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An engineered CRISPR-Cas12a variant and DNA-RNA hybrid guides enable robust and rapid COVID-19 testing.
An engineered CRISPR-Cas12a variant and DNA-RNA hybrid guides enable robust and rapid COVID-19 testing. Nat Commun. 2021 03 19; 12(1):1739.
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PubMed
subject areas
Bacterial Proteins
Clustered Regularly Interspaced Short Palindromic Repeats
CRISPR-Associated Proteins
CRISPR-Cas Systems
Endodeoxyribonucleases
Humans
Molecular Diagnostic Techniques
Mutation
Nasopharynx
Nucleic Acid Amplification Techniques
RNA, Guide
RNA, Viral
Sensitivity and Specificity
authors with profiles
Sebastian Maurer-Stroh
Benedict Yan
Mengying Mandy Liu
Weisi Lin
Jingwen Hou
Gabriel Yan
Shengyang Jin
Pornchai Kaewsapsak
Meng How Tan
Kean Hean Ooi
Chun Kiat Lee
Seok Yee Teo
Yong-Gui Gao
Jie Wen Douglas Tay