"Cardiac Glycosides" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Cyclopentanophenanthrenes with a 5- or 6-membered lactone ring attached at the 17-position and SUGARS attached at the 3-position. Plants they come from have long been used in congestive heart failure. They increase the force of cardiac contraction without significantly affecting other parameters, but are very toxic at larger doses. Their mechanism of action usually involves inhibition of the NA(+)-K(+)-EXCHANGING ATPASE and they are often used in cell biological studies for that purpose.
| Descriptor ID |
D002301
|
| MeSH Number(s) |
D04.210.500.155.580 D09.408.180
|
| Concept/Terms |
Cardiac Glycosides- Cardiac Glycosides
- Glycosides, Cardiac
- Cardiotonic Steroids
- Steroids, Cardiotonic
|
Below are MeSH descriptors whose meaning is more general than "Cardiac Glycosides".
Below are MeSH descriptors whose meaning is more specific than "Cardiac Glycosides".
This graph shows the total number of publications written about "Cardiac Glycosides" by people in this website by year, and whether "Cardiac Glycosides" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2015 | 1 | 0 | 1 |
| 2018 | 1 | 0 | 1 |
| 2020 | 1 | 0 | 1 |
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Below are the most recent publications written about "Cardiac Glycosides" by people in Profiles.
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Cardiac glycosides and COVID-19: would it be a promising therapeutic approach? An Acad Bras Cienc. 2020; 92(4):e20201080.
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A cell-based large-scale screening of natural compounds for inhibitors of SARS-CoV-2. Signal Transduct Target Ther. 2020 10 03; 5(1):218.
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Targeting Intracellular Ion Homeostasis for the Control of Respiratory Syncytial Virus. Am J Respir Cell Mol Biol. 2018 12; 59(6):733-744.
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The Antiviral Effects of Na,K-ATPase Inhibition: A Minireview. Int J Mol Sci. 2018 Jul 24; 19(8).
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ATP1A1-mediated Src signaling inhibits coronavirus entry into host cells. J Virol. 2015 Apr; 89(8):4434-48.