Elaine Holmes

InstitutionMurdoch University
AddressAustralia
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    Publication Timeline
    COVID-19 publications
    Bar chart showing 11 Covid-19 publications, with a maximum of 2 publications in January 2021 and May 2021 and July 2021
    All Publications
    Bar chart showing 326 publications over 20 distinct years, with a maximum of 30 publications in 2008
    These graphs show COVID-19 publications by month since August 2019 and all publications written by authors of COVID-19 publications over the past 30 years.

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    Publication Field Summary
    This graph shows the number and percent of publications by field. Fields are based on how the National Library of Medicine (NLM) classifies the publications' journals and might not represent the specific topics of the publications. Note that an individual publication can be assigned to more than one field. As a result, the publication counts in this graph might add up to more than the number of publications the person has written. To see the data as text, click here.
    Publication List
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Gray N, Lawler NG, Zeng AX, Ryan M, Bong SH, Boughton BA, Bizkarguenaga M, Bruzzone C, Embade N, Wist J, Holmes E, Millet O, Nicholson JK, Whiley L. Diagnostic Potential of the Plasma Lipidome in Infectious Disease: Application to Acute SARS-CoV-2 Infection. Metabolites. 2021 Jul 20; 11(7). PMID: 34357361.
      Citations: 2     
    2. Masuda R, Lodge S, Nitschke P, Spraul M, Schaefer H, Bong SH, Kimhofer T, Hall D, Loo RL, Bizkarguenaga M, Bruzzone C, Gil-Redondo R, Embade N, Mato JM, Holmes E, Wist J, Millet O, Nicholson JK. Integrative Modeling of Plasma Metabolic and Lipoprotein Biomarkers of SARS-CoV-2 Infection in Spanish and Australian COVID-19 Patient Cohorts. J Proteome Res. 2021 08 06; 20(8):4139-4152. PMID: 34251833.
      Citations: 1     Fields:    Translation:Humans
    3. Holmes E, Wist J, Masuda R, Lodge S, Nitschke P, Kimhofer T, Loo RL, Begum S, Boughton B, Yang R, Morillon AC, Chin ST, Hall D, Ryan M, Bong SH, Gay M, Edgar DW, Lindon JC, Richards T, Yeap BB, Pettersson S, Spraul M, Schaefer H, Lawler NG, Gray N, Whiley L, Nicholson JK. Incomplete Systemic Recovery and Metabolic Phenoreversion in Post-Acute-Phase Nonhospitalized COVID-19 Patients: Implications for Assessment of Post-Acute COVID-19 Syndrome. J Proteome Res. 2021 06 04; 20(6):3315-3329. PMID: 34009992.
      Citations: 4     Fields:    Translation:Humans
    4. Kimhofer T, Lodge S, Whiley L, Gray N, Loo RL, Lawler NG, Nitschke P, Bong SH, Morrison DL, Begum S, Richards T, Yeap BB, Smith C, Smith KGC, Holmes E, Nicholson JK. Correction to "Integrative Modeling of Quantitative Plasma Lipoprotein, Metabolic, and Amino Acid Data Reveals a Multiorgan Pathological Signature of SARS-CoV-2 Infection". J Proteome Res. 2021 Jun 04; 20(6):3400. PMID: 33949867.
      Citations:    Fields:    
    5. Lawler NG, Gray N, Kimhofer T, Boughton B, Gay M, Yang R, Morillon AC, Chin ST, Ryan M, Begum S, Bong SH, Coudert JD, Edgar D, Raby E, Pettersson S, Richards T, Holmes E, Whiley L, Nicholson JK. Systemic Perturbations in Amine and Kynurenine Metabolism Associated with Acute SARS-CoV-2 Infection and Inflammatory Cytokine Responses. J Proteome Res. 2021 05 07; 20(5):2796-2811. PMID: 33724837.
      Citations: 9     Fields:    Translation:Humans
    6. Lodge S, Nitschke P, Kimhofer T, Wist J, Bong SH, Loo RL, Masuda R, Begum S, Richards T, Lindon JC, Bermel W, Reinsperger T, Schaefer H, Spraul M, Holmes E, Nicholson JK. Diffusion and Relaxation Edited Proton NMR Spectroscopy of Plasma Reveals a High-Fidelity Supramolecular Biomarker Signature of SARS-CoV-2 Infection. Anal Chem. 2021 03 02; 93(8):3976-3986. PMID: 33577736.
      Citations: 1     Fields:    Translation:Humans
    7. Lodge S, Nitschke P, Loo RL, Kimhofer T, Bong SH, Richards T, Begum S, Spraul M, Schaefer H, Lindon JC, Holmes E, Nicholson JK. Low Volume in Vitro Diagnostic Proton NMR Spectroscopy of Human Blood Plasma for Lipoprotein and Metabolite Analysis: Application to SARS-CoV-2 Biomarkers. J Proteome Res. 2021 02 05; 20(2):1415-1423. PMID: 33491459.
      Citations: 1     Fields:    Translation:Humans
    8. Lodge S, Nitschke P, Kimhofer T, Coudert JD, Begum S, Bong SH, Richards T, Edgar D, Raby E, Spraul M, Schaefer H, Lindon JC, Loo RL, Holmes E, Nicholson JK. NMR Spectroscopic Windows on the Systemic Effects of SARS-CoV-2 Infection on Plasma Lipoproteins and Metabolites in Relation to Circulating Cytokines. J Proteome Res. 2021 02 05; 20(2):1382-1396. PMID: 33426894.
      Citations: 5     Fields:    Translation:Humans
    9. Gray N, Lawler NG, Yang R, Morillon AC, Gay MCL, Bong SH, Holmes E, Nicholson JK, Whiley L. A simultaneous exploratory and quantitative amino acid and biogenic amine metabolic profiling platform for rapid disease phenotyping via UPLC-QToF-MS. Talanta. 2021 Feb 01; 223(Pt 2):121872. PMID: 33298292.
      Citations: 1     Fields:    Translation:Humans
    10. Loo RL, Lodge S, Kimhofer T, Bong SH, Begum S, Whiley L, Gray N, Lindon JC, Nitschke P, Lawler NG, Schäfer H, Spraul M, Richards T, Nicholson JK, Holmes E. Quantitative In-Vitro Diagnostic NMR Spectroscopy for Lipoprotein and Metabolite Measurements in Plasma and Serum: Recommendations for Analytical Artifact Minimization with Special Reference to COVID-19/SARS-CoV-2 Samples. J Proteome Res. 2020 11 06; 19(11):4428-4441. PMID: 32852212.
      Citations: 4     Fields:    Translation:HumansPHPublic Health
    11. Kimhofer T, Lodge S, Whiley L, Gray N, Loo RL, Lawler NG, Nitschke P, Bong SH, Morrison DL, Begum S, Richards T, Yeap BB, Smith C, Smith KGC, Holmes E, Nicholson JK. Integrative Modeling of Quantitative Plasma Lipoprotein, Metabolic, and Amino Acid Data Reveals a Multiorgan Pathological Signature of SARS-CoV-2 Infection. J Proteome Res. 2020 11 06; 19(11):4442-4454. PMID: 32806897.
      Citations: 28     Fields:    Translation:HumansCellsPHPublic Health
    12. Onida S, Tan MKH, Kafeza M, Bergner RT, Shalhoub J, Holmes E, Davies AH. Metabolic Phenotyping in Venous Disease: The Need for Standardization. J Proteome Res. 2019 11 01; 18(11):3809-3820. PMID: 31617359.
      Citations: 4     Fields:    Translation:HumansAnimals
    13. Everett JR, Holmes E, Veselkov KA, Lindon JC, Nicholson JK. A Unified Conceptual Framework for Metabolic Phenotyping in Diagnosis and Prognosis. Trends Pharmacol Sci. 2019 10; 40(10):763-773. PMID: 31511194.
      Citations: 6     Fields:    Translation:HumansAnimals
    14. Tzoulaki I, Castagné R, Boulangé CL, Karaman I, Chekmeneva E, Evangelou E, Ebbels TMD, Kaluarachchi MR, Chadeau-Hyam M, Mosen D, Dehghan A, Moayyeri A, Ferreira DLS, Guo X, Rotter JI, Taylor KD, Kavousi M, de Vries PS, Lehne B, Loh M, Hofman A, Nicholson JK, Chambers J, Gieger C, Holmes E, Tracy R, Kooner J, Greenland P, Franco OH, Herrington D, Lindon JC, Elliott P. Serum metabolic signatures of coronary and carotid atherosclerosis and subsequent cardiovascular disease. Eur Heart J. 2019 09 07; 40(34):2883-2896. PMID: 31102408.
      Citations: 24     Fields:    Translation:Humans
    15. Seow WJ, Shu XO, Nicholson JK, Holmes E, Walker DI, Hu W, Cai Q, Gao YT, Xiang YB, Moore SC, Bassig BA, Wong JYY, Zhang J, Ji BT, Boulangé CL, Kaluarachchi M, Wijeyesekera A, Zheng W, Elliott P, Rothman N, Lan Q. Association of Untargeted Urinary Metabolomics and Lung Cancer Risk Among Never-Smoking Women in China. JAMA Netw Open. 2019 09 04; 2(9):e1911970. PMID: 31539079.
      Citations: 7     Fields:    Translation:HumansPHPublic Health
    16. Ovadia C, Perdones-Montero A, Spagou K, Smith A, Sarafian MH, Gomez-Romero M, Bellafante E, Clarke LCD, Sadiq F, Nikolova V, Mitchell A, Dixon PH, Santa-Pinter N, Wahlström A, Abu-Hayyeh S, Walters JRF, Marschall HU, Holmes E, Marchesi JR, Williamson C. Enhanced Microbial Bile Acid Deconjugation and Impaired Ileal Uptake in Pregnancy Repress Intestinal Regulation of Bile Acid Synthesis. Hepatology. 2019 07; 70(1):276-293. PMID: 30983011.
      Citations: 10     Fields:    Translation:HumansAnimalsCells
    17. Alkandari A, Ashrafian H, Sathyapalan T, Darzi A, Holmes E, Athanasiou T, Atkin SL, Gooderham NJ. Bariatric Surgery Modulates Urinary Levels of MicroRNAs Involved in the Regulation of Renal Function. Front Endocrinol (Lausanne). 2019; 10:319. PMID: 31164867.
      Citations: 4     
    18. Alsaleh M, Barbera TA, Reeves HL, Cramp ME, Ryder S, Gabra H, Nash K, Shen YL, Holmes E, Williams R, Taylor-Robinson SD. Characterization of the urinary metabolic profile of cholangiocarcinoma in a United Kingdom population. Hepat Med. 2019; 11:47-67. PMID: 31118840.
      Citations: 3     
    19. Byrne CS, Chambers ES, Preston T, Tedford C, Brignardello J, Garcia-Perez I, Holmes E, Wallis GA, Morrison DJ, Frost GS. Effects of Inulin Propionate Ester Incorporated into Palatable Food Products on Appetite and Resting Energy Expenditure: A Randomised Crossover Study. Nutrients. 2019 Apr 16; 11(4). PMID: 30995824.
      Citations: 4     Fields:    Translation:Humans
    20. Chambers ES, Byrne CS, Morrison DJ, Murphy KG, Preston T, Tedford C, Garcia-Perez I, Fountana S, Serrano-Contreras JI, Holmes E, Reynolds CJ, Roberts JF, Boyton RJ, Altmann DM, McDonald JAK, Marchesi JR, Akbar AN, Riddell NE, Wallis GA, Frost GS. Dietary supplementation with inulin-propionate ester or inulin improves insulin sensitivity in adults with overweight and obesity with distinct effects on the gut microbiota, plasma metabolome and systemic inflammatory responses: a randomised cross-over trial. Gut. 2019 08; 68(8):1430-1438. PMID: 30971437.
      Citations: 57     Fields:    Translation:Humans
    21. Hegade VS, Pechlivanis A, McDonald JAK, Rees D, Corrigan M, Hirschfield GM, Taylor-Robinson SD, Holmes E, Marchesi JR, Kendrick S, Jones DE. Autotaxin, bile acid profile and effect of ileal bile acid transporter inhibition in primary biliary cholangitis patients with pruritus. Liver Int. 2019 05; 39(5):967-975. PMID: 30735608.
      Citations: 4     Fields:    Translation:Humans
    22. Boulangé CL, Rood IM, Posma JM, Lindon JC, Holmes E, Wetzels JFM, Deegens JKJ, Kaluarachchi MR. NMR and MS urinary metabolic phenotyping in kidney diseases is fit-for-purpose in the presence of a protease inhibitor. Mol Omics. 2019 02 11; 15(1):39-49. PMID: 30672550.
      Citations:    Fields:    Translation:Humans
    23. Antcliffe DB, Wolfer AM, O'Dea KP, Takata M, Holmes E, Gordon AC. Profiling inflammatory markers in patients with pneumonia on intensive care. Sci Rep. 2018 10 03; 8(1):14736. PMID: 30283005.
      Citations: 2     Fields:    Translation:Humans
    24. Byrne CS, Preston T, Brignardello J, Garcia-Perez I, Holmes E, Frost GS, Morrison DJ. The effect of L-rhamnose on intestinal transit time, short chain fatty acids and appetite regulation: a pilot human study using combined 13CO2/H2 breath tests. J Breath Res. 2018 08 06; 12(4):046006. PMID: 30015629.
      Citations: 2     Fields:    Translation:Humans
    25. Puthucheary ZA, Astin R, Mcphail MJW, Saeed S, Pasha Y, Bear DE, Constantin D, Velloso C, Manning S, Calvert L, Singer M, Batterham RL, Gomez-Romero M, Holmes E, Steiner MC, Atherton PJ, Greenhaff P, Edwards LM, Smith K, Harridge SD, Hart N, Montgomery HE. Metabolic phenotype of skeletal muscle in early critical illness. Thorax. 2018 10; 73(10):926-935. PMID: 29980655.
      Citations: 29     Fields:    Translation:HumansCellsCTClinical Trials
    26. Hoyles L, Fernández-Real JM, Federici M, Serino M, Abbott J, Charpentier J, Heymes C, Luque JL, Anthony E, Barton RH, Chilloux J, Myridakis A, Martinez-Gili L, Moreno-Navarrete JM, Benhamed F, Azalbert V, Blasco-Baque V, Puig J, Xifra G, Ricart W, Tomlinson C, Woodbridge M, Cardellini M, Davato F, Cardolini I, Porzio O, Gentileschi P, Lopez F, Foufelle F, Butcher SA, Holmes E, Nicholson JK, Postic C, Burcelin R, Dumas ME. Molecular phenomics and metagenomics of hepatic steatosis in non-diabetic obese women. Nat Med. 2018 07; 24(7):1070-1080. PMID: 29942096.
      Citations: 126     Fields:    Translation:HumansAnimalsCells
    27. Alkandari A, Ashrafian H, Sathyapalan T, Sedman P, Darzi A, Holmes E, Athanasiou T, Atkin SL, Gooderham NJ. Improved physiology and metabolic flux after Roux-en-Y gastric bypass is associated with temporal changes in the circulating microRNAome: a longitudinal study in humans. BMC Obes. 2018; 5:20. PMID: 29881628.
      Citations: 7     
    28. Cronin O, Barton W, Skuse P, Penney NC, Garcia-Perez I, Murphy EF, Woods T, Nugent H, Fanning A, Melgar S, Falvey EC, Holmes E, Cotter PD, O'Sullivan O, Molloy MG, Shanahan F. A Prospective Metagenomic and Metabolomic Analysis of the Impact of Exercise and/or Whey Protein Supplementation on the Gut Microbiome of Sedentary Adults. mSystems. 2018 May-Jun; 3(3). PMID: 29719871.
      Citations: 34     
    29. Sung Y, Spagou K, Kafeza M, Kyriakides M, Dharmarajah B, Shalhoub J, Diaz JA, Wakefield TW, Holmes E, Davies AH. Deep Vein Thrombosis Exhibits Characteristic Serum and Vein Wall Metabolic Phenotypes in the Inferior Vena Cava Ligation Mouse Model. Eur J Vasc Endovasc Surg. 2018 05; 55(5):703-713. PMID: 29526653.
      Citations: 4     Fields:    Translation:Animals
    30. Loo RL, Zou X, Appel LJ, Nicholson JK, Holmes E. Characterization of metabolic responses to healthy diets and association with blood pressure: application to the Optimal Macronutrient Intake Trial for Heart Health (OmniHeart), a randomized controlled study. Am J Clin Nutr. 2018 03 01; 107(3):323-334. PMID: 29506183.
      Citations: 12     Fields:    Translation:Humans
    31. Lamour SD, Alibu VP, Holmes E, Sternberg JM. Metabolic Profiling of Central Nervous System Disease in Trypanosoma brucei rhodesiense Infection. J Infect Dis. 2017 12 05; 216(10):1273-1280. PMID: 28927234.
      Citations:    Fields:    Translation:HumansAnimals
    32. Patiny L, Zasso M, Kostro D, Bernal A, Castillo AM, Bolaños A, Asencio MA, Pellet N, Todd M, Schloerer N, Kuhn S, Holmes E, Javor S, Wist J. The C6H6 NMR repository: An integral solution to control the flow of your data from the magnet to the public. Magn Reson Chem. 2018 06; 56(6):520-528. PMID: 28981966.
