Takehiro Takahashi

InstitutionUniversity of Tokyo Graduate School of Medicine
AddressTokyo
Japan
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    Publication Timeline
    COVID-19 publications
    Bar chart showing 7 Covid-19 publications, with a maximum of 2 publications in July 2020 and August 2020
    All Publications
    Bar chart showing 101 publications over 15 distinct years, with a maximum of 15 publications in 2014
    These graphs show COVID-19 publications by month since August 2019 and all publications written by authors of COVID-19 publications over the past 30 years.

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    Publication Field Summary
    This graph shows the number and percent of publications by field. Fields are based on how the National Library of Medicine (NLM) classifies the publications' journals and might not represent the specific topics of the publications. Note that an individual publication can be assigned to more than one field. As a result, the publication counts in this graph might add up to more than the number of publications the person has written. To see the data as text, click here.
    Publication List
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Wang SY, Takahashi T, Pine AB, Damsky WE, Simonov M, Zhang Y, Kieras E, Price CC, King BA, Siegel MD, Desir GV, Lee AI, Iwasaki A, Chun HJ. Challenges in interpreting cytokine data in COVID-19 affect patient care and management. PLoS Biol. 2021 08; 19(8):e3001373. PMID: 34358229.
      Citations:    Fields:    Translation:HumansPHPublic Health
    2. Cai Y, Kim DJ, Takahashi T, Broadhurst DI, Yan H, Ma S, Rattray NJW, Casanovas-Massana A, Israelow B, Klein J, Lucas C, Mao T, Moore AJ, Muenker MC, Oh JE, Silva J, Wong P, Ko AI, Khan SA, Iwasaki A, Johnson CH. Kynurenic acid may underlie sex-specific immune responses to COVID-19. Sci Signal. 2021 07 06; 14(690). PMID: 34230210.
      Citations: 5     Fields:    Translation:HumansCells
    3. Takahashi T, Iwasaki A. Sex differences in immune responses. Science. 2021 Jan 22; 371(6527):347-348. PMID: 33479140.
      Citations: 19     Fields:    Translation:Humans
    4. Citations: 249     Fields:    Translation:HumansCellsPHPublic Health
    5. Takahashi T, Ellingson MK, Wong P, Israelow B, Lucas C, Klein J, Silva J, Mao T, Oh JE, Tokuyama M, Lu P, Venkataraman A, Park A, Liu F, Meir A, Sun J, Wang EY, Casanovas-Massana A, Wyllie AL, Vogels CBF, Earnest R, Lapidus S, Ott IM, Moore AJ, Shaw A, Fournier JB, Odio CD, Farhadian S, Dela Cruz C, Grubaugh ND, Schulz WL, Ring AM, Ko AI, Omer SB, Iwasaki A. Sex differences in immune responses that underlie COVID-19 disease outcomes. Nature. 2020 12; 588(7837):315-320. PMID: 32846427.
      Citations: 291     Fields:    Translation:HumansCells
    6. Citations: 489     Fields:    Translation:HumansCellsPHPublic Health
    7. Citations: 168     Fields:    Translation:HumansCellsPHPublic Health
    8. Asano Y, Takahashi T, Saigusa R. Systemic sclerosis: Is the epithelium a missing piece of the pathogenic puzzle? J Dermatol Sci. 2019 May; 94(2):259-265. PMID: 31079997.
      Citations: 3     Fields:    Translation:HumansAnimalsCells
    9. Satoh E, Sasaki Y, Ohkuma R, Takahashi T, Kubota Y, Ishida H, Hamada K, Kiuchi Y, Tsunoda T. Lack of correlation between the costs of anticancer drugs and clinical benefits in Japan. Cancer Sci. 2018 Dec; 109(12):3896-3901. PMID: 30315613.
      Citations: 1     Fields:    Translation:Humans
    10. Sumida H, Asano Y, Tamaki Z, Aozasa N, Taniguchi T, Toyama T, Takahashi T, Ichimura Y, Noda S, Akamata K, Saigusa R, Miyazaki M, Kuwano Y, Yanaba K, Yoshizaki A, Sato S. Prediction of therapeutic response before and during i.v. cyclophosphamide pulse therapy for interstitial lung disease in systemic sclerosis: A longitudinal observational study. J Dermatol. 2018 Dec; 45(12):1425-1433. PMID: 30289572.
      Citations: 9     Fields:    Translation:Humans
    11. Sunakawa Y, Mogushi K, Lenz HJ, Zhang W, Tsuji A, Takahashi T, Denda T, Shimada K, Kochi M, Nakamura M, Kotaka M, Segawa Y, Tanioka H, Negoro Y, Moran M, Astrow SH, Hsiang J, Stephens C, Fujii M, Ichikawa W. Tumor Sidedness and Enriched Gene Groups for Efficacy of First-line Cetuximab Treatment in Metastatic Colorectal Cancer. Mol Cancer Ther. 2018 12; 17(12):2788-2795. PMID: 30275242.
      Citations: 1     Translation:HumansCells
    12. Yamashita T, Asano Y, Saigusa R, Taniguchi T, Nakamura K, Miura S, Toyama T, Takahashi T, Ichimura Y, Hirabayashi M, Yoshizaki A, Miyagaki T, Sugaya M, Sato S. Increased expression of aquaporin-1 in dermal fibroblasts and dermal microvascular endothelial cells possibly contributes to skin fibrosis and edema in patients with systemic sclerosis. J Dermatol Sci. 2019 Jan; 93(1):24-32. PMID: 30270117.
      Citations: 2     Fields:    Translation:HumansAnimalsCells
    13. Miyagawa T, Ichimura Y, Nakamura K, Hirabayashi M, Yamashita T, Saigusa R, Miura S, Takahashi T, Toyama T, Taniguchi T, Akamata K, Yoshizaki A, Sato S, Asano Y. Progranulin overproduction due to constitutively activated c-Abl/PKC-d/Fli1 pathway contributes to the resistance of dermal fibroblasts to the anti-fibrotic effect of tumor necrosis factor-a in localized scleroderma. J Dermatol Sci. 2018 Nov; 92(2):207-214. PMID: 30268392.
