"IMP Dehydrogenase" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
An enzyme that catalyzes the dehydrogenation of inosine 5'-phosphate to xanthosine 5'-phosphate in the presence of NAD. EC 1.1.1.205.
| Descriptor ID |
D007168
|
| MeSH Number(s) |
D08.811.682.047.820.450
|
| Concept/Terms |
IMP Dehydrogenase- IMP Dehydrogenase
- Dehydrogenase, IMP
- Inosinic Acid Dehydrogenase
- Acid Dehydrogenase, Inosinic
- Dehydrogenase, Inosinic Acid
- Inosine-5-Monophosphate Dehydrogenase
- Dehydrogenase, Inosine-5-Monophosphate
- Inosine 5 Monophosphate Dehydrogenase
|
Below are MeSH descriptors whose meaning is more general than "IMP Dehydrogenase".
Below are MeSH descriptors whose meaning is more specific than "IMP Dehydrogenase".
This graph shows the total number of publications written about "IMP Dehydrogenase" by people in this website by year, and whether "IMP Dehydrogenase" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 2005 | 1 | 0 | 1 |
| 2017 | 3 | 0 | 3 |
| 2018 | 2 | 0 | 2 |
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Below are the most recent publications written about "IMP Dehydrogenase" by people in Profiles.
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Lifecycle modelling systems support inosine monophosphate dehydrogenase (IMPDH) as a pro-viral factor and antiviral target for New World arenaviruses. Antiviral Res. 2018 09; 157:140-150.
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Expanding Benzoxazole-Based Inosine 5'-Monophosphate Dehydrogenase (IMPDH) Inhibitor Structure-Activity As Potential Antituberculosis Agents. J Med Chem. 2018 06 14; 61(11):4739-4756.
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Inhibition of Calcineurin or IMP Dehydrogenase Exerts Moderate to Potent Antiviral Activity against Norovirus Replication. Antimicrob Agents Chemother. 2017 11; 61(11).
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Autoantibodies against "rods and rings"-related IMPDH2 in hepatitis C genotype 1 and DAA therapy in a "real life" cohort. Med Microbiol Immunol. 2017 Oct; 206(5):379-382.
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High expression of IMPDH2 is associated with aggressive features and poor prognosis of primary nasopharyngeal carcinoma. Sci Rep. 2017 04 07; 7(1):745.
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A novel benzo-heterocyclic amine derivative N30 inhibits influenza virus replication by depression of Inosine-5'-Monophospate Dehydrogenase activity. Virol J. 2017 03 15; 14(1):55.
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Enhancement of the infectivity of SARS-CoV in BALB/c mice by IMP dehydrogenase inhibitors, including ribavirin. Antiviral Res. 2006 Aug; 71(1):53-63.
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The predominant mechanism by which ribavirin exerts its antiviral activity in vitro against flaviviruses and paramyxoviruses is mediated by inhibition of IMP dehydrogenase. J Virol. 2005 Feb; 79(3):1943-7.
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Antivirals and antiviral strategies. Nat Rev Microbiol. 2004 Sep; 2(9):704-20.