      Citations: 7     Fields:    
    33. Bracewell-Milnes T, Saso S, Abdalla H, Nikolau D, Norman-Taylor J, Johnson M, Holmes E, Thum MY. Metabolomics as a tool to identify biomarkers to predict and improve outcomes in reproductive medicine: a systematic review. Hum Reprod Update. 2017 11 01; 23(6):723-736. PMID: 29069503.
      Citations: 29     Fields:    Translation:Humans
    34. Parkinson JRC, Wijeyesekera AD, Hyde MJ, Singhal A, Lucas A, Holmes E, Modi N. Early preterm nutrition and the urinary metabolome in young adult life: follow-up of a randomised controlled trial. BMJ Paediatr Open. 2017; 1(1):e000192. PMID: 29637175.
      Citations: 1     
    35. Bray R, Cacciatore S, Jiménez B, Cartwright R, Digesu A, Fernando R, Holmes E, Nicholson JK, Bennett PR, MacIntyre DA, Khullar V. Urinary Metabolic Phenotyping of Women with Lower Urinary Tract Symptoms. J Proteome Res. 2017 11 03; 16(11):4208-4216. PMID: 28937771.
      Citations: 6     Fields:    Translation:Humans
    36. Ahmad MS, Kimhofer T, Ahmad S, AlAma MN, Mosli HH, Hindawi SI, Mook-Kanamori DO, Šebeková K, Damanhouri ZA, Holmes E. Ethnicity and skin autofluorescence-based risk-engines for cardiovascular disease and diabetes mellitus. PLoS One. 2017; 12(9):e0185175. PMID: 28931094.
      Citations: 4     Fields:    Translation:Humans
    37. Lewis MC, Merrifield CA, Berger B, Cloarec O, Duncker S, Mercenier A, Nicholson JK, Holmes E, Bailey M. Early intervention with Bifidobacterium lactis NCC2818 modulates the host-microbe interface independent of the sustained changes induced by the neonatal environment. Sci Rep. 2017 07 13; 7(1):5310. PMID: 28706260.
      Citations: 5     Fields:    Translation:AnimalsCellsPHPublic Health
    38. Qureshi MI, Greco M, Vorkas PA, Holmes E, Davies AH. Application of Metabolic Profiling to Abdominal Aortic Aneurysm Research. J Proteome Res. 2017 07 07; 16(7):2325-2332. PMID: 28287739.
      Citations: 5     Fields:    Translation:Humans
    39. Anwar MA, Adesina-Georgiadis KN, Spagou K, Vorkas PA, Li JV, Shalhoub J, Holmes E, Davies AH. A comprehensive characterisation of the metabolic profile of varicose veins; implications in elaborating plausible cellular pathways for disease pathogenesis. Sci Rep. 2017 06 07; 7(1):2989. PMID: 28592827.
      Citations: 3     Fields:    Translation:Humans
    40. Cobbold JFL, Atkinson S, Marchesi JR, Smith A, Wai SN, Stove J, Shojaee-Moradie F, Jackson N, Umpleby AM, Fitzpatrick J, Thomas EL, Bell JD, Holmes E, Taylor-Robinson SD, Goldin RD, Yee MS, Anstee QM, Thursz MR. Rifaximin in non-alcoholic steatohepatitis: An open-label pilot study. Hepatol Res. 2018 Jan; 48(1):69-77. PMID: 28425154.
      Citations: 12     
    41. Ahmad MS, Damanhouri ZA, Kimhofer T, Mosli HH, Holmes E. Corrigendum: A new gender-specific model for skin autofluorescence risk stratification. Sci Rep. 2017 05 31; 7:46832. PMID: 28561805.
      Citations:    Fields:    
    42. Wolfer AM, Scott AJ, Rueb C, Gaudin M, Darzi A, Nicholson JK, Holmes E, Kinross JM. Longitudinal analysis of serum oxylipin profile as a novel descriptor of the inflammatory response to surgery. J Transl Med. 2017 04 26; 15(1):83. PMID: 28446191.
      Citations: 8     Fields:    Translation:Humans
    43. Barton W, Penney NC, Cronin O, Garcia-Perez I, Molloy MG, Holmes E, Shanahan F, Cotter PD, O'Sullivan O. The microbiome of professional athletes differs from that of more sedentary subjects in composition and particularly at the functional metabolic level. Gut. 2018 04; 67(4):625-633. PMID: 28360096.
      Citations: 117     Fields:    Translation:Humans
    44. Antcliffe D, Jiménez B, Veselkov K, Holmes E, Gordon AC. Metabolic Profiling in Patients with Pneumonia on Intensive Care. EBioMedicine. 2017 Apr; 18:244-253. PMID: 28373096.
      Citations: 2     Fields:    Translation:Humans
    45. Shariff MIF, Kim JU, Ladep NG, Gomaa AI, Crossey MME, Okeke E, Banwat E, Waked I, Cox IJ, Williams R, Holmes E, Taylor-Robinson SD. The Plasma and Serum Metabotyping of Hepatocellular Carcinoma in a Nigerian and Egyptian Cohort using Proton Nuclear Magnetic Resonance Spectroscopy. J Clin Exp Hepatol. 2017 Jun; 7(2):83-92. PMID: 28663670.
      Citations: 2     
    46. Chekmeneva E, Dos Santos Correia G, Chan Q, Wijeyesekera A, Tin A, Young JH, Elliott P, Nicholson JK, Holmes E. Optimization and Application of Direct Infusion Nanoelectrospray HRMS Method for Large-Scale Urinary Metabolic Phenotyping in Molecular Epidemiology. J Proteome Res. 2017 04 07; 16(4):1646-1658. PMID: 28245357.
      Citations: 7     Fields:    Translation:Humans
    47. Inglese P, McKenzie JS, Mroz A, Kinross J, Veselkov K, Holmes E, Takats Z, Nicholson JK, Glen RC. Deep learning and 3D-DESI imaging reveal the hidden metabolic heterogeneity of cancer. Chem Sci. 2017 May 01; 8(5):3500-3511. PMID: 28507724.
      Citations: 27     
    48. Ahmad MS, Alsaleh M, Kimhofer T, Ahmad S, Jamal W, Wali SO, Nicholson JK, Damanhouri ZA, Holmes E. Metabolic Phenotype of Obesity in a Saudi Population. J Proteome Res. 2017 02 03; 16(2):635-644. PMID: 27966366.
      Citations: 7     Fields:    Translation:Humans
    49. Kindinger LM, Bennett PR, Lee YS, Marchesi JR, Smith A, Cacciatore S, Holmes E, Nicholson JK, Teoh TG, MacIntyre DA. The interaction between vaginal microbiota, cervical length, and vaginal progesterone treatment for preterm birth risk. Microbiome. 2017 01 19; 5(1):6. PMID: 28103952.
      Citations: 80     Fields:    Translation:HumansCells
    50. Garcia-Perez I, Posma JM, Gibson R, Chambers ES, Hansen TH, Vestergaard H, Hansen T, Beckmann M, Pedersen O, Elliott P, Stamler J, Nicholson JK, Draper J, Mathers JC, Holmes E, Frost G. Objective assessment of dietary patterns by use of metabolic phenotyping: a randomised, controlled, crossover trial. Lancet Diabetes Endocrinol. 2017 03; 5(3):184-195. PMID: 28089709.
      Citations: 56     Fields:    Translation:Humans
    51. Pruski P, MacIntyre DA, Lewis HV, Inglese P, Correia GD, Hansel TT, Bennett PR, Holmes E, Takats Z. Medical Swab Analysis Using Desorption Electrospray Ionization Mass Spectrometry: A Noninvasive Approach for Mucosal Diagnostics. Anal Chem. 2017 02 07; 89(3):1540-1550. PMID: 28208268.
      Citations: 6     Fields:    Translation:HumansCells
    52. Heinzmann SS, Holmes E, Kochhar S, Nicholson JK, Schmitt-Kopplin P. Correction to 2-Furoylglycine as a Candidate Biomarker of Coffee Consumption. J Agric Food Chem. 2016 Nov 23; 64(46):8958. PMID: 27934290.
      Citations: 1     Fields:    
    53. Qureshi MI, Vorkas PA, Coupland AP, Jenkins IH, Holmes E, Davies AH. Lessons from Metabonomics on the Neurobiology of Stroke. Neuroscientist. 2017 08; 23(4):374-382. PMID: 28345376.
      Citations: 5     Fields:    Translation:HumansAnimals
    54. Dumas ME, Domange C, Calderari S, Martínez AR, Ayala R, Wilder SP, Suárez-Zamorano N, Collins SC, Wallis RH, Gu Q, Wang Y, Hue C, Otto GW, Argoud K, Navratil V, Mitchell SC, Lindon JC, Holmes E, Cazier JB, Nicholson JK, Gauguier D. Topological analysis of metabolic networks integrating co-segregating transcriptomes and metabolomes in type 2 diabetic rat congenic series. Genome Med. 2016 09 30; 8(1):101. PMID: 27716393.
      Citations: 8     Fields:    Translation:HumansAnimalsCells
    55. Baker L, Lanz B, Andreola F, Ampuero J, Wijeyesekera A, Holmes E, Deutz N. New technologies - new insights into the pathogenesis of hepatic encephalopathy. Metab Brain Dis. 2016 12; 31(6):1259-1267. PMID: 27696270.
      Citations: 2     Fields:    Translation:HumansAnimals
    56. Andreas NJ, Al-Khalidi A, Jaiteh M, Clarke E, Hyde MJ, Modi N, Holmes E, Kampmann B, Mehring Le Doare K. Role of human milk oligosaccharides in Group B Streptococcus colonisation. Clin Transl Immunology. 2016 Aug; 5(8):e99. PMID: 27588204.
      Citations: 17     
    57. Lewis MR, Pearce JT, Spagou K, Green M, Dona AC, Yuen AH, David M, Berry DJ, Chappell K, Horneffer-van der Sluis V, Shaw R, Lovestone S, Elliott P, Shockcor J, Lindon JC, Cloarec O, Takats Z, Holmes E, Nicholson JK. Development and Application of Ultra-Performance Liquid Chromatography-TOF MS for Precision Large Scale Urinary Metabolic Phenotyping. Anal Chem. 2016 09 20; 88(18):9004-13. PMID: 27479709.
      Citations: 30     Fields:    Translation:Humans
    58. Jackson F, Georgakopoulou N, Kaluarachchi M, Kyriakides M, Andreas N, Przysiezna N, Hyde MJ, Modi N, Nicholson JK, Wijeyesekera A, Holmes E. Development of a Pipeline for Exploratory Metabolic Profiling of Infant Urine. J Proteome Res. 2016 09 02; 15(9):3432-40. PMID: 27476583.
      Citations: 2     Fields:    Translation:Humans
    59. Kindinger LM, MacIntyre DA, Lee YS, Marchesi JR, Smith A, McDonald JA, Terzidou V, Cook JR, Lees C, Israfil-Bayli F, Faiza Y, Toozs-Hobson P, Slack M, Cacciatore S, Holmes E, Nicholson JK, Teoh TG, Bennett PR. Relationship between vaginal microbial dysbiosis, inflammation, and pregnancy outcomes in cervical cerclage. Sci Transl Med. 2016 08 03; 8(350):350ra102. PMID: 27488896.
      Citations: 39     Fields:    Translation:Humans
    60. Andreas NJ, Hyde MJ, Herbert BR, Jeffries S, Santhakumaran S, Mandalia S, Holmes E, Modi N. Impact of maternal BMI and sampling strategy on the concentration of leptin, insulin, ghrelin and resistin in breast milk across a single feed: a longitudinal cohort study. BMJ Open. 2016 07 07; 6(7):e010778. PMID: 27388351.
      Citations: 9     Fields:    Translation:Humans
    61. Zou X, Holmes E, Nicholson JK, Loo RL. Automatic Spectroscopic Data Categorization by Clustering Analysis (ASCLAN): A Data-Driven Approach for Distinguishing Discriminatory Metabolites for Phenotypic Subclasses. Anal Chem. 2016 06 07; 88(11):5670-9. PMID: 27149575.
      Citations: 3     Fields:    Translation:Animals
    62. Byrne CS, Chambers ES, Alhabeeb H, Chhina N, Morrison DJ, Preston T, Tedford C, Fitzpatrick J, Irani C, Busza A, Garcia-Perez I, Fountana S, Holmes E, Goldstone AP, Frost GS. Increased colonic propionate reduces anticipatory reward responses in the human striatum to high-energy foods. Am J Clin Nutr. 2016 Jul; 104(1):5-14. PMID: 27169834.
      Citations: 38     Fields:    Translation:Humans
    63. Blaise BJ, Correia G, Tin A, Young JH, Vergnaud AC, Lewis M, Pearce JT, Elliott P, Nicholson JK, Holmes E, Ebbels TM. Power Analysis and Sample Size Determination in Metabolic Phenotyping. Anal Chem. 2016 05 17; 88(10):5179-88. PMID: 27116637.
      Citations: 22     Fields:    Translation:HumansAnimals
    64. Phetcharaburanin J, Lees H, Marchesi JR, Nicholson JK, Holmes E, Seyfried F, Li JV. Systemic Characterization of an Obese Phenotype in the Zucker Rat Model Defining Metabolic Axes of Energy Metabolism and Host-Microbial Interactions. J Proteome Res. 2016 06 03; 15(6):1897-906. PMID: 27087596.
      Citations: 4     Fields:    Translation:Animals
    65. Gratton J, Phetcharaburanin J, Mullish BH, Williams HR, Thursz M, Nicholson JK, Holmes E, Marchesi JR, Li JV. Optimized Sample Handling Strategy for Metabolic Profiling of Human Feces. Anal Chem. 2016 05 03; 88(9):4661-8. PMID: 27065191.
      Citations: 44     Fields:    Translation:Humans
    66. Shariff MI, Kim JU, Ladep NG, Crossey MM, Koomson LK, Zabron A, Reeves H, Cramp M, Ryder S, Greer S, Cox IJ, Williams R, Holmes E, Nash K, Taylor-Robinson SD. Urinary Metabotyping of Hepatocellular Carcinoma in a UK Cohort Using Proton Nuclear Magnetic Resonance Spectroscopy. J Clin Exp Hepatol. 2016 Sep; 6(3):186-194. PMID: 27746614.
      Citations: 6     
    67. Kim JU, Shariff MI, Crossey MM, Gomez-Romero M, Holmes E, Cox IJ, Fye HK, Njie R, Taylor-Robinson SD. Hepatocellular carcinoma: Review of disease and tumor biomarkers. World J Hepatol. 2016 Apr 08; 8(10):471-84. PMID: 27057305.
      Citations: 20     
    68. Garcia-Perez I, Posma JM, Chambers ES, Nicholson JK, C Mathers J, Beckmann M, Draper J, Holmes E, Frost G. An Analytical Pipeline for Quantitative Characterization of Dietary Intake: Application To Assess Grape Intake. J Agric Food Chem. 2016 Mar 23; 64(11):2423-31. PMID: 26909845.
      Citations: 11     Fields:    Translation:HumansAnimals
    69. McPhail MJW, Shawcross DL, Lewis MR, Coltart I, Want EJ, Antoniades CG, Veselkov K, Triantafyllou E, Patel V, Pop O, Gomez-Romero M, Kyriakides M, Zia R, Abeles RD, Crossey MME, Jassem W, O'Grady J, Heaton N, Auzinger G, Bernal W, Quaglia A, Coen M, Nicholson JK, Wendon JA, Holmes E, Taylor-Robinson SD. Multivariate metabotyping of plasma predicts survival in patients with decompensated cirrhosis. J Hepatol. 2016 May; 64(5):1058-1067. PMID: 26795831.
      Citations: 21     Fields:    Translation:Humans
    70. Kyriakides M, Maitre L, Stamper BD, Mohar I, Kavanagh TJ, Foster J, Wilson ID, Holmes E, Nelson SD, Coen M. Comparative metabonomic analysis of hepatotoxicity induced by acetaminophen and its less toxic meta-isomer. Arch Toxicol. 2016 Dec; 90(12):3073-3085. PMID: 26746206.
      Citations: 7     Fields:    Translation:AnimalsCells
    71. Anwar MA, Vorkas PA, Li JV, Shalhoub J, Want EJ, Davies AH, Holmes E. Optimization of metabolite extraction of human vein tissue for ultra performance liquid chromatography-mass spectrometry and nuclear magnetic resonance-based untargeted metabolic profiling. Analyst. 2015 Nov 21; 140(22):7586-97. PMID: 26468486.
      Citations: 7     Fields:    Translation:Humans
    72. Wolfer AM, Gaudin M, Taylor-Robinson SD, Holmes E, Nicholson JK. Development and Validation of a High-Throughput Ultrahigh-Performance Liquid Chromatography-Mass Spectrometry Approach for Screening of Oxylipins and Their Precursors. Anal Chem. 2015 Dec 01; 87(23):11721-31. PMID: 26501362.
