Stanley Perlman

InstitutionUNIVERSITY OF IOWA
AddressIowa City
Iowa
United States
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    Publication Timeline
    COVID-19 publications
    Bar chart showing 47 Covid-19 publications, with a maximum of 5 publications in June 2021 and July 2021
    All Publications
    Bar chart showing 221 publications over 27 distinct years, with a maximum of 26 publications in 2020
    These graphs show COVID-19 publications by month since August 2019 and all publications written by authors of COVID-19 publications over the past 30 years.

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    Publication Field Summary
    This graph shows the number and percent of publications by field. Fields are based on how the National Library of Medicine (NLM) classifies the publications' journals and might not represent the specific topics of the publications. Note that an individual publication can be assigned to more than one field. As a result, the publication counts in this graph might add up to more than the number of publications the person has written. To see the data as text, click here.
    Publication List
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Wang Y, Perlman S. COVID-19: Inflammatory Profile. Annu Rev Med. 2022 01 27; 73:65-80. PMID: 34437814.
      Citations:    Fields:    
    2. Qing E, Kicmal T, Kumar B, Hawkins GM, Timm E, Perlman S, Gallagher T. Dynamics of SARS-CoV-2 Spike Proteins in Cell Entry: Control Elements in the Amino-Terminal Domains. mBio. 2021 08 31; 12(4):e0159021. PMID: 34340537.
      Citations: 1     Fields:    Translation:HumansCells
    3. Ye G, Gallant J, Zheng J, Massey C, Shi K, Tai W, Odle A, Vickers M, Shang J, Wan Y, Du L, Aihara H, Perlman S, LeBeau A, Li F. The development of Nanosota-1 as anti-SARS-CoV-2 nanobody drug candidates. Elife. 2021 08 02; 10. PMID: 34338634.
      Citations: 5     Fields:    Translation:HumansAnimalsCellsPHPublic Health
    4. Xydakis MS, Albers MW, Holbrook EH, Lyon DM, Shih RY, Frasnelli JA, Pagenstecher A, Kupke A, Enquist LW, Perlman S. Post-viral effects of COVID-19 in the olfactory system and their implications. Lancet Neurol. 2021 09; 20(9):753-761. PMID: 34339626.
      Citations: 9     Fields:    Translation:Humans
    5. Littler DR, Mohanty B, Lowery SA, Colson RN, Gully BS, Perlman S, Scanlon MJ, Rossjohn J. Binding of a pyrimidine RNA base-mimic to SARS-CoV-2 nonstructural protein 9. J Biol Chem. 2021 09; 297(3):101018. PMID: 34331944.
      Citations:    Fields:    Translation:Cells
    6. Dampalla CS, Zheng J, Perera KD, Wong LR, Meyerholz DK, Nguyen HN, Kashipathy MM, Battaile KP, Lovell S, Kim Y, Perlman S, Groutas WC, Chang KO. Postinfection treatment with a protease inhibitor increases survival of mice with a fatal SARS-CoV-2 infection. Proc Natl Acad Sci U S A. 2021 07 20; 118(29). PMID: 34210738.
      Citations: 6     Fields:    Translation:AnimalsCells
    7. Dampalla CS, Kim Y, Bickmeier N, Rathnayake AD, Nguyen HN, Zheng J, Kashipathy MM, Baird MA, Battaile KP, Lovell S, Perlman S, Chang KO, Groutas WC. Structure-Guided Design of Conformationally Constrained Cyclohexane Inhibitors of Severe Acute Respiratory Syndrome Coronavirus-2 3CL Protease. J Med Chem. 2021 07 22; 64(14):10047-10058. PMID: 34213885.
      Citations: 1     Fields:    Translation:HumansCells
    8. Sariol A, Perlman S. SARS-CoV-2 takes its Toll. Nat Immunol. 2021 07; 22(7):801-802. PMID: 34103714.
      Citations: 6     Fields:    Translation:Humans
    9. Ortiz ME, Kobayashi T, Imborek K, Alsuhaibani M, Holley S, Trannel A, Marra AR, Etienne W, Jenn KE, Abosi OJ, Meacham H, Sheeler L, Dains A, Kukla ME, McCray PB, Perlman S, Ford B, Diekema DJ, Wellington M, Pezzulo AA, Salinas JL. Molecular epidemiology of large coronavirus disease 2019 (COVID-19) clusters before and after the implementation of routine serial testing at an academic medical center in Iowa, 2020. Infect Control Hosp Epidemiol. 2021 12; 42(12):1514-1516. PMID: 34229775.
      Citations:    Fields:    Translation:Humans
    10. Chu H, Shuai H, Hou Y, Zhang X, Wen L, Huang X, Hu B, Yang D, Wang Y, Yoon C, Wong BH, Li C, Zhao X, Poon VK, Cai JP, Wong KK, Yeung ML, Zhou J, Au-Yeung RK, Yuan S, Jin DY, Kok KH, Perlman S, Chan JF, Yuen KY. Targeting highly pathogenic coronavirus-induced apoptosis reduces viral pathogenesis and disease severity. Sci Adv. 2021 06; 7(25). PMID: 34134991.
      Citations: 7     Fields:    Translation:HumansAnimalsCells
    11. Al-Tawfiq JA, Petersen E, Memish ZA, Perlman S, Zumla A. Middle East respiratory syndrome coronavirus - The need for global proactive surveillance, sequencing and modeling. Travel Med Infect Dis. 2021 Sep-Oct; 43:102118. PMID: 34144180.
      Citations: 2     Fields:    Translation:HumansCellsPHPublic Health
    12. Wong LR, Zheng J, Sariol A, Lowery S, Meyerholz DK, Gallagher T, Perlman S. Middle East respiratory syndrome coronavirus Spike protein variants exhibit geographic differences in virulence. Proc Natl Acad Sci U S A. 2021 06 15; 118(24). PMID: 34099556.
      Citations: 1     Fields:    Translation:HumansAnimalsCellsPHPublic Health
    13. Zheng J, Meyerholz D, Wong LR, Gelb M, Murakami M, Perlman S. Coronavirus-specific antibody production in middle-aged mice requires phospholipase A2G2D. J Clin Invest. 2021 06 01; 131(11). PMID: 34060490.
      Citations:    Fields:    Translation:AnimalsCells
    14. Loftus RW, Dexter F, Evans LC, Robinson ADM, Odle A, Perlman S. An assessment of the impact of recommended anesthesia work area cleaning procedures on intraoperative SARS-CoV-2 contamination, a case-series analysis. J Clin Anesth. 2021 10; 73:110350. PMID: 34098391.
      Citations: 1     Fields:    Translation:HumansPHPublic Health
    15. Lowery SA, Sariol A, Perlman S. Innate immune and inflammatory responses to SARS-CoV-2: Implications for COVID-19. Cell Host Microbe. 2021 07 14; 29(7):1052-1062. PMID: 34022154.
      Citations: 21     Fields:    Translation:HumansAnimals
    16. Alshukairi AN, Tolah AM, Dada A, Al-Tawfiq JA, Almagharbi RS, Saeedi MF, Al-Hamzi MA, El-Kafrawy SA, Bahaudden HA, El-Saed A, Al-Mozaini MA, Khalid I, Hefni LK, Hassan AM, Alandijany TA, Bajrai LH, Bayumi DT, Albishi GE, Althawadi SI, Zabani NA, Perlman S, Azhar EI. Test-based de-isolation in COVID-19 immunocompromised patients: Cycle threshold value versus SARS-CoV-2 viral culture. Int J Infect Dis. 2021 Jul; 108:112-115. PMID: 34004329.
      Citations: 1     Fields:    Translation:HumansPHPublic Health
    17. Vickers MA, Sariol A, Leon J, Ehlers A, Locher AV, Dubay KA, Collins L, Voss D, Odle AE, Holida M, Merrill AE, Perlman S, Knudson CM. Exponential increase in neutralizing and spike specific antibodies following vaccination of COVID-19 convalescent plasma donors. Transfusion. 2021 07; 61(7):2099-2106. PMID: 33829513.
      Citations: 6     Fields:    Translation:HumansPHPublic Health
    18. Kobayashi T, Ortiz ME, Imborek KL, Alsuhaibani M, Holley SA, Trannel A, Marra AR, Etienne W, Jenn KE, Abosi OJ, Meacham H, Sheeler LL, Dains A, Kukla ME, McCray PB, Perlman S, Ford B, Diekema DJ, Wellington M, Salinas JL, Pezzulo AA. Suspected COVID-19 Reinfections at a Tertiary Care Center, Iowa, 2020. Open Forum Infect Dis. 2021 Jul; 8(7):ofab188. PMID: 34322564.
      Citations:    
    19. Zheng J, Wang Y, Li K, Meyerholz DK, Allamargot C, Perlman S. Severe Acute Respiratory Syndrome Coronavirus 2-Induced Immune Activation and Death of Monocyte-Derived Human Macrophages and Dendritic Cells. J Infect Dis. 2021 03 03; 223(5):785-795. PMID: 33277988.
      Citations: 27     Fields:    Translation:HumansCells
    20. Munoz FM, Cramer JP, Dekker CL, Dudley MZ, Graham BS, Gurwith M, Law B, Perlman S, Polack FP, Spergel JM, Van Braeckel E, Ward BJ, Didierlaurent AM, Lambert PH. Vaccine-associated enhanced disease: Case definition and guidelines for data collection, analysis, and presentation of immunization safety data. Vaccine. 2021 05 21; 39(22):3053-3066. PMID: 33637387.
      Citations: 14     Fields:    Translation:HumansPHPublic Health
    21. Meyerholz DK, Perlman S. Does common cold coronavirus infection protect against severe SARS-CoV-2 disease? J Clin Invest. 2021 01 04; 131(1). PMID: 33216734.
      Citations: 3     Fields:    Translation:HumansPHPublic Health
    22. Channappanavar R, Perlman S. Age-related susceptibility to coronavirus infections: role of impaired and dysregulated host immunity. J Clin Invest. 2020 12 01; 130(12):6204-6213. PMID: 33085654.
      Citations: 16     Fields:    Translation:HumansAnimals
    23. Zheng J, Wong LR, Li K, Verma AK, Ortiz ME, Wohlford-Lenane C, Leidinger MR, Knudson CM, Meyerholz DK, McCray PB, Perlman S. COVID-19 treatments and pathogenesis including anosmia in K18-hACE2 mice. Nature. 2021 01; 589(7843):603-607. PMID: 33166988.
      Citations: 72     Fields:    Translation:HumansAnimals
    24. Wong LR, Li K, Sun J, Zhuang Z, Zhao J, McCray PB, Perlman S. Sensitization of Non-permissive Laboratory Mice to SARS-CoV-2 with a Replication-Deficient Adenovirus Expressing Human ACE2. STAR Protoc. 2020 12 18; 1(3):100169. PMID: 33377063.