      Citations: 2     Fields:    Translation:HumansCells
    14. Nakao M, Nakamura K, Fukasawa T, Shida R, Ito A, Ichimura Y, Takahashi T, Mitsui A, Yoshizaki A, Shibata S, Kamata M, Araki M, Watanabe R, Sato S, Asano Y. Assessment of endothelial function during the loading phase of infliximab in psoriasis: a potential predictor of its drug survival. Int J Dermatol. 2019 Jan; 58(1):54-59. PMID: 30168849.
      Citations: 1     Fields:    Translation:Humans
    15. Sunakawa Y, Yang D, Cao S, Zhang W, Moran M, Astrow SH, Hsiang J, Stephens C, Tsuji A, Takahashi T, Tanioka H, Negoro Y, Takagane A, Tani S, Yamaguchi T, Eto T, Fujii M, Ichikawa W, Lenz HJ. Immune-related Genes to Dominate Neutrophil-lymphocyte Ratio (NLR) Associated With Survival of Cetuximab Treatment in Metastatic Colorectal Cancer. Clin Colorectal Cancer. 2018 12; 17(4):e741-e749. PMID: 30219280.
      Citations: 8     Fields:    Translation:HumansCells
    16. Taniguchi T, Miyagawa T, Toyama S, Yamashita T, Nakamura K, Saigusa R, Ichimura Y, Takahashi T, Toyama T, Yoshizaki A, Sato S, Asano Y. CXCL13 produced by macrophages due to Fli1 deficiency may contribute to the development of tissue fibrosis, vasculopathy and immune activation in systemic sclerosis. Exp Dermatol. 2018 09; 27(9):1030-1037. PMID: 29947047.
      Citations: 15     Fields:    Translation:HumansAnimalsCells
    17. Takahashi T, Koga Y, Kainoh M. Anti-IL-12/IL-23p40 antibody ameliorates dermatitis and skin barrier dysfunction in mice with imiquimod-induced psoriasis-like dermatitis. Eur J Pharmacol. 2018 Jun 05; 828:26-30. PMID: 29544684.
      Citations: 6     Fields:    Translation:AnimalsCells
    18. Saigusa R, Asano Y, Taniguchi T, Hirabayashi M, Nakamura K, Miura S, Yamashita T, Takahashi T, Ichimura Y, Toyama T, Yoshizaki A, Trojanowska M, Sato S. Fli1-haploinsufficient dermal fibroblasts promote skin-localized transdifferentiation of Th2-like regulatory T cells. Arthritis Res Ther. 2018 02 07; 20(1):23. PMID: 29415756.
      Citations: 4     Fields:    Translation:AnimalsCells
    19. Bando H, Shimodaira H, Fujitani K, Takashima A, Yamaguchi K, Nakayama N, Takahashi T, Oki E, Azuma M, Nishina T, Hironaka S, Komatsu Y, Shitara K. A phase II study of nab-paclitaxel in combination with ramucirumab in patients with previously treated advanced gastric cancer. Eur J Cancer. 2018 03; 91:86-91. PMID: 29353164.
      Citations: 11     Fields:    Translation:HumansCTClinical Trials
    20. Numajiri H, Yoshizaki A, Ebata S, Fukasawa T, Yamashita T, Takahashi T, Taniguchi T, Asano Y, Sato S. Successful treatment with rituximab in a Japanese patient with systemic sclerosis-associated interstitial lung disease resistant to oral steroid and cyclophosphamide. J Dermatol. 2018 Jun; 45(6):e140-e141. PMID: 29265579.
      Citations: 2     Fields:    Translation:Humans
    21. Saigusa R, Asano Y, Yamashita T, Takahashi T, Nakamura K, Miura S, Ichimura Y, Toyama T, Taniguchi T, Sumida H, Tamaki Z, Miyazaki M, Yoshizaki A, Sato S. Systemic sclerosis complicated with localized scleroderma-like lesions induced by Köbner phenomenon. J Dermatol Sci. 2018 Mar; 89(3):282-289. PMID: 29279288.
      Citations:    Fields:    Translation:HumansCells
    22. Hirabayashi M, Asano Y, Yamashita T, Miura S, Nakamura K, Taniguchi T, Saigusa R, Takahashi T, Ichimura Y, Miyagawa T, Yoshizaki A, Miyagaki T, Sugaya M, Sato S. Possible pro-inflammatory role of heparin-binding epidermal growth factor-like growth factor in the active phase of systemic sclerosis. J Dermatol. 2018 Feb; 45(2):182-188. PMID: 29044628.
      Citations: 1     Fields:    Translation:HumansCells
    23. Taniguchi T, Miyagawa T, Tamaki Z, Nakamura K, Yamashita T, Saigusa R, Takahashi T, Toyama T, Ichimura Y, Yoshizaki A, Tada Y, Sugaya M, Kadono T, Sato S, Asano Y. A possible implication of reduced levels of LIF, LIFR, and gp130 in vasculopathy related to systemic sclerosis. Arch Dermatol Res. 2017 Dec; 309(10):833-842. PMID: 29038846.
      Citations: 2     Fields:    Translation:HumansAnimalsCells
    24. Toyama T, Asano Y, Miyagawa T, Nakamura K, Hirabayashi M, Yamashita T, Saigusa R, Miura S, Ichimura Y, Takahashi T, Taniguchi T, Yoshizaki A, Sato S. The impact of transcription factor Fli1 deficiency on the regulation of angiogenesis. Exp Dermatol. 2017 10; 26(10):912-918. PMID: 28370536.
      Citations: 9     Fields:    Translation:HumansCells
    25. Saigusa R, Asano Y, Nakamura K, Hirabayashi M, Miura S, Yamashita T, Taniguchi T, Ichimura Y, Takahashi T, Yoshizaki A, Miyagaki T, Sugaya M, Sato S. Systemic Sclerosis Dermal Fibroblasts Suppress Th1 Cytokine Production via Galectin-9 Overproduction due to Fli1 Deficiency. J Invest Dermatol. 2017 09; 137(9):1850-1859. PMID: 28528914.
      Citations: 6     Fields:    Translation:HumansAnimalsCells
    26. Taniguchi T, Asano Y, Nakamura K, Yamashita T, Saigusa R, Ichimura Y, Takahashi T, Toyama T, Yoshizaki A, Sato S. Fli1 Deficiency Induces CXCL6 Expression in Dermal Fibroblasts and Endothelial Cells, Contributing to the Development of Fibrosis and Vasculopathy in Systemic Sclerosis. J Rheumatol. 2017 08; 44(8):1198-1205. PMID: 28507181.
