"HMGA1a Protein" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
An 11-kDa AT-hook motif-containing (AT-HOOK MOTIFS) protein that binds to the minor grove of AT-rich regions of DNA. It is the full-length product of the alternatively-spliced HMGA1 gene and may function as an architectural chromatin binding protein that is involved in transcriptional regulation.
| Descriptor ID |
D025741
|
| MeSH Number(s) |
D12.776.260.312.500 D12.776.660.235.400.500.100 D12.776.664.235.400.500.100
|
| Concept/Terms |
HMGA1a Protein- HMGA1a Protein
- High Mobility Group I(Y) Protein
- HMGI(Y) Gene Product
- HMG I-Y Phosphoprotein
- HMG I Y Phosphoprotein
- Phosphoprotein, HMG I-Y
- HMG-I(Y) Protein
- HMGI Protein
- AT-Hook 1a Protein, High Mobility Group
- AT Hook 1a Protein, High Mobility Group
- HMG I-Type Protein
- HMG I Type Protein
|
Below are MeSH descriptors whose meaning is more general than "HMGA1a Protein".
Below are MeSH descriptors whose meaning is more specific than "HMGA1a Protein".
This graph shows the total number of publications written about "HMGA1a Protein" by people in this website by year, and whether "HMGA1a Protein" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2007 | 1 | 0 | 1 |
| 2008 | 1 | 0 | 1 |
| 2017 | 1 | 0 | 1 |
| 2018 | 0 | 2 | 2 |
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Below are the most recent publications written about "HMGA1a Protein" by people in Profiles.
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Comment on Li et al. HMGA1: A novel predisposing gene for acute myocardial infarction. Int J Cardiol. 2018 04 01; 256:38.
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Genome-wide association studies for two exterior traits in Chinese Dongxiang spotted pigs. Anim Sci J. 2018 Jun; 89(6):868-875.
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HMGA1 amplifies Wnt signalling and expands the intestinal stem cell compartment and Paneth cell niche. Nat Commun. 2017 04 28; 8:15008.
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HAND1 gene expression is negatively regulated by the High Mobility Group A1 proteins and is drastically reduced in human thyroid carcinomas. Oncogene. 2009 Feb 12; 28(6):876-85.
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HMGA1 controls transcription of insulin receptor to regulate cyclin D1 translation in pancreatic cancer cells. Cancer Res. 2007 May 15; 67(10):4679-86.