Wei Wang to Structure-Activity Relationship
This is a "connection" page, showing publications Wei Wang has written about Structure-Activity Relationship.
Connection Strength
0.603
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Isolation of Tricin as a Xanthine Oxidase Inhibitor from Sweet White Clover (Melilotus albus) and Its Distribution in Selected Gramineae Species. Molecules. 2018 Oct 22; 23(10).
Score: 0.115
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Synthesis and biological evaluation of 2,4-disubstituted phthalazinones as Aurora kinase inhibitors. Bioorg Med Chem. 2018 07 23; 26(12):3217-3226.
Score: 0.111
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Discovery of ( E)- N1-(3-Fluorophenyl)- N3-(3-(2-(pyridin-2-yl)vinyl)-1 H-indazol-6-yl)malonamide (CHMFL-KIT-033) as a Novel c-KIT T670I Mutant Selective Kinase Inhibitor for Gastrointestinal Stromal Tumors (GISTs). J Med Chem. 2019 05 23; 62(10):5006-5024.
Score: 0.030
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2'O-galloylhyperin attenuates LPS-induced acute lung injury via up-regulation antioxidation and inhibition of inflammatory responses in vivo. Chem Biol Interact. 2019 May 01; 304:20-27.
Score: 0.029
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Design and preparation of derivatives of oleanolic and glycyrrhetinic acids with cytotoxic properties. Drug Des Devel Ther. 2018; 12:1321-1336.
Score: 0.028
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Discovery of 4-((N-(2-(dimethylamino)ethyl)acrylamido)methyl)-N-(4-methyl-3-((4-(pyridin-3-yl)pyrimidin-2-yl)amino)phenyl)benzamide (CHMFL-PDGFR-159) as a highly selective type II PDGFRa kinase inhibitor for PDGFRa driving chronic eosinophilic leukemia. Eur J Med Chem. 2018 Apr 25; 150:366-384.
Score: 0.028
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Design, synthesis and biological evaluation of novel 4-aminoquinazolines as dual target inhibitors of EGFR-PI3Ka. Eur J Med Chem. 2018 Feb 25; 146:460-470.
Score: 0.027
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Synthesis of new sarsasapogenin derivatives with antiproliferative and apoptotic effects in MCF-7 cells. Steroids. 2018 03; 131:23-31.
Score: 0.027
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Discovery of IDO1 and DNA dual targeting antitumor agents. Org Biomol Chem. 2017 Dec 06; 15(47):9992-9995.
Score: 0.027
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Discovery of N-(5-((5-chloro-4-((2-(isopropylsulfonyl)phenyl)amino)pyrimidin-2-yl)amino)-4-methoxy-2-(4-methyl-1,4-diazepan-1-yl)phenyl)acrylamide (CHMFL-ALK/EGFR-050) as a potent ALK/EGFR dual kinase inhibitor capable of overcoming a variety of ALK/EGFR associated drug resistant mutants in NSCLC. Eur J Med Chem. 2017 Oct 20; 139:674-697.
Score: 0.026
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Autotransporter domain-dependent enzymatic analysis of a novel extremely thermostable carboxylesterase with high biodegradability towards pyrethroid pesticides. Sci Rep. 2017 06 14; 7(1):3461.
Score: 0.026
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Structure-activity relationship investigation for benzonaphthyridinone derivatives as novel potent Bruton's tyrosine kinase (BTK) irreversible inhibitors. Eur J Med Chem. 2017 Sep 08; 137:545-557.
Score: 0.026
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Novel natural product therapeutics targeting both inflammation and cancer. Chin J Nat Med. 2017 Jun; 15(6):401-416.
Score: 0.026
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Discovery of N-(3-(5-((3-acrylamido-4-(morpholine-4-carbonyl)phenyl)amino)-1-methyl-6-oxo-1,6-dihydropyridin-3-yl)-2-methylphenyl)-4-(tert-butyl)benzamide (CHMFL-BTK-01) as a highly selective irreversible Bruton's tyrosine kinase (BTK) inhibitor. Eur J Med Chem. 2017 May 05; 131:107-125.
Score: 0.026
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Design and Synthesis of New Anticancer Glycyrrhetinic Acids and Oleanolic Acids. Biol Pharm Bull. 2017; 40(5):703-710.
Score: 0.025
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Stilbene Glucoside, a Putative Sleep Promoting Constituent from Polygonum multiflorum Affects Sleep Homeostasis by Affecting the Activities of Lactate Dehydrogenase and Salivary Alpha Amylase. Chem Pharm Bull (Tokyo). 2017; 65(11):1011-1019.
Score: 0.025