Bruno Canard

InstitutionCNRS and Aix-Marseille Université
AddressMarseille
France
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    Publication Timeline
    COVID-19 publications
    Bar chart showing 13 Covid-19 publications, with a maximum of 2 publications in November 2020 and June 2021
    All Publications
    Bar chart showing 191 publications over 28 distinct years, with a maximum of 21 publications in 2006
    These graphs show COVID-19 publications by month since August 2019 and all publications written by authors of COVID-19 publications over the past 30 years.

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    Publication Field Summary
    This graph shows the number and percent of publications by field. Fields are based on how the National Library of Medicine (NLM) classifies the publications' journals and might not represent the specific topics of the publications. Note that an individual publication can be assigned to more than one field. As a result, the publication counts in this graph might add up to more than the number of publications the person has written. To see the data as text, click here.
    Publication List
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications.
    Sort By:     Newest   |   Oldest   |   Most Cited   |   Most Discussed
    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Bera SC, Seifert M, Kirchdoerfer RN, van Nies P, Wubulikasimu Y, Quack S, Papini FS, Arnold JJ, Canard B, Cameron CE, Depken M, Dulin D. The nucleotide addition cycle of the SARS-CoV-2 polymerase. Cell Rep. 2021 08 31; 36(9):109650. PMID: 34433083.
      Citations: 4     Fields:    Translation:HumansCells
    2. Decroly E, Claverie JM, Canard B. The WHO mission report struggles to trace the origins of the SARS-CoV-2 epidemic. Virologie (Montrouge). 2021 06 01; 25(3):42-46. PMID: 34112630.
      Citations:    Fields:    Translation:HumansPHPublic Health
    3. Decroly E, Claverie JM, Canard B. [The WHO mission report struggles to trace the origins of the SARS-CoV-2 epidemic]. Virologie (Montrouge). 2021 06 01; 25(3):148-152. PMID: 34018943.
      Citations:    Fields:    Translation:HumansPHPublic Health
    4. Lo HS, Hui KPY, Lai HM, He X, Khan KS, Kaur S, Huang J, Li Z, Chan AKN, Cheung HH, Ng KC, Ho JCW, Chen YW, Ma B, Cheung PM, Shin D, Wang K, Lee MH, Selisko B, Eydoux C, Guillemot JC, Canard B, Wu KP, Liang PH, Dikic I, Zuo Z, Chan FKL, Hui DSC, Mok VCT, Wong KB, Mok CKP, Ko H, Aik WS, Chan MCW, Ng WL. Simeprevir Potently Suppresses SARS-CoV-2 Replication and Synergizes with Remdesivir. ACS Cent Sci. 2021 May 26; 7(5):792-802. PMID: 34075346.
      Citations: 8     
    5. Good SS, Westover J, Jung KH, Zhou XJ, Moussa A, La Colla P, Collu G, Canard B, Sommadossi JP. AT-527, a Double Prodrug of a Guanosine Nucleotide Analog, Is a Potent Inhibitor of SARS-CoV-2 In Vitro and a Promising Oral Antiviral for Treatment of COVID-19. Antimicrob Agents Chemother. 2021 03 18; 65(4). PMID: 33558299.
      Citations: 12     Fields:    Translation:HumansAnimalsCells
    6. Bárcena M, Barnes CO, Beck M, Bjorkman PJ, Canard B, Gao GF, Gao Y, Hilgenfeld R, Hummer G, Patwardhan A, Santoni G, Saphire EO, Schaffitzel C, Schendel SL, Smith JL, Thorn A, Veesler D, Zhang P, Zhou Q. Structural biology in the fight against COVID-19. Nat Struct Mol Biol. 2021 01; 28(1):2-7. PMID: 33437043.
      Citations: 3     Fields:    Translation:Humans
    7. Feuillet V, Canard B, Trautmann A. Combining Antivirals and Immunomodulators to Fight COVID-19. Trends Immunol. 2021 01; 42(1):31-44. PMID: 33281063.
      Citations: 7     Fields:    Translation:Humans
    8. Eydoux C, Fattorini V, Shannon A, Le TT, Didier B, Canard B, Guillemot JC. A fluorescence-based high throughput-screening assay for the SARS-CoV RNA synthesis complex. J Virol Methods. 2021 02; 288:114013. PMID: 33166547.
      Citations: 6     Fields:    Translation:HumansCells
    9. Shannon A, Selisko B, Le NT, Huchting J, Touret F, Piorkowski G, Fattorini V, Ferron F, Decroly E, Meier C, Coutard B, Peersen O, Canard B. Rapid incorporation of Favipiravir by the fast and permissive viral RNA polymerase complex results in SARS-CoV-2 lethal mutagenesis. Nat Commun. 2020 09 17; 11(1):4682. PMID: 32943628.