      Citations: 6     
    25. Ghosh S, Dellibovi-Ragheb TA, Kerviel A, Pak E, Qiu Q, Fisher M, Takvorian PM, Bleck C, Hsu VW, Fehr AR, Perlman S, Achar SR, Straus MR, Whittaker GR, de Haan CAM, Kehrl J, Altan-Bonnet G, Altan-Bonnet N. ß-Coronaviruses Use Lysosomes for Egress Instead of the Biosynthetic Secretory Pathway. Cell. 2020 12 10; 183(6):1520-1535.e14. PMID: 33157038.
      Citations: 99     Fields:    Translation:HumansAnimalsCells
    26. Heer CD, Sanderson DJ, Voth LS, Alhammad YMO, Schmidt MS, Trammell SAJ, Perlman S, Cohen MS, Fehr AR, Brenner C. Coronavirus infection and PARP expression dysregulate the NAD metabolome: An actionable component of innate immunity. J Biol Chem. 2020 12 25; 295(52):17986-17996. PMID: 33051211.
      Citations: 33     Fields:    Translation:HumansAnimalsCells
    27. Perlman S, Zumla A. MERS-CoV in Africa-an enigma with relevance to COVID-19. Lancet Infect Dis. 2021 03; 21(3):303-305. PMID: 33035475.
      Citations: 1     Fields:    Translation:HumansAnimalsCellsPHPublic Health
    28. Wang Y, Zhang L, Sang L, Ye F, Ruan S, Zhong B, Song T, Alshukairi AN, Chen R, Zhang Z, Gan M, Zhu A, Huang Y, Luo L, Mok CKP, Mok CKP, Al Gethamy MM, Tan H, Li Z, Huang X, Li F, Sun J, Zhang Y, Wen L, Li Y, Chen Z, Zhuang Z, Zhuo J, Chen C, Kuang L, Wang J, Lv H, Jiang Y, Li M, Lin Y, Deng Y, Tang L, Liang J, Huang J, Perlman S, Zhong N, Zhao J, Malik Peiris JS, Li Y, Zhao J. Kinetics of viral load and antibody response in relation to COVID-19 severity. J Clin Invest. 2020 10 01; 130(10):5235-5244. PMID: 32634129.
      Citations: 181     Fields:    Translation:HumansCellsPHPublic HealthCTClinical Trials
    29. Muñoz-Fontela C, Dowling WE, Funnell SGP, Gsell PS, Riveros-Balta AX, Albrecht RA, Andersen H, Baric RS, Carroll MW, Cavaleri M, Qin C, Crozier I, Dallmeier K, de Waal L, de Wit E, Delang L, Dohm E, Duprex WP, Falzarano D, Finch CL, Frieman MB, Graham BS, Gralinski LE, Guilfoyle K, Haagmans BL, Hamilton GA, Hartman AL, Herfst S, Kaptein SJF, Klimstra WB, Knezevic I, Krause PR, Kuhn JH, Le Grand R, Lewis MG, Liu WC, Maisonnasse P, McElroy AK, Munster V, Oreshkova N, Rasmussen AL, Rocha-Pereira J, Rockx B, Rodríguez E, Rogers TF, Salguero FJ, Schotsaert M, Stittelaar KJ, Thibaut HJ, Tseng CT, Vergara-Alert J, Beer M, Brasel T, Chan JFW, García-Sastre A, Neyts J, Perlman S, Reed DS, Richt JA, Roy CJ, Segalés J, Vasan SS, et al. Animal models for COVID-19. Nature. 2020 10; 586(7830):509-515. PMID: 32967005.
      Citations: 181     Fields:    Translation:HumansAnimalsCellsPHPublic Health
    30. Sariol A, Mackin S, Allred MG, Ma C, Zhou Y, Zhang Q, Zou X, Abrahante JE, Meyerholz DK, Perlman S. Microglia depletion exacerbates demyelination and impairs remyelination in a neurotropic coronavirus infection. Proc Natl Acad Sci U S A. 2020 09 29; 117(39):24464-24474. PMID: 32929007.
      Citations: 11     Fields:    Translation:AnimalsCells
    31. Welch JL, Xiang J, Mackin SR, Perlman S, Thorne P, O'Shaughnessy P, Strzelecki B, Aubin P, Ortiz-Hernandez M, Stapleton JT. Inactivation of Severe Acute Respiratory Coronavirus Virus 2 (SARS-CoV-2) and Diverse RNA and DNA Viruses on Three-Dimensionally Printed Surgical Mask Materials. Infect Control Hosp Epidemiol. 2021 03; 42(3):253-260. PMID: 32783787.
      Citations: 8     Fields:    Translation:HumansCellsPHPublic Health
    32. Rathnayake AD, Zheng J, Kim Y, Perera KD, Mackin S, Meyerholz DK, Kashipathy MM, Battaile KP, Lovell S, Perlman S, Groutas WC, Chang KO. 3C-like protease inhibitors block coronavirus replication in vitro and improve survival in MERS-CoV-infected mice. Sci Transl Med. 2020 08 19; 12(557). PMID: 32747425.
      Citations: 52     Fields:    Translation:HumansAnimalsCellsPHPublic Health
    33. Perlman S. COVID-19 poses a riddle for the immune system. Nature. 2020 08; 584(7821):345-346. PMID: 32807916.
      Citations: 11     Fields:    Translation:HumansCellsPHPublic Health
    34. Sariol A, Perlman S. Lessons for COVID-19 Immunity from Other Coronavirus Infections. Immunity. 2020 08 18; 53(2):248-263. PMID: 32717182.
      Citations: 98     Fields:    Translation:HumansAnimalsCellsPHPublic Health
    35. Pan R, Zhang Q, Anthony SM, Zhou Y, Zou X, Cassell M, Perlman S. Oligodendrocytes that survive acute coronavirus infection induce prolonged inflammatory responses in the CNS. Proc Natl Acad Sci U S A. 2020 07 07; 117(27):15902-15910. PMID: 32571951.
      Citations: 5     Fields:    Translation:AnimalsCells
    36. Sun J, Zhuang Z, Zheng J, Li K, Wong RL, Liu D, Huang J, He J, Zhu A, Zhao J, Li X, Xi Y, Chen R, Alshukairi AN, Chen Z, Zhang Z, Chen C, Huang X, Li F, Lai X, Chen D, Wen L, Zhuo J, Zhang Y, Wang Y, Huang S, Dai J, Shi Y, Zheng K, Leidinger MR, Chen J, Li Y, Zhong N, Meyerholz DK, McCray PB, Perlman S, Zhao J. Generation of a Broadly Useful Model for COVID-19 Pathogenesis, Vaccination, and Treatment. Cell. 2020 08 06; 182(3):734-743.e5. PMID: 32643603.
      Citations: 148     Fields:    Translation:HumansAnimalsCellsPHPublic Health
    37. Hassan AO, Case JB, Winkler ES, Thackray LB, Kafai NM, Bailey AL, McCune BT, Fox JM, Chen RE, Alsoussi WB, Turner JS, Schmitz AJ, Lei T, Shrihari S, Keeler SP, Fremont DH, Greco S, McCray PB, Perlman S, Holtzman MJ, Ellebedy AH, Diamond MS. A SARS-CoV-2 Infection Model in Mice Demonstrates Protection by Neutralizing Antibodies. Cell. 2020 08 06; 182(3):744-753.e4. PMID: 32553273.
      Citations: 206     Fields:    Translation:HumansAnimalsCellsPHPublic Health
    38. Lambert PH, Ambrosino DM, Andersen SR, Baric RS, Black SB, Chen RT, Dekker CL, Didierlaurent AM, Graham BS, Martin SD, Molrine DC, Perlman S, Picard-Fraser PA, Pollard AJ, Qin C, Subbarao K, Cramer JP. Consensus summary report for CEPI/BC March 12-13, 2020 meeting: Assessment of risk of disease enhancement with COVID-19 vaccines. Vaccine. 2020 06 26; 38(31):4783-4791. PMID: 32507409.
      Citations: 39     Fields:    Translation:HumansAnimalsCellsPHPublic Health
    39. Lipsitch M, Perlman S, Waldor MK. Testing COVID-19 therapies to prevent progression of mild disease. Lancet Infect Dis. 2020 12; 20(12):1367. PMID: 32618282.
      Citations: 4     Fields:    Translation:HumansCellsPHPublic Health
    40. Li K, Li Z, Wohlford-Lenane C, Meyerholz DK, Channappanavar R, An D, Perlman S, McCray PB, He B. Single-Dose, Intranasal Immunization with Recombinant Parainfluenza Virus 5 Expressing Middle East Respiratory Syndrome Coronavirus (MERS-CoV) Spike Protein Protects Mice from Fatal MERS-CoV Infection. mBio. 2020 04 07; 11(2). PMID: 32265331.
      Citations: 21     Fields:    Translation:AnimalsCellsPHPublic Health
    41. Memish ZA, Perlman S, Van Kerkhove MD, Zumla A. Middle East respiratory syndrome. Lancet. 2020 03 28; 395(10229):1063-1077. PMID: 32145185.
      Citations: 134     Fields:    Translation:HumansAnimalsCellsPHPublic Health
    42. Calisher C, Carroll D, Colwell R, Corley RB, Daszak P, Drosten C, Enjuanes L, Farrar J, Field H, Golding J, Gorbalenya A, Haagmans B, Hughes JM, Karesh WB, Keusch GT, Lam SK, Lubroth J, Mackenzie JS, Madoff L, Mazet J, Palese P, Perlman S, Poon L, Roizman B, Saif L, Saif L, Subbarao K, Turner M. Statement in support of the scientists, public health professionals, and medical professionals of China combatting COVID-19. Lancet. 2020 03 07; 395(10226):e42-e43. PMID: 32087122.
      Citations: 54     Fields:    Translation:HumansCellsPHPublic Health
    43. Qing E, Hantak M, Perlman S, Gallagher T. Distinct Roles for Sialoside and Protein Receptors in Coronavirus Infection. mBio. 2020 02 11; 11(1). PMID: 32047128.
      Citations: 31     Fields:    Translation:HumansAnimalsCells
    44. Perlman S. Another Decade, Another Coronavirus. N Engl J Med. 2020 02 20; 382(8):760-762. PMID: 31978944.
      Citations: 266     Fields:    Translation:HumansCells
    45. Grunewald ME, Shaban MG, Mackin SR, Fehr AR, Perlman S. Murine Coronavirus Infection Activates the Aryl Hydrocarbon Receptor in an Indoleamine 2,3-Dioxygenase-Independent Manner, Contributing to Cytokine Modulation and Proviral TCDD-Inducible-PARP Expression. J Virol. 2020 01 17; 94(3). PMID: 31694960.
      Citations: 28     Fields:    Translation:AnimalsCells
    46. Channappanavar R, Perlman S. Evaluation of Activation and Inflammatory Activity of Myeloid Cells During Pathogenic Human Coronavirus Infection. Methods Mol Biol. 2020; 2099:195-204. PMID: 31883097.
