Johan Neyts to Antiviral Agents
This is a "connection" page, showing publications Johan Neyts has written about Antiviral Agents.
Connection Strength
1.388
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PI4KIII inhibitor enviroxime impedes the replication of the hepatitis C virus by inhibiting PI3 kinases. J Antimicrob Chemother. 2018 12 01; 73(12):3375-3384.
Score: 0.074
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Favipiravir as a potential countermeasure against neglected and emerging RNA viruses. Antiviral Res. 2018 05; 153:85-94.
Score: 0.070
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The path towards effective antivirals against rabies. Vaccine. 2019 08 02; 37(33):4660-4662.
Score: 0.069
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Rational design of antiviral drug combinations based on equipotency using HCV subgenomic replicon as an in vitro model. Antiviral Res. 2018 01; 149:150-153.
Score: 0.068
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Replication of the Zika virus in different iPSC-derived neuronal cells and implications to assess efficacy of antivirals. Antiviral Res. 2017 Sep; 145:82-86.
Score: 0.067
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A novel method for high-throughput screening to quantify antiviral activity against viruses that induce limited CPE. J Virol Methods. 2012 Aug; 183(2):176-9.
Score: 0.047
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Molecular strategies to inhibit the replication of RNA viruses. Antiviral Res. 2008 Apr; 78(1):9-25.
Score: 0.035
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The predominant mechanism by which ribavirin exerts its antiviral activity in vitro against flaviviruses and paramyxoviruses is mediated by inhibition of IMP dehydrogenase. J Virol. 2005 Feb; 79(3):1943-7.
Score: 0.028
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Molnupiravir Inhibits Replication of the Emerging SARS-CoV-2 Variants of Concern in a Hamster Infection Model. J Infect Dis. 2021 09 01; 224(5):749-753.
Score: 0.022
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Identification and evaluation of potential SARS-CoV-2 antiviral agents targeting mRNA cap guanine N7-Methyltransferase. Antiviral Res. 2021 09; 193:105142.
Score: 0.022
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In vitro activity of itraconazole against SARS-CoV-2. J Med Virol. 2021 Jul; 93(7):4454-4460.
Score: 0.022
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Broad spectrum anti-coronavirus activity of a series of anti-malaria quinoline analogues. Antiviral Res. 2021 09; 193:105127.
Score: 0.022
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A robust SARS-CoV-2 replication model in primary human epithelial cells at the air liquid interface to assess antiviral agents. Antiviral Res. 2021 08; 192:105122.
Score: 0.022
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1,2,4-Triazolo[1,5-a]pyrimidines: Efficient one-step synthesis and functionalization as influenza polymerase PA-PB1 interaction disruptors. Eur J Med Chem. 2021 Oct 05; 221:113494.
Score: 0.022
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Itraconazole for COVID-19: preclinical studies and a proof-of-concept randomized clinical trial. EBioMedicine. 2021 Apr; 66:103288.
Score: 0.022
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SARS-CoV-2 Mpro inhibitors and activity-based probes for patient-sample imaging. Nat Chem Biol. 2021 02; 17(2):222-228.
Score: 0.021
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Favipiravir at high doses has potent antiviral activity in SARS-CoV-2-infected hamsters, whereas hydroxychloroquine lacks activity. Proc Natl Acad Sci U S A. 2020 10 27; 117(43):26955-26965.
Score: 0.021
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Evaluation of SARS-CoV-2 3C-like protease inhibitors using self-assembled monolayer desorption ionization mass spectrometry. Antiviral Res. 2020 10; 182:104924.
Score: 0.021
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Emerging preclinical evidence does not support broad use of hydroxychloroquine in COVID-19 patients. Nat Commun. 2020 08 26; 11(1):4253.
Score: 0.021
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A prospect on the use of antiviral drugs to control local outbreaks of COVID-19. BMC Med. 2020 06 25; 18(1):191.
Score: 0.021
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Medical treatment options for COVID-19. Eur Heart J Acute Cardiovasc Care. 2020 Apr; 9(3):209-214.
Score: 0.020
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a-Ketoamides as Broad-Spectrum Inhibitors of Coronavirus and Enterovirus Replication: Structure-Based Design, Synthesis, and Activity Assessment. J Med Chem. 2020 05 14; 63(9):4562-4578.
Score: 0.020
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Isolation of phenanthrenes and identification of phorbol ester derivatives as potential anti-CHIKV agents using FBMN and NAP from Sagotia racemosa. Phytochemistry. 2019 Nov; 167:112101.