      Citations: 54     Fields:    Translation:AnimalsCellsPHPublic Health
    10. Valle C, Martin B, Touret F, Shannon A, Canard B, Guillemot JC, Coutard B, Decroly E. Drugs against SARS-CoV-2: What do we know about their mode of action? Rev Med Virol. 2020 11; 30(6):1-10. PMID: 32779326.
      Citations: 14     Fields:    Translation:Humans
    11. Ahmed-Belkacem R, Sutto-Ortiz P, Guiraud M, Canard B, Vasseur JJ, Decroly E, Debart F. Synthesis of adenine dinucleosides SAM analogs as specific inhibitors of SARS-CoV nsp14 RNA cap guanine-N7-methyltransferase. Eur J Med Chem. 2020 Sep 01; 201:112557. PMID: 32563813.
      Citations: 14     Fields:    Translation:HumansCellsPHPublic Health
    12. Shannon A, Le NT, Selisko B, Eydoux C, Alvarez K, Guillemot JC, Decroly E, Peersen O, Ferron F, Canard B. Remdesivir and SARS-CoV-2: Structural requirements at both nsp12 RdRp and nsp14 Exonuclease active-sites. Antiviral Res. 2020 06; 178:104793. PMID: 32283108.
      Citations: 121     Fields:    Translation:HumansCellsPHPublic Health
    13. Coutard B, Coutard B, Valle C, de Lamballerie X, de Lamballerie X, Canard B, Seidah NG, Decroly E. The spike glycoprotein of the new coronavirus 2019-nCoV contains a furin-like cleavage site absent in CoV of the same clade. Antiviral Res. 2020 04; 176:104742. PMID: 32057769.
      Citations: 607     Fields:    Translation:Cells
    14. Ogando NS, Ferron F, Decroly E, Canard B, Posthuma CC, Snijder EJ. The Curious Case of the Nidovirus Exoribonuclease: Its Role in RNA Synthesis and Replication Fidelity. Front Microbiol. 2019; 10:1813. PMID: 31440227.
      Citations: 45     
    15. Nguyen THV, Lichière J, Canard B, Papageorgiou N, Attoumani S, Ferron F, Coutard B. Structure and oligomerization state of the C-terminal region of the Middle East respiratory syndrome coronavirus nucleoprotein. Acta Crystallogr D Struct Biol. 2019 Jan 01; 75(Pt 1):8-15. PMID: 30644840.
      Citations: 14     Translation:HumansCells
    16. Ferron F, Subissi L, Silveira De Morais AT, Le NTT, Sevajol M, Gluais L, Decroly E, Vonrhein C, Bricogne G, Canard B, Imbert I. Structural and molecular basis of mismatch correction and ribavirin excision from coronavirus RNA. Proc Natl Acad Sci U S A. 2018 01 09; 115(2):E162-E171. PMID: 29279395.
      Citations: 131     Fields:    Translation:HumansCells
    17. Aouadi W, Eydoux C, Coutard B, Martin B, Debart F, Vasseur JJ, Contreras JM, Morice C, Quérat G, Jung ML, Canard B, Guillemot JC, Decroly E. Toward the identification of viral cap-methyltransferase inhibitors by fluorescence screening assay. Antiviral Res. 2017 08; 144:330-339. PMID: 28676301.
      Citations: 11     Fields:    Translation:HumansCells
    18. Aouadi W, Blanjoie A, Vasseur JJ, Debart F, Canard B, Decroly E. Binding of the Methyl Donor S-Adenosyl-l-Methionine to Middle East Respiratory Syndrome Coronavirus 2'-O-Methyltransferase nsp16 Promotes Recruitment of the Allosteric Activator nsp10. J Virol. 2017 03 01; 91(5). PMID: 28031370.
      Citations: 28     Fields:    Translation:Cells
    19. Li C, Debing Y, Jankevicius G, Neyts J, Ahel I, Coutard B, Canard B. Viral Macro Domains Reverse Protein ADP-Ribosylation. J Virol. 2016 10 01; 90(19):8478-86. PMID: 27440879.
      Citations: 66     Fields:    Translation:HumansCells
    20. Papageorgiou N, Lichière J, Baklouti A, Ferron F, Sévajol M, Canard B, Coutard B. Structural characterization of the N-terminal part of the MERS-CoV nucleocapsid by X-ray diffraction and small-angle X-ray scattering. Acta Crystallogr D Struct Biol. 2016 Feb; 72(Pt 2):192-202. PMID: 26894667.
