"Polypharmacology" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
The design or use of pharmaceutical agents that act on multiple targets or disease pathways.
| Descriptor ID |
D064798
|
| MeSH Number(s) |
E05.295.500.500
|
| Concept/Terms |
|
Below are MeSH descriptors whose meaning is more general than "Polypharmacology".
Below are MeSH descriptors whose meaning is more specific than "Polypharmacology".
This graph shows the total number of publications written about "Polypharmacology" by people in this website by year, and whether "Polypharmacology" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 2017 | 0 | 1 | 1 |
| 2018 | 0 | 3 | 3 |
| 2019 | 1 | 1 | 2 |
| 2021 | 1 | 0 | 1 |
To return to the timeline, click here.
Below are the most recent publications written about "Polypharmacology" by people in Profiles.
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Risks of potential drug-drug interactions in COVID-19 patients treated with corticosteroids: a single-center experience. J Endocrinol Invest. 2021 Dec; 44(12):2849-2851.
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Aframomum melegueta secondary metabolites exhibit polypharmacology against SARS-CoV-2 drug targets: in vitro validation of furin inhibition. Phytother Res. 2021 Feb; 35(2):908-919.
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An up-to-date overview of computational polypharmacology in modern drug discovery. Expert Opin Drug Discov. 2020 09; 15(9):1025-1044.
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Deep Learning Enhancing Kinome-Wide Polypharmacology Profiling: Model Construction and Experiment Validation. J Med Chem. 2020 08 27; 63(16):8723-8737.
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In Silico Oncology Drug Repositioning and Polypharmacology. Methods Mol Biol. 2019; 1878:243-261.
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In silico polypharmacology of natural products. Brief Bioinform. 2018 11 27; 19(6):1153-1171.
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Computational chemical biology and drug design: Facilitating protein structure, function, and modulation studies. Med Res Rev. 2018 05; 38(3):914-950.
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Network Pharmacology: Exploring the Resources and Methodologies. Curr Top Med Chem. 2018; 18(12):949-964.
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Quantitative and systems pharmacology 2. In silico polypharmacology of G protein-coupled receptor ligands via network-based approaches. Pharmacol Res. 2018 03; 129:400-413.