Score: 0.019
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A Viral Polymerase Inhibitor Reduces Zika Virus Replication in the Reproductive Organs of Male Mice. Int J Mol Sci. 2019 Apr 29; 20(9).
Score: 0.019
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Structural and functional similarities in bunyaviruses: Perspectives for pan-bunya antivirals. Rev Med Virol. 2019 05; 29(3):e2039.
Score: 0.019
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Antiviral Compounds from Codiaeum peltatum Targeted by a Multi-informative Molecular Networks Approach. J Nat Prod. 2019 02 22; 82(2):330-340.
Score: 0.019
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Favipiravir inhibits in vitro Usutu virus replication and delays disease progression in an infection model in mice. Antiviral Res. 2018 12; 160:137-142.
Score: 0.018
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A Single Nucleoside Viral Polymerase Inhibitor Against Norovirus, Rotavirus, and Sapovirus-Induced Diarrhea. J Infect Dis. 2018 10 20; 218(11):1753-1758.
Score: 0.018
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Discovery of Indole Derivatives as Novel and Potent Dengue Virus Inhibitors. J Med Chem. 2018 09 27; 61(18):8390-8401.
Score: 0.018
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Structure-Based Drug Design of Potent Pyrazole Derivatives against Rhinovirus Replication. J Med Chem. 2018 09 27; 61(18):8402-8416.
Score: 0.018
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Antiviral effect of the nucleoside analogue cidofovir in the context of sexual transmission of a gammaherpesvirus in mice. J Antimicrob Chemother. 2018 08 01; 73(8):2095-2103.
Score: 0.018
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Antiplasmodial, anti-chikungunya virus and antioxidant activities of 64 endemic plants from the Mascarene Islands. Int J Antimicrob Agents. 2018 Nov; 52(5):622-628.
Score: 0.018
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Identification of fukinolic acid from Cimicifuga heracleifolia and its derivatives as novel antiviral compounds against enterovirus A71 infection. Int J Antimicrob Agents. 2019 Feb; 53(2):128-136.
Score: 0.018
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Identification of Broad-Spectrum Dengue/Zika Virus Replication Inhibitors by Functionalization of Quinoline and 2,6-Diaminopurine Scaffolds. ChemMedChem. 2018 07 18; 13(14):1371-1376.
Score: 0.018
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Rational modifications on a benzylidene-acrylohydrazide antiviral scaffold, synthesis and evaluation of bioactivity against Chikungunya virus. Eur J Med Chem. 2018 Apr 10; 149:56-68.
Score: 0.017
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Inhibition of the Replication of Different Strains of Chikungunya Virus by 3-Aryl-[1,2,3]triazolo[4,5- d]pyrimidin-7(6 H)-ones. ACS Infect Dis. 2018 04 13; 4(4):605-619.
Score: 0.017
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Pan-NS3 protease inhibitors of hepatitis C virus based on an R3-elongated pyrazinone scaffold. Eur J Med Chem. 2018 Mar 25; 148:453-464.
Score: 0.017
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Design, synthesis and evaluation against Chikungunya virus of novel small-molecule antiviral agents. Bioorg Med Chem. 2018 02 15; 26(4):869-874.
Score: 0.017
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Intracellular metabolism of the N7-substituted acyclic nucleoside analog 2-amino-7-(1,3-dihydroxy-2-propoxymethyl)purine, a potent inhibitor of herpesvirus replication. Mol Pharmacol. 1998 Jan; 53(1):157-65.
Score: 0.017
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Antiviral treatment efficiently inhibits chikungunya virus infection in the joints of mice during the acute but not during the chronic phase of the infection. Antiviral Res. 2018 01; 149:113-117.
Score: 0.017
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Heterocyclic pharmacochemistry of new rhinovirus antiviral agents: A combined computational and experimental study. Eur J Med Chem. 2017 Nov 10; 140:528-541.
Score: 0.017
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Fluorination of Naturally Occurring N6-Benzyladenosine Remarkably Increased Its Antiviral Activity and Selectivity. Molecules. 2017 Jul 20; 22(7).
Score: 0.017
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Isolation of Premyrsinane, Myrsinane, and Tigliane Diterpenoids from Euphorbia pithyusa Using a Chikungunya Virus Cell-Based Assay and Analogue Annotation by Molecular Networking. J Nat Prod. 2017 07 28; 80(7):2051-2059.
