"Genetic Heterogeneity" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
The presence of apparently similar characters for which the genetic evidence indicates that different genes or different genetic mechanisms are involved in different pedigrees. In clinical settings genetic heterogeneity refers to the presence of a variety of genetic defects which cause the same disease, often due to mutations at different loci on the same gene, a finding common to many human diseases including ALZHEIMER DISEASE; CYSTIC FIBROSIS; LIPOPROTEIN LIPASE DEFICIENCY, FAMILIAL; and POLYCYSTIC KIDNEY DISEASES. (Rieger, et al., Glossary of Genetics: Classical and Molecular, 5th ed; Segen, Dictionary of Modern Medicine, 1992)
| Descriptor ID |
D018740
|
| MeSH Number(s) |
G05.365.331
|
| Concept/Terms |
Genetic Heterogeneity- Genetic Heterogeneity
- Heterogeneity, Genetic
- Genetic Heterogeneities
- Heterogeneities, Genetic
|
Below are MeSH descriptors whose meaning is more general than "Genetic Heterogeneity".
Below are MeSH descriptors whose meaning is more specific than "Genetic Heterogeneity".
This graph shows the total number of publications written about "Genetic Heterogeneity" by people in this website by year, and whether "Genetic Heterogeneity" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1997 | 0 | 1 | 1 |
| 2011 | 0 | 1 | 1 |
| 2012 | 0 | 1 | 1 |
| 2014 | 0 | 2 | 2 |
| 2015 | 1 | 1 | 2 |
| 2016 | 0 | 5 | 5 |
| 2017 | 6 | 14 | 20 |
| 2018 | 3 | 6 | 9 |
| 2019 | 0 | 2 | 2 |
| 2020 | 1 | 1 | 2 |
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Below are the most recent publications written about "Genetic Heterogeneity" by people in Profiles.
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Metastatic Timing and Genetic Heterogeneity in the Evolution of a Pancreatic Neuroendocrine Tumor. Am J Gastroenterol. 2021 04; 116(4):844-847.
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Genome-wide analysis of SARS-CoV-2 virus strains circulating worldwide implicates heterogeneity. Sci Rep. 2020 08 19; 10(1):14004.
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Understanding heterogeneity to inform the public health response to COVID-19 in Canada. CMAJ. 2020 06 22; 192(25):E684-E685.
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Spatial and Temporal Heterogeneity of Panel-Based Tumor Mutational Burden in Pulmonary Adenocarcinoma: Separating Biology From Technical Artifacts. J Thorac Oncol. 2019 11; 14(11):1935-1947.
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NK cell immune responses differ after prime and boost vaccination. J Leukoc Biol. 2019 05; 105(5):1055-1073.
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Mechanisms of acquired resistance to rapalogs in metastatic renal cell carcinoma. PLoS Genet. 2018 09; 14(9):e1007679.
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Methylation differences reveal heterogeneity in preterm pathophysiology: results from bipartite network analyses. J Perinat Med. 2018 Jul 26; 46(5):509-521.
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Epidermodysplasia Verruciformis: Genetic Heterogeneity and EVER1 and EVER2 Mutations Revealed by Genome-Wide Analysis. J Invest Dermatol. 2019 01; 139(1):241-244.
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Expanding the clinical and genetic spectra of NKX6-2-related disorder. Clin Genet. 2018 05; 93(5):1087-1092.
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Deterministic Evolutionary Trajectories Influence Primary Tumor Growth: TRACERx Renal. Cell. 2018 04 19; 173(3):595-610.e11.