      Citations: 3     Fields:    Translation:HumansAnimalsCells
    27. Ide S, Takahashi T, Takamatsu Y, Uhl GR, Niki H, Sora I, Ikeda K. Distinct Roles of Opioid and Dopamine Systems in Lateral Hypothalamic Intracranial Self-Stimulation. Int J Neuropsychopharmacol. 2017 05 01; 20(5):403-409. PMID: 28031268.
      Citations: 5     Fields:    Translation:Animals
    28. Miyagawa T, Asano Y, de Mestier Y, Saigusa R, Taniguchi T, Yamashita T, Nakamura K, Hirabayashi M, Miura S, Ichimura Y, Takahashi T, Yoshizaki A, Miyagaki T, Sugaya M, Sato S. Serum H-ficolin levels: Clinical association with interstitial lung disease in patients with systemic sclerosis. J Dermatol. 2017 Oct; 44(10):1168-1171. PMID: 28432700.
      Citations: 1     Fields:    Translation:Humans
    29. Oka T, Sugaya M, Takahashi N, Takahashi T, Shibata S, Miyagaki T, Asano Y, Sato S. CXCL17 Attenuates Imiquimod-Induced Psoriasis-like Skin Inflammation by Recruiting Myeloid-Derived Suppressor Cells and Regulatory T Cells. J Immunol. 2017 05 15; 198(10):3897-3908. PMID: 28389593.
      Citations: 13     Fields:    Translation:HumansAnimalsCells
    30. Toyama T, Asano Y, Taniguchi T, Takahashi T, Ichimura Y, Tamaki Z, Kagami S, Mitsui H, Sato S. Ethosuximide-induced lupus-scleroderma syndrome with disease-specific autoantibodies. Eur J Dermatol. 2017 04 01; 27(2):196-197. PMID: 28026802.
      Citations:    Fields:    Translation:Humans
    31. Takahashi T, Asano Y, Taniguchi T, Yoshizaki A, Sato S. Serum LL-37 levels correlate with the efficacy of i.v. cyclophosphamide pulse for skin sclerosis and interstitial lung disease in systemic sclerosis. J Dermatol. 2017 Apr; 44(4):468-469. PMID: 28378437.
      Citations: 1     Fields:    Translation:Humans
    32. Takahashi T, Asano Y, Sugawara K, Yamashita T, Nakamura K, Saigusa R, Ichimura Y, Toyama T, Taniguchi T, Akamata K, Noda S, Yoshizaki A, Tsuruta D, Trojanowska M, Sato S. Epithelial Fli1 deficiency drives systemic autoimmunity and fibrosis: Possible roles in scleroderma. J Exp Med. 2017 04 03; 214(4):1129-1151. PMID: 28232470.
      Citations: 18     Fields:    Translation:HumansAnimalsCells
    33. Takahashi T, Asano Y, Shibata S, Tada Y, Sato S. Serum angiopoietin-2 level as a potential biomarker in psoriasis vulgaris. J Dermatol. 2017 Feb; 44(2):205-206. PMID: 28497874.
      Citations: 1     Fields:    Translation:Humans
    34. Yamashita T, Asano Y, Taniguchi T, Nakamura K, Saigusa R, Miura S, Toyama T, Takahashi T, Ichimura Y, Yoshizaki A, Trojanowska M, Sato S. Glycyrrhizin Ameliorates Fibrosis, Vasculopathy, and Inflammation in Animal Models of Systemic Sclerosis. J Invest Dermatol. 2017 03; 137(3):631-640. PMID: 27777101.
      Citations: 12     Fields:    Translation:HumansAnimalsCells
    35. Takahashi T, Asano Y, Hirakawa M, Nakamura K, Saigusa R, Aozasa N, Sumida H, Fujita H, Sugaya M, Ohmori A, Shimizu J, Sato S. Linear scleroderma with prominent multiple lymphadenopathy followed by the development of polymyositis: A case report and review of published work. J Dermatol. 2016 Oct; 43(10):1224-1227. PMID: 27129435.
      Citations: 1     Fields:    Translation:HumansCells
    36. Saigusa R, Asano Y, Nakamura K, Yamashita T, Ichimura Y, Takahashi T, Toyama T, Taniguchi T, Yoshizaki A, Miyazaki M, Tamaki Z, Sato S. Plasma plasmin-a2-plasmin inhibitor complex levels may predict the effect of cyclophosphamide for systemic sclerosis-related interstitial lung disease. Mod Rheumatol. 2017 Jul; 27(4):618-622. PMID: 27538472.
      Citations: 1     Fields:    Translation:Humans
    37. Nakao M, Asano Y, Nakamura K, Shida R, Takahashi T, Yoshizaki A, Mitsui A, Shibata S, Araki M, Watanabe R, Ikawa Y, Toyoda C, Oka H, Sato S. The development of chronic inflammatory demyelinating polyneuropathy during adalimumab treatment in a patient with psoriasis vulgaris. Eur J Dermatol. 2016 Aug 01; 26(4):404-5. PMID: 27086491.
      Citations: 1     Fields:    Translation:Humans
    38. Sunakawa Y, Yang D, Moran M, Astrow SH, Tsuji A, Stephens C, Zhang W, Cao S, Takahashi T, Denda T, Shimada K, Kochi M, Nakamura M, Kotaka M, Segawa Y, Masuishi T, Takeuchi M, Fujii M, Nakajima T, Ichikawa W, Lenz HJ. Combined assessment of EGFR-related molecules to predict outcome of 1st-line cetuximab-containing chemotherapy for metastatic colorectal cancer. Cancer Biol Ther. 2016 07 02; 17(7):751-9. PMID: 27104867.
      Citations: 9     Translation:Humans
    39. Saigusa R, Asano Y, Nakamura K, Yamashita T, Ichimura Y, Takahashi T, Toyama T, Taniguchi T, Yoshizaki A, Miyazaki M, Tamaki Z, Sato S. Association of anti-RNA polymerase III antibody and silicone breast implants in patients with systemic sclerosis. J Dermatol. 2016 Jul; 43(7):808-10. PMID: 26876001.
