"Polyubiquitin" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
An oligomer formed from the repetitive linking of the C-terminal glycine of one UBIQUITIN molecule via an isopeptide bond to a lysine residue on a second ubiquitin molecule. It is structurally distinct from UBIQUITIN C, which is a single protein containing a tandemly arrayed ubiquitin peptide sequence.
| Descriptor ID |
D025821
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| MeSH Number(s) |
D12.776.947.500.500
|
| Concept/Terms |
|
Below are MeSH descriptors whose meaning is more general than "Polyubiquitin".
Below are MeSH descriptors whose meaning is more specific than "Polyubiquitin".
This graph shows the total number of publications written about "Polyubiquitin" by people in this website by year, and whether "Polyubiquitin" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2015 | 1 | 0 | 1 |
| 2017 | 0 | 2 | 2 |
| 2018 | 2 | 2 | 4 |
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Below are the most recent publications written about "Polyubiquitin" by people in Profiles.
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Genetic analysis reveals functions of atypical polyubiquitin chains. Elife. 2018 12 14; 7.
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The deubiquitinase CYLD is a specific checkpoint of the STING antiviral signaling pathway. PLoS Pathog. 2018 11; 14(11):e1007435.
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Molecular mechanisms of Streptococcus pneumoniae-targeted autophagy via pneumolysin, Golgi-resident Rab41, and Nedd4-1-mediated K63-linked ubiquitination. Cell Microbiol. 2018 08; 20(8):e12846.
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Global ubiquitination analysis reveals extensive modification and proteasomal degradation of cowpox virus proteins, but preservation of viral cores. Sci Rep. 2018 01 29; 8(1):1807.
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The N-terminal ubiquitin-associated domain of Cezanne is crucial for its function to suppress NF-?B pathway. J Cell Biochem. 2018 02; 119(2):1979-1991.
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TRAF2 and OTUD7B govern a ubiquitin-dependent switch that regulates mTORC2 signalling. Nature. 2017 05 18; 545(7654):365-369.
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Recognition of Lys48-Linked Di-ubiquitin and Deubiquitinating Activities of the SARS Coronavirus Papain-like Protease. Mol Cell. 2016 05 19; 62(4):572-85.
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Structural view and substrate specificity of papain-like protease from avian infectious bronchitis virus. J Biol Chem. 2015 Mar 13; 290(11):7160-8.