Score: 0.017
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A Novel Series of Highly Potent Small Molecule Inhibitors of Rhinovirus Replication. J Med Chem. 2017 07 13; 60(13):5472-5492.
Score: 0.017
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Antiviral activity of [1,2,3]triazolo[4,5-d]pyrimidin-7(6H)-ones against chikungunya virus targeting the viral capping nsP1. Antiviral Res. 2017 08; 144:216-222.
Score: 0.017
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Understanding the Mechanism of the Broad-Spectrum Antiviral Activity of Favipiravir (T-705): Key Role of the F1 Motif of the Viral Polymerase. J Virol. 2017 06 15; 91(12).
Score: 0.017
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Chikungunya virus infections: time to act, time to treat. Curr Opin Virol. 2017 06; 24:25-30.
Score: 0.016
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Discovery of Multitarget Agents Active as Broad-Spectrum Antivirals and Correctors of Cystic Fibrosis Transmembrane Conductance Regulator for Associated Pulmonary Diseases. J Med Chem. 2017 02 23; 60(4):1400-1416.
Score: 0.016
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Uncovering oxysterol-binding protein (OSBP) as a target of the anti-enteroviral compound TTP-8307. Antiviral Res. 2017 04; 140:37-44.
Score: 0.016
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Biological or pharmacological activation of protein kinase C alpha constrains hepatitis E virus replication. Antiviral Res. 2017 04; 140:1-12.
Score: 0.016
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Shape-based virtual screening, synthesis and evaluation of novel pyrrolone derivatives as antiviral agents against HCV. Bioorg Med Chem Lett. 2017 02 15; 27(4):936-940.
Score: 0.016
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Structure-activity relationship studies on a Trp dendrimer with dual activities against HIV and enterovirus A71. Modifications on the amino acid. Antiviral Res. 2017 Mar; 139:32-40.
Score: 0.016
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Sofosbuvir Inhibits Hepatitis E Virus Replication In Vitro and Results in an Additive Effect When Combined With Ribavirin. Gastroenterology. 2016 Jan; 150(1):82-85.e4.
Score: 0.015
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Design, synthesis and evaluation of a series of acyclic fleximer nucleoside analogues with anti-coronavirus activity. Bioorg Med Chem Lett. 2015 Aug 01; 25(15):2923-6.
Score: 0.014
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The RNA template channel of the RNA-dependent RNA polymerase as a target for development of antiviral therapy of multiple genera within a virus family. PLoS Pathog. 2015 Mar; 11(3):e1004733.
Score: 0.014
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Screening of an FDA-approved compound library identifies four small-molecule inhibitors of Middle East respiratory syndrome coronavirus replication in cell culture. Antimicrob Agents Chemother. 2014 Aug; 58(8):4875-84.
Score: 0.013
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Acyclic nucleoside thiophosphonates as potent inhibitors of HIV and HBV replication. Eur J Med Chem. 2011 Sep; 46(9):4281-8.
Score: 0.011
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Inhibition of hepatitis C virus replication by semi-synthetic derivatives of glycopeptide antibiotics. J Antimicrob Chemother. 2011 Jun; 66(6):1287-94.
Score: 0.011
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3'-Deoxy phosphoramidate dinucleosides as improved inhibitors of hepatitis C virus subgenomic replicon and NS5B polymerase activity. J Med Chem. 2010 Sep 23; 53(18):6608-17.
Score: 0.010
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Synthesis of 6-arylthio analogs of 2',3'-dideoxy-3'-fluoroguanosine and their effect against hepatitis B virus replication. Nucleosides Nucleotides Nucleic Acids. 2006; 25(4-6):655-65.
Score: 0.008
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Antiviral activity of ganciclovir elaidic acid ester against herpesviruses. Antiviral Res. 2000 Mar; 45(3):157-67.
Score: 0.005
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Structurally Diverse Diterpenoids from Sandwithia guyanensis. J Nat Prod. 2018 04 27; 81(4):901-912.
Score: 0.004
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New class of early-stage enterovirus inhibitors with a novel mechanism of action. Antiviral Res. 2017 Nov; 147:67-74.
Score: 0.004
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In vitro inhibition of severe acute respiratory syndrome coronavirus by chloroquine. Biochem Biophys Res Commun. 2004 Oct 08; 323(1):264-8.
Score: 0.002