      Citations: 6     Fields:    Translation:Humans
    40. Yamashita T, Asano Y, Taniguchi T, Nakamura K, Saigusa R, Takahashi T, Ichimura Y, Toyama T, Yoshizaki A, Miyagaki T, Sugaya M, Sato S. A potential contribution of altered cathepsin L expression to the development of dermal fibrosis and vasculopathy in systemic sclerosis. Exp Dermatol. 2016 Apr; 25(4):287-92. PMID: 26661692.
      Citations: 4     Fields:    Translation:HumansAnimalsCells
    41. Kabasawa M, Sugaya M, Oka T, Takahashi N, Kawaguchi M, Suga H, Miyagaki T, Takahashi T, Shibata S, Fujita H, Asano Y, Tada Y, Kadono T, Okochi H, Sato S. Decreased interleukin-21 expression in skin and blood in advanced mycosis fungoides. J Dermatol. 2016 Jul; 43(7):819-22. PMID: 26825047.
      Citations: 2     Fields:    Translation:HumansCells
    42. Nakamura K, Asano Y, Taniguchi T, Minatsuki S, Inaba T, Maki H, Hatano M, Yamashita T, Saigusa R, Ichimura Y, Takahashi T, Toyama T, Yoshizaki A, Miyagaki T, Sugaya M, Sato S. Serum levels of interleukin-18-binding protein isoform a: Clinical association with inflammation and pulmonary hypertension in systemic sclerosis. J Dermatol. 2016 Aug; 43(8):912-8. PMID: 26777734.
      Citations: 4     Fields:    Translation:HumansCells
    43. Ichimura Y, Asano Y, Akamata K, Noda S, Taniguchi T, Takahashi T, Toyama T, Tada Y, Sugaya M, Sato S, Kadono T. Progranulin Overproduction Due to Fli-1 Deficiency Contributes to the Resistance of Dermal Fibroblasts to Tumor Necrosis Factor in Systemic Sclerosis. Arthritis Rheumatol. 2015 Dec; 67(12):3245-55. PMID: 26245842.
      Citations: 7     Fields:    Translation:HumansAnimalsCells
    44. Saigusa R, Asano Y, Taniguchi T, Yamashita T, Ichimura Y, Takahashi T, Toyama T, Yoshizaki A, Sugawara K, Tsuruta D, Taniguchi T, Sato S. Multifaceted contribution of the TLR4-activated IRF5 transcription factor in systemic sclerosis. Proc Natl Acad Sci U S A. 2015 Dec 08; 112(49):15136-41. PMID: 26598674.
      Citations: 20     Fields:    Translation:AnimalsCells
    45. Toyama T, Asano Y, Akamata K, Noda S, Taniguchi T, Takahashi T, Ichimura Y, Shudo K, Sato S, Kadono T. Tamibarotene Ameliorates Bleomycin-Induced Dermal Fibrosis by Modulating Phenotypes of Fibroblasts, Endothelial Cells, and Immune Cells. J Invest Dermatol. 2016 Feb; 136(2):387-398. PMID: 26967475.
      Citations: 12     Fields:    Translation:HumansAnimalsCells
    46. Yoshizaki A, Taniguchi T, Saigusa R, Fukasawa T, Ebata S, Numajiri H, Nakamura K, Yamashita T, Takahashi T, Toyama T, Asano Y, Tedder TF, Sato S. Nucleosome in patients with systemic sclerosis: possible association with immunological abnormalities via abnormal activation of T and B cells. Ann Rheum Dis. 2016 10; 75(10):1858-65. PMID: 26567180.
      Citations: 7     Fields:    Translation:HumansAnimalsCells
    47. Takahashi T, Asano Y, Oka T, Miyagaki T, Tamaki Z, Nonaka S, Sato S. Scleroderma en coup de sabre with recurrent episodes of brain hemorrhage. J Dermatol. 2016 Feb; 43(2):203-6. PMID: 26173737.
      Citations: 1     Fields:    Translation:Humans
    48. Nakamura K, Asano Y, Shibata S, Nakao M, Shida R, Takahashi T, Mitsui A, Araki M, Yamada A, Sato S. Case of psoriasis vulgaris developing ulcerative colitis during adalimumab treatment. J Dermatol. 2015 Oct; 42(10):1029-30. PMID: 26111055.
      Citations: 2     Fields:    Translation:Humans
    49. Akamata K, Asano Y, Yamashita T, Noda S, Taniguchi T, Takahashi T, Ichimura Y, Toyama T, Trojanowska M, Sato S. Endothelin receptor blockade ameliorates vascular fragility in endothelial cell-specific Fli-1-knockout mice by increasing Fli-1 DNA binding ability. Arthritis Rheumatol. 2015 May; 67(5):1335-44. PMID: 25707716.
      Citations: 12     Fields:    Translation:HumansAnimalsCells
    50. Miura S, Asano Y, Saigusa R, Yamashita T, Taniguchi T, Takahashi T, Ichimura Y, Toyama T, Tamaki Z, Tada Y, Sugaya M, Sato S, Kadono T. Serum omentin levels: A possible contribution to vascular involvement in patients with systemic sclerosis. J Dermatol. 2015 May; 42(5):461-6. PMID: 25766303.
      Citations: 7     Fields:    Translation:Humans
    51. Saigusa R, Asano Y, Nakamura K, Miura S, Ichimura Y, Takahashi T, Toyama T, Taniguchi T, Noda S, Aozasa N, Akamata K, Sumida H, Miyazaki M, Tamaki Z, Yanaba K, Kuwano Y, Sato S. Association of anti-RNA polymerase III antibody and malignancy in Japanese patients with systemic sclerosis. J Dermatol. 2015 May; 42(5):524-7. PMID: 25720827.
      Citations: 15     Fields:    Translation:Humans
    52. Miura S, Asano Y, Saigusa R, Yamashita T, Taniguchi T, Takahashi T, Ichimura Y, Toyama T, Tamaki Z, Tada Y, Sugaya M, Sato S, Kadono T. Serum vaspin levels: A possible correlation with digital ulcers in patients with systemic sclerosis. J Dermatol. 2015 May; 42(5):528-31. PMID: 25708680.