      Citations: 10     Fields:    Translation:HumansCells
    73. Lamour SD, Gomez-Romero M, Vorkas PA, Alibu VP, Saric J, Holmes E, Sternberg JM. Discovery of Infection Associated Metabolic Markers in Human African Trypanosomiasis. PLoS Negl Trop Dis. 2015; 9(10):e0004200. PMID: 26505639.
      Citations: 12     Fields:    Translation:HumansAnimals
    74. Sarafian MH, Lewis MR, Pechlivanis A, Ralphs S, McPhail MJ, Patel VC, Dumas ME, Holmes E, Nicholson JK. Bile acid profiling and quantification in biofluids using ultra-performance liquid chromatography tandem mass spectrometry. Anal Chem. 2015 Oct 06; 87(19):9662-70. PMID: 26327313.
      Citations: 45     Fields:    Translation:Humans
    75. Heinzmann SS, Holmes E, Kochhar S, Nicholson JK, Schmitt-Kopplin P. 2-Furoylglycine as a Candidate Biomarker of Coffee Consumption. J Agric Food Chem. 2015 Sep 30; 63(38):8615-21. PMID: 26357997.
      Citations: 16     Fields:    Translation:Humans
    76. Amiot A, Dona AC, Wijeyesekera A, Tournigand C, Baumgaertner I, Lebaleur Y, Sobhani I, Holmes E. (1)H NMR Spectroscopy of Fecal Extracts Enables Detection of Advanced Colorectal Neoplasia. J Proteome Res. 2015 Sep 04; 14(9):3871-81. PMID: 26211820.
      Citations: 15     Fields:    Translation:Humans
    77. Holmes E, Wijeyesekera A, Taylor-Robinson SD, Nicholson JK. The promise of metabolic phenotyping in gastroenterology and hepatology. Nat Rev Gastroenterol Hepatol. 2015 Aug; 12(8):458-71. PMID: 26194948.
      Citations: 18     Fields:    Translation:Humans
    78. Shariff MI, Tognarelli JM, Lewis MR, Want EJ, Mohamed Fel Z, Ladep NG, Crossey MM, Khan SA, Jalan R, Holmes E, Taylor-Robinson SD. Plasma Lipid Profiling in a Rat Model of Hepatocellular Carcinoma: Potential Modulation Through Quinolone Administration. J Clin Exp Hepatol. 2015 Dec; 5(4):286-94. PMID: 26900269.
      Citations: 3     
    79. Zhang C, Yin A, Li H, Wang R, Wu G, Shen J, Zhang M, Wang L, Hou Y, Ouyang H, Zhang Y, Zheng Y, Wang J, Lv X, Wang Y, Zhang F, Zeng B, Li W, Yan F, Zhao Y, Pang X, Zhang X, Fu H, Chen F, Zhao N, Hamaker BR, Bridgewater LC, Weinkove D, Clement K, Dore J, Holmes E, Xiao H, Zhao G, Yang S, Bork P, Nicholson JK, Wei H, Tang H, Zhang X, Zhao L. Dietary Modulation of Gut Microbiota Contributes to Alleviation of Both Genetic and Simple Obesity in Children. EBioMedicine. 2015 Aug; 2(8):968-84. PMID: 26425705.
      Citations: 117     Fields:    Translation:HumansAnimalsCTClinical Trials
    80. Bower G, Athanasiou T, Isla AM, Harling L, Li JV, Holmes E, Efthimiou E, Darzi A, Ashrafian H. Bariatric surgery and nonalcoholic fatty liver disease. Eur J Gastroenterol Hepatol. 2015 Jul; 27(7):755-68. PMID: 25919774.
      Citations: 9     Fields:    Translation:Humans
    81. Wesseling H, Want EJ, Guest PC, Rahmoune H, Holmes E, Bahn S. Hippocampal Proteomic and Metabonomic Abnormalities in Neurotransmission, Oxidative Stress, and Apoptotic Pathways in a Chronic Phencyclidine Rat Model. J Proteome Res. 2015 Aug 07; 14(8):3174-87. PMID: 26043028.
      Citations: 2     Fields:    Translation:HumansAnimalsCells
    82. Andreas NJ, Hyde MJ, Gomez-Romero M, Lopez-Gonzalvez MA, Villaseñor A, Wijeyesekera A, Barbas C, Modi N, Holmes E, Garcia-Perez I. Multiplatform characterization of dynamic changes in breast milk during lactation. Electrophoresis. 2015 Sep; 36(18):2269-2285. PMID: 25959062.
      Citations: 18     Fields:    
    83. Vorkas PA, Isaac G, Holmgren A, Want EJ, Shockcor JP, Holmes E, Henein MY. Perturbations in fatty acid metabolism and apoptosis are manifested in calcific coronary artery disease: An exploratory lipidomic study. Int J Cardiol. 2015 Oct 15; 197:192-9. PMID: 26142205.
      Citations: 8     Fields:    Translation:Humans
    84. Merrifield CA, Lewis MC, Berger B, Cloarec O, Heinzmann SS, Charton F, Krause L, Levin NS, Duncker S, Mercenier A, Holmes E, Bailey M, Nicholson JK. Neonatal environment exerts a sustained influence on the development of the intestinal microbiota and metabolic phenotype. ISME J. 2016 Jan; 10(1):145-57. PMID: 26066712.
      Citations: 15     Fields:    Translation:HumansAnimals
    85. Ahmad MS, Damanhouri ZA, Kimhofer T, Mosli HH, Holmes E. A new gender-specific model for skin autofluorescence risk stratification. Sci Rep. 2015 May 14; 5:10198. PMID: 25974028.
      Citations: 6     Fields:    Translation:Humans
    86. Elliott P, Posma JM, Chan Q, Garcia-Perez I, Wijeyesekera A, Bictash M, Ebbels TM, Ueshima H, Zhao L, van Horn L, Daviglus M, Stamler J, Holmes E, Nicholson JK. Urinary metabolic signatures of human adiposity. Sci Transl Med. 2015 Apr 29; 7(285):285ra62. PMID: 25925681.
      Citations: 63     Fields:    Translation:Humans
    87. MacIntyre DA, Chandiramani M, Lee YS, Kindinger L, Smith A, Angelopoulos N, Lehne B, Arulkumaran S, Brown R, Teoh TG, Holmes E, Nicoholson JK, Marchesi JR, Bennett PR. The vaginal microbiome during pregnancy and the postpartum period in a European population. Sci Rep. 2015 Mar 11; 5:8988. PMID: 25758319.
      Citations: 142     Fields:    Translation:HumansCells
    88. Vorkas PA, Shalhoub J, Isaac G, Want EJ, Nicholson JK, Holmes E, Davies AH. Metabolic phenotyping of atherosclerotic plaques reveals latent associations between free cholesterol and ceramide metabolism in atherogenesis. J Proteome Res. 2015 Mar 06; 14(3):1389-99. PMID: 25565173.
      Citations: 21     Fields:    
    89. Nye LC, Gray N, McClure M, Boffit M, Holmes E, Plumb RS, Wilson ID. Identification of a novel human circulating metabolite of tenofovir disoproxil fumarate with LC-MS/MS. Bioanalysis. 2015; 7(6):643-52. PMID: 25871584.
      Citations: 3     Fields:    Translation:HumansCTClinical Trials
    90. Chang KL, Pee HN, Tan WP, Dawe GS, Holmes E, Nicholson JK, Chan EC, Ho PC. Metabolic profiling of CHO-AßPP695 cells revealed mitochondrial dysfunction prior to amyloid-ß pathology and potential therapeutic effects of both PPAR? and PPARa Agonisms for Alzheimer's disease. J Alzheimers Dis. 2015; 44(1):215-31. PMID: 25201780.
      Citations: 9     Fields:    Translation:HumansAnimalsCells
    91. Sands CJ, Guha IN, Kyriakides M, Wright M, Beckonert O, Holmes E, Rosenberg WM, Coen M. Metabolic phenotyping for enhanced mechanistic stratification of chronic hepatitis C-induced liver fibrosis. Am J Gastroenterol. 2015 Jan; 110(1):159-69. PMID: 25533003.
      Citations: 12     Fields:    Translation:Humans
    92. Andreas NJ, Hyde MJ, Gale C, Parkinson JR, Jeffries S, Holmes E, Modi N. Effect of maternal body mass index on hormones in breast milk: a systematic review. PLoS One. 2014; 9(12):e115043. PMID: 25536196.
      Citations: 30     Fields:    Translation:Humans
    93. Wild CP, Bucher JR, de Jong BW, Dillner J, von Gertten C, Groopman JD, Herceg Z, Holmes E, Holmila R, Olsen JH, Ringborg U, Scalbert A, Shibata T, Smith MT, Ulrich C, Vineis P, McLaughlin J. Translational cancer research: balancing prevention and treatment to combat cancer globally. J Natl Cancer Inst. 2015 Jan; 107(1):353. PMID: 25515230.
      Citations: 13     Fields:    Translation:Humans
    94. Lamour SD, Veselkov KA, Posma JM, Giraud E, Rogers ME, Croft S, Marchesi JR, Holmes E, Seifert K, Saric J. Metabolic, immune, and gut microbial signals mount a systems response to Leishmania major infection. J Proteome Res. 2015 Jan 02; 14(1):318-29. PMID: 25369177.
      Citations: 4     Fields:    Translation:Animals
    95. Villaseñor A, Kinross JM, Li JV, Penney N, Barton RH, Nicholson JK, Darzi A, Barbas C, Holmes E. 1H NMR global metabolic phenotyping of acute pancreatitis in the emergency unit. J Proteome Res. 2014 Dec 05; 13(12):5362-75. PMID: 25160714.
      Citations: 7     Fields:    Translation:Humans
    96. Lees H, Swann J, Poucher SM, Nicholson JK, Holmes E, Wilson ID, Marchesi JR. Age and microenvironment outweigh genetic influence on the Zucker rat microbiome. PLoS One. 2014; 9(9):e100916. PMID: 25232735.
      Citations: 20     Fields:    Translation:AnimalsCells
    97. Dona AC, Jiménez B, Schäfer H, Humpfer E, Spraul M, Lewis MR, Pearce JT, Holmes E, Lindon JC, Nicholson JK. Precision high-throughput proton NMR spectroscopy of human urine, serum, and plasma for large-scale metabolic phenotyping. Anal Chem. 2014 Oct 07; 86(19):9887-94. PMID: 25180432.
      Citations: 129     Fields:    Translation:Humans
    98. Hall AM, Vilasi A, Garcia-Perez I, Lapsley M, Alston CL, Pitceathly RD, McFarland R, Schaefer AM, Turnbull DM, Beaumont NJ, Hsuan JJ, Cutillas PR, Lindon JC, Holmes E, Unwin RJ, Taylor RW, Gorman GS, Rahman S, Hanna MG. The urinary proteome and metabonome differ from normal in adults with mitochondrial disease. Kidney Int. 2015 Mar; 87(3):610-22. PMID: 25207879.
      Citations: 11     Fields:    Translation:Humans
    99. Ladep NG, Dona AC, Lewis MR, Crossey MM, Lemoine M, Okeke E, Shimakawa Y, Duguru M, Njai HF, Fye HK, Taal M, Chetwood J, Kasstan B, Khan SA, Garside DA, Wijeyesekera A, Thillainayagam AV, Banwat E, Thursz MR, Nicholson JK, Njie R, Holmes E, Taylor-Robinson SD. Discovery and validation of urinary metabotypes for the diagnosis of hepatocellular carcinoma in West Africans. Hepatology. 2014 Oct; 60(4):1291-301. PMID: 24923488.
      Citations: 28     Fields:    Translation:Humans
    100. Kyriakides M, Hardwick RN, Jin Z, Goedken MJ, Holmes E, Cherrington NJ, Coen M. Systems level metabolic phenotype of methotrexate administration in the context of non-alcoholic steatohepatitis in the rat. Toxicol Sci. 2014 Nov; 142(1):105-16. PMID: 25145655.
      Citations: 3     Fields:    Translation:Animals
    101. Villaseñor A, Garcia-Perez I, Garcia A, Posma JM, Fernández-López M, Nicholas AJ, Modi N, Holmes E, Barbas C. Breast milk metabolome characterization in a single-phase extraction, multiplatform analytical approach. Anal Chem. 2014 Aug 19; 86(16):8245-52. PMID: 25058331.
      Citations: 22     Fields:    Translation:Humans
    102. Tritten L, Keiser J, Karwa T, Utzinger J, Holmes E, Saric J. Comparing systemic metabolic responses in mice to single or dual infection with Plasmodium berghei and Heligmosomoides bakeri. Mol Biosyst. 2014 Jul 29; 10(9):2358-67. PMID: 24960299.
      Citations: 2     Fields:    Translation:AnimalsCells
    103. Maitre L, Fthenou E, Athersuch T, Coen M, Toledano MB, Holmes E, Kogevinas M, Chatzi L, Keun HC. Urinary metabolic profiles in early pregnancy are associated with preterm birth and fetal growth restriction in the Rhea mother-child cohort study. BMC Med. 2014 Jul 11; 12:110. PMID: 25012562.
      Citations: 34     Fields:    Translation:Humans
    104. Sarafian MH, Gaudin M, Lewis MR, Martin FP, Holmes E, Nicholson JK, Dumas ME. Objective set of criteria for optimization of sample preparation procedures for ultra-high throughput untargeted blood plasma lipid profiling by ultra performance liquid chromatography-mass spectrometry. Anal Chem. 2014 Jun 17; 86(12):5766-74. PMID: 24820162.
      Citations: 38     Fields:    Translation:Humans
    105. Mirnezami R, Jiménez B, Li JV, Kinross JM, Veselkov K, Goldin RD, Holmes E, Nicholson JK, Darzi A. Rapid diagnosis and staging of colorectal cancer via high-resolution magic angle spinning nuclear magnetic resonance (HR-MAS NMR) spectroscopy of intact tissue biopsies. Ann Surg. 2014 Jun; 259(6):1138-49. PMID: 23860197.
      Citations: 26     Fields:    Translation:Humans
    106. Zou X, Holmes E, Nicholson JK, Loo RL. Statistical HOmogeneous Cluster SpectroscopY (SHOCSY): an optimized statistical approach for clustering of ¹H NMR spectral data to reduce interference and enhance robust biomarkers selection. Anal Chem. 2014 Jun 03; 86(11):5308-15. PMID: 24773160.
      Citations: 3     Fields:    Translation:Animals
    107. Klootwijk ED, Reichold M, Helip-Wooley A, Tolaymat A, Broeker C, Robinette SL, Reinders J, Peindl D, Renner K, Eberhart K, Assmann N, Oefner PJ, Dettmer K, Sterner C, Schroeder J, Zorger N, Witzgall R, Reinhold SW, Stanescu HC, Bockenhauer D, Jaureguiberry G, Courtneidge H, Hall AM, Wijeyesekera AD, Holmes E, Nicholson JK, O'Brien K, Bernardini I, Krasnewich DM, Arcos-Burgos M, Izumi Y, Nonoguchi H, Jia Y, Reddy JK, Ilyas M, Unwin RJ, Gahl WA, Warth R, Kleta R. Mistargeting of peroxisomal EHHADH and inherited renal Fanconi's syndrome. N Engl J Med. 2014 Jan 09; 370(2):129-38. PMID: 24401050.
      Citations: 32     Fields:    Translation:HumansAnimalsCells
    108. Veselkov KA, Mirnezami R, Strittmatter N, Goldin RD, Kinross J, Speller AV, Abramov T, Jones EA, Darzi A, Holmes E, Nicholson JK, Takats Z. Chemo-informatic strategy for imaging mass spectrometry-based hyperspectral profiling of lipid signatures in colorectal cancer. Proc Natl Acad Sci U S A. 2014 Jan 21; 111(3):1216-21. PMID: 24398526.
      Citations: 39     Fields:    Translation:Humans
    109. Ashrafian H, Li JV, Spagou K, Harling L, Masson P, Darzi A, Nicholson JK, Holmes E, Athanasiou T. Bariatric surgery modulates circulating and cardiac metabolites. J Proteome Res. 2014 Feb 07; 13(2):570-80. PMID: 24279706.
      Citations: 25     Fields:    Translation:Animals
    110. Posma JM, Robinette SL, Holmes E, Nicholson JK. MetaboNetworks, an interactive Matlab-based toolbox for creating, customizing and exploring sub-networks from KEGG. Bioinformatics. 2014 Mar 15; 30(6):893-5. PMID: 24177720.
      Citations: 28     Fields:    
    111. Li JV, Saric J, Yap IK, Utzinger J, Holmes E. Metabonomic investigations of age- and batch-related variations in female NMRI mice using proton nuclear magnetic resonance spectroscopy. Mol Biosyst. 2013 Dec; 9(12):3155-65. PMID: 24121299.
      Citations: 2     Fields:    Translation:Animals
    112. Stamler J, Brown IJ, Yap IK, Chan Q, Wijeyesekera A, Garcia-Perez I, Chadeau-Hyam M, Ebbels TM, De Iorio M, Posma J, Daviglus ML, Carnethon M, Holmes E, Nicholson JK, Elliott P. Dietary and urinary metabonomic factors possibly accounting for higher blood pressure of black compared with white Americans: results of International Collaborative Study on macro-/micronutrients and blood pressure. Hypertension. 2013 Dec; 62(6):1074-80. PMID: 24101663.