      Citations: 14     Fields:    Translation:HumansAnimalsCells
    47. Wang Y, Grunewald M, Perlman S. Coronaviruses: An Updated Overview of Their Replication and Pathogenesis. Methods Mol Biol. 2020; 2203:1-29. PMID: 32833200.
      Citations: 25     Fields:    Translation:HumansAnimalsCellsPHPublic Health
    48. Zheng J, Hassan S, Alagaili AN, Alshukairi AN, Amor NMS, Mukhtar N, Nazeer IM, Tahir Z, Akhter N, Perlman S, Yaqub T. Middle East Respiratory Syndrome Coronavirus Seropositivity in Camel Handlers and Their Families, Pakistan. Emerg Infect Dis. 2019 12; 25(12). PMID: 31742530.
      Citations: 4     Fields:    Translation:HumansAnimalsCellsPHPublic Health
    49. Zumla A, Memish ZA, Hui DS, Perlman S. Vaccine against Middle East respiratory syndrome coronavirus. Lancet Infect Dis. 2019 10; 19(10):1054-1055. PMID: 31559955.
      Citations: 6     Fields:    Translation:HumansCells
    50. Channappanavar R, Fehr AR, Zheng J, Wohlford-Lenane C, Abrahante JE, Mack M, Sompallae R, McCray PB, Meyerholz DK, Perlman S. IFN-I response timing relative to virus replication determines MERS coronavirus infection outcomes. J Clin Invest. 2019 07 29; 129(9):3625-3639. PMID: 31355779.
      Citations: 206     Fields:    Translation:HumansAnimalsCells
    51. Grunewald ME, Chen Y, Kuny C, Maejima T, Lease R, Ferraris D, Aikawa M, Sullivan CS, Perlman S, Fehr AR. The coronavirus macrodomain is required to prevent PARP-mediated inhibition of virus replication and enhancement of IFN expression. PLoS Pathog. 2019 05; 15(5):e1007756. PMID: 31095648.
      Citations: 48     Fields:    Translation:HumansAnimalsCells
    52. Liu L, Wei Q, Lin Q, Fang J, Wang H, Kwok H, Tang H, Nishiura K, Peng J, Tan Z, Wu T, Cheung KW, Chan KH, Alvarez X, Qin C, Lackner A, Perlman S, Yuen KY, Chen Z. Anti-spike IgG causes severe acute lung injury by skewing macrophage responses during acute SARS-CoV infection. JCI Insight. 2019 02 21; 4(4). PMID: 30830861.
      Citations: 343     Fields:    Translation:HumansAnimalsCells
    53. Yuan S, Chu H, Chan JF, Ye ZW, Wen L, Yan B, Lai PM, Tee KM, Huang J, Chen D, Li C, Zhao X, Yang D, Chiu MC, Yip C, Poon VK, Chan CC, Sze KH, Zhou J, Chan IH, Kok KH, To KK, Kao RY, Lau JY, Jin DY, Perlman S, Yuen KY. SREBP-dependent lipidomic reprogramming as a broad-spectrum antiviral target. Nat Commun. 2019 01 10; 10(1):120. PMID: 30631056.
      Citations: 65     Fields:    Translation:Cells
    54. Jia W, Channappanavar R, Zhang C, Li M, Zhou H, Zhang S, Zhou P, Xu J, Shan S, Shi X, Wang X, Zhao J, Zhou D, Perlman S, Zhang L. Single intranasal immunization with chimpanzee adenovirus-based vaccine induces sustained and protective immunity against MERS-CoV infection. Emerg Microbes Infect. 2019; 8(1):760-772. PMID: 31130102.
      Citations: 20     Fields:    Translation:HumansAnimalsCells
    55. Alshukairi AN, Zheng J, Zhao J, Nehdi A, Baharoon SA, Layqah L, Bokhari A, Al Johani SM, Samman N, Boudjelal M, Ten Eyck P, Al-Mozaini MA, Zhao J, Perlman S, Alagaili AN. High Prevalence of MERS-CoV Infection in Camel Workers in Saudi Arabia. mBio. 2018 10 30; 9(5). PMID: 30377284.
      Citations: 47     Fields:    Translation:HumansAnimalsCellsPHPublic Health
    56. Hua X, Vijay R, Channappanavar R, Athmer J, Meyerholz DK, Pagedar N, Tilley S, Perlman S. Nasal priming by a murine coronavirus provides protective immunity against lethal heterologous virus pneumonia. JCI Insight. 2018 06 07; 3(11). PMID: 29875310.
      Citations: 14     Fields:    Translation:HumansAnimalsCells
    57. Castaño-Rodriguez C, Honrubia JM, Gutiérrez-Álvarez J, DeDiego ML, Nieto-Torres JL, Jimenez-Guardeño JM, Regla-Nava JA, Fernandez-Delgado R, Verdia-Báguena C, Queralt-Martín M, Kochan G, Perlman S, Aguilella VM, Sola I, Enjuanes L. Role of Severe Acute Respiratory Syndrome Coronavirus Viroporins E, 3a, and 8a in Replication and Pathogenesis. mBio. 2018 05 22; 9(3). PMID: 29789363.
      Citations: 105     Fields:    Translation:HumansAnimalsCells
    58. Athmer J, Fehr AR, Grunewald ME, Qu W, Wheeler DL, Graepel KW, Channappanavar R, Sekine A, Aldabeeb DS, Gale M, Denison MR, Perlman S. Selective Packaging in Murine Coronavirus Promotes Virulence by Limiting Type I Interferon Responses. mBio. 2018 05 01; 9(3). PMID: 29717007.
      Citations: 9     Fields:    Translation:AnimalsCells
    59. Galasiti Kankanamalage AC, Kim Y, Damalanka VC, Rathnayake AD, Fehr AR, Mehzabeen N, Battaile KP, Lovell S, Lushington GH, Perlman S, Chang KO, Groutas WC. Structure-guided design of potent and permeable inhibitors of MERS coronavirus 3CL protease that utilize a piperidine moiety as a novel design element. Eur J Med Chem. 2018 Apr 25; 150:334-346. PMID: 29544147.
      Citations: 37     Fields:    Translation:AnimalsCells
    60. Chu DKW, Hui KPY, Perera RAPM, Miguel E, Niemeyer D, Zhao J, Channappanavar R, Dudas G, Oladipo JO, Traoré A, Fassi-Fihri O, Ali A, Demissié GF, Muth D, Chan MCW, Nicholls JM, Meyerholz DK, Kuranga SA, Mamo G, Zhou Z, So RTY, Hemida MG, Webby RJ, Roger F, Rambaut A, Poon LLM, Perlman S, Drosten C, Chevalier V, Peiris M. MERS coronaviruses from camels in Africa exhibit region-dependent genetic diversity. Proc Natl Acad Sci U S A. 2018 03 20; 115(12):3144-3149. PMID: 29507189.
      Citations: 69     Fields:    Translation:HumansAnimalsCells
    61. Wheeler DL, Sariol A, Meyerholz DK, Perlman S. Microglia are required for protection against lethal coronavirus encephalitis in mice. J Clin Invest. 2018 03 01; 128(3):931-943. PMID: 29376888.
      Citations: 62     Fields:    Translation:AnimalsCells
    62. Canton J, Fehr AR, Fernandez-Delgado R, Gutierrez-Alvarez FJ, Sanchez-Aparicio MT, García-Sastre A, Perlman S, Enjuanes L, Sola I. MERS-CoV 4b protein interferes with the NF-?B-dependent innate immune response during infection. PLoS Pathog. 2018 01; 14(1):e1006838. PMID: 29370303.
      Citations: 54     Fields:    Translation:HumansAnimalsCells
    63. Grunewald ME, Fehr AR, Athmer J, Perlman S. The coronavirus nucleocapsid protein is ADP-ribosylated. Virology. 2018 04; 517:62-68. PMID: 29199039.
      Citations: 22     Fields:    Translation:HumansAnimalsCells
    64. Zheng J, Perlman S. Immune responses in influenza A virus and human coronavirus infections: an ongoing battle between the virus and host. Curr Opin Virol. 2018 02; 28:43-52. PMID: 29172107.
      Citations: 21     Fields:    Translation:HumansAnimalsCells
    65. Wheeler DL, Athmer J, Meyerholz DK, Perlman S. Murine Olfactory Bulb Interneurons Survive Infection with a Neurotropic Coronavirus. J Virol. 2017 Nov 15; 91(22). PMID: 28835503.
      Citations: 11     Fields:    
    66. Zhao J, Alshukairi AN, Baharoon SA, Ahmed WA, Bokhari AA, Nehdi AM, Layqah LA, Alghamdi MG, Al Gethamy MM, Dada AM, Khalid I, Boujelal M, Al Johani SM, Vogel L, Subbarao K, Mangalam A, Wu C, Ten Eyck P, Perlman S, Zhao J. Recovery from the Middle East respiratory syndrome is associated with antibody and T-cell responses. Sci Immunol. 2017 Aug 04; 2(14). PMID: 28778905.
      Citations: 106     Fields:    
    67. Earnest JT, Hantak MP, Li K, McCray PB, Perlman S, Gallagher T. The tetraspanin CD9 facilitates MERS-coronavirus entry by scaffolding host cell receptors and proteases. PLoS Pathog. 2017 Jul; 13(7):e1006546. PMID: 28759649.
      Citations: 59     Fields:    Translation:HumansAnimalsCells
    68. Vijay R, Fehr AR, Janowski AM, Athmer J, Wheeler DL, Grunewald M, Sompallae R, Kurup SP, Meyerholz DK, Sutterwala FS, Narumiya S, Perlman S. Virus-induced inflammasome activation is suppressed by prostaglandin D2/DP1 signaling. Proc Natl Acad Sci U S A. 2017 07 03; 114(27):E5444-E5453. PMID: 28630327.
      Citations: 18     Fields:    Translation:HumansAnimalsCells
    69. Channappanavar R, Perlman S. Pathogenic human coronavirus infections: causes and consequences of cytokine storm and immunopathology. Semin Immunopathol. 2017 07; 39(5):529-539. PMID: 28466096.
      Citations: 908     Fields:    Translation:HumansAnimalsCells
    70. Channappanavar R, Fett C, Mack M, Ten Eyck PP, Meyerholz DK, Perlman S. Sex-Based Differences in Susceptibility to Severe Acute Respiratory Syndrome Coronavirus Infection. J Immunol. 2017 05 15; 198(10):4046-4053. PMID: 28373583.
      Citations: 282     Fields:    Translation:AnimalsCells
    71. Li K, Wohlford-Lenane CL, Channappanavar R, Park JE, Earnest JT, Bair TB, Bates AM, Brogden KA, Flaherty HA, Gallagher T, Meyerholz DK, Perlman S, McCray PB. Mouse-adapted MERS coronavirus causes lethal lung disease in human DPP4 knockin mice. Proc Natl Acad Sci U S A. 2017 04 11; 114(15):E3119-E3128. PMID: 28348219.