      Citations: 5     Fields:    Translation:Humans
    53. Zhang Q, Tsang D, Kuwabara H, Hatae Y, Li B, Takahashi T, Lee SY, Yasuda T, Adachi C. Nearly 100% internal quantum efficiency in undoped electroluminescent devices employing pure organic emitters. Adv Mater. 2015 Mar 25; 27(12):2096-100. PMID: 25678335.
      Citations: 29     
    54. Taniguchi T, Asano Y, Akamata K, Noda S, Takahashi T, Ichimura Y, Toyama T, Trojanowska M, Sato S. Fibrosis, vascular activation, and immune abnormalities resembling systemic sclerosis in bleomycin-treated Fli-1-haploinsufficient mice. Arthritis Rheumatol. 2015 Feb; 67(2):517-26. PMID: 25385187.
      Citations: 28     Fields:    Translation:AnimalsCells
    55. Saigusa R, Asano Y, Taniguchi T, Yamashita T, Takahashi T, Ichimura Y, Toyama T, Tamaki Z, Tada Y, Sugaya M, Kadono T, Sato S. A possible contribution of endothelial CCN1 downregulation due to Fli1 deficiency to the development of digital ulcers in systemic sclerosis. Exp Dermatol. 2015 Feb; 24(2):127-32. PMID: 25421497.
      Citations: 10     Fields:    Translation:HumansAnimalsCells
    56. Takahashi T, Asano Y, Ichimura Y, Toyama T, Taniguchi T, Noda S, Akamata K, Tada Y, Sugaya M, Kadono T, Sato S. Amelioration of tissue fibrosis by toll-like receptor 4 knockout in murine models of systemic sclerosis. Arthritis Rheumatol. 2015 Jan; 67(1):254-65. PMID: 25302613.
      Citations: 22     Fields:    Translation:AnimalsCells
    57. Akamata K, Asano Y, Taniguchi T, Yamashita T, Saigusa R, Nakamura K, Noda S, Aozasa N, Toyama T, Takahashi T, Ichimura Y, Sumida H, Tada Y, Sugaya M, Kadono T, Sato S. Increased expression of chemerin in endothelial cells due to Fli1 deficiency may contribute to the development of digital ulcers in systemic sclerosis. Rheumatology (Oxford). 2015 Jul; 54(7):1308-16. PMID: 25539827.
      Citations: 8     Fields:    Translation:HumansAnimalsCells
    58. Takahashi T, Yamamoto M, Amikura K, Kato K, Serizawa T, Serizawa K, Akazawa D, Aoki T, Kawai K, Ogasawara E, Hayashi J, Nakada K, Kainoh M. A novel MitoNEET ligand, TT01001, improves diabetes and ameliorates mitochondrial function in db/db mice. J Pharmacol Exp Ther. 2015 Feb; 352(2):338-45. PMID: 25503385.
      Citations: 10     Fields:    Translation:HumansAnimalsCells
    59. Ichimura Y, Asano Y, Takahashi T, Toyama T, Taniguchi T, Tamaki Z, Isomura S, Miyagaki T, Mitsui H, Sato S. Development of systemic sclerosis in patients with Behçet's disease: remission of Behçet's disease in parallel with the progression of skin sclerosis. J Dermatol. 2014 Dec; 41(12):1113-4. PMID: 25389081.
      Citations: 1     Fields:    Translation:Humans
    60. Taniguchi T, Asano Y, Tamaki Z, Takahashi T, Ichimura Y, Toyama T, Kagami S, Mitsui H, Sato S. Late-onset anaphylactic reactions following i.v. cyclophosphamide pulse in a patient with systemic sclerosis and systemic lupus erythematosus overlap syndrome. J Dermatol. 2014 Oct; 41(10):912-4. PMID: 25227247.
      Citations: 1     Fields:    Translation:Humans
    61. Okazaki S, Takahashi T, Iwamura T, Nakaki J, Sekiya Y, Yagi M, Kumagai H, Sato M, Sakami S, Nitta A, Kawai K, Kainoh M. HIS-388, a novel orally active and long-acting 11ß-hydroxysteroid dehydrogenase type 1 inhibitor, ameliorates insulin sensitivity and glucose intolerance in diet-induced obesity and nongenetic type 2 diabetic murine models. J Pharmacol Exp Ther. 2014 Oct; 351(1):181-9. PMID: 25100752.
      Citations: 3     Fields:    Translation:HumansAnimalsCells
    62. Takahashi T, Shizu K, Yasuda T, Togashi K, Adachi C. Donor-acceptor-structured 1,4-diazatriphenylene derivatives exhibiting thermally activated delayed fluorescence: design and synthesis, photophysical properties and OLED characteristics. Sci Technol Adv Mater. 2014 Jun; 15(3):034202. PMID: 27877670.
      Citations: 5     
    63. Takahashi T, Asano Y, Sunaga R, Ichimura Y, Taniguchi T, Yamamoto M, Tamaki Z, Takekoshi T, Mitsui H, Sugaya M, Ohse T, Sato S. Successful use of intravenous cyclophosphamide pulse therapy for interstitial lung disease in a patient with systemic sclerosis on hemodialysis. J Dermatol. 2014 Jun; 41(6):533-5. PMID: 24814462.
      Citations:    Fields:    Translation:Humans
    64. Sumida H, Asano Y, Tamaki Z, Aozasa N, Taniguchi T, Takahashi T, Toyama T, Ichimura Y, Noda S, Akamata K, Miyazaki M, Kuwano Y, Yanaba K, Sato S. Successful experience of rituximab therapy for systemic sclerosis-associated interstitial lung disease with concomitant systemic lupus erythematosus. J Dermatol. 2014 May; 41(5):418-20. PMID: 24801917.
      Citations: 8     Fields:    Translation:HumansCells
    65. Takahashi T, Namiki K, Matsumoto H, Konno F, Mitsui K, Yoshida R. [A case of advanced rectal cancer that showed complete response to the addition of XELOX+bevacizumab therapy to preoperative chemoradiotherapy with S-1/CPT-11]. Gan To Kagaku Ryoho. 2014 May; 41(5):653-5. PMID: 24917016.
