"Amiloride" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A pyrazine compound inhibiting SODIUM reabsorption through SODIUM CHANNELS in renal EPITHELIAL CELLS. This inhibition creates a negative potential in the luminal membranes of principal cells, located in the distal convoluted tubule and collecting duct. Negative potential reduces secretion of potassium and hydrogen ions. Amiloride is used in conjunction with DIURETICS to spare POTASSIUM loss. (From Gilman et al., Goodman and Gilman's The Pharmacological Basis of Therapeutics, 9th ed, p705)
| Descriptor ID |
D000584
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| MeSH Number(s) |
D03.383.679.149
|
| Concept/Terms |
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Below are MeSH descriptors whose meaning is more general than "Amiloride".
Below are MeSH descriptors whose meaning is more specific than "Amiloride".
This graph shows the total number of publications written about "Amiloride" by people in this website by year, and whether "Amiloride" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2011 | 1 | 0 | 1 |
| 2017 | 0 | 1 | 1 |
| 2018 | 2 | 0 | 2 |
| 2021 | 1 | 0 | 1 |
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Below are the most recent publications written about "Amiloride" by people in Profiles.
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Contribution of Syndecans to the Cellular Entry of SARS-CoV-2. Int J Mol Sci. 2021 May 19; 22(10).
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Interactions of SARS-CoV-2 envelope protein with amilorides correlate with antiviral activity. PLoS Pathog. 2021 05; 17(5):e1009519.
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Structure and drug binding of the SARS-CoV-2 envelope protein transmembrane domain in lipid bilayers. Nat Struct Mol Biol. 2020 12; 27(12):1202-1208.
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Is amiloride a promising cardiovascular medication to persist in the COVID-19 crisis? Drug Discov Ther. 2020 Nov 04; 14(5):256-258.
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Understanding SARS-CoV-2 endocytosis for COVID-19 drug repurposing. FEBS J. 2020 09; 287(17):3664-3671.
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Amelioration of Lipopolysaccharide-Induced Acute Lung Injury in Rats by Na-H Exchanger-1 Inhibitor Amiloride Is Associated with Reversal of ERK Mitogen-Activated Protein Kinase. Biomed Res Int. 2018; 2018:3560234.
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Effectiveness of low-dose diuretics for blood pressure reduction to optimal values in prehypertension: a randomized clinical trial. J Hypertens. 2018 04; 36(4):933-938.
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Na+/H+ Exchanger Regulates Amino Acid-Mediated Autophagy in Intestinal Epithelial Cells. Cell Physiol Biochem. 2017; 42(6):2418-2429.
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Differential effects of viroporin inhibitors against feline infectious peritonitis virus serotypes I and II. Arch Virol. 2015 May; 160(5):1163-70.
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A comparison between diuretics and angiotensin-receptor blocker agents in patients with stage I hypertension (PREVER-treatment trial): study protocol for a randomized double-blind controlled trial. Trials. 2011 Feb 24; 12:53.