"Anoctamins" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A family of transmembrane proteins that function primarily as calcium-activated chloride channels. Structurally, they form a homodimer where each subunit consists of eight transmembrane helices with the N and C terminals exposed to the cytosol. The regions between helices 5 and 7 may be important for ion pore formation and calcium ion binding.
| Descriptor ID |
D000075368
|
| MeSH Number(s) |
D12.776.157.530.400.175.032 D12.776.543.550.450.175.032 D12.776.543.585.400.175.032
|
| Concept/Terms |
Anoctamins- Anoctamins
- Anoctamin
- TMEM16 Protein Family
- Protein Family, TMEM16
- TMEM16 Proteins
|
Below are MeSH descriptors whose meaning is more general than "Anoctamins".
Below are MeSH descriptors whose meaning is more specific than "Anoctamins".
This graph shows the total number of publications written about "Anoctamins" by people in this website by year, and whether "Anoctamins" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2017 | 1 | 1 | 2 |
| 2021 | 1 | 0 | 1 |
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Below are the most recent publications written about "Anoctamins" by people in Profiles.
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Drugs that inhibit TMEM16 proteins block SARS-CoV-2 spike-induced syncytia. Nature. 2021 06; 594(7861):88-93.
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Hyperckemia and myalgia are common presentations of anoctamin-5-related myopathy in French patients. Muscle Nerve. 2017 Dec; 56(6):1096-1100.
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6q12 and 11p14 variants are associated with postnatal exhaled nitric oxide levels and respiratory symptoms. J Allergy Clin Immunol. 2017 Oct; 140(4):1015-1023.