"Tissue Distribution" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Accumulation of a drug or chemical substance in various organs (including those not relevant to its pharmacologic or therapeutic action). This distribution depends on the blood flow or perfusion rate of the organ, the ability of the drug to penetrate organ membranes, tissue specificity, protein binding. The distribution is usually expressed as tissue to plasma ratios.
| Descriptor ID |
D014018
|
| MeSH Number(s) |
G03.787.917 G07.690.725.949
|
| Concept/Terms |
Tissue Distribution- Tissue Distribution
- Distribution, Tissue
- Distributions, Tissue
- Tissue Distributions
|
Below are MeSH descriptors whose meaning is more general than "Tissue Distribution".
Below are MeSH descriptors whose meaning is more specific than "Tissue Distribution".
This graph shows the total number of publications written about "Tissue Distribution" by people in this website by year, and whether "Tissue Distribution" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1997 | 0 | 1 | 1 |
| 2003 | 0 | 2 | 2 |
| 2004 | 0 | 1 | 1 |
| 2006 | 0 | 3 | 3 |
| 2007 | 0 | 3 | 3 |
| 2008 | 0 | 4 | 4 |
| 2010 | 0 | 1 | 1 |
| 2011 | 0 | 1 | 1 |
| 2012 | 0 | 1 | 1 |
| 2013 | 0 | 1 | 1 |
| 2015 | 0 | 1 | 1 |
| 2016 | 0 | 3 | 3 |
| 2017 | 0 | 45 | 45 |
| 2018 | 2 | 33 | 35 |
| 2019 | 0 | 16 | 16 |
| 2020 | 0 | 4 | 4 |
| 2021 | 0 | 5 | 5 |
To return to the timeline, click here.
Below are the most recent publications written about "Tissue Distribution" by people in Profiles.
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Characteristics of Angiotensin I-converting enzyme 2, type II transmembrane serine protease 2 and 4 in tree shrew indicate it as a potential animal model for SARS-CoV-2 infection. Bioengineered. 2021 12; 12(1):2836-2850.
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Ionization and structural properties of mRNA lipid nanoparticles influence expression in intramuscular and intravascular administration. Commun Biol. 2021 08 11; 4(1):956.
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Favipiravir-Based Ionic Liquids as Potent Antiviral Drugs for Oral Delivery: Synthesis, Solubility, and Pharmacokinetic Evaluation. Mol Pharm. 2021 08 02; 18(8):3108-3115.
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Molecular PET/CT Profiling of ACE2 Expression In Vivo: Implications for Infection and Outcome from SARS-CoV-2. Adv Sci (Weinh). 2021 08; 8(16):e2100965.
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Multivalency transforms SARS-CoV-2 antibodies into ultrapotent neutralizers. Nat Commun. 2021 06 16; 12(1):3661.
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Chemistry and biology of ferritin. Metallomics. 2021 05 12; 13(5).
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Identification of the absorbed ingredients and metabolites in rats after an intravenous administration of Tanreqing injection using high-performance liquid chromatography coupled with quadrupole time-of-flight mass spectrometry. J Sep Sci. 2021 May; 44(10):2097-2112.
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Prodrugs of a 1'-CN-4-Aza-7,9-dideazaadenosine C-Nucleoside Leading to the Discovery of Remdesivir (GS-5734) as a Potent Inhibitor of Respiratory Syncytial Virus with Efficacy in the African Green Monkey Model of RSV. J Med Chem. 2021 04 22; 64(8):5001-5017.
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Accelerated Repurposing and Drug Development of Pulmonary Hypertension Therapies for COVID-19 Treatment Using an AI-Integrated Biosimulation Platform. Molecules. 2021 Mar 29; 26(7).
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In Translation: FcRn across the Therapeutic Spectrum. Int J Mol Sci. 2021 Mar 17; 22(6).