"Podosomes" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Actin-rich adhesive structures found at the ventral surface of metazoan ENDOTHELIAL CELLS. When found in cultured cancer cells they are referred to as invadopodia. These are matrix-degrading structures composed of an ACTIN CYTOSKELETON core and an INTEGRINS-containing ring complex.
| Descriptor ID |
D000069261
|
| MeSH Number(s) |
A11.284.180.695 A11.436.275.841
|
| Concept/Terms |
Podosomes- Podosomes
- Podosome
- Invadopodium
- Invadopodiums
- Invadopodia
- Invadosomes
- Invadosome
|
Below are MeSH descriptors whose meaning is more general than "Podosomes".
Below are MeSH descriptors whose meaning is more specific than "Podosomes".
This graph shows the total number of publications written about "Podosomes" by people in this website by year, and whether "Podosomes" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2017 | 1 | 0 | 1 |
| 2018 | 2 | 0 | 2 |
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Below are the most recent publications written about "Podosomes" by people in Profiles.
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Inhibition of RhoA and mTORC2/Rictor by Fingolimod (FTY720) induces p21-activated kinase 1, PAK-1 and amplifies podosomes in mouse peritoneal macrophages. Immunobiology. 2018 11; 223(11):634-647.
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Circulating Exosomes Isolated from Septic Mice Induce Cardiovascular Hyperpermeability Through Promoting Podosome Cluster Formation. Shock. 2018 04; 49(4):429-441.
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LPP is a Src substrate required for invadopodia formation and efficient breast cancer lung metastasis. Nat Commun. 2017 04 24; 8:15059.