      Citations:    Fields:    Translation:Humans
    66. Akamata K, Asano Y, Aozasa N, Noda S, Taniguchi T, Takahashi T, Ichimura Y, Toyama T, Sato S. Bosentan reverses the pro-fibrotic phenotype of systemic sclerosis dermal fibroblasts via increasing DNA binding ability of transcription factor Fli1. Arthritis Res Ther. 2014 Apr 03; 16(2):R86. PMID: 24708674.
      Citations: 11     Fields:    Translation:HumansAnimalsCells
    67. Sumida H, Asano Y, Hatano M, Aozasa N, Toyama T, Akamata K, Miyazaki M, Taniguchi T, Takahashi T, Ichimura Y, Noda S, Kuwano Y, Yanaba K, Sato S. Effect of ambrisentan on peripheral circulation in patients with systemic sclerosis. Mod Rheumatol. 2016; 26(3):454-7. PMID: 24593173.
      Citations:    Fields:    Translation:Humans
    68. Ichimura Y, Asano Y, Akamata K, Aozasa N, Noda S, Taniguchi T, Takahashi T, Toyama T, Sumida H, Kuwano Y, Yanaba K, Tada Y, Sugaya M, Sato S, Kadono T. Serum angiopoietin-like protein 3 levels: possible correlation with progressive skin sclerosis, digital ulcers and pulmonary vascular involvement in patients with systemic sclerosis. Acta Derm Venereol. 2014 Mar; 94(2):157-62. PMID: 23995677.
      Citations: 4     Fields:    Translation:Humans
    69. Yanaba K, Asano Y, Akamata K, Noda S, Aozasa N, Taniguchi T, Takahashi T, Toyama T, Ichimura Y, Sumida H, Kuwano Y, Miyazaki M, Sato S. Circulating galectin-1 concentrations in systemic sclerosis: potential contribution to digital vasculopathy. Int J Rheum Dis. 2016 Jun; 19(6):622-7. PMID: 24517166.
      Citations: 1     Fields:    Translation:Humans
    70. Yoshimura J, Asano Y, Takahashi T, Uwajima Y, Kagami S, Honda H, Idezuki T, Igarashi A, Sato S. A case of scleredema adultorum successfully treated with narrow-band ultraviolet B phototherapy. Mod Rheumatol. 2016; 26(2):302-6. PMID: 24499427.
      Citations: 2     Fields:    Translation:Humans
    71. Takahashi T, Asano Y, Amiya E, Hatano M, Tamaki Z, Takata M, Ozeki A, Watanabe A, Kawarasaki S, Taniguchi T, Ichimura Y, Toyama T, Watanabe M, Hirata Y, Nagai R, Komuro I, Sato S. Clinical correlation of brachial artery flow-mediated dilation in patients with systemic sclerosis. Mod Rheumatol. 2014 Jan; 24(1):106-11. PMID: 24261766.
      Citations: 2     Fields:    Translation:Humans
    72. Akamata K, Asano Y, Aozasa N, Noda S, Taniguchi T, Takahashi T, Ichimura Y, Toyama T, Sumida H, Kuwano Y, Yanaba K, Tada Y, Sugaya M, Kadono T, Sato S. Serum levels of mannose-binding lectin in systemic sclerosis: a possible contribution to the initiation of skin sclerosis in the diffuse cutaneous subtype. Eur J Dermatol. 2014 Jan-Feb; 24(1):123-5. PMID: 24566202.
      Citations: 2     Fields:    Translation:Humans
    73. Ichimura Y, Asano Y, Akamata K, Takahashi T, Noda S, Taniguchi T, Toyama T, Aozasa N, Sumida H, Kuwano Y, Yanaba K, Tada Y, Sugaya M, Sato S, Kadono T. Fli1 deficiency contributes to the suppression of endothelial CXCL5 expression in systemic sclerosis. Arch Dermatol Res. 2014 May; 306(4):331-8. PMID: 24292093.
      Citations: 7     Fields:    Translation:HumansAnimalsCells
    74. Sunakawa Y, Takahashi T, Ichikawa W, Shimada K, Sasaki Y. Complicated puzzle in cetuximab-based chemotherapy: skin toxicity and resection rate in patients with initially unresectable colorectal liver metastases. J Clin Oncol. 2013 Dec 10; 31(35):4473. PMID: 24166514.
      Citations:    Fields:    Translation:Humans
    75. Masui Y, Asano Y, Akamata K, Aozasa N, Noda S, Taniguchi T, Takahashi T, Ichimura Y, Toyama T, Sumida H, Kuwano Y, Yanaba K, Tada Y, Sugaya M, Sato S, Kadono T. Serum resistin levels: a possible correlation with pulmonary vascular involvement in patients with systemic sclerosis. Rheumatol Int. 2014 Aug; 34(8):1165-70. PMID: 24141536.
      Citations: 10     Fields:    Translation:HumansCells
    76. Amiya E, Takata M, Watanabe M, Takahashi T, Asano Y, Hatano M, Ozeki A, Watanabe A, Kawarasaki S, Tamaki Z, Taniguchi T, Ichimura Y, Toyama T, Nagai R, Sato S, Komuro I. Presence of desaturated hemoglobin enhances the contribution of blood cells to flow-mediated dilation in subjects with systemic sclerosis. Int J Cardiol. 2013 Oct 03; 168(3):3125-7. PMID: 23647588.
      Citations: 1     Fields:    Translation:HumansCells
    77. Akamata K, Asano Y, Noda S, Taniguchi T, Takahashi T, Ichimura Y, Toyama T, Sumida H, Kuwano Y, Yanaba K, Tada Y, Sugaya M, Kadono T, Sato S. An inverse correlation of serum angiogenin levels with estimated glomerular filtration rate in systemic sclerosis patients with renal dysfunction. Eur J Dermatol. 2013 Apr 01; 23(2):269-70. PMID: 23557602.
      Citations:    Fields:    Translation:Humans
    78. Takahashi T, Asano Y, Amiya E, Hatano M, Tamaki Z, Takata M, Ozeki A, Watanabe A, Kawarasaki S, Taniguchi T, Ichimura Y, Toyama T, Watanabe M, Hirata Y, Nagai R, Komuro I, Sato S. Clinical correlation of brachial artery flow-mediated dilation in patients with systemic sclerosis. Mod Rheumatol. 2013 Mar 30. PMID: 23543079.
