"Mice, Inbred MRL lpr" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A mouse substrain that is genetically predisposed to the development of systemic lupus erythematosus-like syndrome, which has been found to be clinically similar to the human disease. It has been determined that this mouse strain carries a mutation in the fas gene. Also, the MRL/lpr is a useful model to study behavioral and cognitive deficits found in autoimmune diseases and the efficacy of immunosuppressive agents.
| Descriptor ID |
D019463
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| MeSH Number(s) |
B01.050.050.199.520.520.555 B01.050.150.900.649.313.992.635.505.500.400.555
|
| Concept/Terms |
Mice, Inbred MRL lpr- Mice, Inbred MRL lpr
- Mouse, MRL lpr
- MRL lpr Mouse
- Mice, MRL lpr
- MRL lpr Mice
- Mouse, Inbred MRL lpr
|
Below are MeSH descriptors whose meaning is more general than "Mice, Inbred MRL lpr".
Below are MeSH descriptors whose meaning is more specific than "Mice, Inbred MRL lpr".
This graph shows the total number of publications written about "Mice, Inbred MRL lpr" by people in this website by year, and whether "Mice, Inbred MRL lpr" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2008 | 0 | 1 | 1 |
| 2017 | 0 | 5 | 5 |
| 2019 | 0 | 1 | 1 |
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Below are the most recent publications written about "Mice, Inbred MRL lpr" by people in Profiles.
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Erythropoietin inhibits SGK1-dependent TH17 induction and TH17-dependent kidney disease. JCI Insight. 2019 04 23; 5.
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The Unknown Aspect of BAFF: Inducing IL-35 Production by a CD5+CD1dhiFc?RIIbhi Regulatory B-Cell Subset in Lupus. J Invest Dermatol. 2017 12; 137(12):2532-2543.
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Restoration of CFTR Activity in Ducts Rescues Acinar Cell Function and Reduces Inflammation in Pancreatic and Salivary Glands of Mice. Gastroenterology. 2017 10; 153(4):1148-1159.
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Neutrophil Extracellular Traps Drive Endothelial-to-Mesenchymal Transition. Arterioscler Thromb Vasc Biol. 2017 07; 37(7):1371-1379.
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TIGIT signalling pathway negatively regulates CD4+ T-cell responses in systemic lupus erythematosus. Immunology. 2017 07; 151(3):280-290.
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CCL2 deficient mesenchymal stem cells fail to establish long-lasting contact with T cells and no longer ameliorate lupus symptoms. Sci Rep. 2017 01 24; 7:41258.
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Dynamic in vivo imaging of microvasculature and perfusion by miniaturized confocal laser microscopy. Eur Surg Res. 2008; 41(3):290-7.