"Superantigens" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Microbial antigens that have in common an extremely potent activating effect on T-cells that bear a specific variable region. Superantigens cross-link the variable region with class II MHC proteins regardless of the peptide binding in the T-cell receptor's pocket. The result is a transient expansion and subsequent death and anergy of the T-cells with the appropriate variable regions.
| Descriptor ID |
D018089
|
| MeSH Number(s) |
D23.050.820
|
| Concept/Terms |
|
Below are MeSH descriptors whose meaning is more general than "Superantigens".
Below are MeSH descriptors whose meaning is more specific than "Superantigens".
This graph shows the total number of publications written about "Superantigens" by people in this website by year, and whether "Superantigens" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 2001 | 0 | 1 | 1 |
| 2004 | 0 | 1 | 1 |
| 2005 | 1 | 0 | 1 |
| 2010 | 1 | 0 | 1 |
| 2012 | 1 | 0 | 1 |
| 2017 | 1 | 2 | 3 |
| 2018 | 2 | 2 | 4 |
| 2019 | 1 | 2 | 3 |
| 2020 | 2 | 0 | 2 |
| 2021 | 0 | 1 | 1 |
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Below are the most recent publications written about "Superantigens" by people in Profiles.
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SARS-CoV-2 as a superantigen in multisystem inflammatory syndrome in children. J Clin Invest. 2021 05 17; 131(10).
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A monoclonal antibody against staphylococcal enterotoxin B superantigen inhibits SARS-CoV-2 entry in vitro. Structure. 2021 09 02; 29(9):951-962.e3.
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Resveratrol-mediated attenuation of superantigen-driven acute respiratory distress syndrome is mediated by microbiota in the lungs and gut. Pharmacol Res. 2021 05; 167:105548.
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Persistent SARS-2 infections contribute to long COVID-19. Med Hypotheses. 2021 Apr; 149:110538.
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COVID-19-associated multisystem inflammatory syndrome in children (MIS-C): A novel disease that mimics toxic shock syndrome-the superantigen hypothesis. J Allergy Clin Immunol. 2021 01; 147(1):57-59.
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Superantigenic character of an insert unique to SARS-CoV-2 spike supported by skewed TCR repertoire in patients with hyperinflammation. Proc Natl Acad Sci U S A. 2020 10 13; 117(41):25254-25262.
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Are superantigens the cause of cytokine storm and viral sepsis in severe COVID-19? Observations and hypothesis. Scand J Immunol. 2020 Dec; 92(6):e12944.
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Lack of correlation of virulence gene profiles of Staphylococcus aureus bacteremia isolates with mortality. Microb Pathog. 2019 Aug; 133:103543.
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Staphylococcal scarlet fever associated with staphylococcal enterotoxin M in an elderly patient. Int J Infect Dis. 2019 Aug; 85:7-9.
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The theory of a "staphylococcus superantigen" in chronic rhinosinusitis with nasal polyps: myth or reality? Eur Rev Med Pharmacol Sci. 2019 Mar; 23(1 Suppl):48-54.