"Carboxylesterase" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Carboxylesterase is a serine-dependent esterase with wide substrate specificity. The enzyme is involved in the detoxification of XENOBIOTICS and the activation of ester and of amide PRODRUGS.
| Descriptor ID |
D043182
|
| MeSH Number(s) |
D08.811.277.352.100.100
|
| Concept/Terms |
Carboxylesterase- Carboxylesterase
- Isocarboxazid amidase
- amidase, Isocarboxazid
- Non-specific Esterase
- Esterase, Non-specific
- Non specific Esterase
- Nonspecific Esterase
- Esterase, Nonspecific
- Procaine Esterase
- Esterase, Procaine
- Ali-esterase
- Ali esterase
- B-esterase
- B esterase
- CAP-hydrolyzing Enzyme
- CAP hydrolyzing Enzyme
- Enzyme, CAP-hydrolyzing
- Capsaicin-Hydrolyzing Enzyme
- Capsaicin Hydrolyzing Enzyme
- Enzyme, Capsaicin-Hydrolyzing
- Carboxyesterase
- Carboxylate Esterase
- Esterase, Carboxylate
- Carboxylester Lipase
- Lipase, Carboxylester
- Carboxylesterase B
- Carboxylic Ester Hydrolase
- Ester Hydrolase, Carboxylic
- Hydrolase, Carboxylic Ester
- Naproxen Esterase
- Esterase, Naproxen
- Non-specific Carboxylesterase
- Carboxylesterase, Non-specific
- Non specific Carboxylesterase
|
Below are MeSH descriptors whose meaning is more general than "Carboxylesterase".
Below are MeSH descriptors whose meaning is more specific than "Carboxylesterase".
This graph shows the total number of publications written about "Carboxylesterase" by people in this website by year, and whether "Carboxylesterase" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 2011 | 1 | 0 | 1 |
| 2017 | 1 | 0 | 1 |
| 2018 | 2 | 0 | 2 |
| 2019 | 1 | 0 | 1 |
| 2020 | 0 | 1 | 1 |
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Below are the most recent publications written about "Carboxylesterase" by people in Profiles.
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Remdesivir potently inhibits carboxylesterase-2 through covalent modifications: signifying strong drug-drug interactions. Fundam Clin Pharmacol. 2021 Apr; 35(2):432-434.
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Comparative therapeutic efficacy of remdesivir and combination lopinavir, ritonavir, and interferon beta against MERS-CoV. Nat Commun. 2020 01 10; 11(1):222.
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Synthesis, Biological Evaluation, and Molecular Docking of Combretastatin and Colchicine Derivatives and their hCE1-Activated Prodrugs as Antiviral Agents. ChemMedChem. 2019 02 19; 14(4):469-483.
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Biodegradation of di-n-butyl phthalate by psychrotolerant Sphingobium yanoikuyae strain P4 and protein structural analysis of carboxylesterase involved in the pathway. Int J Biol Macromol. 2019 Feb 01; 122:806-816.
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Multiple mutations and overexpression of the MdaE7 carboxylesterase gene associated with male-linked malathion resistance in housefly, Musca domestica (Diptera: Muscidae). Sci Rep. 2018 01 09; 8(1):224.
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Autotransporter domain-dependent enzymatic analysis of a novel extremely thermostable carboxylesterase with high biodegradability towards pyrethroid pesticides. Sci Rep. 2017 06 14; 7(1):3461.
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Contribution of carboxylesterase in hamster to the intestinal first-pass loss and low bioavailability of ethyl piperate, an effective lipid-lowering drug candidate. Drug Metab Dispos. 2011 May; 39(5):796-802.