"Calgranulin A" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A 10.8-kDa member of the S-100 family of calcium-binding proteins that can form homo- or heterocomplexes with CALGRANULIN B and a variety of other proteins. The calgranulin A/B heterodimer is known as LEUKOCYTE L1 ANTIGEN COMPLEX. Calgranulin A is found in many cell types including GRANULOCYTES; KERATINOCYTES; and myelomonocytes, and has been shown to act as a chemotactic substance for NEUTROPHILS. Because it is present in acute inflammation but absent in chronic inflammation, it is a useful biological marker for a number of pathological conditions.
| Descriptor ID |
D040501
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| MeSH Number(s) |
D12.776.157.125.750.500.100 D12.776.631.655.500.100 D23.050.301.562.100
|
| Concept/Terms |
Calgranulin A- Calgranulin A
- 60B8-B Antigen
- 60B8 B Antigen
- Antigen, 60B8-B
- CABP-P8
- MRP8 Protein
- Leukocyte L1 Protein Light Chain
- Myeloid Calcium-Binding Protein P8
- Myeloid Calcium Binding Protein P8
- MRP-8 Protein
- MRP 8 Protein
- S100 A8 Protein
- A8 Protein, S100
- S100A8 Protein
- Cystic Fibrosis Antigen
- Antigen, Cystic Fibrosis
- Macrophage-Related Protein-8
- Macrophage Related Protein 8
|
Below are MeSH descriptors whose meaning is more general than "Calgranulin A".
Below are MeSH descriptors whose meaning is more specific than "Calgranulin A".
This graph shows the total number of publications written about "Calgranulin A" by people in this website by year, and whether "Calgranulin A" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2014 | 1 | 0 | 1 |
| 2017 | 2 | 0 | 2 |
| 2018 | 1 | 1 | 2 |
| 2019 | 0 | 1 | 1 |
| 2020 | 2 | 0 | 2 |
| 2021 | 1 | 0 | 1 |
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Below are the most recent publications written about "Calgranulin A" by people in Profiles.
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S100A8 may govern hyper-inflammation in severe COVID-19. FASEB J. 2021 09; 35(9):e21798.
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Comparative transcriptome analyses reveal genes associated with SARS-CoV-2 infection of human lung epithelial cells. Sci Rep. 2021 08 10; 11(1):16212.
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Circulating Calprotectin as a Biomarker of COVID-19 Severity. Expert Rev Clin Immunol. 2021 05; 17(5):431-443.
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The Inflammatory Factors Associated with Disease Severity to Predict COVID-19 Progression. J Immunol. 2021 04 01; 206(7):1597-1608.
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DAMPening Mortality in COVID-19: Therapeutic Insights From Basic Cardiometabolic Studies on S100A8/A9. Circulation. 2021 03 09; 143(10):971-973.
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Neutrophil calprotectin identifies severe pulmonary disease in COVID-19. J Leukoc Biol. 2021 01; 109(1):67-72.
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Elevated serum levels of S100A8/A9 and HMGB1 at hospital admission are correlated with inferior clinical outcomes in COVID-19 patients. Cell Mol Immunol. 2020 09; 17(9):992-994.
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Elevated serum levels of alarmin S100A8/A9 in patients with hand osteoarthritis. Clin Exp Rheumatol. 2019 Sep-Oct; 37(5):885.
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S100A8/A9 promotes parenchymal damage and renal fibrosis in obstructive nephropathy. Clin Exp Immunol. 2018 09; 193(3):361-375.
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Zinc finger and interferon-stimulated genes play a vital role in TB-IRIS following HAART in AIDS. Per Med. 2018 07 01; 15(4):251-269.