Po-Huang Liang

InstitutionInstitute of Biological Chemistry
AddressTaiwan
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    Publication Timeline
    COVID-19 publications
    Bar chart showing 4 Covid-19 publications, with a maximum of 1 publications in December 2020 and March 2021 and April 2021 and May 2021
    All Publications
    Bar chart showing 92 publications over 20 distinct years, with a maximum of 10 publications in 2004
    These graphs show COVID-19 publications by month since August 2019 and all publications written by authors of COVID-19 publications over the past 30 years.

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    Publication Field Summary
    This graph shows the number and percent of publications by field. Fields are based on how the National Library of Medicine (NLM) classifies the publications' journals and might not represent the specific topics of the publications. Note that an individual publication can be assigned to more than one field. As a result, the publication counts in this graph might add up to more than the number of publications the person has written. To see the data as text, click here.
    Publication List
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Lee JY, Kuo CJ, Shin JS, Jung E, Liang PH, Jung YS. Identification of non-covalent 3C-like protease inhibitors against severe acute respiratory syndrome coronavirus-2 via virtual screening of a Korean compound library. Bioorg Med Chem Lett. 2021 06 15; 42:128067. PMID: 33957246.
      Citations: 1     Fields:    Translation:AnimalsCells
    2. Lo HS, Hui KPY, Lai HM, He X, Khan KS, Kaur S, Huang J, Li Z, Chan AKN, Cheung HH, Ng KC, Ho JCW, Chen YW, Ma B, Cheung PM, Shin D, Wang K, Lee MH, Selisko B, Eydoux C, Guillemot JC, Canard B, Wu KP, Liang PH, Dikic I, Zuo Z, Chan FKL, Hui DSC, Mok VCT, Wong KB, Mok CKP, Ko H, Aik WS, Chan MCW, Ng WL. Simeprevir Potently Suppresses SARS-CoV-2 Replication and Synergizes with Remdesivir. ACS Cent Sci. 2021 May 26; 7(5):792-802. PMID: 34075346.
      Citations: 8     
    3. Kuo CJ, Chao TL, Kao HC, Tsai YM, Liu YK, Wang LH, Hsieh MC, Chang SY, Liang PH. Kinetic Characterization and Inhibitor Screening for the Proteases Leading to Identification of Drugs against SARS-CoV-2. Antimicrob Agents Chemother. 2021 03 18; 65(4). PMID: 33526482.
      Citations: 7     Fields:    Translation:HumansAnimalsCells
    4. Pathak N, Chen YT, Hsu YC, Hsu NY, Kuo CJ, Tsai HP, Kang JJ, Huang CH, Chang SY, Chang YH, Liang PH, Yang JM. Uncovering Flexible Active Site Conformations of SARS-CoV-2 3CL Proteases through Protease Pharmacophore Clusters and COVID-19 Drug Repurposing. ACS Nano. 2021 01 26; 15(1):857-872. PMID: 33373194.
      Citations: 9     Fields:    Translation:HumansAnimalsCells
    5. Kumar V, Shin JS, Shie JJ, Ku KB, Kim C, Go YY, Huang KF, Kim M, Liang PH. Identification and evaluation of potent Middle East respiratory syndrome coronavirus (MERS-CoV) 3CLPro inhibitors. Antiviral Res. 2017 05; 141:101-106. PMID: 28216367.
      Citations: 42     Fields:    Translation:HumansAnimalsCells
    6. Kumar V, Tan KP, Wang YM, Lin SW, Liang PH. Identification, synthesis and evaluation of SARS-CoV and MERS-CoV 3C-like protease inhibitors. Bioorg Med Chem. 2016 07 01; 24(13):3035-3042. PMID: 27240464.
      Citations: 30     Fields:    Translation:HumansCells
    7. Kumar V, Jung YS, Liang PH. Anti-SARS coronavirus agents: a patent review (2008 - present). Expert Opin Ther Pat. 2013 Oct; 23(10):1337-48. PMID: 23905913.
      Citations: 45     Fields:    Translation:HumansAnimalsCells
    8. Ramajayam R, Tan KP, Liang PH. Recent development of 3C and 3CL protease inhibitors for anti-coronavirus and anti-picornavirus drug discovery. Biochem Soc Trans. 2011 Oct; 39(5):1371-5. PMID: 21936817.
