"Glycyrrhizic Acid" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A widely used anti-inflammatory agent isolated from the licorice root. It is metabolized to GLYCYRRHETINIC ACID, which inhibits 11-BETA-HYDROXYSTEROID DEHYDROGENASES and other enzymes involved in the metabolism of CORTICOSTEROIDS. Therefore, glycyrrhizic acid, which is the main and sweet component of licorice, has been investigated for its ability to cause hypermineralocorticoidism with sodium retention and potassium loss, edema, increased blood pressure, as well as depression of the renin-angiotensin-aldosterone system.
| Descriptor ID |
D019695
|
| MeSH Number(s) |
D02.455.849.919.530.466
|
| Concept/Terms |
Glycyrrhizic Acid- Glycyrrhizic Acid
- Acid, Glycyrrhizic
- Glycyrrhizinic Acid
- Acid, Glycyrrhizinic
- Glycyrrhizin
|
Below are MeSH descriptors whose meaning is more general than "Glycyrrhizic Acid".
Below are MeSH descriptors whose meaning is more specific than "Glycyrrhizic Acid".
This graph shows the total number of publications written about "Glycyrrhizic Acid" by people in this website by year, and whether "Glycyrrhizic Acid" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2003 | 1 | 0 | 1 |
| 2004 | 1 | 1 | 2 |
| 2005 | 1 | 0 | 1 |
| 2011 | 1 | 0 | 1 |
| 2014 | 1 | 0 | 1 |
| 2016 | 1 | 0 | 1 |
| 2017 | 1 | 0 | 1 |
| 2018 | 1 | 0 | 1 |
| 2019 | 1 | 0 | 1 |
| 2021 | 3 | 0 | 3 |
| 2022 | 0 | 1 | 1 |
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Below are the most recent publications written about "Glycyrrhizic Acid" by people in Profiles.
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Efficacy of diammonium glycyrrhizinate combined with vitamin C for treating hospitalized COVID-19 patients: a retrospective, observational study. QJM. 2022 Feb 21; 115(2):77-83.
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Repurposing Methotrexate in Dampening SARS-CoV2-S1-Mediated IL6 Expression: Lessons Learnt from Lung Cancer. Inflammation. 2022 Feb; 45(1):172-179.
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Clinical efficacy and security of glycyrrhizic acid preparation in the treatment of anti-SARS-CoV-2 drug-induced liver injury: a protocol of systematic review and meta-analysis. BMJ Open. 2021 07 09; 11(7):e051484.
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Food Enrichment with Glycyrrhiza glabra Extract Suppresses ACE2 mRNA and Protein Expression in Rats-Possible Implications for COVID-19. Nutrients. 2021 Jul 06; 13(7).
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Molecular screening of glycyrrhizin-based inhibitors against ACE2 host receptor of SARS-CoV-2. J Mol Model. 2021 Jun 24; 27(7):206.
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Development and validation of a rapid high-performance thin-layer chromatographic method for quantification of gallic acid, cinnamic acid, piperine, eugenol, and glycyrrhizin in Divya-Swasari-Vati, an ayurvedic medicine for respiratory ailments. J Sep Sci. 2021 Aug; 44(16):3146-3157.
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Can Antiviral Activity of Licorice Help Fight COVID-19 Infection? Biomolecules. 2021 06 08; 11(6).
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Glycyrrhizic Acid Nanoparticles as Antiviral and Anti-inflammatory Agents for COVID-19 Treatment. ACS Appl Mater Interfaces. 2021 May 12; 13(18):20995-21006.
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Glycyrrhizin Effectively Inhibits SARS-CoV-2 Replication by Inhibiting the Viral Main Protease. Viruses. 2021 04 02; 13(4).
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Drug repurposing for COVID-19: could vitamin C combined with glycyrrhizic acid be at play by the findings of Li et al.'s database-based network pharmacology analysis? Brief Bioinform. 2021 03 22; 22(2):1508-1510.