"Acetylcholinesterase" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
An enzyme that catalyzes the hydrolysis of ACETYLCHOLINE to CHOLINE and acetate. In the CNS, this enzyme plays a role in the function of peripheral neuromuscular junctions. EC 3.1.1.7.
Descriptor ID |
D000110
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MeSH Number(s) |
D08.811.277.352.100.170.176
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Concept/Terms |
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Below are MeSH descriptors whose meaning is more general than "Acetylcholinesterase".
Below are MeSH descriptors whose meaning is more specific than "Acetylcholinesterase".
This graph shows the total number of publications written about "Acetylcholinesterase" by people in this website by year, and whether "Acetylcholinesterase" was a major or minor topic of these publications.
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Year | Major Topic | Minor Topic | Total |
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2017 | 2 | 5 | 7 |
2018 | 2 | 6 | 8 |
2019 | 3 | 5 | 8 |
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Below are the most recent publications written about "Acetylcholinesterase" by people in Profiles.
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Rationale, study design and implementation of the LUCINDA Trial: Leuprolide plus Cholinesterase Inhibition to reduce Neurologic Decline in Alzheimer's. Contemp Clin Trials. 2021 08; 107:106488.
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Molecular modeling-guided optimization of acetylcholinesterase reactivators: A proof for reactivation of covalently inhibited targets. Eur J Med Chem. 2021 Apr 05; 215:113286.
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Impairment of the cholinergic anti-inflammatory pathway in older subjects with severe COVID-19. Med Hypotheses. 2020 11; 144:110274.
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De Novo Drug Design of Targeted Chemical Libraries Based on Artificial Intelligence and Pair-Based Multiobjective Optimization. J Chem Inf Model. 2020 10 26; 60(10):4582-4593.
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Computer modeling of a potential agent against SARS-Cov-2 (COVID-19) protease. Proteins. 2020 12; 88(12):1557-1558.
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Exosomal Th1/Th2 cytokines in preeclampsia and HIV-positive preeclamptic women on highly active anti-retroviral therapy. Cytokine. 2020 01; 125:154795.
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Design, Synthesis, and Cholinesterase Inhibition Assay of Coumarin-3-carboxamide-N-morpholine Hybrids as New Anti-Alzheimer Agents. Chem Biodivers. 2019 Jul; 16(7):e1900144.
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a-bisabolol ß-D-fucopyranoside as a potential modulator of ß-amyloid peptide induced neurotoxicity: An in vitro &in silico study. Bioorg Chem. 2019 07; 88:102935.
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Novel eugenol bearing oxypropanolamines: Synthesis, characterization, antibacterial, antidiabetic, and anticholinergic potentials. Bioorg Chem. 2019 07; 88:102931.
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Synthesis and Biological Activity of Some Benzochromenoquinolinones: Tacrine Analogs as Potent Anti-Alzheimer's Agents. Chem Biodivers. 2019 Apr; 16(4):e1800488.