"Alarmins" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A structurally diverse group of endogenous molecules that are multifunctional, having physiological functions inside the cell, but when released from dying cells or from cells under stress or certain immune cells, they function to activate INNATE IMMUNITY. Uncontrolled and excessive release of alarmins may contribute to INFLAMMATION; CARCINOGENESIS, and NEOPLASM METASTASIS. Alarmins are also critical for heart and nerve tissue homeostasis.
| Descriptor ID |
D000067531
|
| MeSH Number(s) |
D23.035
|
| Concept/Terms |
Alarmins- Alarmins
- Damage-Associated Molecular Pattern Molecules
- Damage Associated Molecular Pattern Molecules
- Danger-Associated Molecular Pattern Molecules
- Danger Associated Molecular Pattern Molecules
- Alarmin Proteins
- Alarmin
|
Below are MeSH descriptors whose meaning is more general than "Alarmins".
Below are MeSH descriptors whose meaning is more specific than "Alarmins".
This graph shows the total number of publications written about "Alarmins" by people in this website by year, and whether "Alarmins" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2015 | 0 | 1 | 1 |
| 2017 | 2 | 4 | 6 |
| 2018 | 4 | 2 | 6 |
| 2019 | 3 | 1 | 4 |
| 2020 | 2 | 1 | 3 |
| 2021 | 1 | 2 | 3 |
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Below are the most recent publications written about "Alarmins" by people in Profiles.
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Alarmins, COVID-19 and comorbidities. Ann Med. 2021 12; 53(1):777-785.
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DAMPening COVID-19 Severity by Attenuating Danger Signals. Front Immunol. 2021; 12:720192.
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Network-based repurposing identifies anti-alarmins as drug candidates to control severe lung inflammation in COVID-19. PLoS One. 2021; 16(7):e0254374.
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The interplay of DAMPs, TLR4, and proinflammatory cytokines in pulmonary fibrosis. J Mol Med (Berl). 2021 10; 99(10):1373-1384.
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Endothelial Immunity Trained by Coronavirus Infections, DAMP Stimulations and Regulated by Anti-Oxidant NRF2 May Contribute to Inflammations, Myelopoiesis, COVID-19 Cytokine Storms and Thromboembolism. Front Immunol. 2021; 12:653110.
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Unknown/enigmatic functions of extracellular ASC. Immunology. 2021 08; 163(4):377-388.
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Role of DAMPs in respiratory virus-induced acute respiratory distress syndrome-with a preliminary reference to SARS-CoV-2 pneumonia. Genes Immun. 2021 07; 22(3):141-160.
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Interferon-Independent Restriction of RNA Virus Entry and Replication by a Class of Damage-Associated Molecular Patterns. mBio. 2021 04 13; 12(2).
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Immune dysregulation and autoreactivity correlate with disease severity in SARS-CoV-2-associated multisystem inflammatory syndrome in children. Immunity. 2021 05 11; 54(5):1083-1095.e7.
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Dysregulation of lipid metabolism and pathological inflammation in patients with COVID-19. Sci Rep. 2021 02 03; 11(1):2941.