      Citations: 31     Fields:    Translation:HumansCells
    9. Wen CC, Shyur LF, Jan JT, Liang PH, Kuo CJ, Arulselvan P, Wu JB, Kuo SC, Yang NS. Traditional Chinese medicine herbal extracts of Cibotium barometz, Gentiana scabra, Dioscorea batatas, Cassia tora, and Taxillus chinensis inhibit SARS-CoV replication. J Tradit Complement Med. 2011 Oct; 1(1):41-50. PMID: 24716104.
      Citations: 45     
    10. Ramajayam R, Tan KP, Liu HG, Liang PH. Synthesis and evaluation of pyrazolone compounds as SARS-coronavirus 3C-like protease inhibitors. Bioorg Med Chem. 2010 Nov 15; 18(22):7849-54. PMID: 20947359.
      Citations: 21     Fields:    Translation:HumansCells
    11. Ramajayam R, Tan KP, Liu HG, Liang PH. Synthesis, docking studies, and evaluation of pyrimidines as inhibitors of SARS-CoV 3CL protease. Bioorg Med Chem Lett. 2010 Jun 15; 20(12):3569-72. PMID: 20494577.
      Citations: 22     Fields:    Translation:Cells
    12. Wang HM, Liang PH. Picornaviral 3C protease inhibitors and the dual 3C protease/coronaviral 3C-like protease inhibitors. Expert Opin Ther Pat. 2010 Jan; 20(1):59-71. PMID: 20021285.
      Citations: 7     Fields:    Translation:HumansAnimalsCells
    13. Kuo CJ, Shih YP, Kan D, Liang PH. Engineering a novel endopeptidase based on SARS 3CL(pro). Biotechniques. 2009 Dec; 47(6):1029-32. PMID: 20041855.
      Citations:    Fields:    Translation:AnimalsCells
    14. Kuo CJ, Liu HG, Lo YK, Seong CM, Lee KI, Jung YS, Liang PH. Individual and common inhibitors of coronavirus and picornavirus main proteases. FEBS Lett. 2009 Feb 04; 583(3):549-55. PMID: 19166843.
      Citations: 22     Fields:    Translation:Cells
    15. Lee CC, Kuo CJ, Ko TP, Hsu MF, Tsui YC, Chang SC, Yang S, Chen SJ, Chen HC, Hsu MC, Shih SR, Liang PH, Wang AH. Structural basis of inhibition specificities of 3C and 3C-like proteases by zinc-coordinating and peptidomimetic compounds. J Biol Chem. 2009 Mar 20; 284(12):7646-55. PMID: 19144641.
      Citations: 47     Fields:    Translation:HumansCells
    16. Shao YM, Yang WB, Kuo TH, Tsai KC, Lin CH, Yang AS, Liang PH, Wong CH. Design, synthesis, and evaluation of trifluoromethyl ketones as inhibitors of SARS-CoV 3CL protease. Bioorg Med Chem. 2008 Apr 15; 16(8):4652-60. PMID: 18329272.
      Citations: 20     Fields:    Translation:Cells
    17. Lee CC, Kuo CJ, Hsu MF, Liang PH, Fang JM, Shie JJ, Wang AH. Structural basis of mercury- and zinc-conjugated complexes as SARS-CoV 3C-like protease inhibitors. FEBS Lett. 2007 Nov 27; 581(28):5454-8. PMID: 17981158.
      Citations: 12     Fields:    Translation:Cells
    18. Shao YM, Yang WB, Peng HP, Hsu MF, Tsai KC, Kuo TH, Wang AH, Liang PH, Lin CH, Yang AS, Wong CH. Structure-based design and synthesis of highly potent SARS-CoV 3CL protease inhibitors. Chembiochem. 2007 Sep 24; 8(14):1654-7. PMID: 17722121.
      Citations: 16     Fields:    Translation:Cells
    19. Yang CW, Yang YN, Liang PH, Chen CM, Chen WL, Chang HY, Chao YS, Lee SJ. Novel small-molecule inhibitors of transmissible gastroenteritis virus. Antimicrob Agents Chemother. 2007 Nov; 51(11):3924-31. PMID: 17709464.