      Citations: 7     Fields:    Translation:HumansAnimals
    113. Tritten L, Keiser J, Godejohann M, Utzinger J, Vargas M, Beckonert O, Holmes E, Saric J. Metabolic profiling framework for discovery of candidate diagnostic markers of malaria. Sci Rep. 2013 Sep 26; 3:2769. PMID: 24067624.
      Citations: 9     Fields:    Translation:HumansAnimals
    114. Ismail NA, Posma JM, Frost G, Holmes E, Garcia-Perez I. The role of metabonomics as a tool for augmenting nutritional information in epidemiological studies. Electrophoresis. 2013 Oct; 34(19):2776-86. PMID: 23893902.
      Citations: 6     Fields:    Translation:HumansAnimals
    115. Wesseling H, Chan MK, Tsang TM, Ernst A, Peters F, Guest PC, Holmes E, Bahn S. A combined metabonomic and proteomic approach identifies frontal cortex changes in a chronic phencyclidine rat model in relation to human schizophrenia brain pathology. Neuropsychopharmacology. 2013 Nov; 38(12):2532-44. PMID: 23942359.
      Citations: 12     Fields:    Translation:HumansAnimals
    116. Richards SE, Wang Y, Claus SP, Lawler D, Kochhar S, Holmes E, Nicholson JK. Metabolic phenotype modulation by caloric restriction in a lifelong dog study. J Proteome Res. 2013 Jul 05; 12(7):3117-27. PMID: 23713866.
      Citations: 7     Fields:    Translation:HumansAnimals
    117. Swann JR, Spagou K, Lewis M, Nicholson JK, Glei DA, Seeman TE, Coe CL, Goldman N, Ryff CD, Weinstein M, Holmes E. Microbial-mammalian cometabolites dominate the age-associated urinary metabolic phenotype in Taiwanese and American populations. J Proteome Res. 2013 Jul 05; 12(7):3166-80. PMID: 23701591.
      Citations: 10     Fields:    Translation:Humans
    118. Kirkby NS, Chan MV, Lundberg MH, Massey KA, Edmands WM, MacKenzie LS, Holmes E, Nicolaou A, Warner TD, Mitchell JA. Aspirin-triggered 15-epi-lipoxin A4 predicts cyclooxygenase-2 in the lungs of LPS-treated mice but not in the circulation: implications for a clinical test. FASEB J. 2013 Oct; 27(10):3938-46. PMID: 23792301.
      Citations: 7     Fields:    Translation:Animals
    119. Boulangé CL, Claus SP, Chou CJ, Collino S, Montoliu I, Kochhar S, Holmes E, Rezzi S, Nicholson JK, Dumas ME, Martin FP. Early metabolic adaptation in C57BL/6 mice resistant to high fat diet induced weight gain involves an activation of mitochondrial oxidative pathways. J Proteome Res. 2013 Apr 05; 12(4):1956-68. PMID: 23473242.
      Citations: 19     Fields:    Translation:AnimalsCells
    120. Lees HJ, Swann JR, Wilson ID, Nicholson JK, Holmes E. Hippurate: the natural history of a mammalian-microbial cometabolite. J Proteome Res. 2013 Apr 05; 12(4):1527-46. PMID: 23342949.
      Citations: 87     Fields:    Translation:HumansAnimals
    121. Hankinson AL, Daviglus ML, Van Horn L, Chan Q, Brown I, Holmes E, Elliott P, Stamler J. Diet composition and activity level of at risk and metabolically healthy obese American adults. Obesity (Silver Spring). 2013 Mar; 21(3):637-43. PMID: 23592673.
      Citations: 39     Fields:    Translation:Humans
    122. Seyfried F, Li JV, Miras AD, Cluny NL, Lannoo M, Fenske WK, Sharkey KA, Nicholson JK, le Roux CW, Holmes E. Urinary phenotyping indicates weight loss-independent metabolic effects of Roux-en-Y gastric bypass in mice. J Proteome Res. 2013 Mar 01; 12(3):1245-53. PMID: 23336719.
      Citations: 6     Fields:    Translation:Animals
    123. Smith MI, Yatsunenko T, Manary MJ, Trehan I, Mkakosya R, Cheng J, Kau AL, Rich SS, Concannon P, Mychaleckyj JC, Liu J, Houpt E, Li JV, Holmes E, Nicholson J, Knights D, Ursell LK, Knight R, Gordon JI. Gut microbiomes of Malawian twin pairs discordant for kwashiorkor. Science. 2013 Feb 01; 339(6119):548-54. PMID: 23363771.
      Citations: 434     Fields:    Translation:HumansAnimalsCells
    124. Jiménez B, Mirnezami R, Kinross J, Cloarec O, Keun HC, Holmes E, Goldin RD, Ziprin P, Darzi A, Nicholson JK. 1H HR-MAS NMR spectroscopy of tumor-induced local metabolic "field-effects" enables colorectal cancer staging and prognostication. J Proteome Res. 2013 Feb 01; 12(2):959-68. PMID: 23240862.
      Citations: 39     Fields:    Translation:Humans
    125. Fonville JM, Carter CL, Pizarro L, Steven RT, Palmer AD, Griffiths RL, Lalor PF, Lindon JC, Nicholson JK, Holmes E, Bunch J. Hyperspectral visualization of mass spectrometry imaging data. Anal Chem. 2013 Feb 05; 85(3):1415-23. PMID: 23249247.
      Citations: 20     Fields:    Translation:HumansAnimals
    126. Want EJ, Masson P, Michopoulos F, Wilson ID, Theodoridis G, Plumb RS, Shockcor J, Loftus N, Holmes E, Nicholson JK. Global metabolic profiling of animal and human tissues via UPLC-MS. Nat Protoc. 2013 Jan; 8(1):17-32. PMID: 23222455.
      Citations: 125     Fields:    Translation:HumansAnimals
    127. Posma JM, Garcia-Perez I, De Iorio M, Lindon JC, Elliott P, Holmes E, Ebbels TM, Nicholson JK. Subset optimization by reference matching (STORM): an optimized statistical approach for recovery of metabolic biomarker structural information from 1H NMR spectra of biofluids. Anal Chem. 2012 Dec 18; 84(24):10694-701. PMID: 23151027.
      Citations: 23     Fields:    Translation:Humans
    128. El Aidy S, Derrien M, Merrifield CA, Levenez F, Doré J, Boekschoten MV, Dekker J, Holmes E, Zoetendal EG, van Baarlen P, Claus SP, Kleerebezem M. Gut bacteria-host metabolic interplay during conventionalisation of the mouse germfree colon. ISME J. 2013 Apr; 7(4):743-55. PMID: 23178667.
      Citations: 40     Fields:    Translation:AnimalsCells
    129. Nicholson JK, Holmes E, Kinross JM, Darzi AW, Takats Z, Lindon JC. Metabolic phenotyping in clinical and surgical environments. Nature. 2012 Nov 15; 491(7424):384-92. PMID: 23151581.
      Citations: 150     Fields:    Translation:HumansAnimalsCells
    130. Holmes E, Li JV, Marchesi JR, Nicholson JK. Gut microbiota composition and activity in relation to host metabolic phenotype and disease risk. Cell Metab. 2012 Nov 07; 16(5):559-64. PMID: 23140640.
      Citations: 152     Fields:    Translation:HumansAnimalsCells
    131. Arora T, Loo RL, Anastasovska J, Gibson GR, Tuohy KM, Sharma RK, Swann JR, Deaville ER, Sleeth ML, Thomas EL, Holmes E, Bell JD, Frost G. Differential effects of two fermentable carbohydrates on central appetite regulation and body composition. PLoS One. 2012; 7(8):e43263. PMID: 22952656.
      Citations: 21     Fields:    Translation:AnimalsCells
    132. Garcia-Perez I, Villaseñor A, Wijeyesekera A, Posma JM, Jiang Z, Stamler J, Aronson P, Unwin R, Barbas C, Elliott P, Nicholson J, Holmes E. Urinary metabolic phenotyping the slc26a6 (chloride-oxalate exchanger) null mouse model. J Proteome Res. 2012 Sep 07; 11(9):4425-35. PMID: 22594923.
      Citations: 10     Fields:    Translation:Animals
    133. Saric J, Want EJ, Duthaler U, Lewis M, Keiser J, Shockcor JP, Ross GA, Nicholson JK, Holmes E, Tavares MF. Systematic evaluation of extraction methods for multiplatform-based metabotyping: application to the Fasciola hepatica metabolome. Anal Chem. 2012 Aug 21; 84(16):6963-72. PMID: 22799605.
      Citations: 6     Fields:    Translation:Animals
    134. Cunningham K, Claus SP, Lindon JC, Holmes E, Everett JR, Nicholson JK, Coen M. Pharmacometabonomic characterization of xenobiotic and endogenous metabolic phenotypes that account for inter-individual variation in isoniazid-induced toxicological response. J Proteome Res. 2012 Sep 07; 11(9):4630-42. PMID: 22873827.
      Citations: 5     Fields:    Translation:Animals
    135. El Aidy S, Merrifield CA, Derrien M, van Baarlen P, Hooiveld G, Levenez F, Doré J, Dekker J, Holmes E, Claus SP, Reijngoud DJ, Kleerebezem M. The gut microbiota elicits a profound metabolic reorientation in the mouse jejunal mucosa during conventionalisation. Gut. 2013 Sep; 62(9):1306-14. PMID: 22722618.
      Citations: 50     Fields:    Translation:HumansAnimalsCells
    136. Nicholson JK, Holmes E, Kinross J, Burcelin R, Gibson G, Jia W, Pettersson S. Host-gut microbiota metabolic interactions. Science. 2012 Jun 08; 336(6086):1262-7. PMID: 22674330.
      Citations: 1216     Fields:    Translation:HumansAnimalsCells
    137. Holmes E, Kinross J, Gibson GR, Burcelin R, Jia W, Pettersson S, Nicholson JK. Therapeutic modulation of microbiota-host metabolic interactions. Sci Transl Med. 2012 Jun 06; 4(137):137rv6. PMID: 22674556.
      Citations: 77     Fields:    Translation:Humans
    138. Zhao L, Nicholson JK, Lu A, Wang Z, Tang H, Holmes E, Shen J, Zhang X, Li JV, Lindon JC. Targeting the human genome-microbiome axis for drug discovery: inspirations from global systems biology and traditional Chinese medicine. J Proteome Res. 2012 Jul 06; 11(7):3509-19. PMID: 22624854.
      Citations: 19     Fields:    Translation:HumansAnimals
    139. Merrifield CA, Lewis MC, Claus SP, Pearce JT, Cloarec O, Duncker S, Heinzmann SS, Dumas ME, Kochhar S, Rezzi S, Mercenier A, Nicholson JK, Bailey M, Holmes E. Weaning diet induces sustained metabolic phenotype shift in the pig and influences host response to Bifidobacterium lactis NCC2818. Gut. 2013 Jun; 62(6):842-51. PMID: 22661492.
      Citations: 8     Fields:    Translation:AnimalsCells
    140. Ernst A, Ma D, Garcia-Perez I, Tsang TM, Kluge W, Schwarz E, Guest PC, Holmes E, Sarnyai Z, Bahn S. Molecular validation of the acute phencyclidine rat model for schizophrenia: identification of translational changes in energy metabolism and neurotransmission. J Proteome Res. 2012 Jul 06; 11(7):3704-14. PMID: 22613019.
      Citations: 10     Fields:    Translation:HumansAnimalsCells
    141. Mirnezami R, Kinross JM, Vorkas PA, Goldin R, Holmes E, Nicholson J, Darzi A. Implementation of molecular phenotyping approaches in the personalized surgical patient journey. Ann Surg. 2012 May; 255(5):881-9. PMID: 22156927.
      Citations: 12     Fields:    Translation:Humans
    142. Robinette SL, Holmes E, Nicholson JK, Dumas ME. Genetic determinants of metabolism in health and disease: from biochemical genetics to genome-wide associations. Genome Med. 2012 Apr 30; 4(4):30. PMID: 22546284.
      Citations: 9     Fields:    
    143. Wong A, Jiménez B, Li X, Holmes E, Nicholson JK, Lindon JC, Sakellariou D. Evaluation of high resolution magic-angle coil spinning NMR spectroscopy for metabolic profiling of nanoliter tissue biopsies. Anal Chem. 2012 Apr 17; 84(8):3843-8. PMID: 22449140.
      Citations: 9     Fields:    Translation:HumansAnimals
    144. Coen M, Goldfain-Blanc F, Rolland-Valognes G, Walther B, Robertson DG, Holmes E, Lindon JC, Nicholson JK. Pharmacometabonomic investigation of dynamic metabolic phenotypes associated with variability in response to galactosamine hepatotoxicity. J Proteome Res. 2012 Apr 06; 11(4):2427-40. PMID: 22384821.
      Citations: 8     Fields:    Translation:Animals
    145. Benton HP, Want E, Keun HC, Amberg A, Plumb RS, Goldfain-Blanc F, Walther B, Reily MD, Lindon JC, Holmes E, Nicholson JK, Ebbels TM. Intra- and interlaboratory reproducibility of ultra performance liquid chromatography-time-of-flight mass spectrometry for urinary metabolic profiling. Anal Chem. 2012 Mar 06; 84(5):2424-32. PMID: 22304021.
      Citations: 7     Fields:    Translation:HumansCells
    146. Fonville JM, Carter C, Cloarec O, Nicholson JK, Lindon JC, Bunch J, Holmes E. Robust data processing and normalization strategy for MALDI mass spectrometric imaging. Anal Chem. 2012 Feb 07; 84(3):1310-9. PMID: 22148759.
      Citations: 27     Fields:    Translation:Animals
    147. Loo RL, Chan Q, Brown IJ, Robertson CE, Stamler J, Nicholson JK, Holmes E, Elliott P. A comparison of self-reported analgesic use and detection of urinary ibuprofen and acetaminophen metabolites by means of metabonomics: the INTERMAP Study. Am J Epidemiol. 2012 Feb 15; 175(4):348-58. PMID: 22223708.
      Citations: 10     Fields:    Translation:Humans
    148. Wijeyesekera A, Clarke PA, Bictash M, Brown IJ, Fidock M, Ryckmans T, Yap IK, Chan Q, Stamler J, Elliott P, Holmes E, Nicholson JK. Quantitative UPLC-MS/MS analysis of the gut microbial co-metabolites phenylacetylglutamine, 4-cresyl sulphate and hippurate in human urine: INTERMAP Study. Anal Methods. 2012 Jan 01; 4(1):65-72. PMID: 23946767.
      Citations: 6     
    149. Heinzmann SS, Merrifield CA, Rezzi S, Kochhar S, Lindon JC, Holmes E, Nicholson JK. Stability and robustness of human metabolic phenotypes in response to sequential food challenges. J Proteome Res. 2012 Feb 03; 11(2):643-55. PMID: 21999107.
      Citations: 37     Fields:    Translation:Humans
    150. Mestdagh R, Dumas ME, Rezzi S, Kochhar S, Holmes E, Claus SP, Nicholson JK. Gut microbiota modulate the metabolism of brown adipose tissue in mice. J Proteome Res. 2012 Feb 03; 11(2):620-30. PMID: 22053906.
      Citations: 36     Fields:    Translation:Animals
    151. Rezzonico E, Mestdagh R, Delley M, Combremont S, Dumas ME, Holmes E, Nicholson J, Bibiloni R. Bacterial adaptation to the gut environment favors successful colonization: microbial and metabonomic characterization of a simplified microbiota mouse model. Gut Microbes. 2011 Nov-Dec; 2(6):307-18. PMID: 22157236.
      Citations: 8     Fields:    Translation:AnimalsCells
    152. Thomas EL, Parkinson JR, Hyde MJ, Yap IK, Holmes E, Doré CJ, Bell JD, Modi N. Aberrant adiposity and ectopic lipid deposition characterize the adult phenotype of the preterm infant. Pediatr Res. 2011 Nov; 70(5):507-12. PMID: 21772225.
      Citations: 32     Fields:    Translation:Humans
    153. Hradetzky E, Sanderson TM, Tsang TM, Sherwood JL, Fitzjohn SM, Lakics V, Malik N, Schoeffmann S, O'Neill MJ, Cheng TM, Harris LW, Rahmoune H, Guest PC, Sher E, Collingridge GL, Holmes E, Tricklebank MD, Bahn S. The methylazoxymethanol acetate (MAM-E17) rat model: molecular and functional effects in the hippocampus. Neuropsychopharmacology. 2012 Jan; 37(2):364-77. PMID: 21956444.
      Citations: 23     Fields:    Translation:HumansAnimalsCells
    154. Li JV, Saric J, Wang Y, Keiser J, Utzinger J, Holmes E. Chemometric analysis of biofluids from mice experimentally infected with Schistosoma mansoni. Parasit Vectors. 2011 Sep 19; 4:179. PMID: 21929782.