      Citations: 76     Fields:    Translation:HumansAnimalsCells
    72. Chi H, Zheng X, Wang X, Wang C, Wang H, Gai W, Perlman S, Yang S, Zhao J, Xia X. DNA vaccine encoding Middle East respiratory syndrome coronavirus S1 protein induces protective immune responses in mice. Vaccine. 2017 04 11; 35(16):2069-2075. PMID: 28314561.
      Citations: 28     Fields:    Translation:AnimalsCells
    73. Athmer J, Fehr AR, Grunewald M, Smith EC, Denison MR, Perlman S. In Situ Tagged nsp15 Reveals Interactions with Coronavirus Replication/Transcription Complex-Associated Proteins. mBio. 2017 01 31; 8(1). PMID: 28143984.
      Citations: 22     Fields:    Translation:HumansAnimalsCells
    74. Perlman S, Zhao J. Roles of regulatory T cells and IL-10 in virus-induced demyelination. J Neuroimmunol. 2017 07 15; 308:6-11. PMID: 28065579.
      Citations: 6     Fields:    Translation:HumansAnimalsCells
    75. Tai W, Wang Y, Fett CA, Zhao G, Li F, Perlman S, Jiang S, Zhou Y, Du L. Recombinant Receptor-Binding Domains of Multiple Middle East Respiratory Syndrome Coronaviruses (MERS-CoVs) Induce Cross-Neutralizing Antibodies against Divergent Human and Camel MERS-CoVs and Antibody Escape Mutants. J Virol. 2017 Jan 01; 91(1). PMID: 27795425.
      Citations: 36     Fields:    Translation:HumansAnimalsCellsPHPublic Health
    76. Fehr AR, Channappanavar R, Jankevicius G, Fett C, Zhao J, Athmer J, Meyerholz DK, Ahel I, Perlman S. The Conserved Coronavirus Macrodomain Promotes Virulence and Suppresses the Innate Immune Response during Severe Acute Respiratory Syndrome Coronavirus Infection. mBio. 2016 12 13; 7(6). PMID: 27965448.
      Citations: 83     Fields:    Translation:HumansAnimalsCells
    77. Zhao Y, Wang C, Qiu B, Li C, Wang H, Jin H, Gai W, Zheng X, Wang T, Sun W, Yan F, Gao Y, Wang Q, Yan J, Chen L, Perlman S, Zhong N, Zhao J, Yang S, Xia X. Passive immunotherapy for Middle East Respiratory Syndrome coronavirus infection with equine immunoglobulin or immunoglobulin fragments in a mouse model. Antiviral Res. 2017 01; 137:125-130. PMID: 27890674.
      Citations: 14     Fields:    Translation:HumansAnimalsCells
    78. Du L, Tai W, Yang Y, Zhao G, Zhu Q, Sun S, Liu C, Tao X, Tseng CK, Perlman S, Jiang S, Zhou Y, Li F. Introduction of neutralizing immunogenicity index to the rational design of MERS coronavirus subunit vaccines. Nat Commun. 2016 11 22; 7:13473. PMID: 27874853.
      Citations: 57     Fields:    Translation:HumansAnimalsCells
    79. de Wilde AH, Falzarano D, Zevenhoven-Dobbe JC, Beugeling C, Fett C, Martellaro C, Posthuma CC, Feldmann H, Perlman S, Snijder EJ. Alisporivir inhibits MERS- and SARS-coronavirus replication in cell culture, but not SARS-coronavirus infection in a mouse model. Virus Res. 2017 01 15; 228:7-13. PMID: 27840112.
      Citations: 33     Fields:    Translation:HumansAnimalsCells
    80. Park JE, Li K, Barlan A, Fehr AR, Perlman S, McCray PB, Gallagher T. Proteolytic processing of Middle East respiratory syndrome coronavirus spikes expands virus tropism. Proc Natl Acad Sci U S A. 2016 10 25; 113(43):12262-12267. PMID: 27791014.
      Citations: 134     Fields:    Translation:HumansCells
    81. Fehr AR, Channappanavar R, Perlman S. Middle East Respiratory Syndrome: Emergence of a Pathogenic Human Coronavirus. Annu Rev Med. 2017 01 14; 68:387-399. PMID: 27576010.
      Citations: 98     Fields:    Translation:HumansAnimalsCellsPHPublic Health
    82. Zhao J, Zhao J, Mangalam AK, Channappanavar R, Fett C, Meyerholz DK, Agnihothram S, Baric RS, David CS, Perlman S. Airway Memory CD4(+) T Cells Mediate Protective Immunity against Emerging Respiratory Coronaviruses. Immunity. 2016 06 21; 44(6):1379-91. PMID: 27287409.
      Citations: 180     Fields:    Translation:HumansAnimalsCellsPHPublic Health
    83. Alshukairi AN, Khalid I, Ahmed WA, Dada AM, Bayumi DT, Malic LS, Althawadi S, Ignacio K, Alsalmi HS, Al-Abdely HM, Wali GY, Qushmaq IA, Alraddadi BM, Perlman S. Antibody Response and Disease Severity in Healthcare Worker MERS Survivors. Emerg Infect Dis. 2016 06; 22(6). PMID: 27192543.
      Citations: 62     Fields:    Translation:HumansCells
    84. Perlman S, Vijay R. Middle East respiratory syndrome vaccines. Int J Infect Dis. 2016 Jun; 47:23-8. PMID: 27062985.
      Citations: 12     Fields:    Translation:HumansAnimalsCells
    85. Luke T, Wu H, Zhao J, Channappanavar R, Coleman CM, Jiao JA, Matsushita H, Liu Y, Postnikova EN, Ork BL, Glenn G, Flyer D, Defang G, Raviprakash K, Kochel T, Wang J, Nie W, Smith G, Hensley LE, Olinger GG, Kuhn JH, Holbrook MR, Johnson RF, Perlman S, Sullivan E, Frieman MB. Human polyclonal immunoglobulin G from transchromosomic bovines inhibits MERS-CoV in vivo. Sci Transl Med. 2016 Feb 17; 8(326):326ra21. PMID: 26888429.
      Citations: 56     Fields:    Translation:HumansAnimalsCellsPHPublic Health
    86. Vijay R, Perlman S. Middle East respiratory syndrome and severe acute respiratory syndrome. Curr Opin Virol. 2016 Feb; 16:70-76. PMID: 26855039.
      Citations: 28     Fields:    Translation:HumansAnimalsCells
    87. Channappanavar R, Fehr AR, Vijay R, Mack M, Zhao J, Meyerholz DK, Perlman S. Dysregulated Type I Interferon and Inflammatory Monocyte-Macrophage Responses Cause Lethal Pneumonia in SARS-CoV-Infected Mice. Cell Host Microbe. 2016 Feb 10; 19(2):181-93. PMID: 26867177.
      Citations: 603     Translation:HumansAnimalsCells
    88. Bedell K, Buchaklian AH, Perlman S. Efficacy of an Automated Multiple Emitter Whole-Room Ultraviolet-C Disinfection System Against Coronaviruses MHV and MERS-CoV. Infect Control Hosp Epidemiol. 2016 May; 37(5):598-9. PMID: 26818469.
      Citations: 40     Fields:    Translation:HumansAnimalsCellsPHPublic Health
    89. Jimenez-Guardeño JM, Regla-Nava JA, Nieto-Torres JL, DeDiego ML, Castaño-Rodriguez C, Fernandez-Delgado R, Perlman S, Enjuanes L. Identification of the Mechanisms Causing Reversion to Virulence in an Attenuated SARS-CoV for the Design of a Genetically Stable Vaccine. PLoS Pathog. 2015 Oct; 11(10):e1005215. PMID: 26513244.
      Citations: 67     Fields:    Translation:AnimalsCells
    90. Li K, Wohlford-Lenane C, Perlman S, Zhao J, Jewell AK, Reznikov LR, Gibson-Corley KN, Meyerholz DK, McCray PB. Middle East Respiratory Syndrome Coronavirus Causes Multiple Organ Damage and Lethal Disease in Mice Transgenic for Human Dipeptidyl Peptidase 4. J Infect Dis. 2016 Mar 01; 213(5):712-22. PMID: 26486634.
      Citations: 186     Fields:    Translation:HumansAnimalsCells
    91. Li Y, Wan Y, Liu P, Zhao J, Lu G, Qi J, Wang Q, Lu X, Wu Y, Liu W, Zhang B, Yuen KY, Perlman S, Gao GF, Yan J. A humanized neutralizing antibody against MERS-CoV targeting the receptor-binding domain of the spike protein. Cell Res. 2015 Nov; 25(11):1237-49. PMID: 26391698.
      Citations: 68     Fields:    Translation:AnimalsCells
    92. Vijay R, Hua X, Meyerholz DK, Miki Y, Yamamoto K, Gelb M, Murakami M, Perlman S. Critical role of phospholipase A2 group IID in age-related susceptibility to severe acute respiratory syndrome-CoV infection. J Exp Med. 2015 Oct 19; 212(11):1851-68. PMID: 26392224.
      Citations: 47     Fields:    Translation:HumansAnimalsCells
    93. Corti D, Zhao J, Pedotti M, Simonelli L, Agnihothram S, Fett C, Fernandez-Rodriguez B, Foglierini M, Agatic G, Vanzetta F, Gopal R, Langrish CJ, Barrett NA, Sallusto F, Baric RS, Varani L, Zambon M, Perlman S, Lanzavecchia A. Prophylactic and postexposure efficacy of a potent human monoclonal antibody against MERS coronavirus. Proc Natl Acad Sci U S A. 2015 Aug 18; 112(33):10473-8. PMID: 26216974.
      Citations: 104     Fields:    Translation:HumansAnimalsCells
    94. Perlman S. Research Driven by Curiosity: The Journey from Basic Molecular Biology and Virology to Studies of Human Pathogenic Coronaviruses. PLoS Pathog. 2015 Jul; 11(7):e1005023. PMID: 26172373.
      Citations: 1     Fields:    Translation:HumansAnimalsCells
    95. Channappanavar R, Lu L, Xia S, Du L, Meyerholz DK, Perlman S, Jiang S. Protective Effect of Intranasal Regimens Containing Peptidic Middle East Respiratory Syndrome Coronavirus Fusion Inhibitor Against MERS-CoV Infection. J Infect Dis. 2015 Dec 15; 212(12):1894-903. PMID: 26164863.
      Citations: 46     Fields:    Translation:HumansAnimalsCells
    96. Hui DS, Perlman S, Zumla A. Spread of MERS to South Korea and China. Lancet Respir Med. 2015 Jul; 3(7):509-10. PMID: 26050550.