      Citations: 13     Translation:Cells
    21. Sevajol M, Subissi L, Decroly E, Canard B, Imbert I. Insights into RNA synthesis, capping, and proofreading mechanisms of SARS-coronavirus. Virus Res. 2014 Dec 19; 194:90-9. PMID: 25451065.
      Citations: 76     Fields:    Translation:Cells
    22. Subissi L, Posthuma CC, Collet A, Zevenhoven-Dobbe JC, Gorbalenya AE, Decroly E, Snijder EJ, Canard B, Imbert I. One severe acute respiratory syndrome coronavirus protein complex integrates processive RNA polymerase and exonuclease activities. Proc Natl Acad Sci U S A. 2014 Sep 16; 111(37):E3900-9. PMID: 25197083.
      Citations: 198     Fields:    Translation:HumansCells
    23. Bouvet M, Lugari A, Posthuma CC, Zevenhoven JC, Bernard S, Betzi S, Imbert I, Canard B, Guillemot JC, Lécine P, Pfefferle S, Drosten C, Snijder EJ, Decroly E, Morelli X. Coronavirus Nsp10, a critical co-factor for activation of multiple replicative enzymes. J Biol Chem. 2014 Sep 12; 289(37):25783-96. PMID: 25074927.
      Citations: 66     Fields:    Translation:HumansCells
    24. Subissi L, Imbert I, Ferron F, Collet A, Coutard B, Decroly E, Canard B. SARS-CoV ORF1b-encoded nonstructural proteins 12-16: replicative enzymes as antiviral targets. Antiviral Res. 2014 Jan; 101:122-30. PMID: 24269475.
      Citations: 56     Fields:    Translation:HumansCells
    25. Bouvet M, Imbert I, Ferron F, Canard B, Decroly E. Structures and exoribonuclease activity fonctions in arenavirus and coronavirus. Virologie (Montrouge). 2013 Oct 01; 17(5):317-330. PMID: 31910588.
      Citations:    Fields:    
    26. Bouvet M, Imbert I, Subissi L, Gluais L, Canard B, Decroly E. RNA 3'-end mismatch excision by the severe acute respiratory syndrome coronavirus nonstructural protein nsp10/nsp14 exoribonuclease complex. Proc Natl Acad Sci U S A. 2012 Jun 12; 109(24):9372-7. PMID: 22635272.
      Citations: 116     Fields:    Translation:Cells
    27. Decroly E, Debarnot C, Ferron F, Bouvet M, Coutard B, Imbert I, Gluais L, Papageorgiou N, Sharff A, Bricogne G, Ortiz-Lombardia M, Lescar J, Canard B. Crystal structure and functional analysis of the SARS-coronavirus RNA cap 2'-O-methyltransferase nsp10/nsp16 complex. PLoS Pathog. 2011 May; 7(5):e1002059. PMID: 21637813.
      Citations: 142     Fields:    Translation:Cells
    28. Debarnot C, Imbert I, Ferron F, Gluais L, Varlet I, Papageorgiou N, Bouvet M, Lescar J, Decroly E, Canard B. Crystallization and diffraction analysis of the SARS coronavirus nsp10-nsp16 complex. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2011 Mar 01; 67(Pt 3):404-8. PMID: 21393853.
      Citations: 12     Fields:    Translation:HumansCells
    29. Lugari A, Betzi S, Decroly E, Bonnaud E, Hermant A, Guillemot JC, Debarnot C, Borg JP, Bouvet M, Canard B, Morelli X, Lécine P. Molecular mapping of the RNA Cap 2'-O-methyltransferase activation interface between severe acute respiratory syndrome coronavirus nsp10 and nsp16. J Biol Chem. 2010 Oct 22; 285(43):33230-33241. PMID: 20699222.
      Citations: 32     Fields:    Translation:HumansCells
    30. Bouvet M, Debarnot C, Imbert I, Selisko B, Snijder EJ, Canard B, Decroly E. In vitro reconstitution of SARS-coronavirus mRNA cap methylation. PLoS Pathog. 2010 Apr 22; 6(4):e1000863. PMID: 20421945.
      Citations: 145     Fields:    Translation:Cells
    31. Decroly E, Imbert I, Coutard B, Bouvet M, Selisko B, Alvarez K, Gorbalenya AE, Snijder EJ, Canard B. Coronavirus nonstructural protein 16 is a cap-0 binding enzyme possessing (nucleoside-2'O)-methyltransferase activity. J Virol. 2008 Aug; 82(16):8071-84. PMID: 18417574.
      Citations: 121     Fields:    Translation:AnimalsCells
    32. Imbert I, Snijder EJ, Dimitrova M, Guillemot JC, Lécine P, Canard B. The SARS-Coronavirus PLnc domain of nsp3 as a replication/transcription scaffolding protein. Virus Res. 2008 May; 133(2):136-48. PMID: 18255185.
