Polypyrimidine Tract-Binding Protein
"Polypyrimidine Tract-Binding Protein" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A RNA-binding protein that binds to polypyriminidine rich regions in the INTRONS of messenger RNAs. Polypyrimidine tract-binding protein may be involved in regulating the ALTERNATIVE SPLICING of mRNAs since its presence on an intronic RNA region that is upstream of an EXON inhibits the splicing of the exon into the final mRNA product.
Descriptor ID |
D038941
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MeSH Number(s) |
D12.776.157.725.829.250 D12.776.664.962.829.250
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Concept/Terms |
Polypyrimidine Tract-Binding Protein- Polypyrimidine Tract-Binding Protein
- Polypyrimidine Tract Binding Protein
- Tract-Binding Protein, Polypyrimidine
- p57 Cytoplasmic RNA-Binding Protein
- p57 Cytoplasmic RNA Binding Protein
- PTB Splicing Factor
- Splicing Factor, PTB
- pPTB
- PTB Protein
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Below are MeSH descriptors whose meaning is more general than "Polypyrimidine Tract-Binding Protein".
Below are MeSH descriptors whose meaning is more specific than "Polypyrimidine Tract-Binding Protein".
This graph shows the total number of publications written about "Polypyrimidine Tract-Binding Protein" by people in this website by year, and whether "Polypyrimidine Tract-Binding Protein" was a major or minor topic of these publications.
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Year | Major Topic | Minor Topic | Total |
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1996 | 0 | 1 | 1 |
2017 | 3 | 0 | 3 |
2019 | 1 | 0 | 1 |
2020 | 1 | 0 | 1 |
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Below are the most recent publications written about "Polypyrimidine Tract-Binding Protein" by people in Profiles.
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SARS-CoV-2 dysregulation of PTBP1 and YWHAE/Z gene expression: A primer of neurodegeneration. Med Hypotheses. 2020 Nov; 144:110212.
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Polypyrimidine Tract-Binding Protein Regulates Enterovirus 71 Translation Through Interaction with the Internal Ribosomal Entry Site. Virol Sin. 2019 Feb; 34(1):66-77.
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Identification of MicroRNA-124 as a Major Regulator of Enhanced Endothelial Cell Glycolysis in Pulmonary Arterial Hypertension via PTBP1 (Polypyrimidine Tract Binding Protein) and Pyruvate Kinase M2. Circulation. 2017 Dec 19; 136(25):2451-2467.
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Metabolic and Proliferative State of Vascular Adventitial Fibroblasts in Pulmonary Hypertension Is Regulated Through a MicroRNA-124/PTBP1 (Polypyrimidine Tract Binding Protein 1)/Pyruvate Kinase Muscle Axis. Circulation. 2017 Dec 19; 136(25):2468-2485.
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High expression of PTBP1 promote invasion of colorectal cancer by alternative splicing of cortactin. Oncotarget. 2017 May 30; 8(22):36185-36202.
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The polypyrimidine tract-binding protein affects coronavirus RNA accumulation levels and relocalizes viral RNAs to novel cytoplasmic domains different from replication-transcription sites. J Virol. 2011 May; 85(10):5136-49.
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Viral and cellular proteins involved in coronavirus replication. Curr Top Microbiol Immunol. 2005; 287:95-131.
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Polypyrimidine-tract-binding protein affects transcription but not translation of mouse hepatitis virus RNA. Virology. 2002 Nov 10; 303(1):58-68.
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Heterogeneous nuclear ribonucleoprotein a1 binds to the 3'-untranslated region and mediates potential 5'-3'-end cross talks of mouse hepatitis virus RNA. J Virol. 2001 Jun; 75(11):5009-17.
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Polypyrimidine tract-binding protein binds to the complementary strand of the mouse hepatitis virus 3' untranslated region, thereby altering RNA conformation. J Virol. 1999 Nov; 73(11):9110-6.