"Chlorpromazine" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
The prototypical phenothiazine antipsychotic drug. Like the other drugs in this class chlorpromazine's antipsychotic actions are thought to be due to long-term adaptation by the brain to blocking DOPAMINE RECEPTORS. Chlorpromazine has several other actions and therapeutic uses, including as an antiemetic and in the treatment of intractable hiccup.
| Descriptor ID |
D002746
|
| MeSH Number(s) |
D02.886.369.198 D03.633.300.741.198
|
| Concept/Terms |
|
Below are MeSH descriptors whose meaning is more general than "Chlorpromazine".
Below are MeSH descriptors whose meaning is more specific than "Chlorpromazine".
This graph shows the total number of publications written about "Chlorpromazine" by people in this website by year, and whether "Chlorpromazine" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 2002 | 0 | 1 | 1 |
| 2006 | 0 | 1 | 1 |
| 2010 | 1 | 0 | 1 |
| 2014 | 0 | 1 | 1 |
| 2017 | 0 | 2 | 2 |
| 2018 | 0 | 1 | 1 |
| 2020 | 2 | 2 | 4 |
| 2021 | 1 | 0 | 1 |
To return to the timeline, click here.
Below are the most recent publications written about "Chlorpromazine" by people in Profiles.
-
Case Report: Two Cases of Persistent Hiccups Complicating COVID-19. Am J Trop Med Hyg. 2021 Apr 01; 104(5):1713-1715.
-
Drugs, Metabolites, and Lung Accumulating Small Lysosomotropic Molecules: Multiple Targeting Impedes SARS-CoV-2 Infection and Progress to COVID-19. Int J Mol Sci. 2021 Feb 11; 22(4).
-
Observational Study of Chlorpromazine in Hospitalized Patients with COVID-19. Clin Drug Investig. 2021 Mar; 41(3):221-233.
-
Inhibition of the replication of SARS-CoV-2 in human cells by the FDA-approved drug chlorpromazine. Int J Antimicrob Agents. 2021 Mar; 57(3):106274.
-
Persistent hiccups in a patient with mild congenital factor V deficiency and COVID-19; clinical and laboratory finding of a rare bleeding disorder. Int J Lab Hematol. 2021 04; 43(2):e87-e88.
-
Psychosis Treatment During COVID-19 Pandemic and the Potential Role of Phenothiazines: A Call for Research Studies. J Clin Psychopharmacol. 2020 Nov/Dec; 40(6):641-642.
-
Broad Anti-coronavirus Activity of Food and Drug Administration-Approved Drugs against SARS-CoV-2 In Vitro and SARS-CoV In Vivo. J Virol. 2020 10 14; 94(21).
-
Antiviral activity of chlorpromazine, fluphenazine, perphenazine, prochlorperazine, and thioridazine towards RNA-viruses. A review. Eur J Pharmacol. 2020 Nov 15; 887:173553.
-
Could the antipsychotic chlorpromazine be a potential treatment for SARS-CoV-2? Schizophr Res. 2020 09; 223:373-375.
-
Advances and challenges in the prevention and treatment of COVID-19. Int J Med Sci. 2020; 17(12):1803-1810.