      Citations: 43     Fields:    Translation:HumansPHPublic Health
    97. Zumla A, Hui DS, Perlman S. Middle East respiratory syndrome. Lancet. 2015 Sep 05; 386(9997):995-1007. PMID: 26049252.
      Citations: 417     Fields:    Translation:HumansAnimalsCellsPHPublic Health
    98. Zhao J, Perera RA, Kayali G, Meyerholz D, Perlman S, Peiris M. Passive immunotherapy with dromedary immune serum in an experimental animal model for Middle East respiratory syndrome coronavirus infection. J Virol. 2015 Jun; 89(11):6117-20. PMID: 25787284.
      Citations: 39     Fields:    Translation:AnimalsCells
    99. Mielech AM, Deng X, Chen Y, Kindler E, Wheeler DL, Mesecar AD, Thiel V, Perlman S, Baker SC. Murine coronavirus ubiquitin-like domain is important for papain-like protease stability and viral pathogenesis. J Virol. 2015 May; 89(9):4907-17. PMID: 25694594.
      Citations: 26     Fields:    Translation:AnimalsCells
    100. Zhang N, Channappanavar R, Ma C, Wang L, Tang J, Garron T, Tao X, Tasneem S, Lu L, Tseng CT, Zhou Y, Perlman S, Jiang S, Du L. Identification of an ideal adjuvant for receptor-binding domain-based subunit vaccines against Middle East respiratory syndrome coronavirus. Cell Mol Immunol. 2016 Mar; 13(2):180-90. PMID: 25640653.
      Citations: 65     Fields:    Translation:HumansAnimalsCells
    101. Regla-Nava JA, Nieto-Torres JL, Jimenez-Guardeño JM, Fernandez-Delgado R, Fett C, Castaño-Rodríguez C, Perlman S, Enjuanes L, DeDiego ML. Severe acute respiratory syndrome coronaviruses with mutations in the E protein are attenuated and promising vaccine candidates. J Virol. 2015 Apr; 89(7):3870-87. PMID: 25609816.
      Citations: 54     Fields:    Translation:HumansAnimalsCells
    102. Zumla A, Perlman S, McNabb SJN, Shaikh A, Heymann DL, McCloskey B, Hui DS. Middle East respiratory syndrome in the shadow of Ebola. Lancet Respir Med. 2015 Feb; 3(2):100-102. PMID: 25592990.
      Citations: 8     Fields:    Translation:HumansCells
    103. Fehr AR, Perlman S. Coronaviruses: an overview of their replication and pathogenesis. Methods Mol Biol. 2015; 1282:1-23. PMID: 25720466.
      Citations: 1014     Fields:    Translation:HumansAnimalsCells
    104. Fehr AR, Athmer J, Channappanavar R, Phillips JM, Meyerholz DK, Perlman S. The nsp3 macrodomain promotes virulence in mice with coronavirus-induced encephalitis. J Virol. 2015 Feb; 89(3):1523-36. PMID: 25428866.
      Citations: 63     Fields:    Translation:AnimalsCells
    105. Trujillo JA, Croft NP, Dudek NL, Channappanavar R, Theodossis A, Webb AI, Dunstone MA, Illing PT, Butler NS, Fett C, Tscharke DC, Rossjohn J, Perlman S, Purcell AW. The cellular redox environment alters antigen presentation. J Biol Chem. 2014 Oct 03; 289(40):27979-91. PMID: 25135637.
      Citations: 17     Fields:    Translation:AnimalsCells
    106. Zhao J, Zhao J, Perlman S. Virus-specific regulatory T cells ameliorate encephalitis by repressing effector T cell functions from priming to effector stages. PLoS Pathog. 2014 Aug; 10(8):e1004279. PMID: 25102154.
      Citations: 22     Fields:    Translation:AnimalsCells
    107. Channappanavar R, Zhao J, Perlman S. T cell-mediated immune response to respiratory coronaviruses. Immunol Res. 2014 Aug; 59(1-3):118-28. PMID: 24845462.
      Citations: 223     Fields:    Translation:HumansAnimalsCells
    108. Channappanavar R, Fett C, Zhao J, Meyerholz DK, Perlman S. Virus-specific memory CD8 T cells provide substantial protection from lethal severe acute respiratory syndrome coronavirus infection. J Virol. 2014 Oct; 88(19):11034-44. PMID: 25056892.
      Citations: 179     Fields:    Translation:HumansAnimalsCellsPHPublic Health
    109. Trujillo JA, Gras S, Twist KA, Croft NP, Channappanavar R, Rossjohn J, Purcell AW, Perlman S. Structural and functional correlates of enhanced antiviral immunity generated by heteroclitic CD8 T cell epitopes. J Immunol. 2014 Jun 01; 192(11):5245-56. PMID: 24795457.
      Citations: 6     Fields:    Translation:HumansAnimalsCells
    110. Lin SY, Liu CL, Chang YM, Zhao J, Perlman S, Hou MH. Structural basis for the identification of the N-terminal domain of coronavirus nucleocapsid protein as an antiviral target. J Med Chem. 2014 Mar 27; 57(6):2247-57. PMID: 24564608.
      Citations: 43     Fields:    Translation:HumansCells
    111. Zhao J, Li K, Wohlford-Lenane C, Agnihothram SS, Fett C, Zhao J, Gale MJ, Baric RS, Enjuanes L, Gallagher T, McCray PB, Perlman S. Rapid generation of a mouse model for Middle East respiratory syndrome. Proc Natl Acad Sci U S A. 2014 Apr 01; 111(13):4970-5. PMID: 24599590.
      Citations: 237     Fields:    Translation:HumansAnimalsCells
    112. Barlan A, Zhao J, Sarkar MK, Li K, McCray PB, Perlman S, Gallagher T. Receptor variation and susceptibility to Middle East respiratory syndrome coronavirus infection. J Virol. 2014 May; 88(9):4953-61. PMID: 24554656.
      Citations: 53     Fields:    Translation:HumansAnimalsCells
    113. DeDiego ML, Nieto-Torres JL, Regla-Nava JA, Jimenez-Guardeño JM, Fernandez-Delgado R, Fett C, Castaño-Rodriguez C, Perlman S, Enjuanes L. Inhibition of NF-?B-mediated inflammation in severe acute respiratory syndrome coronavirus-infected mice increases survival. J Virol. 2014 Jan; 88(2):913-24. PMID: 24198408.
      Citations: 178     Fields:    Translation:HumansAnimalsCells
    114. Perlman S. The Middle East respiratory syndrome--how worried should we be? mBio. 2013 Aug 20; 4(4). PMID: 23963179.
      Citations: 8     Fields:    Translation:HumansAnimalsCellsPHPublic Health
    115. Zhao J, Fett C, Pewe L, Zhao J, Perlman S. Development of transgenic mice expressing a coronavirus-specific public CD4 T cell receptor. J Immunol Methods. 2013 Oct 31; 396(1-2):56-64. PMID: 23928495.
      Citations: 1     Fields:    Translation:AnimalsCells
    116. Perlman S, McCray PB. Person-to-person spread of the MERS coronavirus--an evolving picture. N Engl J Med. 2013 Aug 01; 369(5):466-7. PMID: 23902487.
      Citations: 18     Fields:    Translation:HumansCellsPHPublic Health
    117. de Groot RJ, Baker SC, Baric RS, Brown CS, Drosten C, Enjuanes L, Fouchier RA, Galiano M, Gorbalenya AE, Memish ZA, Perlman S, Poon LL, Snijder EJ, Stephens GM, Woo PC, Zaki AM, Zambon M, Ziebuhr J. Middle East respiratory syndrome coronavirus (MERS-CoV): announcement of the Coronavirus Study Group. J Virol. 2013 Jul; 87(14):7790-2. PMID: 23678167.
      Citations: 498     Fields:    Translation:HumansCells
    118. Fett C, DeDiego ML, Regla-Nava JA, Enjuanes L, Perlman S. Complete protection against severe acute respiratory syndrome coronavirus-mediated lethal respiratory disease in aged mice by immunization with a mouse-adapted virus lacking E protein. J Virol. 2013 Jun; 87(12):6551-9. PMID: 23576515.
      Citations: 63     Fields:    Translation:HumansAnimalsCellsPHPublic Health
    119. Chen IJ, Yuann JM, Chang YM, Lin SY, Zhao J, Perlman S, Shen YY, Huang TH, Hou MH. Crystal structure-based exploration of the important role of Arg106 in the RNA-binding domain of human coronavirus OC43 nucleocapsid protein. Biochim Biophys Acta. 2013 Jun; 1834(6):1054-62. PMID: 23501675.
      Citations: 16     Fields:    Translation:HumansCells
    120. Gallagher T, Perlman S. Public health: Broad reception for coronavirus. Nature. 2013 Mar 14; 495(7440):176-7. PMID: 23486053.
      Citations: 17     Fields:    Translation:HumansAnimalsCells
    121. Perlman S, Zhao J. Human coronavirus EMC is not the same as severe acute respiratory syndrome coronavirus. mBio. 2013 Jan 15; 4(1). PMID: 23322635.
      Citations: 13     Fields:    Translation:HumansAnimalsCells
    122. Trujillo JA, Fleming EL, Perlman S. Transgenic CCL2 expression in the central nervous system results in a dysregulated immune response and enhanced lethality after coronavirus infection. J Virol. 2013 Mar; 87(5):2376-89. PMID: 23269787.
      Citations: 22     Fields:    Translation:AnimalsCells
    123. Zhao J, Wohlford-Lenane C, Zhao J, Fleming E, Lane TE, McCray PB, Perlman S. Intranasal treatment with poly(I•C) protects aged mice from lethal respiratory virus infections. J Virol. 2012 Nov; 86(21):11416-24. PMID: 22915814.
      Citations: 58     Fields:    Translation:AnimalsCells
    124. Zhao J, Zhao J, Legge K, Perlman S. Age-related increases in PGD(2) expression impair respiratory DC migration, resulting in diminished T cell responses upon respiratory virus infection in mice. J Clin Invest. 2011 Dec; 121(12):4921-30. PMID: 22105170.
      Citations: 126     Fields:    Translation:AnimalsCells
    125. DeDiego ML, Nieto-Torres JL, Jiménez-Guardeño JM, Regla-Nava JA, Alvarez E, Oliveros JC, Zhao J, Fett C, Perlman S, Enjuanes L. Severe acute respiratory syndrome coronavirus envelope protein regulates cell stress response and apoptosis. PLoS Pathog. 2011 Oct; 7(10):e1002315. PMID: 22028656.
      Citations: 96     Fields:    Translation:HumansCells
    126. Zhao J, Zhao J, Fett C, Trandem K, Fleming E, Perlman S. IFN-?- and IL-10-expressing virus epitope-specific Foxp3(+) T reg cells in the central nervous system during encephalomyelitis. J Exp Med. 2011 Aug 01; 208(8):1571-7. PMID: 21746812.