      Citations: 7     Fields:    Translation:Animals
    155. Edmands WM, Beckonert OP, Stella C, Campbell A, Lake BG, Lindon JC, Holmes E, Gooderham NJ. Identification of human urinary biomarkers of cruciferous vegetable consumption by metabonomic profiling. J Proteome Res. 2011 Oct 07; 10(10):4513-21. PMID: 21770373.
      Citations: 18     Fields:    Translation:HumansAnimals
    156. Nicholson G, Rantalainen M, Maher AD, Li JV, Malmodin D, Ahmadi KR, Faber JH, Hallgrímsdóttir IB, Barrett A, Toft H, Krestyaninova M, Viksna J, Neogi SG, Dumas ME, Sarkans U, Silverman BW, Donnelly P, Nicholson JK, Allen M, Zondervan KT, Lindon JC, Spector TD, McCarthy MI, Holmes E, Baunsgaard D, Holmes CC. Human metabolic profiles are stably controlled by genetic and environmental variation. Mol Syst Biol. 2011 Aug 30; 7:525. PMID: 21878913.
      Citations: 57     Fields:    Translation:Humans
    157. Merrifield CA, Lewis M, Claus SP, Beckonert OP, Dumas ME, Duncker S, Kochhar S, Rezzi S, Lindon JC, Bailey M, Holmes E, Nicholson JK. A metabolic system-wide characterisation of the pig: a model for human physiology. Mol Biosyst. 2011 Sep; 7(9):2577-88. PMID: 21761043.
      Citations: 31     Fields:    Translation:HumansAnimals
    158. Legido-Quigley C, McDermott L, Vilca-Melendez H, Murphy GM, Heaton N, Lindon JC, Nicholson JK, Holmes E. Bile UPLC-MS fingerprinting and bile acid fluxes during human liver transplantation. Electrophoresis. 2011 Aug; 32(15):2063-70. PMID: 21732555.
      Citations: 14     Fields:    Translation:Humans
    159. Veselkov KA, Vingara LK, Masson P, Robinette SL, Want E, Li JV, Barton RH, Boursier-Neyret C, Walther B, Ebbels TM, Pelczer I, Holmes E, Lindon JC, Nicholson JK. Optimized preprocessing of ultra-performance liquid chromatography/mass spectrometry urinary metabolic profiles for improved information recovery. Anal Chem. 2011 Aug 01; 83(15):5864-72. PMID: 21526840.
      Citations: 69     Fields:    Translation:Animals
    160. Swann JR, Tuohy KM, Lindfors P, Brown DT, Gibson GR, Wilson ID, Sidaway J, Nicholson JK, Holmes E. Variation in antibiotic-induced microbial recolonization impacts on the host metabolic phenotypes of rats. J Proteome Res. 2011 Aug 05; 10(8):3590-603. PMID: 21591676.
      Citations: 46     Fields:    Translation:AnimalsCells
    161. Holmes E, Li JV, Athanasiou T, Ashrafian H, Nicholson JK. Understanding the role of gut microbiome-host metabolic signal disruption in health and disease. Trends Microbiol. 2011 Jul; 19(7):349-59. PMID: 21684749.
      Citations: 148     Fields:    Translation:HumansAnimalsCells
    162. Kinross JM, Holmes E, Darzi AW, Nicholson JK. Metabolic phenotyping for monitoring surgical patients. Lancet. 2011 May 28; 377(9780):1817-9. PMID: 21596428.
      Citations: 21     Fields:    Translation:HumansAnimals
    163. Li JV, Ashrafian H, Bueter M, Kinross J, Sands C, le Roux CW, Bloom SR, Darzi A, Athanasiou T, Marchesi JR, Nicholson JK, Holmes E. Metabolic surgery profoundly influences gut microbial-host metabolic cross-talk. Gut. 2011 Sep; 60(9):1214-23. PMID: 21572120.
      Citations: 165     Fields:    Translation:Animals
    164. Fonville JM, Bylesjö M, Coen M, Nicholson JK, Holmes E, Lindon JC, Rantalainen M. Non-linear modeling of 1H NMR metabonomic data using kernel-based orthogonal projections to latent structures optimized by simulated annealing. Anal Chim Acta. 2011 Oct 31; 705(1-2):72-80. PMID: 21962350.
      Citations: 2     Fields:    
    165. Sands CJ, Coen M, Ebbels TM, Holmes E, Lindon JC, Nicholson JK. Data-driven approach for metabolite relationship recovery in biological 1H NMR data sets using iterative statistical total correlation spectroscopy. Anal Chem. 2011 Mar 15; 83(6):2075-82. PMID: 21323345.
      Citations: 7     Fields:    Translation:Animals
    166. Li JV, Saric J, Wang Y, Utzinger J, Holmes E, Balmer O. Metabonomic investigation of single and multiple strain Trypanosoma brucei brucei infections. Am J Trop Med Hyg. 2011 Jan; 84(1):91-8. PMID: 21212208.
      Citations: 2     Fields:    Translation:HumansAnimals
    167. Gavaghan CL, Li JV, Hadfield ST, Hole S, Nicholson JK, Wilson ID, Howe PW, Stanley PD, Holmes E. Application of NMR-based metabolomics to the investigation of salt stress in maize (Zea mays). Phytochem Anal. 2011 May-Jun; 22(3):214-24. PMID: 21204151.
      Citations: 19     Fields:    Translation:Animals
    168. Spagou K, Wilson ID, Masson P, Theodoridis G, Raikos N, Coen M, Holmes E, Lindon JC, Plumb RS, Nicholson JK, Want EJ. HILIC-UPLC-MS for exploratory urinary metabolic profiling in toxicological studies. Anal Chem. 2011 Jan 01; 83(1):382-90. PMID: 21142126.
      Citations: 27     Fields:    Translation:Animals
    169. Chadeau-Hyam M, Athersuch TJ, Keun HC, De Iorio M, Ebbels TM, Jenab M, Sacerdote C, Bruce SJ, Holmes E, Vineis P. Meeting-in-the-middle using metabolic profiling - a strategy for the identification of intermediate biomarkers in cohort studies. Biomarkers. 2011 Feb; 16(1):83-8. PMID: 21114379.
      Citations: 31     Fields:    Translation:Humans
    170. Ashrafian H, Ahmed K, Rowland SP, Patel VM, Gooderham NJ, Holmes E, Darzi A, Athanasiou T. Metabolic surgery and cancer: protective effects of bariatric procedures. Cancer. 2011 May 01; 117(9):1788-99. PMID: 21509756.
      Citations: 50     Fields:    Translation:Humans
    171. Kinross JM, Alkhamesi N, Barton RH, Silk DB, Yap IK, Darzi AW, Holmes E, Nicholson JK. Global metabolic phenotyping in an experimental laparotomy model of surgical trauma. J Proteome Res. 2011 Jan 07; 10(1):277-87. PMID: 21105667.
      Citations: 13     Fields:    Translation:Animals
    172. Yap IK, Brown IJ, Chan Q, Wijeyesekera A, Garcia-Perez I, Bictash M, Loo RL, Chadeau-Hyam M, Ebbels T, De Iorio M, Maibaum E, Zhao L, Kesteloot H, Daviglus ML, Stamler J, Nicholson JK, Elliott P, Holmes E. Metabolome-wide association study identifies multiple biomarkers that discriminate north and south Chinese populations at differing risks of cardiovascular disease: INTERMAP study. J Proteome Res. 2010 Dec 03; 9(12):6647-54. PMID: 20853909.
      Citations: 42     Fields:    Translation:Humans
    173. Shipkova P, Vassallo JD, Aranibar N, Hnatyshyn S, Zhang H, Clayton TA, Cantor GH, Sanders M, Coen M, Lindon JC, Holmes E, Nicholson JK, Lehman-McKeeman L. Urinary metabolites of 2-bromoethanamine identified by stable isotope labelling: evidence for carbamoylation and glutathione conjugation. Xenobiotica. 2011 Feb; 41(2):144-54. PMID: 21043805.
      Citations:    Fields:    Translation:Animals
    174. Vecht JA, Saso S, Rao C, Dimopoulos K, Grapsa J, Terracciano CM, Peters NS, Nihoyannopoulos P, Holmes E, Gatzoulis MA, Athanasiou T. Atrial septal defect closure is associated with a reduced prevalence of atrial tachyarrhythmia in the short to medium term: a systematic review and meta-analysis. Heart. 2010 Nov; 96(22):1789-97. PMID: 20965992.
      Citations: 16     Fields:    Translation:Humans
    175. Swann JR, Want EJ, Geier FM, Spagou K, Wilson ID, Sidaway JE, Nicholson JK, Holmes E. Systemic gut microbial modulation of bile acid metabolism in host tissue compartments. Proc Natl Acad Sci U S A. 2011 Mar 15; 108 Suppl 1:4523-30. PMID: 20837534.
      Citations: 233     Fields:    Translation:AnimalsCells
    176. Chadeau-Hyam M, Ebbels TM, Brown IJ, Chan Q, Stamler J, Huang CC, Daviglus ML, Ueshima H, Zhao L, Holmes E, Nicholson JK, Elliott P, De Iorio M. Metabolic profiling and the metabolome-wide association study: significance level for biomarker identification. J Proteome Res. 2010 Sep 03; 9(9):4620-7. PMID: 20701291.
      Citations: 36     Fields:    Translation:Humans
    177. Veselkov KA, Pahomov VI, Lindon JC, Volynkin VS, Crockford D, Osipenko GS, Davies DB, Barton RH, Bang JW, Holmes E, Nicholson JK. A metabolic entropy approach for measurements of systemic metabolic disruptions in patho-physiological States. J Proteome Res. 2010 Jul 02; 9(7):3537-44. PMID: 20423051.
      Citations: 2     Fields:    Translation:Animals
    178. Legido-Quigley C, Stella C, Perez-Jimenez F, Lopez-Miranda J, Ordovas J, Powell J, van-der-Ouderaa F, Ware L, Lindon JC, Nicholson JK, Holmes E. Liquid chromatography-mass spectrometry methods for urinary biomarker detection in metabonomic studies with application to nutritional studies. Biomed Chromatogr. 2010 Jul; 24(7):737-43. PMID: 19908208.
      Citations: 7     Fields:    Translation:Humans
    179. Saric J, Li JV, Utzinger J, Wang Y, Keiser J, Dirnhofer S, Beckonert O, Sharabiani MT, Fonville JM, Nicholson JK, Holmes E. Systems parasitology: effects of Fasciola hepatica on the neurochemical profile in the rat brain. Mol Syst Biol. 2010 Jul; 6:396. PMID: 20664642.
      Citations: 13     Fields:    Translation:Animals
    180. Garcia-Perez I, Angulo S, Utzinger J, Holmes E, Legido-Quigley C, Barbas C. Chemometric and biological validation of a capillary electrophoresis metabolomic experiment of Schistosoma mansoni infection in mice. Electrophoresis. 2010 Jul; 31(14):2338-48. PMID: 20583011.
      Citations: 3     Fields:    Translation:Animals
    181. Heinzmann SS, Brown IJ, Chan Q, Bictash M, Dumas ME, Kochhar S, Stamler J, Holmes E, Elliott P, Nicholson JK. Metabolic profiling strategy for discovery of nutritional biomarkers: proline betaine as a marker of citrus consumption. Am J Clin Nutr. 2010 Aug; 92(2):436-43. PMID: 20573794.
      Citations: 53     Fields:    Translation:HumansAnimalsCTClinical Trials
    182. Want EJ, Coen M, Masson P, Keun HC, Pearce JT, Reily MD, Robertson DG, Rohde CM, Holmes E, Lindon JC, Plumb RS, Nicholson JK. Ultra performance liquid chromatography-mass spectrometry profiling of bile acid metabolites in biofluids: application to experimental toxicology studies. Anal Chem. 2010 Jun 15; 82(12):5282-9. PMID: 20469835.
      Citations: 14     Fields:    Translation:Animals
    183. Yap IK, Angley M, Veselkov KA, Holmes E, Lindon JC, Nicholson JK. Urinary metabolic phenotyping differentiates children with autism from their unaffected siblings and age-matched controls. J Proteome Res. 2010 Jun 04; 9(6):2996-3004. PMID: 20337404.
      Citations: 101     Fields:    Translation:Humans
    184. Want EJ, Wilson ID, Gika H, Theodoridis G, Plumb RS, Shockcor J, Holmes E, Nicholson JK. Global metabolic profiling procedures for urine using UPLC-MS. Nat Protoc. 2010 Jun; 5(6):1005-18. PMID: 20448546.
      Citations: 210     Fields:    Translation:HumansCells
    185. Beckonert O, Coen M, Keun HC, Wang Y, Ebbels TM, Holmes E, Lindon JC, Nicholson JK. High-resolution magic-angle-spinning NMR spectroscopy for metabolic profiling of intact tissues. Nat Protoc. 2010 Jun; 5(6):1019-32. PMID: 20539278.
      Citations: 97     Fields:    Translation:HumansAnimals
    186. Saric J, Li JV, Swann JR, Utzinger J, Calvert G, Nicholson JK, Dirnhofer S, Dallman MJ, Bictash M, Holmes E. Integrated cytokine and metabolic analysis of pathological responses to parasite exposure in rodents. J Proteome Res. 2010 May 07; 9(5):2255-64. PMID: 20092362.
      Citations: 15     Fields:    Translation:Animals
    187. Fonville JM, Maher AD, Coen M, Holmes E, Lindon JC, Nicholson JK. Evaluation of full-resolution J-resolved 1H NMR projections of biofluids for metabonomics information retrieval and biomarker identification. Anal Chem. 2010 Mar 01; 82(5):1811-21. PMID: 20131799.
      Citations: 25     Fields:    Translation:Animals
    188. Dominiczak AF, Herget-Rosenthal S, Delles C, Fliser D, Fournier I, Graber A, Girolami M, Holmes E, Lang F, Molina F, Nicholson J, Remuzzi G, Rossing P, Rudolph KL, Wolkenhauer O, Xenarios I, Zubarev R, Zubov D, Vlahou A, Schanstra JP. Systems biology to battle vascular disease. Nephrol Dial Transplant. 2010 Apr; 25(4):1019-22. PMID: 20133282.
      Citations: 6     Fields:    Translation:Humans
    189. Bictash M, Ebbels TM, Chan Q, Loo RL, Yap IK, Brown IJ, de Iorio M, Daviglus ML, Holmes E, Stamler J, Nicholson JK, Elliott P. Opening up the "Black Box": metabolic phenotyping and metabolome-wide association studies in epidemiology. J Clin Epidemiol. 2010 Sep; 63(9):970-9. PMID: 20056386.
      Citations: 60     Fields:    Translation:Humans
    190. Wang Y, Li JV, Saric J, Keiser J, Wu J, Utzinger J, Holmes E. Advances in metabolic profiling of experimental nematode and trematode infections. Adv Parasitol. 2010; 73:373-404. PMID: 20627148.
      Citations: 9     Fields:    Translation:HumansAnimals
    191. Wang Y, Xiao SH, Xue J, Singer BH, Utzinger J, Holmes E. Systems metabolic effects of a necator americanus infection in Syrian hamster. J Proteome Res. 2009 Dec; 8(12):5442-50. PMID: 19810771.
      Citations: 8     Fields:    Translation:Animals
    192. Legido-Quigley C, Cloarec O, Parker DA, Murphy GM, Holmes E, Lindon JC, Nicholson JK, Mitry RR, Vilca-Melendez H, Rela M, Dhawan A, Heaton N. First example of hepatocyte transplantation to alleviate ornithine transcarbamylase deficiency, monitored by NMR-based metabonomics. Bioanalysis. 2009 Dec; 1(9):1527-35. PMID: 21083101.
      Citations: 3     Fields:    Translation:HumansCells
    193. Bohus E, Rácz A, Noszál B, Coen M, Beckonert O, Keun HC, Ebbels TM, Cantor GH, Wijsman JA, Holmes E, Lindon JC, Nicholson JK. Metabonomic investigations into the global biochemical sequelae of exposure to the pancreatic toxin 1-cyano-2-hydroxy-3-butene in the rat. Magn Reson Chem. 2009 Dec; 47 Suppl 1:S26-35. PMID: 19639609.
      Citations: 6     Fields:    Translation:AnimalsCells
    194. Hong YS, Coen M, Rhode CM, Reily MD, Robertson DG, Holmes E, Lindon JC, Nicholson JK. Chemical shift calibration of 1H MAS NMR liver tissue spectra exemplified using a study of glycine protection of galactosamine toxicity. Magn Reson Chem. 2009 Dec; 47 Suppl 1:S47-53. PMID: 19856339.
      Citations: 3     Fields:    Translation:Animals
    195. Wu JF, Holmes E, Xue J, Xiao SH, Singer BH, Tang HR, Utzinger J, Wang YL. Metabolic alterations in the hamster co-infected with Schistosoma japonicum and Necator americanus. Int J Parasitol. 2010 May; 40(6):695-703. PMID: 19951707.
      Citations: 12     Fields:    Translation:Animals
    196. Coen M, Want EJ, Clayton TA, Rhode CM, Hong YS, Keun HC, Cantor GH, Metz AL, Robertson DG, Reily MD, Holmes E, Lindon JC, Nicholson JK. Mechanistic aspects and novel biomarkers of responder and non-responder phenotypes in galactosamine-induced hepatitis. J Proteome Res. 2009 Nov; 8(11):5175-87. PMID: 19821561.
