"RNA Caps" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Nucleic acid structures found on the 5' end of eukaryotic cellular and viral messenger RNA and some heterogeneous nuclear RNAs. These structures, which are positively charged, protect the above specified RNAs at their termini against attack by phosphatases and other nucleases and promote mRNA function at the level of initiation of translation. Analogs of the RNA caps (RNA CAP ANALOGS), which lack the positive charge, inhibit the initiation of protein synthesis.
| Descriptor ID |
D012315
|
| MeSH Number(s) |
D03.633.100.759.646.454.700 D13.444.735.544.500 D13.695.667.454.700 D13.695.827.426.700
|
| Concept/Terms |
RNA Caps- RNA Caps
- Caps, RNA
- 5' Capped RNA
- RNA, 5' Capped
- 5' mRNA Cap Structure
|
Below are MeSH descriptors whose meaning is more general than "RNA Caps".
Below are MeSH descriptors whose meaning is more specific than "RNA Caps".
This graph shows the total number of publications written about "RNA Caps" by people in this website by year, and whether "RNA Caps" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 2008 | 1 | 0 | 1 |
| 2010 | 2 | 0 | 2 |
| 2011 | 1 | 1 | 2 |
| 2012 | 2 | 1 | 3 |
| 2013 | 1 | 0 | 1 |
| 2014 | 1 | 0 | 1 |
| 2016 | 0 | 2 | 2 |
| 2017 | 2 | 1 | 3 |
| 2018 | 0 | 1 | 1 |
| 2019 | 1 | 0 | 1 |
| 2020 | 2 | 2 | 4 |
| 2021 | 4 | 1 | 5 |
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Below are the most recent publications written about "RNA Caps" by people in Profiles.
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Enzymatic Assays to Explore Viral mRNA Capping Machinery. Chembiochem. 2021 12 02; 22(23):3236-3253.
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Localization of SARS-CoV-2 Capping Enzymes Revealed by an Antibody against the nsp10 Subunit. Viruses. 2021 07 29; 13(8).
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Identification and evaluation of potential SARS-CoV-2 antiviral agents targeting mRNA cap guanine N7-Methyltransferase. Antiviral Res. 2021 09; 193:105142.
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Identifying SARS-CoV-2 antiviral compounds by screening for small molecule inhibitors of Nsp14 RNA cap methyltransferase. Biochem J. 2021 07 16; 478(13):2481-2497.
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Mn2+ coordinates Cap-0-RNA to align substrates for efficient 2'-O-methyl transfer by SARS-CoV-2 nsp16. Sci Signal. 2021 06 29; 14(689).
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A metal ion orients SARS-CoV-2 mRNA to ensure accurate 2'-O methylation of its first nucleotide. Nat Commun. 2021 06 02; 12(1):3287.
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2'-O methylation of RNA cap in SARS-CoV-2 captured by serial crystallography. Proc Natl Acad Sci U S A. 2021 05 25; 118(21).
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Chemo-Enzymatic Modification of the 5' Cap Maintains Translation and Increases Immunogenic Properties of mRNA. Angew Chem Int Ed Engl. 2021 06 07; 60(24):13280-13286.
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A High-Throughput Radioactivity-Based Assay for Screening SARS-CoV-2 nsp10-nsp16 Complex. SLAS Discov. 2021 07; 26(6):757-765.
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Development of a High-Throughput Screening Assay to Identify Inhibitors of the SARS-CoV-2 Guanine-N7-Methyltransferase Using RapidFire Mass Spectrometry. SLAS Discov. 2021 07; 26(6):749-756.