D Lorne Tyrrell

InstitutionUniversity of Alberta
AddressAlberta
Canada
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    Publication Timeline
    COVID-19 publications
    Bar chart showing 12 Covid-19 publications, with a maximum of 2 publications in October 2020 and March 2021 and May 2021
    All Publications
    Bar chart showing 96 publications over 20 distinct years, with a maximum of 14 publications in 2013
    These graphs show COVID-19 publications by month since August 2019 and all publications written by authors of COVID-19 publications over the past 30 years.

    To see the data from both graphs as text, click here.
    Publication Field Summary
    This graph shows the number and percent of publications by field. Fields are based on how the National Library of Medicine (NLM) classifies the publications' journals and might not represent the specific topics of the publications. Note that an individual publication can be assigned to more than one field. As a result, the publication counts in this graph might add up to more than the number of publications the person has written. To see the data as text, click here.
    Publication List
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications.
    Sort By:     Newest   |   Oldest   |   Most Cited   |   Most Discussed
    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Bai B, Belovodskiy A, Hena M, Kandadai AS, Joyce MA, Saffran HA, Shields JA, Khan MB, Arutyunova E, Lu J, Bajwa SK, Hockman D, Fischer C, Lamer T, Vuong W, van Belkum MJ, Gu Z, Lin F, Du Y, Xu J, Rahim M, Young HS, Vederas JC, Tyrrell DL, Lemieux MJ, Nieman JA. Peptidomimetic a-Acyloxymethylketone Warheads with Six-Membered Lactam P1 Glutamine Mimic: SARS-CoV-2 3CL Protease Inhibition, Coronavirus Antiviral Activity, and in Vitro Biological Stability. J Med Chem. 2022 02 24; 65(4):2905-2925. PMID: 34242027.
      Citations: 3     Fields:    
    2. Vuong W, Fischer C, Khan MB, van Belkum MJ, Lamer T, Willoughby KD, Lu J, Arutyunova E, Joyce MA, Saffran HA, Shields JA, Young HS, Nieman JA, Tyrrell DL, Lemieux MJ, Vederas JC. Improved SARS-CoV-2 Mpro inhibitors based on feline antiviral drug GC376: Structural enhancements, increased solubility, and micellar studies. Eur J Med Chem. 2021 Oct 15; 222:113584. PMID: 34118724.
      Citations: 6     Fields:    Translation:HumansAnimalsCells
    3. Shahbaz S, Xu L, Osman M, Sligl W, Shields J, Joyce M, Tyrrell DL, Oyegbami O, Elahi S. Erythroid precursors and progenitors suppress adaptive immunity and get invaded by SARS-CoV-2. Stem Cell Reports. 2021 05 11; 16(5):1165-1181. PMID: 33979601.
      Citations: 9     Fields:    Translation:HumansAnimalsCells
    4. Arutyunova E, Khan MB, Fischer C, Lu J, Lamer T, Vuong W, van Belkum MJ, McKay RT, Tyrrell DL, Vederas JC, Young HS, Lemieux MJ. N-Terminal Finger Stabilizes the S1 Pocket for the Reversible Feline Drug GC376 in the SARS-CoV-2 Mpro Dimer. J Mol Biol. 2021 06 25; 433(13):167003. PMID: 33895266.
      Citations: 3     Fields:    Translation:Animals
    5. Pandey M, Ozberk V, Eskandari S, Shalash AO, Joyce MA, Saffran HA, Day CJ, Lepletier A, Spillings BL, Mills JL, Calcutt A, Fan F, Williams JT, Stanisic DI, Hattingh L, Gerrard J, Skwarczynski M, Mak J, Jennings MP, Toth I, Tyrrell DL, Good MF. Antibodies to neutralising epitopes synergistically block the interaction of the receptor-binding domain of SARS-CoV-2 to ACE 2. Clin Transl Immunology. 2021; 10(3):e1260. PMID: 33732459.
      Citations: 4     
    6. Feng W, Newbigging AM, Tao J, Cao Y, Peng H, Le C, Wu J, Pang B, Li J, Tyrrell DL, Zhang H, Le XC. CRISPR technology incorporating amplification strategies: molecular assays for nucleic acids, proteins, and small molecules. Chem Sci. 2021 Mar 02; 12(13):4683-4698. PMID: 34163728.