      Citations: 6     Fields:    Translation:HumansAnimalsCells
    197. Barton RH, Waterman D, Bonner FW, Holmes E, Clarke R, Nicholson JK, Lindon JC. The influence of EDTA and citrate anticoagulant addition to human plasma on information recovery from NMR-based metabolic profiling studies. Mol Biosyst. 2010 Jan; 6(1):215-24. PMID: 20024083.
      Citations: 18     Fields:    Translation:Humans
    198. Sands CJ, Coen M, Maher AD, Ebbels TM, Holmes E, Lindon JC, Nicholson JK. Statistical total correlation spectroscopy editing of 1H NMR spectra of biofluids: application to drug metabolite profile identification and enhanced information recovery. Anal Chem. 2009 Aug 01; 81(15):6458-66. PMID: 19580292.
      Citations: 7     Fields:    Translation:HumansAnimals
    199. Saric J, Li JV, Wang Y, Keiser J, Veselkov K, Dirnhofer S, Yap IK, Nicholson JK, Holmes E, Utzinger J. Panorganismal metabolic response modeling of an experimental Echinostoma caproni infection in the mouse. J Proteome Res. 2009 Aug; 8(8):3899-911. PMID: 19489577.
      Citations: 9     Fields:    Translation:Animals
    200. Martin FP, Wang Y, Yap IK, Sprenger N, Lindon JC, Rezzi S, Kochhar S, Holmes E, Nicholson JK. Topographical variation in murine intestinal metabolic profiles in relation to microbiome speciation and functional ecological activity. J Proteome Res. 2009 Jul; 8(7):3464-74. PMID: 19492798.
      Citations: 15     Fields:    Translation:Animals
    201. Loo RL, Coen M, Ebbels T, Cloarec O, Maibaum E, Bictash M, Yap I, Elliott P, Stamler J, Nicholson JK, Holmes E. Metabolic profiling and population screening of analgesic usage in nuclear magnetic resonance spectroscopy-based large-scale epidemiologic studies. Anal Chem. 2009 Jul 01; 81(13):5119-29. PMID: 19489597.
      Citations: 9     Fields:    Translation:Humans
    202. Smith LM, Maher AD, Want EJ, Elliott P, Stamler J, Hawkes GE, Holmes E, Lindon JC, Nicholson JK. Large-scale human metabolic phenotyping and molecular epidemiological studies via 1H NMR spectroscopy of urine: investigation of borate preservation. Anal Chem. 2009 Jun 15; 81(12):4847-56. PMID: 19453167.
      Citations: 12     Fields:    Translation:Humans
    203. Waldram A, Holmes E, Wang Y, Rantalainen M, Wilson ID, Tuohy KM, McCartney AL, Gibson GR, Nicholson JK. Top-down systems biology modeling of host metabotype-microbiome associations in obese rodents. J Proteome Res. 2009 May; 8(5):2361-75. PMID: 19275195.
      Citations: 81     Fields:    Translation:AnimalsCells
    204. McLoughlin GA, Ma D, Tsang TM, Jones DN, Cilia J, Hill MD, Robbins MJ, Benzel IM, Maycox PR, Holmes E, Bahn S. Analyzing the effects of psychotropic drugs on metabolite profiles in rat brain using 1H NMR spectroscopy. J Proteome Res. 2009 Apr; 8(4):1943-52. PMID: 19714815.
      Citations: 27     Fields:    Translation:AnimalsCells
    205. Martin FP, Sprenger N, Yap IK, Wang Y, Bibiloni R, Rochat F, Rezzi S, Cherbut C, Kochhar S, Lindon JC, Holmes E, Nicholson JK. Panorganismal gut microbiome-host metabolic crosstalk. J Proteome Res. 2009 Apr; 8(4):2090-105. PMID: 19281268.
      Citations: 43     Fields:    Translation:HumansAnimals
    206. Kinross J, Warren O, Basson S, Holmes E, Silk D, Darzi A, Nicholson JK. Intestinal ischemia/reperfusion injury: defining the role of the gut microbiome. Biomark Med. 2009 Apr; 3(2):175-92. PMID: 20477509.
      Citations: 7     Fields:    
    207. Alves AC, Rantalainen M, Holmes E, Nicholson JK, Ebbels TM. Analytic properties of statistical total correlation spectroscopy based information recovery in 1H NMR metabolic data sets. Anal Chem. 2009 Mar 15; 81(6):2075-84. PMID: 19220030.
      Citations: 12     Fields:    Translation:Animals
    208. Swann J, Wang Y, Abecia L, Costabile A, Tuohy K, Gibson G, Roberts D, Sidaway J, Jones H, Wilson ID, Nicholson J, Holmes E. Gut microbiome modulates the toxicity of hydrazine: a metabonomic study. Mol Biosyst. 2009 Apr; 5(4):351-5. PMID: 19396371.
      Citations: 18     Fields:    Translation:Animals
    209. Maher AD, Cloarec O, Patki P, Craggs M, Holmes E, Lindon JC, Nicholson JK. Dynamic biochemical information recovery in spontaneous human seminal fluid reactions via 1H NMR kinetic statistical total correlation spectroscopy. Anal Chem. 2009 Jan 01; 81(1):288-95. PMID: 19117456.
      Citations: 8     Fields:    Translation:Humans
    210. Veselkov KA, Lindon JC, Ebbels TM, Crockford D, Volynkin VV, Holmes E, Davies DB, Nicholson JK. Recursive segment-wise peak alignment of biological (1)h NMR spectra for improved metabolic biomarker recovery. Anal Chem. 2009 Jan 01; 81(1):56-66. PMID: 19049366.
      Citations: 77     Fields:    Translation:Animals
    211. Kinross J, von Roon AC, Penney N, Holmes E, Silk D, Nicholson JK, Darzi A. The gut microbiota as a target for improved surgical outcome and improved patient care. Curr Pharm Des. 2009; 15(13):1537-45. PMID: 19442171.
      Citations: 11     Fields:    Translation:HumansAnimals
    212. Duarte IF, Legido-Quigley C, Parker DA, Swann JR, Spraul M, Braumann U, Gil AM, Holmes E, Nicholson JK, Murphy GM, Vilca-Melendez H, Heaton N, Lindon JC. Identification of metabolites in human hepatic bile using 800 MHz 1H NMR spectroscopy, HPLC-NMR/MS and UPLC-MS. Mol Biosyst. 2009 Feb; 5(2):180-90. PMID: 19156264.
      Citations: 7     Fields:    Translation:Humans
    213. Cavill R, Keun HC, Holmes E, Lindon JC, Nicholson JK, Ebbels TM. Genetic algorithms for simultaneous variable and sample selection in metabonomics. Bioinformatics. 2009 Jan 01; 25(1):112-8. PMID: 19010803.
      Citations: 12     Fields:    Translation:Animals
    214. Li JV, Holmes E, Saric J, Keiser J, Dirnhofer S, Utzinger J, Wang Y. Metabolic profiling of a Schistosoma mansoni infection in mouse tissues using magic angle spinning-nuclear magnetic resonance spectroscopy. Int J Parasitol. 2009 Apr; 39(5):547-58. PMID: 19068218.
      Citations: 22     Fields:    Translation:Animals
    215. Claus SP, Tsang TM, Wang Y, Cloarec O, Skordi E, Martin FP, Rezzi S, Ross A, Kochhar S, Holmes E, Nicholson JK. Systemic multicompartmental effects of the gut microbiome on mouse metabolic phenotypes. Mol Syst Biol. 2008; 4:219. PMID: 18854818.
      Citations: 115     Fields:    Translation:Animals
    216. Maher AD, Patki P, Lindon JC, Want EJ, Holmes E, Craggs M, Nicholson JK. Seminal oligouridinosis: low uridine secretion as a biomarker for infertility in spinal neurotrauma. Clin Chem. 2008 Dec; 54(12):2063-6. PMID: 18832471.
      Citations: 5     Fields:    Translation:Humans
    217. Holmes E, Wilson ID, Nicholson JK. Metabolic phenotyping in health and disease. Cell. 2008 Sep 05; 134(5):714-7. PMID: 18775301.
      Citations: 243     Fields:    Translation:Humans
    218. Papaspyridonos K, Garcia-Perez I, Angulo S, Domann PJ, Vilca-Melendez H, Heaton N, Murphy GM, Holmes E, Barbas C, Legido-Quigley C. Fingerprinting of human bile during liver transplantation by capillary electrophoresis. J Sep Sci. 2008 Sep; 31(16-17):3058-64. PMID: 18693311.
      Citations: 1     Fields:    Translation:Humans
    219. Maher AD, Crockford D, Toft H, Malmodin D, Faber JH, McCarthy MI, Barrett A, Allen M, Walker M, Holmes E, Lindon JC, Nicholson JK. Optimization of human plasma 1H NMR spectroscopic data processing for high-throughput metabolic phenotyping studies and detection of insulin resistance related to type 2 diabetes. Anal Chem. 2008 Oct 01; 80(19):7354-62. PMID: 18759460.
      Citations: 16     Fields:    Translation:Humans
    220. Bohus E, Coen M, Keun HC, Ebbels TM, Beckonert O, Lindon JC, Holmes E, Noszál B, Nicholson JK. Temporal metabonomic modeling of l-arginine-induced exocrine pancreatitis. J Proteome Res. 2008 Oct; 7(10):4435-45. PMID: 18710274.
      Citations: 11     Fields:    Translation:HumansAnimals
    221. Nicholson JK, Holmes E, Elliott P. The metabolome-wide association study: a new look at human disease risk factors. J Proteome Res. 2008 Sep; 7(9):3637-8. PMID: 18707153.
      Citations: 31     Fields:    Translation:Humans
    222. Yap IK, Li JV, Saric J, Martin FP, Davies H, Wang Y, Wilson ID, Nicholson JK, Utzinger J, Marchesi JR, Holmes E. Metabonomic and microbiological analysis of the dynamic effect of vancomycin-induced gut microbiota modification in the mouse. J Proteome Res. 2008 Sep; 7(9):3718-28. PMID: 18698804.
      Citations: 75     Fields:    Translation:AnimalsCells
    223. Khaitovich P, Lockstone HE, Wayland MT, Tsang TM, Jayatilaka SD, Guo AJ, Zhou J, Somel M, Harris LW, Holmes E, Pääbo S, Bahn S. Metabolic changes in schizophrenia and human brain evolution. Genome Biol. 2008; 9(8):R124. PMID: 18681948.
      Citations: 34     Fields:    Translation:HumansAnimals
    224. Kinross JM, von Roon AC, Holmes E, Darzi A, Nicholson JK. The human gut microbiome: implications for future health care. Curr Gastroenterol Rep. 2008 Aug; 10(4):396-403. PMID: 18627653.
      Citations: 45     Fields:    Translation:HumansAnimalsCells
    225. Li JV, Wang Y, Saric J, Nicholson JK, Dirnhofer S, Singer BH, Tanner M, Wittlin S, Holmes E, Utzinger J. Global metabolic responses of NMRI mice to an experimental Plasmodium berghei infection. J Proteome Res. 2008 Sep; 7(9):3948-56. PMID: 18646786.
      Citations: 32     Fields:    Translation:Animals
    226. Martin FP, Wang Y, Sprenger N, Yap IK, Rezzi S, Ramadan Z, Peré-Trepat E, Rochat F, Cherbut C, van Bladeren P, Fay LB, Kochhar S, Lindon JC, Holmes E, Nicholson JK. Top-down systems biology integration of conditional prebiotic modulated transgenomic interactions in a humanized microbiome mouse model. Mol Syst Biol. 2008; 4:205. PMID: 18628745.
      Citations: 25     Fields:    Translation:HumansAnimalsCells
    227. Saric J, Li JV, Wang Y, Keiser J, Bundy JG, Holmes E, Utzinger J. Metabolic profiling of an Echinostoma caproni infection in the mouse for biomarker discovery. PLoS Negl Trop Dis. 2008 Jul 02; 2(7):e254. PMID: 18596973.
      Citations: 18     Fields:    Translation:HumansAnimals
    228. Richards SE, Wang Y, Lawler D, Kochhar S, Holmes E, Lindon JC, Nicholson JK. Self-modeling curve resolution recovery of temporal metabolite signal modulation in NMR spectroscopic data sets: application to a life-long caloric restriction study in dogs. Anal Chem. 2008 Jul 01; 80(13):4876-85. PMID: 18510345.
      Citations: 4     Fields:    Translation:Animals
    229. Holmes E, Loo RL, Stamler J, Bictash M, Yap IK, Chan Q, Ebbels T, De Iorio M, Brown IJ, Veselkov KA, Daviglus ML, Kesteloot H, Ueshima H, Zhao L, Nicholson JK, Elliott P. Human metabolic phenotype diversity and its association with diet and blood pressure. Nature. 2008 May 15; 453(7193):396-400. PMID: 18425110.
      Citations: 312     Fields:    Translation:HumansAnimals
    230. Wang Y, Utzinger J, Saric J, Li JV, Burckhardt J, Dirnhofer S, Nicholson JK, Singer BH, Brun R, Holmes E. Global metabolic responses of mice to Trypanosoma brucei brucei infection. Proc Natl Acad Sci U S A. 2008 Apr 22; 105(16):6127-32. PMID: 18413599.
      Citations: 39     Fields:    Translation:HumansAnimals
    231. Barton RH, Nicholson JK, Elliott P, Holmes E. High-throughput 1H NMR-based metabolic analysis of human serum and urine for large-scale epidemiological studies: validation study. Int J Epidemiol. 2008 Apr; 37 Suppl 1:i31-40. PMID: 18381391.
      Citations: 39     Fields:    Translation:Humans
    232. Scanlan PD, Shanahan F, Clune Y, Collins JK, O'Sullivan GC, O'Riordan M, Holmes E, Wang Y, Marchesi JR. Culture-independent analysis of the gut microbiota in colorectal cancer and polyposis. Environ Microbiol. 2008 Mar; 10(3):789-98. PMID: 18237311.
      Citations: 86     Fields:    Translation:HumansCells
    233. Fearnside JF, Dumas ME, Rothwell AR, Wilder SP, Cloarec O, Toye A, Blancher C, Holmes E, Tatoud R, Barton RH, Scott J, Nicholson JK, Gauguier D. Phylometabonomic patterns of adaptation to high fat diet feeding in inbred mice. PLoS One. 2008 Feb 27; 3(2):e1668. PMID: 18301746.
      Citations: 44     Fields:    Translation:Animals
    234. Rantalainen M, Cloarec O, Ebbels TM, Lundstedt T, Nicholson JK, Holmes E, Trygg J. Piecewise multivariate modelling of sequential metabolic profiling data. BMC Bioinformatics. 2008 Feb 19; 9:105. PMID: 18284665.
      Citations: 10     Fields:    Translation:Animals
    235. Bylesjö M, Rantalainen M, Nicholson JK, Holmes E, Trygg J. K-OPLS package: kernel-based orthogonal projections to latent structures for prediction and interpretation in feature space. BMC Bioinformatics. 2008 Feb 19; 9:106. PMID: 18284666.
      Citations: 16     Fields:    Translation:Cells
    236. Li M, Wang B, Zhang M, Rantalainen M, Wang S, Zhou H, Zhang Y, Shen J, Pang X, Zhang M, Wei H, Chen Y, Lu H, Zuo J, Su M, Qiu Y, Jia W, Xiao C, Smith LM, Yang S, Holmes E, Tang H, Zhao G, Nicholson JK, Li L, Zhao L. Symbiotic gut microbes modulate human metabolic phenotypes. Proc Natl Acad Sci U S A. 2008 Feb 12; 105(6):2117-22. PMID: 18252821.
      Citations: 364     Fields:    Translation:HumansCells
    237. Keun HC, Athersuch TJ, Beckonert O, Wang Y, Saric J, Shockcor JP, Lindon JC, Wilson ID, Holmes E, Nicholson JK. Heteronuclear 19F-1H statistical total correlation spectroscopy as a tool in drug metabolism: study of flucloxacillin biotransformation. Anal Chem. 2008 Feb 15; 80(4):1073-9. PMID: 18211034.
      Citations: 7     Fields:    Translation:Humans
    238. Wang Y, Cloarec O, Tang H, Lindon JC, Holmes E, Kochhar S, Nicholson JK. Magic angle spinning NMR and 1H-31P heteronuclear statistical total correlation spectroscopy of intact human gut biopsies. Anal Chem. 2008 Feb 15; 80(4):1058-66. PMID: 18205334.
      Citations: 9     Fields:    Translation:Humans
    239. Martin FP, Wang Y, Sprenger N, Yap IK, Lundstedt T, Lek P, Rezzi S, Ramadan Z, van Bladeren P, Fay LB, Kochhar S, Lindon JC, Holmes E, Nicholson JK. Probiotic modulation of symbiotic gut microbial-host metabolic interactions in a humanized microbiome mouse model. Mol Syst Biol. 2008; 4:157. PMID: 18197175.
