25783-96. PMID: 25074927.
      Citations: 66     Fields:    Translation:HumansCells
    16. de Wilde AH, Jochmans D, Posthuma CC, Zevenhoven-Dobbe JC, van Nieuwkoop S, Bestebroer TM, van den Hoogen BG, Neyts J, Snijder EJ. Screening of an FDA-approved compound library identifies four small-molecule inhibitors of Middle East respiratory syndrome coronavirus replication in cell culture. Antimicrob Agents Chemother. 2014 Aug; 58(8):4875-84. PMID: 24841269.
      Citations: 304     Fields:    Translation:HumansAnimalsCells
    17. de Wilde AH, Raj VS, Oudshoorn D, Bestebroer TM, van Nieuwkoop S, Limpens RWAL, Posthuma CC, van der Meer Y, Bárcena M, Haagmans BL, Snijder EJ, van den Hoogen BG. MERS-coronavirus replication induces severe in vitro cytopathology and is strongly inhibited by cyclosporin A or interferon-a treatment. J Gen Virol. 2013 Aug; 94(Pt 8):1749-1760. PMID: 23620378.
      Citations: 177     Fields:    Translation:HumansAnimalsCells
    18. Raaben M, Posthuma CC, Verheije MH, te Lintelo EG, Kikkert M, Drijfhout JW, Snijder EJ, Rottier PJ, de Haan CA. The ubiquitin-proteasome system plays an important role during various stages of the coronavirus infection cycle. J Virol. 2010 Aug; 84(15):7869-79. PMID: 20484504.
      Citations: 51     Fields:    Translation:AnimalsCells
    19. van den Born E, Posthuma CC, Knoops K, Snijder EJ. An infectious recombinant equine arteritis virus expressing green fluorescent protein from its replicase gene. J Gen Virol. 2007 Apr; 88(Pt 4):1196-1205. PMID: 17374763.
      Citations: 15     Fields:    Translation:AnimalsCells
    20. Posthuma CC, Nedialkova DD, Zevenhoven-Dobbe JC, Blokhuis JH, Gorbalenya AE, Snijder EJ. Site-directed mutagenesis of the Nidovirus replicative endoribonuclease NendoU exerts pleiotropic effects on the arterivirus life cycle. J Virol. 2006 Feb; 80(4):1653-61. PMID: 16439522.
      Citations: 44     Fields:    Translation:AnimalsCells
    21. van den Born E, Posthuma CC, Gultyaev AP, Snijder EJ. Discontinuous subgenomic RNA synthesis in arteriviruses is guided by an RNA hairpin structure located in the genomic leader region. J Virol. 2005 May; 79(10):6312-24. PMID: 15858015.
      Citations: 37     Fields:    Translation:Cells
    22. Seybert A, Posthuma CC, van Dinten LC, Snijder EJ, Gorbalenya AE, Ziebuhr J. A complex zinc finger controls the enzymatic activities of nidovirus helicases. J Virol. 2005 Jan; 79(2):696-704. PMID: 15613297.
      Citations: 62     Fields:    Translation:Cells