      Citations: 47     Fields:    Translation:AnimalsCells
    127. Trandem K, Jin Q, Weiss KA, James BR, Zhao J, Perlman S. Virally expressed interleukin-10 ameliorates acute encephalomyelitis and chronic demyelination in coronavirus-infected mice. J Virol. 2011 Jul; 85(14):6822-31. PMID: 21593179.
      Citations: 17     Fields:    Translation:AnimalsCells
    128. Trandem K, Zhao J, Fleming E, Perlman S. Highly activated cytotoxic CD8 T cells express protective IL-10 at the peak of coronavirus-induced encephalitis. J Immunol. 2011 Mar 15; 186(6):3642-52. PMID: 21317392.
      Citations: 80     Fields:    Translation:AnimalsCells
    129. Shulla A, Heald-Sargent T, Subramanya G, Zhao J, Perlman S, Gallagher T. A transmembrane serine protease is linked to the severe acute respiratory syndrome coronavirus receptor and activates virus entry. J Virol. 2011 Jan; 85(2):873-82. PMID: 21068237.
      Citations: 306     Fields:    Translation:HumansCells
    130. Zhou H, Zhao J, Perlman S. Autocrine interferon priming in macrophages but not dendritic cells results in enhanced cytokine and chemokine production after coronavirus infection. mBio. 2010 Oct 19; 1(4). PMID: 20978536.
      Citations: 22     Fields:    Translation:HumansAnimalsCells
    131. Zhao J, Zhao J, Perlman S. T cell responses are required for protection from clinical disease and for virus clearance in severe acute respiratory syndrome coronavirus-infected mice. J Virol. 2010 Sep; 84(18):9318-25. PMID: 20610717.
      Citations: 152     Fields:    Translation:AnimalsCells
    132. Trandem K, Anghelina D, Zhao J, Perlman S. Regulatory T cells inhibit T cell proliferation and decrease demyelination in mice chronically infected with a coronavirus. J Immunol. 2010 Apr 15; 184(8):4391-400. PMID: 20208000.
      Citations: 35     Fields:    Translation:HumansAnimalsCells
    133. Zhou H, Ferraro D, Zhao J, Hussain S, Shao J, Trujillo J, Netland J, Gallagher T, Perlman S. The N-terminal region of severe acute respiratory syndrome coronavirus protein 6 induces membrane rearrangement and enhances virus replication. J Virol. 2010 Apr; 84(7):3542-51. PMID: 20106914.
      Citations: 24     Fields:    Translation:HumansCells
    134. Netland J, DeDiego ML, Zhao J, Fett C, Álvarez E, Nieto-Torres JL, Enjuanes L, Perlman S. Immunization with an attenuated severe acute respiratory syndrome coronavirus deleted in E protein protects against lethal respiratory disease. Virology. 2010 Mar 30; 399(1):120-128. PMID: 20110095.
      Citations: 70     Fields:    Translation:HumansAnimalsCells
    135. Zhao J, Zhao J, Van Rooijen N, Perlman S. Evasion by stealth: inefficient immune activation underlies poor T cell response and severe disease in SARS-CoV-infected mice. PLoS Pathog. 2009 Oct; 5(10):e1000636. PMID: 19851468.
      Citations: 91     Fields:    Translation:AnimalsCells
    136. Zhao J, Zhao J, Perlman S. De novo recruitment of antigen-experienced and naive T cells contributes to the long-term maintenance of antiviral T cell populations in the persistently infected central nervous system. J Immunol. 2009 Oct 15; 183(8):5163-70. PMID: 19786545.
      Citations: 19     Fields:    Translation:AnimalsCells
    137. Wohlford-Lenane CL, Meyerholz DK, Perlman S, Zhou H, Tran D, Selsted ME, McCray PB. Rhesus theta-defensin prevents death in a mouse model of severe acute respiratory syndrome coronavirus pulmonary disease. J Virol. 2009 Nov; 83(21):11385-90. PMID: 19710146.
      Citations: 55     Fields:    Translation:HumansAnimalsCells
    138. Perlman S, Netland J. Coronaviruses post-SARS: update on replication and pathogenesis. Nat Rev Microbiol. 2009 Jun; 7(6):439-50. PMID: 19430490.
      Citations: 662     Fields:    Translation:HumansAnimalsCells
    139. Anghelina D, Zhao J, Trandem K, Perlman S. Role of regulatory T cells in coronavirus-induced acute encephalitis. Virology. 2009 Mar 15; 385(2):358-67. PMID: 19141357.
      Citations: 32     Fields:    Translation:AnimalsCells
    140. Zhao J, Falcón A, Zhou H, Netland J, Enjuanes L, Pérez Breña P, Perlman S. Severe acute respiratory syndrome coronavirus protein 6 is required for optimal replication. J Virol. 2009 Mar; 83(5):2368-73. PMID: 19091867.
      Citations: 32     Fields:    Translation:AnimalsCells
    141. Whitman L, Zhou H, Perlman S, Lane TE. IFN-gamma-mediated suppression of coronavirus replication in glial-committed progenitor cells. Virology. 2009 Feb 05; 384(1):209-15. PMID: 19059617.
      Citations: 12     Fields:    Translation:AnimalsCells
    142. Butler NS, Theodossis A, Webb AI, Nastovska R, Ramarathinam SH, Dunstone MA, Rossjohn J, Purcell AW, Perlman S. Prevention of cytotoxic T cell escape using a heteroclitic subdominant viral T cell determinant. PLoS Pathog. 2008 Oct; 4(10):e1000186. PMID: 18949029.
      Citations: 7     Fields:    Translation:AnimalsCells
    143. Netland J, Meyerholz DK, Moore S, Cassell M, Perlman S. Severe acute respiratory syndrome coronavirus infection causes neuronal death in the absence of encephalitis in mice transgenic for human ACE2. J Virol. 2008 Aug; 82(15):7264-75. PMID: 18495771.
      Citations: 494     Fields:    Translation:HumansAnimalsCells
    144. Dediego ML, Pewe L, Alvarez E, Rejas MT, Perlman S, Enjuanes L. Pathogenicity of severe acute respiratory coronavirus deletion mutants in hACE-2 transgenic mice. Virology. 2008 Jul 05; 376(2):379-89. PMID: 18452964.
      Citations: 87     Fields:    Translation:HumansAnimalsCells
    145. Hussain S, Perlman S, Gallagher TM. Severe acute respiratory syndrome coronavirus protein 6 accelerates murine hepatitis virus infections by more than one mechanism. J Virol. 2008 Jul; 82(14):7212-22. PMID: 18448520.
      Citations: 24     Fields:    Translation:HumansCells
    146. Butler NS, Theodossis A, Webb AI, Dunstone MA, Nastovska R, Ramarathinam SH, Rossjohn J, Purcell AW, Perlman S. Structural and biological basis of CTL escape in coronavirus-infected mice. J Immunol. 2008 Mar 15; 180(6):3926-37. PMID: 18322201.
      Citations: 11     Fields:    Translation:AnimalsCells
    147. Templeton SP, Perlman S. Role of IFN-gamma responsiveness in CD8 T-cell-mediated viral clearance and demyelination in coronavirus-infected mice. J Neuroimmunol. 2008 Feb; 194(1-2):18-26. PMID: 18082272.
      Citations: 5     Fields:    Translation:AnimalsCells
    148. Templeton SP, Kim TS, O'Malley K, Perlman S. Maturation and localization of macrophages and microglia during infection with a neurotropic murine coronavirus. Brain Pathol. 2008 Jan; 18(1):40-51. PMID: 17935605.
      Citations: 38     Fields:    Translation:HumansAnimalsCells
    149. Butler NS, Dandekar AA, Perlman S. Antiviral antibodies are necessary to prevent cytotoxic T-lymphocyte escape in mice infected with a coronavirus. J Virol. 2007 Dec; 81(24):13291-8. PMID: 17913802.
      Citations: 4     Fields:    Translation:HumansAnimalsCells
    150. Netland J, Ferraro D, Pewe L, Olivares H, Gallagher T, Perlman S. Enhancement of murine coronavirus replication by severe acute respiratory syndrome coronavirus protein 6 requires the N-terminal hydrophobic region but not C-terminal sorting motifs. J Virol. 2007 Oct; 81(20):11520-5. PMID: 17670827.
      Citations: 18     Fields:    Translation:AnimalsCells
    151. Templeton SP, Perlman S. Pathogenesis of acute and chronic central nervous system infection with variants of mouse hepatitis virus, strain JHM. Immunol Res. 2007; 39(1-3):160-72. PMID: 17917063.
      Citations: 21     Fields:    Translation:AnimalsCells
    152. Kedzierska K, Day EB, Pi J, Heard SB, Doherty PC, Turner SJ, Perlman S. Quantification of repertoire diversity of influenza-specific epitopes with predominant public or private TCR usage. J Immunol. 2006 Nov 15; 177(10):6705-12. PMID: 17082583.
      Citations: 34     Fields:    Translation:AnimalsCells
    153. Tangudu C, Olivares H, Netland J, Perlman S, Gallagher T. Severe acute respiratory syndrome coronavirus protein 6 accelerates murine coronavirus infections. J Virol. 2007 Feb; 81(3):1220-9. PMID: 17108045.
      Citations: 33     Fields:    Translation:HumansAnimalsCells
    154. Zhou H, Perlman S. Mouse hepatitis virus does not induce Beta interferon synthesis and does not inhibit its induction by double-stranded RNA. J Virol. 2007 Jan; 81(2):568-74. PMID: 17079305.
      Citations: 66     Fields:    Translation:HumansAnimalsCells
    155. McCray PB, Pewe L, Wohlford-Lenane C, Hickey M, Manzel L, Shi L, Netland J, Jia HP, Halabi C, Sigmund CD, Meyerholz DK, Kirby P, Look DC, Perlman S. Lethal infection of K18-hACE2 mice infected with severe acute respiratory syndrome coronavirus. J Virol. 2007 Jan; 81(2):813-21. PMID: 17079315.
      Citations: 344     Fields:    Translation:HumansAnimalsCells
    156. Anghelina D, Pewe L, Perlman S. Pathogenic role for virus-specific CD4 T cells in mice with coronavirus-induced acute encephalitis. Am J Pathol. 2006 Jul; 169(1):209-22. PMID: 16816374.
      Citations: 22     Fields:    Translation:HumansAnimalsCells
    157. Zhou H, Perlman S. Preferential infection of mature dendritic cells by mouse hepatitis virus strain JHM. J Virol. 2006 Mar; 80(5):2506-14. PMID: 16474157.
      Citations: 24     Fields:    Translation:AnimalsCells
    158. Butler N, Pewe L, Trandem K, Perlman S. Murine encephalitis caused by HCoV-OC43, a human coronavirus with broad species specificity, is partly immune-mediated. Virology. 2006 Apr 10; 347(2):410-21. PMID: 16413043.