      Citations: 125     Fields:    Translation:HumansAnimals
    240. Bang JW, Crockford DJ, Holmes E, Pazos F, Sternberg MJ, Muggleton SH, Nicholson JK. Integrative top-down system metabolic modeling in experimental disease states via data-driven Bayesian methods. J Proteome Res. 2008 Feb; 7(2):497-503. PMID: 18179164.
      Citations: 6     Fields:    Translation:Animals
    241. Coen M, Holmes E, Lindon JC, Nicholson JK. NMR-based metabolic profiling and metabonomic approaches to problems in molecular toxicology. Chem Res Toxicol. 2008 Jan; 21(1):9-27. PMID: 18171018.
      Citations: 74     Fields:    Translation:HumansAnimals
    242. Saric J, Wang Y, Li J, Coen M, Utzinger J, Marchesi JR, Keiser J, Veselkov K, Lindon JC, Nicholson JK, Holmes E. Species variation in the fecal metabolome gives insight into differential gastrointestinal function. J Proteome Res. 2008 Jan; 7(1):352-60. PMID: 18052033.
      Citations: 49     Fields:    Translation:HumansAnimals
    243. Coen M, Hong YS, Cloarec O, Rhode CM, Reily MD, Robertson DG, Holmes E, Lindon JC, Nicholson JK. Heteronuclear 1H-31P statistical total correlation NMR spectroscopy of intact liver for metabolic biomarker assignment: application to galactosamine-induced hepatotoxicity. Anal Chem. 2007 Dec 01; 79(23):8956-66. PMID: 17973499.
      Citations: 7     Fields:    Translation:Animals
    244. Skordi E, Yap IK, Claus SP, Martin FP, Cloarec O, Lindberg J, Schuppe-Koistinen I, Holmes E, Nicholson JK. Analysis of time-related metabolic fluctuations induced by ethionine in the rat. J Proteome Res. 2007 Dec; 6(12):4572-81. PMID: 17966971.
      Citations: 7     Fields:    Translation:AnimalsCells
    245. Ebbels TM, Keun HC, Beckonert OP, Bollard ME, Lindon JC, Holmes E, Nicholson JK. Prediction and classification of drug toxicity using probabilistic modeling of temporal metabolic data: the consortium on metabonomic toxicology screening approach. J Proteome Res. 2007 Nov; 6(11):4407-22. PMID: 17915905.
      Citations: 16     Fields:    Translation:HumansAnimals
    246. Huang JT, Leweke FM, Tsang TM, Koethe D, Kranaster L, Gerth CW, Gross S, Schreiber D, Ruhrmann S, Schultze-Lutter F, Klosterkötter J, Holmes E, Bahn S. CSF metabolic and proteomic profiles in patients prodromal for psychosis. PLoS One. 2007 Aug 22; 2(8):e756. PMID: 17712404.
      Citations: 26     Fields:    Translation:Humans
    247. Wang Y, Holmes E, Comelli EM, Fotopoulos G, Dorta G, Tang H, Rantalainen MJ, Lindon JC, Corthésy-Theulaz IE, Fay LB, Kochhar S, Nicholson JK. Topographical variation in metabolic signatures of human gastrointestinal biopsies revealed by high-resolution magic-angle spinning 1H NMR spectroscopy. J Proteome Res. 2007 Oct; 6(10):3944-51. PMID: 17711324.
      Citations: 19     Fields:    Translation:Humans
    248. Smith LM, Maher AD, Cloarec O, Rantalainen M, Tang H, Elliott P, Stamler J, Lindon JC, Holmes E, Nicholson JK. Statistical correlation and projection methods for improved information recovery from diffusion-edited NMR spectra of biological samples. Anal Chem. 2007 Aug 01; 79(15):5682-9. PMID: 17585837.
      Citations: 10     Fields:    Translation:HumansCells
    249. Li J, Wang Y, Fenwick A, Clayton TA, Lau YY, Legido-Quigley C, Lindon JC, Utzinger J, Holmes E. A high-performance liquid chromatography and nuclear magnetic resonance spectroscopy-based analysis of commercially available praziquantel tablets. J Pharm Biomed Anal. 2007 Oct 18; 45(2):263-7. PMID: 17659859.
      Citations: 2     Fields:    Translation:Cells
    250. Maher AD, Zirah SF, Holmes E, Nicholson JK. Experimental and analytical variation in human urine in 1H NMR spectroscopy-based metabolic phenotyping studies. Anal Chem. 2007 Jul 15; 79(14):5204-11. PMID: 17555297.
      Citations: 24     Fields:    Translation:HumansCells
    251. Martin FP, Dumas ME, Wang Y, Legido-Quigley C, Yap IK, Tang H, Zirah S, Murphy GM, Cloarec O, Lindon JC, Sprenger N, Fay LB, Kochhar S, van Bladeren P, Holmes E, Nicholson JK. A top-down systems biology view of microbiome-mammalian metabolic interactions in a mouse model. Mol Syst Biol. 2007; 3:112. PMID: 17515922.
      Citations: 156     Fields:    Translation:HumansAnimals
    252. Vilasi A, Cutillas PR, Maher AD, Zirah SF, Capasso G, Norden AW, Holmes E, Nicholson JK, Unwin RJ. Combined proteomic and metabonomic studies in three genetic forms of the renal Fanconi syndrome. Am J Physiol Renal Physiol. 2007 Aug; 293(2):F456-67. PMID: 17494094.
      Citations: 18     Fields:    Translation:Humans
    253. Teague CR, Dhabhar FS, Barton RH, Beckwith-Hall B, Powell J, Cobain M, Singer B, McEwen BS, Lindon JC, Nicholson JK, Holmes E. Metabonomic studies on the physiological effects of acute and chronic psychological stress in Sprague-Dawley rats. J Proteome Res. 2007 Jun; 6(6):2080-93. PMID: 17474765.
      Citations: 24     Fields:    Translation:Animals
    254. Wang Y, Lawler D, Larson B, Ramadan Z, Kochhar S, Holmes E, Nicholson JK. Metabonomic investigations of aging and caloric restriction in a life-long dog study. J Proteome Res. 2007 May; 6(5):1846-54. PMID: 17411081.
      Citations: 39     Fields:    Translation:HumansAnimals
    255. Lindon JC, Holmes E, Nicholson JK. Metabonomics in pharmaceutical R&D. FEBS J. 2007 Mar; 274(5):1140-51. PMID: 17298438.
      Citations: 59     Fields:    Translation:HumansAnimals
    256. Holmes E, Loo RL, Cloarec O, Coen M, Tang H, Maibaum E, Bruce S, Chan Q, Elliott P, Stamler J, Wilson ID, Lindon JC, Nicholson JK. Detection of urinary drug metabolite (xenometabolome) signatures in molecular epidemiology studies via statistical total correlation (NMR) spectroscopy. Anal Chem. 2007 Apr 01; 79(7):2629-40. PMID: 17323917.
      Citations: 19     Fields:    Translation:HumansCells
    257. Martin FP, Wang Y, Sprenger N, Holmes E, Lindon JC, Kochhar S, Nicholson JK. Effects of probiotic Lactobacillus paracasei treatment on the host gut tissue metabolic profiles probed via magic-angle-spinning NMR spectroscopy. J Proteome Res. 2007 Apr; 6(4):1471-81. PMID: 17316039.
      Citations: 21     Fields:    Translation:AnimalsCells
    258. Trygg J, Holmes E, Lundstedt T. Chemometrics in metabonomics. J Proteome Res. 2007 Feb; 6(2):469-79. PMID: 17269704.
      Citations: 277     Fields:    
    259. Marchesi JR, Holmes E, Khan F, Kochhar S, Scanlan P, Shanahan F, Wilson ID, Wang Y. Rapid and noninvasive metabonomic characterization of inflammatory bowel disease. J Proteome Res. 2007 Feb; 6(2):546-51. PMID: 17269711.
      Citations: 155     Fields:    Translation:Humans
    260. Beckonert O, Keun HC, Ebbels TM, Bundy J, Holmes E, Lindon JC, Nicholson JK. Metabolic profiling, metabolomic and metabonomic procedures for NMR spectroscopy of urine, plasma, serum and tissue extracts. Nat Protoc. 2007; 2(11):2692-703. PMID: 18007604.
      Citations: 538     Fields:    Translation:HumansAnimals
    261. Rantalainen M, Cloarec O, Beckonert O, Wilson ID, Jackson D, Tonge R, Rowlinson R, Rayner S, Nickson J, Wilkinson RW, Mills JD, Trygg J, Nicholson JK, Holmes E. Statistically integrated metabonomic-proteomic studies on a human prostate cancer xenograft model in mice. J Proteome Res. 2006 Oct; 5(10):2642-55. PMID: 17022635.
      Citations: 29     Fields:    Translation:HumansAnimalsCells
    262. Stella C, Beckwith-Hall B, Cloarec O, Holmes E, Lindon JC, Powell J, van der Ouderaa F, Bingham S, Cross AJ, Nicholson JK. Susceptibility of human metabolic phenotypes to dietary modulation. J Proteome Res. 2006 Oct; 5(10):2780-8. PMID: 17022649.
      Citations: 93     Fields:    Translation:Humans
    263. Martin FP, Verdu EF, Wang Y, Dumas ME, Yap IK, Cloarec O, Bergonzelli GE, Corthesy-Theulaz I, Kochhar S, Holmes E, Lindon JC, Collins SM, Nicholson JK. Transgenomic metabolic interactions in a mouse disease model: interactions of Trichinella spiralis infection with dietary Lactobacillus paracasei supplementation. J Proteome Res. 2006 Sep; 5(9):2185-93. PMID: 16944930.
      Citations: 24     Fields:    Translation:AnimalsCells
    264. Dumas ME, Barton RH, Toye A, Cloarec O, Blancher C, Rothwell A, Fearnside J, Tatoud R, Blanc V, Lindon JC, Mitchell SC, Holmes E, McCarthy MI, Scott J, Gauguier D, Nicholson JK. Metabolic profiling reveals a contribution of gut microbiota to fatty liver phenotype in insulin-resistant mice. Proc Natl Acad Sci U S A. 2006 Aug 15; 103(33):12511-6. PMID: 16895997.
      Citations: 339     Fields:    Translation:Animals
    265. Holmes E, Tang H, Wang Y, Seger C. The assessment of plant metabolite profiles by NMR-based methodologies. Planta Med. 2006 Jul; 72(9):771-85. PMID: 16881014.
      Citations: 12     Fields:    Translation:Animals
    266. Craig A, Sidaway J, Holmes E, Orton T, Jackson D, Rowlinson R, Nickson J, Tonge R, Wilson I, Nicholson J. Systems toxicology: integrated genomic, proteomic and metabonomic analysis of methapyrilene induced hepatotoxicity in the rat. J Proteome Res. 2006 Jul; 5(7):1586-601. PMID: 16823966.
      Citations: 32     Fields:    Translation:AnimalsCells
    267. Wang Y, Holmes E, Tang H, Lindon JC, Sprenger N, Turini ME, Bergonzelli G, Fay LB, Kochhar S, Nicholson JK. Experimental metabonomic model of dietary variation and stress interactions. J Proteome Res. 2006 Jul; 5(7):1535-42. PMID: 16823960.
      Citations: 10     Fields:    Translation:Animals
    268. Crockford DJ, Lindon JC, Cloarec O, Plumb RS, Bruce SJ, Zirah S, Rainville P, Stumpf CL, Johnson K, Holmes E, Nicholson JK. Statistical search space reduction and two-dimensional data display approaches for UPLC-MS in biomarker discovery and pathway analysis. Anal Chem. 2006 Jul 01; 78(13):4398-408. PMID: 16808447.
      Citations: 3     Fields:    Translation:Animals
    269. Holmes E, Tsang TM, Tabrizi SJ. The application of NMR-based metabonomics in neurological disorders. NeuroRx. 2006 Jul; 3(3):358-72. PMID: 16815219.
      Citations: 15     Fields:    Translation:HumansAnimals
    270. Teahan O, Gamble S, Holmes E, Waxman J, Nicholson JK, Bevan C, Keun HC. Impact of analytical bias in metabonomic studies of human blood serum and plasma. Anal Chem. 2006 Jul 01; 78(13):4307-18. PMID: 16808437.
      Citations: 54     Fields:    Translation:Humans
    271. Waters NJ, Waterfield CJ, Farrant RD, Holmes E, Nicholson JK. Integrated metabonomic analysis of bromobenzene-induced hepatotoxicity: novel induction of 5-oxoprolinosis. J Proteome Res. 2006 Jun; 5(6):1448-59. PMID: 16739996.
      Citations: 12     Fields:    Translation:Animals
    272. Lindon JC, Holmes E, Nicholson JK. Metabonomics techniques and applications to pharmaceutical research & development. Pharm Res. 2006 Jun; 23(6):1075-88. PMID: 16715371.
      Citations: 60     Fields:    Translation:HumansAnimals
    273. Craig A, Cloarec O, Holmes E, Nicholson JK, Lindon JC. Scaling and normalization effects in NMR spectroscopic metabonomic data sets. Anal Chem. 2006 Apr 01; 78(7):2262-7. PMID: 16579606.
      Citations: 94     Fields:    
    274. Tsang TM, Huang JT, Holmes E, Bahn S. Metabolic profiling of plasma from discordant schizophrenia twins: correlation between lipid signals and global functioning in female schizophrenia patients. J Proteome Res. 2006 Apr; 5(4):756-60. PMID: 16602681.
      Citations: 13     Fields:    Translation:Humans
    275. Dumas ME, Maibaum EC, Teague C, Ueshima H, Zhou B, Lindon JC, Nicholson JK, Stamler J, Elliott P, Chan Q, Holmes E. Assessment of analytical reproducibility of 1H NMR spectroscopy based metabonomics for large-scale epidemiological research: the INTERMAP Study. Anal Chem. 2006 Apr 01; 78(7):2199-208. PMID: 16579598.
      Citations: 72     Fields:    Translation:Humans
    276. Nicholson JK, Holmes E. Global systems biology and personalized healthcare solutions. Discov Med. 2006 Apr; 6(32):63-70. PMID: 17234128.
      Citations: 9     Fields:    Translation:HumansAnimals
    277. Tsang TM, Woodman B, McLoughlin GA, Griffin JL, Tabrizi SJ, Bates GP, Holmes E. Metabolic characterization of the R6/2 transgenic mouse model of Huntington's disease by high-resolution MAS 1H NMR spectroscopy. J Proteome Res. 2006 Mar; 5(3):483-92. PMID: 16512662.
      Citations: 29     Fields:    Translation:Animals
    278. Crockford DJ, Holmes E, Lindon JC, Plumb RS, Zirah S, Bruce SJ, Rainville P, Stumpf CL, Nicholson JK. Statistical heterospectroscopy, an approach to the integrated analysis of NMR and UPLC-MS data sets: application in metabonomic toxicology studies. Anal Chem. 2006 Jan 15; 78(2):363-71. PMID: 16408915.
      Citations: 62     Fields:    Translation:Animals
    279. Wang Y, Utzinger J, Xiao SH, Xue J, Nicholson JK, Tanner M, Singer BH, Holmes E. System level metabolic effects of a Schistosoma japonicum infection in the Syrian hamster. Mol Biochem Parasitol. 2006 Mar; 146(1):1-9. PMID: 16337285.
      Citations: 16     Fields:    Translation:HumansAnimalsCells
    280. Lindon JC, Keun HC, Ebbels TM, Pearce JM, Holmes E, Nicholson JK. The Consortium for Metabonomic Toxicology (COMET): aims, activities and achievements. Pharmacogenomics. 2005 Oct; 6(7):691-9. PMID: 16207146.
      Citations: 42     Fields:    Translation:Animals
    281. Wang Y, Bollard ME, Nicholson JK, Holmes E. Exploration of the direct metabolic effects of mercury II chloride on the kidney of Sprague-Dawley rats using high-resolution magic angle spinning 1H NMR spectroscopy of intact tissue and pattern recognition. J Pharm Biomed Anal. 2006 Feb 13; 40(2):375-81. PMID: 16146678.
      Citations: 3     Fields:    Translation:Animals
    282. Holmes E, Nicholson J. Variation in gut microbiota strongly influences individual rodent phenotypes. Toxicol Sci. 2005 Sep; 87(1):1-2. PMID: 16158497.
      Citations: 13     Fields:    Translation:AnimalsCells
    283. Duarte IF, Stanley EG, Holmes E, Lindon JC, Gil AM, Tang H, Ferdinand R, McKee CG, Nicholson JK, Vilca-Melendez H, Heaton N, Murphy GM. Metabolic assessment of human liver transplants from biopsy samples at the donor and recipient stages using high-resolution magic angle spinning 1H NMR spectroscopy. Anal Chem. 2005 Sep 01; 77(17):5570-8. PMID: 16131067.
      Citations: 23     Fields:    Translation:Humans
    284. Wang Y, Tang H, Holmes E, Lindon JC, Turini ME, Sprenger N, Bergonzelli G, Fay LB, Kochhar S, Nicholson JK. Biochemical characterization of rat intestine development using high-resolution magic-angle-spinning 1H NMR spectroscopy and multivariate data analysis. J Proteome Res. 2005 Jul-Aug; 4(4):1324-9. PMID: 16083283.
