"Fibrillin-1" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A fibrillin (FBN1) that functions as a structural support protein for MICROFIBRILS. It also regulates the maturation of OSTEOBLASTS by controlling the availability and concentration of TGF-BETA and BONE MORPHOGENETIC PROTEINS. Mutations in the FBN1 gene are associated with MARFAN SYNDROME.
| Descriptor ID |
D000071838
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| MeSH Number(s) |
D09.400.430.875.500 D12.776.395.341.500 D12.776.860.300.400.500
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| Concept/Terms |
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Below are MeSH descriptors whose meaning is more general than "Fibrillin-1".
Below are MeSH descriptors whose meaning is more specific than "Fibrillin-1".
This graph shows the total number of publications written about "Fibrillin-1" by people in this website by year, and whether "Fibrillin-1" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2017 | 2 | 0 | 2 |
| 2018 | 1 | 3 | 4 |
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Below are the most recent publications written about "Fibrillin-1" by people in Profiles.
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Whole-exome sequencing reveals known and novel variants in a cohort of intracranial vertebral-basilar artery dissection (IVAD). J Hum Genet. 2018 Nov; 63(11):1119-1128.
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The Effect of a Nonpeptide Angiotensin II Type 2 Receptor Agonist, Compound 21, on Aortic Aneurysm Growth in a Mouse Model of Marfan Syndrome. J Cardiovasc Pharmacol. 2018 04; 71(4):215-222.
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The importance of genotype-phenotype correlation in the clinical management of Marfan syndrome. Orphanet J Rare Dis. 2018 01 22; 13(1):16.
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Aortic dilatation in Marfan syndrome: role of arterial stiffness and fibrillin-1 variants. J Hypertens. 2018 01; 36(1):77-84.
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FBN1 mutations largely contribute to sporadic non-syndromic aortic dissection. Hum Mol Genet. 2017 12 15; 26(24):4814-4822.
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Gross deletions in FBN1 results in variable phenotypes of Marfan syndrome. Clin Chim Acta. 2017 Nov; 474:54-59.