      Citations: 8     Fields:    Translation:AnimalsCells
    20. Wen CC, Kuo YH, Jan JT, Liang PH, Wang SY, Liu HG, Lee CK, Chang ST, Kuo CJ, Lee SS, Hou CC, Hsiao PW, Chien SC, Shyur LF, Yang NS. Specific plant terpenoids and lignoids possess potent antiviral activities against severe acute respiratory syndrome coronavirus. J Med Chem. 2007 Aug 23; 50(17):4087-95. PMID: 17663539.
      Citations: 160     Fields:    Translation:AnimalsCells
    21. Lu IL, Mahindroo N, Liang PH, Peng YH, Kuo CJ, Tsai KC, Hsieh HP, Chao YS, Wu SY. Structure-based drug design and structural biology study of novel nonpeptide inhibitors of severe acute respiratory syndrome coronavirus main protease. J Med Chem. 2006 Aug 24; 49(17):5154-61. PMID: 16913704.
      Citations: 38     Fields:    Translation:Cells
    22. Tsai KC, Chen SY, Liang PH, Lu IL, Mahindroo N, Hsieh HP, Chao YS, Liu L, Liu D, Lien W, Lin TH, Wu SY. Discovery of a novel family of SARS-CoV protease inhibitors by virtual screening and 3D-QSAR studies. J Med Chem. 2006 Jun 15; 49(12):3485-95. PMID: 16759091.
      Citations: 13     Fields:    Translation:Cells
    23. Wu CY, King KY, Kuo CJ, Fang JM, Wu YT, Ho MY, Liao CL, Shie JJ, Liang PH, Wong CH. Stable benzotriazole esters as mechanism-based inactivators of the severe acute respiratory syndrome 3CL protease. Chem Biol. 2006 Mar; 13(3):261-8. PMID: 16638531.
      Citations: 39     Fields:    Translation:HumansCells
    24. Liang PH. Characterization and inhibition of SARS-coronavirus main protease. Curr Top Med Chem. 2006; 6(4):361-76. PMID: 16611148.
      Citations: 34     Fields:    Translation:Cells
    25. Shie JJ, Fang JM, Kuo TH, Kuo CJ, Liang PH, Huang HJ, Wu YT, Jan JT, Cheng YS, Wong CH. Inhibition of the severe acute respiratory syndrome 3CL protease by peptidomimetic alpha,beta-unsaturated esters. Bioorg Med Chem. 2005 Sep 01; 13(17):5240-52. PMID: 15994085.
      Citations: 48     Fields:    Translation:AnimalsCells
    26. Shie JJ, Fang JM, Kuo CJ, Kuo TH, Liang PH, Huang HJ, Yang WB, Lin CH, Chen JL, Wu YT, Wong CH. Discovery of potent anilide inhibitors against the severe acute respiratory syndrome 3CL protease. J Med Chem. 2005 Jun 30; 48(13):4469-73. PMID: 15974598.
      Citations: 37     Fields:    Translation:Cells
    27. Hsu MF, Kuo CJ, Chang KT, Chang HC, Chou CC, Ko TP, Shr HL, Chang GG, Wang AH, Liang PH. Mechanism of the maturation process of SARS-CoV 3CL protease. J Biol Chem. 2005 Sep 02; 280(35):31257-66. PMID: 15788388.
      Citations: 88     Fields:    Translation:HumansCells
    28. Hsu JT, Kuo CJ, Hsieh HP, Wang YC, Huang KK, Lin CP, Huang PF, Chen X, Liang PH. Evaluation of metal-conjugated compounds as inhibitors of 3CL protease of SARS-CoV. FEBS Lett. 2004 Sep 10; 574(1-3):116-20. PMID: 15358550.
      Citations: 36     Fields:    Translation:AnimalsCells
    29. Wu CY, Jan JT, Ma SH, Kuo CJ, Juan HF, Cheng YS, Hsu HH, Huang HC, Wu D, Brik A, Liang FS, Liu RS, Fang JM, Chen ST, Liang PH, Wong CH. Small molecules targeting severe acute respiratory syndrome human coronavirus. Proc Natl Acad Sci U S A. 2004 Jul 06; 101(27):10012-7. PMID: 15226499.
      Citations: 199     Fields:    Translation:AnimalsCells
    30. Kuo CJ, Chi YH, Hsu JT, Liang PH. Characterization of SARS main protease and inhibitor assay using a fluorogenic substrate. Biochem Biophys Res Commun. 2004 Jun 11; 318(4):862-7. PMID: 15147951.
      Citations: 72     Fields:    Translation:Cells