      Citations: 11     Fields:    Translation:Animals
    285. Lindon JC, Nicholson JK, Holmes E, Keun HC, Craig A, Pearce JT, Bruce SJ, Hardy N, Sansone SA, Antti H, Jonsson P, Daykin C, Navarange M, Beger RD, Verheij ER, Amberg A, Baunsgaard D, Cantor GH, Lehman-McKeeman L, Earll M, Wold S, Johansson E, Haselden JN, Kramer K, Thomas C, Lindberg J, Schuppe-Koistinen I, Wilson ID, Reily MD, Robertson DG, Senn H, Krotzky A, Kochhar S, Powell J, van der Ouderaa F, Plumb R, Schaefer H, Spraul M. Summary recommendations for standardization and reporting of metabolic analyses. Nat Biotechnol. 2005 Jul; 23(7):833-8. PMID: 16003371.
      Citations: 42     Fields:    Translation:HumansAnimals
    286. Nicholson JK, Holmes E, Wilson ID. Gut microorganisms, mammalian metabolism and personalized health care. Nat Rev Microbiol. 2005 May; 3(5):431-8. PMID: 15821725.
      Citations: 249     Fields:    Translation:HumansAnimals
    287. Bollard ME, Stanley EG, Lindon JC, Nicholson JK, Holmes E. NMR-based metabonomic approaches for evaluating physiological influences on biofluid composition. NMR Biomed. 2005 May; 18(3):143-62. PMID: 15627238.
      Citations: 93     Fields:    Translation:HumansAnimals
    288. Bollard ME, Keun HC, Beckonert O, Ebbels TM, Antti H, Nicholls AW, Shockcor JP, Cantor GH, Stevens G, Lindon JC, Holmes E, Nicholson JK. Comparative metabonomics of differential hydrazine toxicity in the rat and mouse. Toxicol Appl Pharmacol. 2005 Apr 15; 204(2):135-51. PMID: 15808519.
      Citations: 22     Fields:    Translation:Animals
    289. Solanky KS, Bailey NJ, Beckwith-Hall BM, Bingham S, Davis A, Holmes E, Nicholson JK, Cassidy A. Biofluid 1H NMR-based metabonomic techniques in nutrition research - metabolic effects of dietary isoflavones in humans. J Nutr Biochem. 2005 Apr; 16(4):236-44. PMID: 15808328.
      Citations: 21     Fields:    Translation:HumansAnimals
    290. Waters NJ, Waterfield CJ, Farrant RD, Holmes E, Nicholson JK. Metabonomic deconvolution of embedded toxicity: application to thioacetamide hepato- and nephrotoxicity. Chem Res Toxicol. 2005 Apr; 18(4):639-54. PMID: 15833024.
      Citations: 27     Fields:    Translation:Animals
    291. Jonsson P, Bruce SJ, Moritz T, Trygg J, Sjöström M, Plumb R, Granger J, Maibaum E, Nicholson JK, Holmes E, Antti H. Extraction, interpretation and validation of information for comparing samples in metabolic LC/MS data sets. Analyst. 2005 May; 130(5):701-7. PMID: 15852140.
      Citations: 17     Fields:    Translation:Humans
    292. Cloarec O, Dumas ME, Craig A, Barton RH, Trygg J, Hudson J, Blancher C, Gauguier D, Lindon JC, Holmes E, Nicholson J. Statistical total correlation spectroscopy: an exploratory approach for latent biomarker identification from metabolic 1H NMR data sets. Anal Chem. 2005 Mar 01; 77(5):1282-9. PMID: 15732908.
      Citations: 198     Fields:    Translation:Animals
    293. Garrod S, Bollard ME, Nicholls AW, Connor SC, Connelly J, Nicholson JK, Holmes E. Integrated metabonomic analysis of the multiorgan effects of hydrazine toxicity in the rat. Chem Res Toxicol. 2005 Feb; 18(2):115-22. PMID: 15720114.
      Citations: 20     Fields:    Translation:Animals
    294. Wang Y, Tang H, Nicholson JK, Hylands PJ, Sampson J, Holmes E. A metabonomic strategy for the detection of the metabolic effects of chamomile (Matricaria recutita L.) ingestion. J Agric Food Chem. 2005 Jan 26; 53(2):191-6. PMID: 15656647.
      Citations: 37     Fields:    Translation:HumansAnimals
    295. Cloarec O, Dumas ME, Trygg J, Craig A, Barton RH, Lindon JC, Nicholson JK, Holmes E. Evaluation of the orthogonal projection on latent structure model limitations caused by chemical shift variability and improved visualization of biomarker changes in 1H NMR spectroscopic metabonomic studies. Anal Chem. 2005 Jan 15; 77(2):517-26. PMID: 15649048.
      Citations: 134     Fields:    Translation:Animals
    296. Ebbels TM, Holmes E, Lindon JC, Nicholson JK. Evaluation of metabolic variation in normal rat strains from a statistical analysis of 1H NMR spectra of urine. J Pharm Biomed Anal. 2004 Nov 19; 36(4):823-33. PMID: 15533676.
      Citations: 5     Fields:    Translation:Animals
    297. Nicholson JK, Holmes E, Lindon JC, Wilson ID. The challenges of modeling mammalian biocomplexity. Nat Biotechnol. 2004 Oct; 22(10):1268-74. PMID: 15470467.
      Citations: 73     Fields:    Translation:HumansAnimalsCells
    298. Eriksson L, Antti H, Gottfries J, Holmes E, Johansson E, Lindgren F, Long I, Lundstedt T, Trygg J, Wold S. Using chemometrics for navigating in the large data sets of genomics, proteomics, and metabonomics (gpm). Anal Bioanal Chem. 2004 Oct; 380(3):419-29. PMID: 15448969.
      Citations: 77     Fields:    Translation:Animals
    299. Wang Y, Holmes E, Nicholson JK, Cloarec O, Chollet J, Tanner M, Singer BH, Utzinger J. Metabonomic investigations in mice infected with Schistosoma mansoni: an approach for biomarker identification. Proc Natl Acad Sci U S A. 2004 Aug 24; 101(34):12676-81. PMID: 15314235.
      Citations: 69     Fields:    Translation:HumansAnimals
    300. Raso G, Luginbühl A, Adjoua CA, Tian-Bi NT, Silué KD, Matthys B, Vounatsou P, Wang Y, Dumas ME, Holmes E, Singer BH, Tanner M, N'goran EK, Utzinger J. Multiple parasite infections and their relationship to self-reported morbidity in a community of rural Côte d'Ivoire. Int J Epidemiol. 2004 Oct; 33(5):1092-102. PMID: 15256525.
      Citations: 93     Fields:    Translation:Humans
    301. Lindon JC, Holmes E, Nicholson JK. Metabonomics: systems biology in pharmaceutical research and development. Curr Opin Mol Ther. 2004 Jun; 6(3):265-72. PMID: 15264428.
      Citations: 20     Fields:    Translation:HumansAnimals
    302. Keun HC, Ebbels TM, Bollard ME, Beckonert O, Antti H, Holmes E, Lindon JC, Nicholson JK. Geometric trajectory analysis of metabolic responses to toxicity can define treatment specific profiles. Chem Res Toxicol. 2004 May; 17(5):579-87. PMID: 15144214.
      Citations: 22     Fields:    Translation:Animals
    303. Bailey NJ, Wang Y, Sampson J, Davis W, Whitcombe I, Hylands PJ, Croft SL, Holmes E. Prediction of anti-plasmodial activity of Artemisia annua extracts: application of 1H NMR spectroscopy and chemometrics. J Pharm Biomed Anal. 2004 Apr 01; 35(1):117-26. PMID: 15030886.
      Citations: 11     Fields:    Translation:HumansAnimalsCells
    304. Lindon JC, Holmes E, Nicholson JK. Metabonomics and its role in drug development and disease diagnosis. Expert Rev Mol Diagn. 2004 Mar; 4(2):189-99. PMID: 14995905.
      Citations: 28     Fields:    Translation:HumansAnimals
    305. Wang Y, Tang H, Nicholson JK, Hylands PJ, Sampson J, Whitcombe I, Stewart CG, Caiger S, Oru I, Holmes E. Metabolomic strategy for the classification and quality control of phytomedicine: a case study of chamomile flower (Matricaria recutita L.). Planta Med. 2004 Mar; 70(3):250-5. PMID: 15114503.
      Citations: 11     Fields:    Translation:HumansAnimals
    306. Teague C, Holmes E, Maibaum E, Nicholson J, Tang H, Chan Q, Elliott P, Stamler J, Ueshima H, Zhou B, Wilson I. Ethyl glucoside in human urine following dietary exposure: detection by 1H NMR spectroscopy as a result of metabonomic screening of humans. Analyst. 2004 Mar; 129(3):259-64. PMID: 14978530.
      Citations: 6     Fields:    Translation:HumansAnimals
    307. Lindon JC, Holmes E, Bollard ME, Stanley EG, Nicholson JK. Metabonomics technologies and their applications in physiological monitoring, drug safety assessment and disease diagnosis. Biomarkers. 2004 Jan-Feb; 9(1):1-31. PMID: 15204308.
      Citations: 70     Fields:    Translation:HumansAnimals
    308. Solanky KS, Bailey NJ, Beckwith-Hall BM, Davis A, Bingham S, Holmes E, Nicholson JK, Cassidy A. Application of biofluid 1H nuclear magnetic resonance-based metabonomic techniques for the analysis of the biochemical effects of dietary isoflavones on human plasma profile. Anal Biochem. 2003 Dec 15; 323(2):197-204. PMID: 14656525.
      Citations: 25     Fields:    Translation:HumansAnimals
    309. Wang Y, Bollard ME, Keun H, Antti H, Beckonert O, Ebbels TM, Lindon JC, Holmes E, Tang H, Nicholson JK. Spectral editing and pattern recognition methods applied to high-resolution magic-angle spinning 1H nuclear magnetic resonance spectroscopy of liver tissues. Anal Biochem. 2003 Dec 01; 323(1):26-32. PMID: 14622955.
      Citations: 13     Fields:    Translation:Animals
    310. Lindon JC, Holmes E, Nicholson JK. So what's the deal with metabonomics? Anal Chem. 2003 Sep 01; 75(17):384A-391A. PMID: 14632032.
      Citations: 47     Fields:    Translation:HumansAnimals
    311. Solanky KS, Bailey NJ, Holmes E, Lindon JC, Davis AL, Mulder TP, Van Duynhoven JP, Nicholson JK. NMR-based metabonomic studies on the biochemical effects of epicatechin in the rat. J Agric Food Chem. 2003 Jul 02; 51(14):4139-45. PMID: 12822959.
      Citations: 4     Fields:    Translation:Animals
    312. Beckwith-Hall BM, Thompson NA, Nicholson JK, Lindon JC, Holmes E. A metabonomic investigation of hepatotoxicity using diffusion-edited 1H NMR spectroscopy of blood serum. Analyst. 2003 Jul; 128(7):814-8. PMID: 12894815.
      Citations: 13     Fields:    Translation:Animals
    313. Lindon JC, Nicholson JK, Holmes E, Antti H, Bollard ME, Keun H, Beckonert O, Ebbels TM, Reily MD, Robertson D, Stevens GJ, Luke P, Breau AP, Cantor GH, Bible RH, Niederhauser U, Senn H, Schlotterbeck G, Sidelmann UG, Laursen SM, Tymiak A, Car BD, Lehman-McKeeman L, Colet JM, Loukaci A, Thomas C. Contemporary issues in toxicology the role of metabonomics in toxicology and its evaluation by the COMET project. Toxicol Appl Pharmacol. 2003 Mar 15; 187(3):137-46. PMID: 12662897.
      Citations: 30     Fields:    Translation:HumansAnimals
    314. Bailey NJ, Oven M, Holmes E, Nicholson JK, Zenk MH. Metabolomic analysis of the consequences of cadmium exposure in Silene cucubalus cell cultures via 1H NMR spectroscopy and chemometrics. Phytochemistry. 2003 Mar; 62(6):851-8. PMID: 12590112.
      Citations: 14     Fields:    Translation:AnimalsCells
    315. Brindle JT, Nicholson JK, Schofield PM, Grainger DJ, Holmes E. Application of chemometrics to 1H NMR spectroscopic data to investigate a relationship between human serum metabolic profiles and hypertension. Analyst. 2003 Jan; 128(1):32-6. PMID: 12572799.
      Citations: 41     Fields:    Translation:Humans
    316. Connelly JC, Connor SC, Monte S, Bailey NJ, Borgeaud N, Holmes E, Troke J, Nicholson JK, Gavaghan CL. Application of directly coupled high performance liquid chromatography-NMR-mass spectometry and 1H NMR spectroscopic studies to the investigation of 2,3-benzofuran metabolism in Sprague-Dawley rats. Drug Metab Dispos. 2002 Dec; 30(12):1357-63. PMID: 12433803.
      Citations: 1     Fields:    Translation:Animals
    317. Brindle JT, Antti H, Holmes E, Tranter G, Nicholson JK, Bethell HW, Clarke S, Schofield PM, McKilligin E, Mosedale DE, Grainger DJ. Rapid and noninvasive diagnosis of the presence and severity of coronary heart disease using 1H-NMR-based metabonomics. Nat Med. 2002 Dec; 8(12):1439-44. PMID: 12447357.
      Citations: 204     Fields:    Translation:Humans
    318. Keun HC, Ebbels TM, Antti H, Bollard ME, Beckonert O, Schlotterbeck G, Senn H, Niederhauser U, Holmes E, Lindon JC, Nicholson JK. Analytical reproducibility in (1)H NMR-based metabonomic urinalysis. Chem Res Toxicol. 2002 Nov; 15(11):1380-6. PMID: 12437328.
      Citations: 41     Fields:    Translation:Animals
    319. Bollard ME, Xu J, Purcell W, Griffin JL, Quirk C, Holmes E, Nicholson JK. Metabolic profiling of the effects of D-galactosamine in liver spheroids using (1)H NMR and MAS-NMR spectroscopy. Chem Res Toxicol. 2002 Nov; 15(11):1351-9. PMID: 12437325.
      Citations: 6     Fields:    Translation:AnimalsCells
    320. Mitchell S, Holmes E, Carmichael P. Metabonomics and medicine: the Biochemical Oracle. Biologist (London). 2002 Oct; 49(5):217-21. PMID: 12391413.
      Citations:    Fields:    Translation:HumansAnimals
    321. Beckwith-Hall BM, Brindle JT, Barton RH, Coen M, Holmes E, Nicholson JK, Antti H. Application of orthogonal signal correction to minimise the effects of physical and biological variation in high resolution 1H NMR spectra of biofluids. Analyst. 2002 Oct; 127(10):1283-8. PMID: 12430596.
      Citations: 12     Fields:    Translation:Humans
    322. Beckwith-Hall BM, Holmes E, Lindon JC, Gounarides J, Vickers A, Shapiro M, Nicholson JK. NMR-based metabonomic studies on the biochemical effects of commonly used drug carrier vehicles in the rat. Chem Res Toxicol. 2002 Sep; 15(9):1136-41. PMID: 12230406.
      Citations: 1     Fields:    Translation:Animals
    323. Bailey NJ, Sampson J, Hylands PJ, Nicholson JK, Holmes E. Multi-component metabolic classification of commercial feverfew preparations via high-field 1H-NMR spectroscopy and chemometrics. Planta Med. 2002 Aug; 68(8):734-8. PMID: 12221598.
      Citations: 3     Fields:    Translation:Animals
    324. Waters NJ, Holmes E, Waterfield CJ, Farrant RD, Nicholson JK. NMR and pattern recognition studies on liver extracts and intact livers from rats treated with alpha-naphthylisothiocyanate. Biochem Pharmacol. 2002 Jul 01; 64(1):67-77. PMID: 12106607.
      Citations: 24     Fields:    Translation:Animals
    325. Nicholson JK, Connelly J, Lindon JC, Holmes E. Metabonomics: a platform for studying drug toxicity and gene function. Nat Rev Drug Discov. 2002 Feb; 1(2):153-61. PMID: 12120097.
      Citations: 313     Fields:    Translation:HumansAnimals
    326. Azmi J, Griffin JL, Antti H, Shore RF, Johansson E, Nicholson JK, Holmes E. Metabolic trajectory characterisation of xenobiotic-induced hepatotoxic lesions using statistical batch processing of NMR data. Analyst. 2002 Feb; 127(2):271-6. PMID: 11913873.
      Citations: 6     Fields:    Translation:Animals
    327. Talbert AM, Tranter GE, Holmes E, Francis PL. Determination of drug-plasma protein binding kinetics and equilibria by chromatographic profiling: exemplification of the method using L-tryptophan and albumin. Anal Chem. 2002 Jan 15; 74(2):446-52. PMID: 11811421.
      Citations: 25     Fields:    Translation:HumansAnimalsCells
    328. Shockcor JP, Holmes E. Metabonomic applications in toxicity screening and disease diagnosis. Curr Top Med Chem. 2002 Jan; 2(1):35-51. PMID: 11899064.
      Citations: 20     Fields:    Translation:HumansAnimals
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