"Dextromethorphan" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Methyl analog of DEXTRORPHAN that shows high affinity binding to several regions of the brain, including the medullary cough center. This compound is an NMDA receptor antagonist (RECEPTORS, N-METHYL-D-ASPARTATE) and acts as a non-competitive channel blocker. It is one of the widely used ANTITUSSIVES, and is also used to study the involvement of glutamate receptors in neurotoxicity.
| Descriptor ID |
D003915
|
| MeSH Number(s) |
D03.132.577.249.200 D03.605.497.212 D03.633.400.686.212 D04.615.723.795.200
|
| Concept/Terms |
|
Below are MeSH descriptors whose meaning is more general than "Dextromethorphan".
Below are MeSH descriptors whose meaning is more specific than "Dextromethorphan".
This graph shows the total number of publications written about "Dextromethorphan" by people in this website by year, and whether "Dextromethorphan" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 2017 | 2 | 0 | 2 |
To return to the timeline, click here.
Below are the most recent publications written about "Dextromethorphan" by people in Profiles.
-
Insights into the biased activity of dextromethorphan and haloperidol towards SARS-CoV-2 NSP6: in silico binding mechanistic analysis. J Mol Med (Berl). 2020 12; 98(12):1659-1673.
-
Enhanced Bulbar Function in Amyotrophic Lateral Sclerosis: The Nuedexta Treatment Trial. Neurotherapeutics. 2017 Jul; 14(3):762-772.
-
Dextromethorphan/quinidine pharmacotherapy in patients with treatment resistant depression: A proof of concept clinical trial. J Affect Disord. 2017 08 15; 218:277-283.