"Dizocilpine Maleate" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A potent noncompetitive antagonist of the NMDA receptor (RECEPTORS, N-METHYL-D-ASPARTATE) used mainly as a research tool. The drug has been considered for the wide variety of neurodegenerative conditions or disorders in which NMDA receptors may play an important role. Its use has been primarily limited to animal and tissue experiments because of its psychotropic effects.
| Descriptor ID |
D016291
|
| MeSH Number(s) |
D02.455.426.559.847.181.384.380 D04.615.181.384.380
|
| Concept/Terms |
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Below are MeSH descriptors whose meaning is more general than "Dizocilpine Maleate".
Below are MeSH descriptors whose meaning is more specific than "Dizocilpine Maleate".
This graph shows the total number of publications written about "Dizocilpine Maleate" by people in this website by year, and whether "Dizocilpine Maleate" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2005 | 0 | 1 | 1 |
| 2009 | 0 | 1 | 1 |
| 2014 | 1 | 0 | 1 |
| 2017 | 1 | 1 | 2 |
| 2018 | 1 | 1 | 2 |
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Below are the most recent publications written about "Dizocilpine Maleate" by people in Profiles.
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Enhancement of 5-HT2A receptor function and blockade of Kv1.5 by MK801 and ketamine: implications for PCP derivative-induced disease models. Exp Mol Med. 2018 04 27; 50(4):1-8.
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NMDA-Type Glutamate Receptor Activation Promotes Vascular Remodeling and Pulmonary Arterial Hypertension. Circulation. 2018 05 29; 137(22):2371-2389.
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Neurosteroid-sensitive d-GABAA receptors: A role in epileptogenesis? Epilepsia. 2017 03; 58(3):494-504.
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MK-801-Treated Oligodendrocytes as a Cellular Model to Study Schizophrenia. Adv Exp Med Biol. 2017; 974:269-277.
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Blockade of voltage-gated K? currents in rat mesenteric arterial smooth muscle cells by MK801. J Pharmacol Sci. 2015 Jan; 127(1):92-102.
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[Relationship between NR1 subunit of N-methyl-D-aspartate receptor and visceral hypersensitivity caused by acute restraint stress: experiment with rats]. Zhonghua Yi Xue Za Zhi. 2009 Apr 14; 89(14):939-42.
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NMDA or AMPA/kainate receptor blockade prevents acquisition of conditioned place preference induced by D(2/3) dopamine receptor stimulation in rats. Psychopharmacology (Berl). 2005 Apr; 179(1):189-97.