      Citations: 4     
    7. Feld JJ, Kandel C, Biondi MJ, Kozak RA, Zahoor MA, Lemieux C, Borgia SM, Boggild AK, Powis J, McCready J, Tan DHS, Chan T, Coburn B, Kumar D, Humar A, Chan A, O'Neil B, Noureldin S, Booth J, Hong R, Smookler D, Aleyadeh W, Patel A, Barber B, Casey J, Hiebert R, Mistry H, Choong I, Hislop C, Santer DM, Lorne Tyrrell D, Glenn JS, Gehring AJ, Janssen HLA, Hansen BE. Peginterferon lambda for the treatment of outpatients with COVID-19: a phase 2, placebo-controlled randomised trial. Lancet Respir Med. 2021 05; 9(5):498-510. PMID: 33556319.
      Citations: 39     Fields:    Translation:HumansCTClinical Trials
    8. Pang B, Xu J, Liu Y, Peng H, Feng W, Cao Y, Wu J, Xiao H, Pabbaraju K, Tipples G, Joyce MA, Saffran HA, Tyrrell DL, Zhang H, Le XC. Isothermal Amplification and Ambient Visualization in a Single Tube for the Detection of SARS-CoV-2 Using Loop-Mediated Amplification and CRISPR Technology. Anal Chem. 2020 12 15; 92(24):16204-16212. PMID: 33238709.
      Citations: 21     Fields:    Translation:HumansCells
    9. Vuong W, Khan MB, Fischer C, Arutyunova E, Lamer T, Shields J, Saffran HA, McKay RT, van Belkum MJ, Joyce MA, Young HS, Tyrrell DL, Vederas JC, Lemieux MJ. Author Correction: Feline coronavirus drug inhibits the main protease of SARS-CoV-2 and blocks virus replication. Nat Commun. 2020 Oct 20; 11(1):5409. PMID: 33082353.
      Citations: 2     Fields:    
    10. Onabajo OO, Banday AR, Stanifer ML, Yan W, Obajemu A, Santer DM, Florez-Vargas O, Piontkivska H, Vargas JM, Ring TJ, Kee C, Doldan P, Tyrrell DL, Mendoza JL, Boulant S, Prokunina-Olsson L. Interferons and viruses induce a novel truncated ACE2 isoform and not the full-length SARS-CoV-2 receptor. Nat Genet. 2020 12; 52(12):1283-1293. PMID: 33077916.
      Citations: 69     Fields:    Translation:HumansCells
    11. Vuong W, Khan MB, Fischer C, Arutyunova E, Lamer T, Shields J, Saffran HA, McKay RT, van Belkum MJ, Joyce MA, Young HS, Tyrrell DL, Vederas JC, Lemieux MJ. Feline coronavirus drug inhibits the main protease of SARS-CoV-2 and blocks virus replication. Nat Commun. 2020 08 27; 11(1):4282. PMID: 32855413.
      Citations: 85     Fields:    Translation:HumansAnimalsCells
    12. Feng W, Newbigging AM, Le C, Pang B, Peng H, Cao Y, Wu J, Abbas G, Song J, Wang DB, Cui M, Tao J, Tyrrell DL, Zhang XE, Zhang H, Le XC. Molecular Diagnosis of COVID-19: Challenges and Research Needs. Anal Chem. 2020 08 04; 92(15):10196-10209. PMID: 32573207.
      Citations: 58     Fields:    Translation:HumansCellsPHPublic Health
    13. Kumar R, Semaine W, Johar M, Tyrrell DL, Agrawal B. Effect of various pyrimidines possessing the 1-[(2-hydroxy-1-(hydroxymethyl)ethoxy)methyl] moiety, able to mimic natural 2'-deoxyribose, on wild-type and mutant hepatitis B virus replication. J Med Chem. 2006 Jun 15; 49(12):3693-700. PMID: 16759112.
      Citations: 2     Fields:    Translation:HumansAnimalsCells
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