      Citations: 1     Fields:    
    79. Masui Y, Asano Y, Shibata S, Noda S, Akamata K, Aozasa N, Taniguchi T, Takahashi T, Ichimura Y, Toyama T, Sumida H, Yanaba K, Tada Y, Sugaya M, Sato S, Kadono T. A possible contribution of visfatin to the resolution of skin sclerosis in patients with diffuse cutaneous systemic sclerosis via a direct anti-fibrotic effect on dermal fibroblasts and Th1 polarization of the immune response. Rheumatology (Oxford). 2013 Jul; 52(7):1239-44. PMID: 23443327.
      Citations: 9     Fields:    Translation:HumansCells
    80. Udagawa S, Sakami S, Takemura T, Sato M, Arai T, Nitta A, Aoki T, Kawai K, Iwamura T, Okazaki S, Takahashi T, Kaino M. Discovery of novel 7-membered cyclic amide derivatives that inhibit 11beta-hydroxysteroid dehydrogenase type 1. Bioorg Med Chem Lett. 2013 Mar 15; 23(6):1617-21. PMID: 23414800.
      Citations:    Fields:    Translation:HumansAnimalsCells
    81. Sunakawa Y, Ichikawa W, Takahashi T, Shimada K, Sasaki Y. Does a higher response rate to systemic chemotherapy result in a higher resection rate in patients with initially unresectable colorectal liver metastases? Acta Oncol. 2013 Jun; 52(5):1039-40. PMID: 23327338.
      Citations:    Fields:    Translation:Humans
    82. Noda S, Asano Y, Takahashi T, Akamata K, Aozasa N, Taniguchi T, Ichimura Y, Toyama T, Sumida H, Kuwano Y, Yanaba K, Tada Y, Sugaya M, Kadono T, Sato S. Decreased cathepsin V expression due to Fli1 deficiency contributes to the development of dermal fibrosis and proliferative vasculopathy in systemic sclerosis. Rheumatology (Oxford). 2013 May; 52(5):790-9. PMID: 23287360.
      Citations: 11     Fields:    Translation:HumansCells
    83. Noda S, Asano Y, Aozasa N, Akamata K, Taniguchi T, Takahashi T, Ichimura Y, Toyama T, Sumida H, Kuwano Y, Yanaba K, Tada Y, Sugaya M, Kadono T, Sato S. Clinical significance of serum soluble Tie1 levels in patients with systemic sclerosis. Arch Dermatol Res. 2013 May; 305(4):325-31. PMID: 23233281.
      Citations: 1     Fields:    Translation:Humans
    84. Yanaba K, Asano Y, Noda S, Akamata K, Aozasa N, Taniguchi T, Takahashi T, Ichimura Y, Toyama T, Sumida H, Kuwano Y, Tada Y, Sugaya M, Kadono T, Sato S. Increased production of soluble inducible costimulator in patients with diffuse cutaneous systemic sclerosis. Arch Dermatol Res. 2013 Jan; 305(1):17-23. PMID: 23053221.
      Citations: 2     Fields:    Translation:HumansCells
    85. Yanaba K, Asano Y, Noda S, Akamata K, Aozasa N, Taniguchi T, Takahashi T, Ichimura Y, Toyama T, Sumida H, Kuwano Y, Tada Y, Sugaya M, Kadono T, Sato S. Increased circulating fibrinogen-like protein 2 in patients with systemic sclerosis. Clin Rheumatol. 2013 Jan; 32(1):43-7. PMID: 22983266.
      Citations: 4     Fields:    Translation:Humans
    86. Takahashi T, Asano Y, Akamata K, Aozasa N, Taniguchi T, Noda S, Masui Y, Ichimura Y, Toyama T, Tamaki Z, Tada Y, Sugaya M, Kadono T, Sato S. Dynamics of serum angiopoietin-2 levels correlate with efficacy of intravenous pulse cyclophosphamide therapy for interstitial lung disease associated with systemic sclerosis. Mod Rheumatol. 2013 Sep; 23(5):884-90. PMID: 22972016.
      Citations: 3     Fields:    Translation:Humans
    87. Sunakawa Y, Takahashi T, Sasaki Y, Ichikawa W. [Efficacy assessments for chemotherapy and timing of changing treatment in gastric cancer]. Gan To Kagaku Ryoho. 2012 Sep; 39(9):1320-5. PMID: 22996766.
      Citations:    Fields:    Translation:Humans
    88. Masui Y, Asano Y, Takahashi T, Shibata S, Akamata K, Aozasa N, Noda S, Taniguchi T, Ichimura Y, Toyama T, Tamaki Z, Sumida H, Yanaba K, Tada Y, Sugaya M, Sato S, Kadono T. Clinical significance of monitoring serum adiponectin levels during intravenous pulse cyclophosphamide therapy in interstitial lung disease associated with systemic sclerosis. Mod Rheumatol. 2013 Mar; 23(2):323-9. PMID: 22610787.
      Citations: 11     Fields:    Translation:Humans
    89. Yamada D, Asano Y, Takahashi T, Masui Y, Aozasa N, Akamata K, Noda S, Tamaki Z, Tada Y, Sugaya M, Sato S, Kadono T. Clinical significance of serum decoy receptor 3 levels in patients with systemic sclerosis. Eur J Dermatol. 2012 May-Jun; 22(3):351-7. PMID: 22456116.
      Citations: 3     Fields:    Translation:Humans
    90. Noda S, Asano Y, Akamata K, Aozasa N, Taniguchi T, Takahashi T, Ichimura Y, Toyama T, Sumida H, Yanaba K, Tada Y, Sugaya M, Kadono T, Sato S. A possible contribution of altered cathepsin B expression to the development of skin sclerosis and vasculopathy in systemic sclerosis. PLoS One. 2012; 7(2):e32272. PMID: 22384200.
      Citations: 11     Fields:    Translation:HumansAnimalsCells
    91. Taniguchi T, Asano Y, Akamata K, Noda S, Masui Y, Yamada D, Takahashi T, Ichimura Y, Toyama T, Tamaki Z, Tada Y, Sugaya M, Kadono T, Sato S. Serum levels of galectin-3: possible association with fibrosis, aberrant angiogenesis, and immune activation in patients with systemic sclerosis. J Rheumatol. 2012 Mar; 39(3):539-44. PMID: 22247367.