      Citations: 37     Fields:    Translation:HumansAnimalsCells
    159. Zhou H, Perlman S. Preferential infection of mature dendritic cells by the JHM strain of mouse hepatitis virus. Adv Exp Med Biol. 2006; 581:411-4. PMID: 17037570.
      Citations: 2     Fields:    Translation:AnimalsCells
    160. Jia HP, Look DC, Hickey M, Shi L, Pewe L, Netland J, Farzan M, Wohlford-Lenane C, Perlman S, McCray PB. Infection of human airway epithelia by SARS coronavirus is associated with ACE2 expression and localization. Adv Exp Med Biol. 2006; 581:479-84. PMID: 17037581.
      Citations: 13     Fields:    Translation:HumansCells
    161. Pewe L, Zhou H, Netland J, Tangadu C, Olivares H, Shi L, Look D, Gallagher T, Perlman S. A SARS-CoV-specific protein enhances virulence of an attenuated strain of mouse hepatitis virus. Adv Exp Med Biol. 2006; 581:493-8. PMID: 17037583.
      Citations: 3     Fields:    Translation:Cells
    162. Butler N, Pewe L, Trandem K, Perlman S. HCoV-OC43-induced encephalitis is in part immune-mediated. Adv Exp Med Biol. 2006; 581:531-4. PMID: 17037592.
      Citations:    Fields:    Translation:HumansAnimalsCells
    163. Jia HP, Look DC, Shi L, Hickey M, Pewe L, Netland J, Farzan M, Wohlford-Lenane C, Perlman S, McCray PB. ACE2 receptor expression and severe acute respiratory syndrome coronavirus infection depend on differentiation of human airway epithelia. J Virol. 2005 Dec; 79(23):14614-21. PMID: 16282461.
      Citations: 341     Fields:    Translation:HumansCells
    164. Perlman S, Dandekar AA. Immunopathogenesis of coronavirus infections: implications for SARS. Nat Rev Immunol. 2005 Dec; 5(12):917-27. PMID: 16322745.
      Citations: 225     Fields:    Translation:HumansAnimalsCells
    165. Pewe L, Zhou H, Netland J, Tangudu C, Olivares H, Shi L, Look D, Gallagher T, Perlman S. A severe acute respiratory syndrome-associated coronavirus-specific protein enhances virulence of an attenuated murine coronavirus. J Virol. 2005 Sep; 79(17):11335-42. PMID: 16103185.
      Citations: 58     Fields:    Translation:HumansAnimalsCells
    166. Dandekar AA, O'Malley K, Perlman S. Important roles for gamma interferon and NKG2D in gammadelta T-cell-induced demyelination in T-cell receptor beta-deficient mice infected with a coronavirus. J Virol. 2005 Aug; 79(15):9388-96. PMID: 16014902.
      Citations: 14     Fields:    Translation:AnimalsCells
    167. Kim TS, Perlman S. Viral expression of CCL2 is sufficient to induce demyelination in RAG1-/- mice infected with a neurotropic coronavirus. J Virol. 2005 Jun; 79(11):7113-20. PMID: 15890951.
      Citations: 26     Fields:    Translation:HumansAnimalsCells
    168. Kim TS, Perlman S. Virus-specific antibody, in the absence of T cells, mediates demyelination in mice infected with a neurotropic coronavirus. Am J Pathol. 2005 Mar; 166(3):801-9. PMID: 15743792.
      Citations: 14     Fields:    Translation:AnimalsCells
    169. Pewe LL, Netland JM, Heard SB, Perlman S. Very diverse CD8 T cell clonotypic responses after virus infections. J Immunol. 2004 Mar 01; 172(5):3151-6. PMID: 14978121.
      Citations: 25     Fields:    Translation:AnimalsCells
    170. Dandekar AA, Anghelina D, Perlman S. Bystander CD8 T-cell-mediated demyelination is interferon-gamma-dependent in a coronavirus model of multiple sclerosis. Am J Pathol. 2004 Feb; 164(2):363-9. PMID: 14742242.
      Citations: 17     Fields:    Translation:AnimalsCells
    171. Dandekar AA, Jacobsen G, Waldschmidt TJ, Perlman S. Antibody-mediated protection against cytotoxic T-cell escape in coronavirus-induced demyelination. J Virol. 2003 Nov; 77(22):11867-74. PMID: 14581523.
      Citations: 9     Fields:    Translation:AnimalsCells
    172. Ontiveros E, Kim TS, Gallagher TM, Perlman S. Enhanced virulence mediated by the murine coronavirus, mouse hepatitis virus strain JHM, is associated with a glycine at residue 310 of the spike glycoprotein. J Virol. 2003 Oct; 77(19):10260-9. PMID: 12970410.
      Citations: 45     Fields:    Translation:AnimalsCells
    173. Kim TS, Perlman S. Protection against CTL escape and clinical disease in a murine model of virus persistence. J Immunol. 2003 Aug 15; 171(4):2006-13. PMID: 12902505.
      Citations: 11     Fields:    Translation:HumansAnimalsCells
    174. Haring JS, Perlman S. Bystander CD4 T cells do not mediate demyelination in mice infected with a neurotropic coronavirus. J Neuroimmunol. 2003 Apr; 137(1-2):42-50. PMID: 12667646.
      Citations: 8     Fields:    Translation:AnimalsCells
    175. Dandekar AA, Perlman S. Virus-induced demyelination in nude mice is mediated by gamma delta T cells. Am J Pathol. 2002 Oct; 161(4):1255-63. PMID: 12368199.
      Citations: 22     Fields:    Translation:AnimalsCells
    176. Haring JS, Pewe LL, Perlman S. Bystander CD8 T cell-mediated demyelination after viral infection of the central nervous system. J Immunol. 2002 Aug 01; 169(3):1550-5. PMID: 12133983.
      Citations: 27     Fields:    Translation:AnimalsCells
    177. Pewe L, Haring J, Perlman S. CD4 T-cell-mediated demyelination is increased in the absence of gamma interferon in mice infected with mouse hepatitis virus. J Virol. 2002 Jul; 76(14):7329-33. PMID: 12072531.
      Citations: 25     Fields:    Translation:AnimalsCells
    178. Pewe L, Perlman S. Cutting edge: CD8 T cell-mediated demyelination is IFN-gamma dependent in mice infected with a neurotropic coronavirus. J Immunol. 2002 Feb 15; 168(4):1547-51. PMID: 11823480.
      Citations: 36     Fields:    Translation:AnimalsCells
    179. Ontiveros E, Kuo L, Masters PS, Perlman S. Inactivation of expression of gene 4 of mouse hepatitis virus strain JHM does not affect virulence in the murine CNS. Virology. 2001 Oct 25; 289(2):230-8. PMID: 11689046.
      Citations: 56     Fields:    Translation:AnimalsCells
    180. Haring J, Perlman S. Mouse hepatitis virus. Curr Opin Microbiol. 2001 Aug; 4(4):462-6. PMID: 11495812.
      Citations: 33     Fields:    Translation:HumansAnimalsCells
    181. Dandekar AA, Wu GF, Pewe L, Perlman S. Axonal damage is T cell mediated and occurs concomitantly with demyelination in mice infected with a neurotropic coronavirus. J Virol. 2001 Jul; 75(13):6115-20. PMID: 11390613.
      Citations: 36     Fields:    Translation:AnimalsCells
    182. Kolb AF, Pewe L, Webster J, Perlman S, Whitelaw CB, Siddell SG. Virus-neutralizing monoclonal antibody expressed in milk of transgenic mice provides full protection against virus-induced encephalitis. J Virol. 2001 Mar; 75(6):2803-9. PMID: 11222704.
      Citations: 13     Fields:    Translation:AnimalsCells
    183. Haring JS, Pewe LL, Perlman S. High-magnitude, virus-specific CD4 T-cell response in the central nervous system of coronavirus-infected mice. J Virol. 2001 Mar; 75(6):3043-7. PMID: 11222733.
      Citations: 20     Fields:    Translation:AnimalsCells
    184. Wu GF, Dandekar AA, Pewe L, Perlman S. The role of CD4 and CD8 T cells in MHV-JHM-induced demyelination. Adv Exp Med Biol. 2001; 494:341-7. PMID: 11774490.
      Citations: 7     Fields:    Translation:AnimalsCells
    185. Ontiveros E, Kuo L, Masters P, Perlman S. Analysis of nonessential gene function in recombinant MHV-JHM. Gene 4 knockout recombinant virus. Adv Exp Med Biol. 2001; 494:83-9. PMID: 11774550.
      Citations: 5     Fields:    Translation:AnimalsCells
    186. Wang G, Deering C, Macke M, Shao J, Burns R, Blau DM, Holmes KV, Davidson BL, Perlman S, McCray PB. Human coronavirus 229E infects polarized airway epithelia from the apical surface. J Virol. 2000 Oct; 74(19):9234-9. PMID: 10982370.
      Citations: 37     Fields:    Translation:HumansCells
    187. Wu GF, Dandekar AA, Pewe L, Perlman S. CD4 and CD8 T cells have redundant but not identical roles in virus-induced demyelination. J Immunol. 2000 Aug 15; 165(4):2278-86. PMID: 10925317.
      Citations: 105     Fields:    Translation:AnimalsCells
    188. Wu GF, Pewe L, Perlman S. Coronavirus-induced demyelination occurs in the absence of inducible nitric oxide synthase. J Virol. 2000 Aug; 74(16):7683-6. PMID: 10906226.
      Citations: 13     Fields:    Translation:AnimalsCells
    189. Pewe L, Heard SB, Bergmann C, Dailey MO, Perlman S. Selection of CTL escape mutants in mice infected with a neurotropic coronavirus: quantitative estimate of TCR diversity in the infected central nervous system. J Immunol. 1999 Dec 01; 163(11):6106-13. PMID: 10570300.
      Citations: 20     Fields:    Translation:AnimalsCells
    190. Wu GF, Perlman S. Macrophage infiltration, but not apoptosis, is correlated with immune-mediated demyelination following murine infection with a neurotropic coronavirus. J Virol. 1999 Oct; 73(10):8771-80. PMID: 10482631.
      Citations: 67     Fields:    Translation:AnimalsCells
    191. Xue S, Sun N, Van Rooijen N, Perlman S. Depletion of blood-borne macrophages does not reduce demyelination in mice infected with a neurotropic coronavirus. J Virol. 1999 Aug; 73(8):6327-34. PMID: 10400724.
      Citations: 29     Fields:    Translation:AnimalsCells
    192. Pewe L, Perlman S. Immune response to the immunodominant epitope of mouse hepatitis virus is polyclonal, but functionally monospecific in C57Bl/6 mice. Virology. 1999 Mar 01; 255(1):106-16. PMID: 10049826.
      Citations: 8     Fields:    Translation:AnimalsCells
    193. Pewe L, Xue S, Perlman S. Infection with cytotoxic T-lymphocyte escape mutants results in increased mortality and growth retardation in mice infected with a neurotropic coronavirus. J Virol. 1998 Jul; 72(7):5912-8. PMID: 9621053.
