Connective Tissue Growth Factor
"Connective Tissue Growth Factor" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A CCN protein family member that regulates a variety of extracellular functions including CELL ADHESION; CELL MIGRATION; and EXTRACELLULAR MATRIX synthesis. It is found in hypertrophic CHONDROCYTES where it may play a role in CHONDROGENESIS and endochondral ossification.
| Descriptor ID |
D055513
|
| MeSH Number(s) |
D12.644.276.200.100 D12.776.467.200.100 D12.776.860.300.200.100 D23.529.237.100
|
| Concept/Terms |
Connective Tissue Growth Factor- Connective Tissue Growth Factor
- Hypertrophic Chondrocyte-Specific Protein 24
- Hypertrophic Chondrocyte Specific Protein 24
- IGF-Binding Protein-Related Protein-2
- IGF Binding Protein Related Protein 2
- IGFBP-rP2
- Insulin-Like Growth Factor Binding Protein 8
- Insulin Like Growth Factor Binding Protein 8
- CCN2 Protein
- IGFBP-8
|
Below are MeSH descriptors whose meaning is more general than "Connective Tissue Growth Factor".
Below are MeSH descriptors whose meaning is more specific than "Connective Tissue Growth Factor".
This graph shows the total number of publications written about "Connective Tissue Growth Factor" by people in this website by year, and whether "Connective Tissue Growth Factor" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2013 | 0 | 1 | 1 |
| 2015 | 1 | 1 | 2 |
| 2017 | 1 | 1 | 2 |
| 2018 | 1 | 1 | 2 |
| 2019 | 1 | 0 | 1 |
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Below are the most recent publications written about "Connective Tissue Growth Factor" by people in Profiles.
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Irregular pacing of ventricular cardiomyocytes induces pro-fibrotic signalling involving paracrine effects of transforming growth factor beta and connective tissue growth factor. Eur J Heart Fail. 2019 04; 21(4):482-491.
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Soluble stroma-related biomarkers of pancreatic cancer. EMBO Mol Med. 2018 08; 10(8).
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Connective tissue growth factor induces renal fibrosis via epidermal growth factor receptor activation. J Pathol. 2018 02; 244(2):227-241.
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The status of pulmonary fibrosis in systemic sclerosis is associated with IRF5, STAT4, IRAK1, and CTGF polymorphisms. Rheumatol Int. 2017 Aug; 37(8):1303-1310.
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Treatment of Renal Fibrosis-Turning Challenges into Opportunities. Adv Chronic Kidney Dis. 2017 03; 24(2):117-129.
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Fibroblast growth factor 21 deletion aggravates diabetes-induced pathogenic changes in the aorta in type 1 diabetic mice. Cardiovasc Diabetol. 2015 06 11; 14(1):77.
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The C-terminal module IV of connective tissue growth factor, through EGFR/Nox1 signaling, activates the NF-?B pathway and proinflammatory factors in vascular smooth muscle cells. Antioxid Redox Signal. 2015 Jan 01; 22(1):29-47.
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HIF-1a/GPER signaling mediates the expression of VEGF induced by hypoxia in breast cancer associated fibroblasts (CAFs). Breast Cancer Res. 2013; 15(4):R64.