"Isatin" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
An indole-dione that is obtained by oxidation of indigo blue. It is a MONOAMINE OXIDASE INHIBITOR and high levels have been found in urine of PARKINSONISM patients.
| Descriptor ID |
D007510
|
| MeSH Number(s) |
D03.633.100.473.525
|
| Concept/Terms |
Isatin- Isatin
- 2,3-Dioxoindoline
- 2,3 Dioxoindoline
|
Below are MeSH descriptors whose meaning is more general than "Isatin".
Below are MeSH descriptors whose meaning is more specific than "Isatin".
This graph shows the total number of publications written about "Isatin" by people in this website by year, and whether "Isatin" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2018 | 1 | 0 | 1 |
| 2019 | 1 | 0 | 1 |
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Below are the most recent publications written about "Isatin" by people in Profiles.
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Potent inhibitors of SARS-CoV-2 3C-like protease derived from N-substituted isatin compounds. Eur J Med Chem. 2020 Nov 15; 206:112702.
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Isatin Derivatives and Their Antiviral Properties Against Arboviruses: A Review. Mini Rev Med Chem. 2019; 19(1):56-62.
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Design and development of Isatin-triazole hydrazones as potential inhibitors of microtubule affinity-regulating kinase 4 for the therapeutic management of cell proliferation and metastasis. Eur J Med Chem. 2019 Feb 01; 163:840-852.
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Synthesis, modification and docking studies of 5-sulfonyl isatin derivatives as SARS-CoV 3C-like protease inhibitors. Bioorg Med Chem. 2014 Jan 01; 22(1):292-302.
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Maturation mechanism of severe acute respiratory syndrome (SARS) coronavirus 3C-like proteinase. J Biol Chem. 2010 Sep 03; 285(36):28134-40.
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Isatin compounds as noncovalent SARS coronavirus 3C-like protease inhibitors. J Med Chem. 2006 Jun 15; 49(12):3440-3.
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Synthesis and evaluation of isatin derivatives as effective SARS coronavirus 3CL protease inhibitors. Bioorg Med Chem Lett. 2005 Jun 15; 15(12):3058-62.