"Methacholine Chloride" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A quaternary ammonium parasympathomimetic agent with the muscarinic actions of ACETYLCHOLINE. It is hydrolyzed by ACETYLCHOLINESTERASE at a considerably slower rate than ACETYLCHOLINE and is more resistant to hydrolysis by nonspecific CHOLINESTERASES so that its actions are more prolonged. It is used as a parasympathomimetic bronchoconstrictor agent and as a diagnostic aid for bronchial asthma. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1116)
| Descriptor ID |
D016210
|
| MeSH Number(s) |
D02.092.877.883.555.500 D02.675.276.534.500
|
| Concept/Terms |
Methacholine Chloride- Methacholine Chloride
- Chloride, Methacholine
- Acetyl-beta-methacholine Chloride
- Acetyl beta methacholine Chloride
- Mecholine
- 2-(Acetyloxy)-N,N,N-trimethyl-1-propanaminium Chloride
- Acetyl-2-methylcholine Chloride
- Acetyl 2 methylcholine Chloride
|
Below are MeSH descriptors whose meaning is more general than "Methacholine Chloride".
Below are MeSH descriptors whose meaning is more specific than "Methacholine Chloride".
This graph shows the total number of publications written about "Methacholine Chloride" by people in this website by year, and whether "Methacholine Chloride" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 1999 | 1 | 0 | 1 |
| 2009 | 1 | 0 | 1 |
| 2013 | 0 | 1 | 1 |
| 2017 | 1 | 2 | 3 |
| 2018 | 1 | 1 | 2 |
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Below are the most recent publications written about "Methacholine Chloride" by people in Profiles.
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Microfabricated potentiometric sensor for personalized methacholine challenge tests during the COVID-19 pandemic. Biosens Bioelectron. 2021 Oct 15; 190:113439.
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ERS technical standard on bronchial challenge testing: pathophysiology and methodology of indirect airway challenge testing. Eur Respir J. 2018 11; 52(5).
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Tiotropium inhibits methacholine-induced extracellular matrix production via ß-catenin signaling in human airway smooth muscle cells. Int J Chron Obstruct Pulmon Dis. 2018; 13:1469-1481.
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Sputum TWEAK expression correlates with severity and degree of control in non-eosinophilic childhood asthma. Pediatr Allergy Immunol. 2018 02; 29(1):42-49.
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Roles of Bronchopulmonary C-fibers in airway Hyperresponsiveness and airway remodeling induced by house dust mite. Respir Res. 2017 Nov 29; 18(1):199.
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Exhaled nitric oxide's ability to predict methacholine challenge: A matter of definition. Ann Allergy Asthma Immunol. 2017 Feb; 118(2):236.
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Airway responsiveness to adenosine after a single dose of fluticasone propionate discriminates asthma from COPD. Pulm Pharmacol Ther. 2014 Feb; 27(1):70-5.
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A MCh test pre-post esophageal acidification in detecting GER-related asthma. J Asthma. 2009 May; 46(4):351-5.
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Airway responsiveness to methacholine: effects of deep inhalations and airway inflammation. J Appl Physiol (1985). 1999 Aug; 87(2):567-73.