      Citations: 9     Fields:    Translation:AnimalsCells
    194. Perlman S. Pathogenesis of coronavirus-induced infections. Review of pathological and immunological aspects. Adv Exp Med Biol. 1998; 440:503-13. PMID: 9782322.
      Citations: 31     Fields:    Translation:AnimalsCells
    195. Perlman S, Pewe L. Role of CTL mutants in demyelination induced by mouse hepatitis virus, strain JHM. Adv Exp Med Biol. 1998; 440:515-9. PMID: 9782323.
      Citations: 5     Fields:    Translation:AnimalsCells
    196. Xue S, Perlman S. Antigen specificity of CD4 T cell response in the central nervous system of mice infected with mouse hepatitis virus. Virology. 1997 Nov 10; 238(1):68-78. PMID: 9375010.
      Citations: 13     Fields:    Translation:AnimalsCells
    197. Pewe L, Xue S, Perlman S. Cytotoxic T-cell-resistant variants arise at early times after infection in C57BL/6 but not in SCID mice infected with a neurotropic coronavirus. J Virol. 1997 Oct; 71(10):7640-7. PMID: 9311846.
      Citations: 11     Fields:    Translation:AnimalsCells
    198. Grzybicki DM, Kwack KB, Perlman S, Murphy SP. Nitric oxide synthase type II expression by different cell types in MHV-JHM encephalitis suggests distinct roles for nitric oxide in acute versus persistent virus infection. J Neuroimmunol. 1997 Mar; 73(1-2):15-27. PMID: 9058755.
      Citations: 10     Fields:    Translation:AnimalsCells
    199. Pewe L, Wu GF, Barnett EM, Castro RF, Perlman S. Cytotoxic T cell-resistant variants are selected in a virus-induced demyelinating disease. Immunity. 1996 Sep; 5(3):253-62. PMID: 8808680.
      Citations: 38     Fields:    Translation:AnimalsCells
    200. Castro RF, Perlman S. Differential antigen recognition by T cells from the spleen and central nervous system of coronavirus-infected mice. Virology. 1996 Aug 01; 222(1):247-51. PMID: 8806504.
      Citations: 6     Fields:    Translation:AnimalsCells
    201. Castro RF, Perlman S. CD8+ T-cell epitopes within the surface glycoprotein of a neurotropic coronavirus and correlation with pathogenicity. J Virol. 1995 Dec; 69(12):8127-31. PMID: 7494335.
      Citations: 50     Fields:    Translation:AnimalsCells
    202. Sun N, Grzybicki D, Castro RF, Murphy S, Perlman S. Activation of astrocytes in the spinal cord of mice chronically infected with a neurotropic coronavirus. Virology. 1995 Nov 10; 213(2):482-93. PMID: 7491773.
      Citations: 54     Fields:    Translation:AnimalsCells
    203. Xue S, Jaszewski A, Perlman S. Identification of a CD4+ T cell epitope within the M protein of a neurotropic coronavirus. Virology. 1995 Apr 01; 208(1):173-9. PMID: 11831697.
      Citations: 18     Fields:    Translation:AnimalsCells
    204. Sun N, Perlman S. Spread of a neurotropic coronavirus to spinal cord white matter via neurons and astrocytes. J Virol. 1995 Feb; 69(2):633-41. PMID: 7815526.
      Citations: 22     Fields:    Translation:AnimalsCells
    205. Perlman S, Sun N, Barnett EM. Spread of MHV-JHM from nasal cavity to white matter of spinal cord. Transneuronal movement and involvement of astrocytes. Adv Exp Med Biol. 1995; 380:73-8. PMID: 8830549.
      Citations: 7     Fields:    Translation:AnimalsCells
    206. Chung S, Gorczynski R, Cruz B, Fingerote R, Skamene E, Perlman S, Leibowitz J, Fung L, Flowers M, Levy G. A Th1 cell line (3E9.1) from resistant A/J mice inhibits induction of macrophage procoagulant activity in vitro and protects against MHV-3 mortality in vivo. Immunology. 1994 Nov; 83(3):353-61. PMID: 7835959.
      Citations: 7     Fields:    Translation:AnimalsCells
    207. Castro RF, Evans GD, Jaszewski A, Perlman S. Coronavirus-induced demyelination occurs in the presence of virus-specific cytotoxic T cells. Virology. 1994 May 01; 200(2):733-43. PMID: 8178457.
      Citations: 23     Fields:    Translation:AnimalsCells
    208. Barnett EM, Perlman S. The olfactory nerve and not the trigeminal nerve is the major site of CNS entry for mouse hepatitis virus, strain JHM. Virology. 1993 May; 194(1):185-91. PMID: 8386871.
      Citations: 33     Fields:    Translation:AnimalsCells
    209. Perlman S, Barnett E, Jacobsen G. Mouse hepatitis virus and herpes simplex virus move along different CNS pathways. Adv Exp Med Biol. 1993; 342:313-8. PMID: 7516106.
      Citations: 5     Fields:    Translation:AnimalsCells
    210. Oleszak EL, Perlman S, Parr R, Collisson EW, Leibowitz JL. Molecular mimicry between S peplomer proteins of coronaviruses (MHV, BCV, TGEV and IBV) and Fc receptor. Adv Exp Med Biol. 1993; 342:183-8. PMID: 8209728.
      Citations: 3     Fields:    Translation:AnimalsCells
    211. Chung S, Li C, Fung LS, Crow A, Gorczynski R, Cole E, Perlman S, Leibowitz J, Levy G. Role of macrophage procoagulant activity in mouse hepatitis virus (MHV) infection: studies using T cell MHV-3 clones and monoclonal antibody 3D4.3. Adv Exp Med Biol. 1993; 342:377-84. PMID: 8209757.
      Citations:    Fields:    Translation:AnimalsCells
    212. Gallagher TM, Buchmeier MJ, Perlman S. Cell receptor-independent infection by a neurotropic murine coronavirus. Virology. 1992 Nov; 191(1):517-22. PMID: 1413526.
      Citations: 45     Fields:    Translation:HumansAnimalsCells
    213. Denison MR, Zoltick PW, Hughes SA, Giangreco B, Olson AL, Perlman S, Leibowitz JL, Weiss SR. Intracellular processing of the N-terminal ORF 1a proteins of the coronavirus MHV-A59 requires multiple proteolytic events. Virology. 1992 Jul; 189(1):274-84. PMID: 1318604.
      Citations: 47     Fields:    Translation:Cells
    214. Mobley J, Evans G, Dailey MO, Perlman S. Immune response to a murine coronavirus: identification of a homing receptor-negative CD4+ T cell subset that responds to viral glycoproteins. Virology. 1992 Apr; 187(2):443-52. PMID: 1347668.
      Citations: 13     Fields:    Translation:AnimalsCells
    215. Oleszak EL, Perlman S, Leibowitz JL. MHV S peplomer protein expressed by a recombinant vaccinia virus vector exhibits IgG Fc-receptor activity. Virology. 1992 Jan; 186(1):122-32. PMID: 1309271.
      Citations: 11     Fields:    Translation:HumansAnimalsCells
    216. Perlman S, Evans G, Afifi A. Effect of olfactory bulb ablation on spread of a neurotropic coronavirus into the mouse brain. J Exp Med. 1990 Oct 01; 172(4):1127-32. PMID: 1698910.
      Citations: 46     Fields:    Translation:AnimalsCells
    217. Perlman S, Jacobsen G, Olson AL, Afifi A. Identification of the spinal cord as a major site of persistence during chronic infection with a murine coronavirus. Virology. 1990 Apr; 175(2):418-26. PMID: 2158180.
      Citations: 27     Fields:    Translation:AnimalsCells
    218. Jacobsen G, Perlman S. Localization of virus and antibody response in mice infected persistently with MHV-JHM. Adv Exp Med Biol. 1990; 276:573-8. PMID: 1966451.
      Citations: 5     Fields:    Translation:AnimalsCells
    219. Perlman S, Jacobsen G, Afifi A. Spread of a neurotropic murine coronavirus into the CNS via the trigeminal and olfactory nerves. Virology. 1989 Jun; 170(2):556-60. PMID: 2543129.
      Citations: 31     Fields:    Translation:AnimalsCells
    220. Perlman S, Jacobsen G, Moore S. Regional localization of virus in the central nervous system of mice persistently infected with murine coronavirus JHM. Virology. 1988 Oct; 166(2):328-38. PMID: 2845647.
      Citations: 7     Fields:    Translation:AnimalsCells
    221. Leibowitz JL, Perlman S, Weinstock G, DeVries JR, Budzilowicz C, Weissemann JM, Weiss SR. Detection of a murine coronavirus nonstructural protein encoded in a downstream open reading frame. Virology. 1988 May; 164(1):156-64. PMID: 2834866.
      Citations: 17     Fields:    Translation:Cells
    222. Perlman S, Ries D. The astrocyte is a target cell in mice persistently infected with mouse hepatitis virus, strain JHM. Microb Pathog. 1987 Oct; 3(4):309-14. PMID: 2849022.
      Citations: 23     Fields:    Translation:AnimalsCells
    223. Denison M, Perlman S. Identification of putative polymerase gene product in cells infected with murine coronavirus A59. Virology. 1987 Apr; 157(2):565-8. PMID: 3029990.
      Citations: 29     Fields:    Translation:AnimalsCells
    224. Perlman S, Schelper R, Bolger E, Ries D. Late onset, symptomatic, demyelinating encephalomyelitis in mice infected with MHV-JHM in the presence of maternal antibody. Microb Pathog. 1987 Mar; 2(3):185-94. PMID: 2853274.
      Citations: 44     Fields:    Translation:AnimalsPHPublic Health
    225. Denison M, Perlman S. Translation and processing of MHV-A59 virion RNA in reticulocyte lysates and infected cells. Adv Exp Med Biol. 1987; 218:155-6. PMID: 2829524.
      Citations: 2     Fields:    Translation:AnimalsCells
    226. Perlman S, Schelper R, Ries D. Maternal antibody-modulated MHV-JHM infection in C57BL/6 and BALB/c mice. Adv Exp Med Biol. 1987; 218:297-305. PMID: 2829543.
      Citations: 7     Fields:    Translation:AnimalsCells
    227. Perlman S, Ries D, Bolger E, Chang LJ, Stoltzfus CM. MHV nucleocapsid synthesis in the presence of cycloheximide and accumulation of negative strand MHV RNA. Virus Res. 1986 Dec; 6(3):261-72. PMID: 3033933.
      Citations: 10     Fields:    Translation:Cells
    228. Denison MR, Perlman S. Translation and processing of mouse hepatitis virus virion RNA in a cell-free system. J Virol. 1986 Oct; 60(1):12-8. PMID: 3018279.
      Citations: 38     Fields:    Translation:AnimalsCells
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