"Conotoxins" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Peptide neurotoxins from the marine fish-hunting snails of the genus CONUS. They contain 13 to 29 amino acids which are strongly basic and are highly cross-linked by disulfide bonds. There are three types of conotoxins, omega-, alpha-, and mu-. OMEGA-CONOTOXINS inhibit voltage-activated entry of calcium into the presynaptic membrane and therefore the release of ACETYLCHOLINE. Alpha-conotoxins inhibit the postsynaptic acetylcholine receptor. Mu-conotoxins prevent the generation of muscle action potentials. (From Concise Encyclopedia Biochemistry and Molecular Biology, 3rd ed)
| Descriptor ID |
D020916
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| MeSH Number(s) |
D20.888.590.162 D23.946.580.590.162 D23.946.833.590.162
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| Concept/Terms |
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Below are MeSH descriptors whose meaning is more general than "Conotoxins".
Below are MeSH descriptors whose meaning is more specific than "Conotoxins".
This graph shows the total number of publications written about "Conotoxins" by people in this website by year, and whether "Conotoxins" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2016 | 1 | 0 | 1 |
| 2017 | 2 | 1 | 3 |
| 2019 | 1 | 0 | 1 |
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Below are the most recent publications written about "Conotoxins" by people in Profiles.
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Aptamer Efficacies for In Vitro and In Vivo Modulation of aC-Conotoxin PrXA Pharmacology. Molecules. 2019 Jan 09; 24(2).
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Efficient functional neutralization of lethal peptide toxins in vivo by oligonucleotides. Sci Rep. 2017 08 03; 7(1):7202.
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Recent Advances in Conotoxin Classification by Using Machine Learning Methods. Molecules. 2017 Jun 25; 22(7).
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The crystal structure of Ac-AChBP in complex with a-conotoxin LvIA reveals the mechanism of its selectivity towards different nAChR subtypes. Protein Cell. 2017 Sep; 8(9):675-685.
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Conotoxins: Structure, Therapeutic Potential and Pharmacological Applications. Curr Pharm Des. 2016; 22(5):582-9.