      Citations: 18     Fields:    Translation:Humans
    92. Takahashi T, Asano Y, Amiya E, Hatano M, Tamaki Z, Ozeki A, Watanabe A, Kawarasaki S, Nakao T, Taniguchi T, Ichimura Y, Toyama T, Watanabe M, Hirata Y, Nagai R, Sato S. Improvement of endothelial function in parallel with the amelioration of dry cough and dyspnea due to interstitial pneumonia by intravenous cyclophosphamide pulse therapy in patients with systemic sclerosis: a preliminary report of two cases. Mod Rheumatol. 2012 Aug; 22(4):598-601. PMID: 22015621.
      Citations: 2     Fields:    Translation:Humans
    93. Aozasa N, Sugaya M, Noda S, Takahashi T, Kogure A, Araki M, Fujita H, Kadono T, Sato S. Cutaneous polyarteritis nodosa: complete clearance of the leg ulcer after the amputation of the contralateral leg. Eur J Dermatol. 2011 Jul-Aug; 21(4):623-4. PMID: 21684840.
      Citations:    Fields:    Translation:Humans
    94. Ichimura Y, Asano Y, Hatano M, Tamaki Z, Takekoshi T, Kogure A, Tomita M, Kawashima T, Miyazaki M, Taniguchi T, Takahashi T, Mitsui H, Sugaya M, Yao A, Kinugawa K, Sato S. Significant attenuation of macrovascular involvement by bosentan in a patient with diffuse cutaneous systemic sclerosis with multiple digital ulcers and gangrene. Mod Rheumatol. 2011 Oct; 21(5):548-52. PMID: 21547701.
      Citations: 4     Fields:    Translation:Humans
    95. Kubota T, Kubota N, Kumagai H, Yamaguchi S, Kozono H, Takahashi T, Inoue M, Itoh S, Takamoto I, Sasako T, Kumagai K, Kawai T, Hashimoto S, Kobayashi T, Sato M, Tokuyama K, Nishimura S, Tsunoda M, Ide T, Murakami K, Yamazaki T, Ezaki O, Kawamura K, Masuda H, Moroi M, Sugi K, Oike Y, Shimokawa H, Yanagihara N, Tsutsui M, Terauchi Y, Tobe K, Nagai R, Kamata K, Inoue K, Kodama T, Ueki K, Kadowaki T. Impaired insulin signaling in endothelial cells reduces insulin-induced glucose uptake by skeletal muscle. Cell Metab. 2011 Mar 02; 13(3):294-307. PMID: 21356519.
      Citations: 173     Fields:    Translation:AnimalsCells
    96. Ichikawa W, Takahashi T, Suto K, Shirota Y, Nihei Z, Shimizu M, Sasaki Y, Hirayama R. Simple combinations of 5-FU pathway genes predict the outcome of metastatic gastric cancer patients treated by S-1. Int J Cancer. 2006 Oct 15; 119(8):1927-33. PMID: 16736497.
      Citations: 19     Fields:    Translation:Humans
    97. Ichikawa W, Takahashi T, Suto K, Sasaki Y, Hirayama R. Orotate phosphoribosyltransferase gene polymorphism predicts toxicity in patients treated with bolus 5-fluorouracil regimen. Clin Cancer Res. 2006 Jul 01; 12(13):3928-34. PMID: 16818689.
      Citations: 18     Fields:    Translation:HumansCellsCTClinical Trials
    98. Han W, Kasai S, Hata H, Takahashi T, Takamatsu Y, Yamamoto H, Uhl GR, Sora I, Ikeda K. Intracisternal A-particle element in the 3' noncoding region of the mu-opioid receptor gene in CXBK mice: a new genetic mechanism underlying differences in opioid sensitivity. Pharmacogenet Genomics. 2006 Jun; 16(6):451-60. PMID: 16708053.
      Citations: 14     Fields:    Translation:AnimalsCells
    99. Ichikawa W, Ooyama A, Toda E, Sugimoto Y, Oka T, Takahashi T, Shimizu M, Sasaki Y, Hirayama R. Gene expression of ferredoxin reductase predicts outcome in patients with metastatic colorectal cancer treated by 5-fluorouracil plus leucovorin. Cancer Chemother Pharmacol. 2006 Dec; 58(6):794-801. PMID: 16528528.
      Citations: 2     Fields:    Translation:Humans
    100. Takahashi T, Kobayashi T, Ozaki M, Takamatsu Y, Ogai Y, Ohta M, Yamamoto H, Ikeda K. G protein-activated inwardly rectifying K+ channel inhibition and rescue of weaver mouse motor functions by antidepressants. Neurosci Res. 2006 Feb; 54(2):104-11. PMID: 16310876.
      Citations: 6     Fields:    Translation:AnimalsCells
    101. Murakami S, Okubo K, Tsuji Y, Sakata H, Kikuchi M, Takahashi T, Kato T, Hirayama R. Serum levels of interleukin-12 in Graves' disease and their dynamic changes after surgery. Surg Today. 2005; 35(12):1016-20. PMID: 16341480.
      Citations: 1     Fields:    Translation:Humans
    102. Ichikawa W, Takahashi T, Suto K, Nihei Z, Shirota Y, Shimizu M, Sasaki Y, Hirayama R. Thymidylate synthase and dihydropyrimidine dehydrogenase gene expression in relation to differentiation of gastric cancer. Int J Cancer. 2004 Dec 20; 112(6):967-73. PMID: 15316940.
      Citations: 15     Fields:    Translation:Humans
    103. Murakami S, Okubo K, Tsuji Y, Sakata H, Takahashi T, Kikuchi M, Hirayama R. Changes in liver enzymes after surgery in anti-hepatitis C virus-positive patients. World J Surg. 2004 Jul; 28(7):671-4. PMID: 15175902.
      Citations: 6     Fields:    Translation:Humans
    104. Murakami S, Sakata H, Tsuji Y, Okubo K, Takahashi T, Kikuchi M, Hirayama R. Changes in the levels of serum-soluble interleukin-2 receptor after surgical stress. Surg Today. 2003; 33(8):565-70. PMID: 12884092.
      Citations: 1     Fields:    Translation:HumansCells