      Citations: 70     Fields:    Translation:HumansAnimalsCells
    33. Canard B, Joseph JS, Kuhn P. International research networks in viral structural proteomics: again, lessons from SARS. Antiviral Res. 2008 Apr; 78(1):47-50. PMID: 18054092.
      Citations: 2     Fields:    Translation:HumansCells
    34. Beerens N, Selisko B, Ricagno S, Imbert I, van der Zanden L, Snijder EJ, Canard B. De novo initiation of RNA synthesis by the arterivirus RNA-dependent RNA polymerase. J Virol. 2007 Aug; 81(16):8384-95. PMID: 17537850.
      Citations: 34     Fields:    Translation:Cells
    35. Imbert I, Guillemot JC, Bourhis JM, Bussetta C, Coutard B, Egloff MP, Ferron F, Gorbalenya AE, Canard B. A second, non-canonical RNA-dependent RNA polymerase in SARS coronavirus. EMBO J. 2006 Oct 18; 25(20):4933-42. PMID: 17024178.
      Citations: 133     Fields:    Translation:Cells
    36. Egloff MP, Malet H, Putics A, Heinonen M, Dutartre H, Frangeul A, Gruez A, Campanacci V, Cambillau C, Ziebuhr J, Ahola T, Canard B. Structural and functional basis for ADP-ribose and poly(ADP-ribose) binding by viral macro domains. J Virol. 2006 Sep; 80(17):8493-502. PMID: 16912299.
      Citations: 128     Fields:    Translation:Cells
    37. Ricagno S, Egloff MP, Ulferts R, Coutard B, Nurizzo D, Campanacci V, Cambillau C, Ziebuhr J, Canard B. Crystal structure and mechanistic determinants of SARS coronavirus nonstructural protein 15 define an endoribonuclease family. Proc Natl Acad Sci U S A. 2006 Aug 08; 103(32):11892-7. PMID: 16882730.
      Citations: 94     Fields:    Translation:Cells
    38. Matthes N, Mesters JR, Coutard B, Canard B, Snijder EJ, Moll R, Hilgenfeld R. The non-structural protein Nsp10 of mouse hepatitis virus binds zinc ions and nucleic acids. FEBS Lett. 2006 Jul 24; 580(17):4143-9. PMID: 16828088.
      Citations: 21     Fields:    Translation:Cells
    39. Malet H, Dalle K, Brémond N, Tocque F, Blangy S, Campanacci V, Coutard B, Grisel S, Lichière J, Lantez V, Cambillau C, Canard B, Egloff MP. Expression, purification and crystallization of the SARS-CoV macro domain. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2006 Apr 01; 62(Pt 4):405-8. PMID: 16582497.
      Citations: 6     Fields:    Translation:Cells
    40. Ricagno S, Coutard B, Grisel S, Brémond N, Dalle K, Tocque F, Campanacci V, Lichière J, Lantez V, Debarnot C, Cambillau C, Canard B, Egloff MP. Crystallization and preliminary X-ray diffraction analysis of Nsp15 from SARS coronavirus. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2006 Apr 01; 62(Pt 4):409-11. PMID: 16582498.
      Citations: 6     Fields:    Translation:Cells
    41. Minskaia E, Hertzig T, Gorbalenya AE, Campanacci V, Cambillau C, Canard B, Ziebuhr J. Discovery of an RNA virus 3'->5' exoribonuclease that is critically involved in coronavirus RNA synthesis. Proc Natl Acad Sci U S A. 2006 Mar 28; 103(13):5108-13. PMID: 16549795.
      Citations: 253     Fields:    Translation:Cells
    42. Egloff MP, Ferron F, Campanacci V, Longhi S, Rancurel C, Dutartre H, Snijder EJ, Gorbalenya AE, Cambillau C, Canard B. The severe acute respiratory syndrome-coronavirus replicative protein nsp9 is a single-stranded RNA-binding subunit unique in the RNA virus world. Proc Natl Acad Sci U S A. 2004 Mar 16; 101(11):3792-6. PMID: 15007178.
      Citations: 110     Fields:    Translation:Cells
    43. Campanacci V, Egloff MP, Longhi S, Ferron F, Rancurel C, Salomoni A, Durousseau C, Tocque F, Brémond N, Dobbe JC, Snijder EJ, Canard B, Cambillau C. Structural genomics of the SARS coronavirus: cloning, expression, crystallization and preliminary crystallographic study of the Nsp9 protein. Acta Crystallogr D Biol Crystallogr. 2003 Sep; 59(Pt 9):1628-31. PMID: 12925794.
      Citations: 18     Fields:    Translation:Cells
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